<human>: He literally smells worse than anyone I have ever smelled before, and it's getting worse. He never bathes or washes his clothes.

I've looked up info about confronting someone about this, and most of it is along the lines that you have to be very direct, which I think is probably true. But he is EXTREMELY depressed, has anxiety, and very low self esteem. I'm kind of afraid that saying something to him could cause a meltdown or something, but it's getting to the point where I feel I have no choice. My furniture and even my pets sometimes smell like body odor and filth when he leaves my house.

Provide a brief overview of the text.
<bot>: Friend with depression, low self esteem, and anxiety won't bathe, smells terrible, how do I tell him without causing a breakdown?