<human>:  What effects can prolonged stress have on health?
<bot>: Prolonged stress can have a major negative effect on both physical and mental health. It can lead to a weakened immune system, increased risk of heart disease, high blood pressure, insomnia, depression and anxiety. It can also contribute to behavioral changes such as overeating or undereating, substance abuse, and social withdrawal. Long-term stress can also cause permanent damage to certain parts of the brain, impairing memory and decision making.