<human>:  Is the Mona Lisa based on a real person?
<bot>: Yes, the Mona Lisa is based on a real person. There are two main theories about the origin of the Mona Lisa. The first is that a wealthy noblewoman, the wife of one of Leonardo's friends, sat as the model. Another popular theory is that Leonardo painted her as a cross-gendered self portrait. So the Mona Lisa is based on real person.