<human>:  What are the major symptoms and treatments of depression?
<bot>: Major symptoms of depression include feelings of sadness, hopelessness, loss of interest in activities that are usually enjoyable, decreased energy, difficulty concentrating, feelings of guilt or worthlessness, changes in appetite and/or sleeping patterns, and thoughts of death/suicide. Treatment for depression typically includes a combination of medication, psychotherapy, and lifestyle changes. Psychotherapy might involve cognitive behavioral therapy, interpersonal therapy, and/or problem-solving therapy, while lifestyle changes may include improving physical activity and nutrition, and addressing social activities, stress, and leisure activities.