<human>:  What could be the risk factors involved in long-term marijuana use?
<bot>: Risk factors associated with long-term marijuana use include increased risk of mental health issues such as depression, anxiety and psychosis, increased risk of respiratory problems from smoking, increased risk of addiction or dependence, increased risk of declines in cognitive and memory functions, increased risk of developing chronic and debilitating physical health conditions such as cardiovascular disease, weakened immune system, and reduced educational and career achievement.