<human>:  What is the biggest difference between velcro and zippers?
<bot>: The biggest difference between velcro and zippers is that velcro uses a hook-and-loop type fastening system, while zippers use teeth fused together to form a secure, sliding closure. Velcro is considered a more user-friendly option, since it doesn't require as much precision and strength as a zipper does to open and close.