<human>:  What is the best way to prune a rose bush?
<bot>: The best way to prune a rose bush is to cut it back selectively, removing dead or diseased wood, and cutting the stems of healthy, vigorous growth back to the desired size and shape. After pruning, make sure to fertilize the plant to help the new growth. Additionally, consider using mulch or compost around the bush to protect the roots and to maintain moisture levels.