<human>: Condense the text into a few key points

A little background info before I get started: I live in a family of 6: my father, mother, older brother (moved out), me, and my two younger sisters. My parents have a healthy relationship and my sisters and I all receive generous amounts of love from them. I am 16 and have a healthy relationship with my youngest sister and older brother. The issue lies between my second sister and I.

The issue is that she always seems to be irritated or angry at me. No matter what I ask her or what comment I give her she always responds with an irritable tone of voice. She will yell at me if I knock and open her to door to ask her somethings or to tell her that our parents need her. All of it just seems so unnecessary. I'm by no means trying to come off as the nice guy here. I get angry at her sometimes, but not as much as she is with me. Even in the mornings when I haven't talked to her in 12+ hours she still yells at me. 

As a side note, I understand that she has begun receiving her 
"gift from nature", but in no way does that justify her being angry and irritable all the time.

I have honestly tried everything I can think of, and nothing has resulted in a normal conversation or normal tone of voice. I really don't want to grow up with my sister hating me and not speaking to me once I move out, so some advice about things I can do or not do would be awesome.

And, obviously, just ask if more clarity is needed. I understand that this is a large wall of jumbled words, but hopefully it will give everyone a decent idea of the situation.
<bot>: My younger sister (13) always seems to be irritated and angry with me (16). Looking for some good advice to help remove said irritation from our relationship.