<human>: Can you provide a brief rundown of the text in within 3 sentences?

Factors....
We just had twins(1st two) and we are considering having a 3rd in a few years. We are both 30 years old and we have $140K in our 401K plan(this money is seperate from the money below). 
We have around $265k of which (125K is cash)/(140k is aprox equity in our current home)
My wife is going to quit her job and stay at home so that leaves us with just my salary of $50k...

so we are looking at a $300k house, but I am not sure what is the best way to do this. Do I put 200k down and hold a 100k mortgage with payments that dont put us in the red every month. Or do I just do a standard 20% down and invest a bunch of the cash, and probably run in the red every month? 
 
Important side notes...We are very frugal(not cheap) and we have zero debt.
We have an uncle(very rich and very generous) that has given us aprox $95k in 3 checks over the last 3 years. He has not said the checks will stop but he has made no indication that they will continue either. For my purposes I am assuming they will stop and we wont get any more cash...however this is still a bit of a wild card factor. 
We intend for this home to be the place we spend the rest of our lives and we don't want to have to move again.
<bot>: My household makes $50k...I have 260k in cash...how much do I put down on a $300k home.