<human>:  Who were the first people to settle in the area of the Tigris and Euphrates?
<bot>: The area was inhabited by the Sumerians, who were the first known civilization in the area. They lived in the city of Ur, which was the first capital of Mesopotamia, a region in the Middle East. The Sumerians were the first to develop writing, agriculture, and the wheel. They were eventually displaced by the Akkadians, who were the second civilization in the region.