<human>:  What is the best way to drive from Seattle to San Francisco?
<bot>: The best way to drive from Seattle to San Francisco is by taking Interstate 5 (I-5) south all the way to California. It is the most direct route, spanning about 800 miles and taking about 12 hours of non-stop driving to complete the trip. To break up the long drive, consider making stops in Portland, Oregon and Redding, California, both of which are about halfway between Seattle and San Francisco.