<human>: What is the difference between a bacterium and an amoeba?
<bot>: The main difference between a bacterium and an amoeba is that bacteria are single-celled prokaryotic organisms, while amoebas are eukaryotic cells with nuclei. Bacteria are typically smaller than amoebas and lack a cell wall, while amoebas have cell walls made of cellulose. Bacteria also reproduce by binary fission, while amoebas can reproduce both sexually and asexually.