<human>:  What are the long-term effects of drug abuse?
<bot>: The long-term effects of drug abuse can vary greatly depending on the type of drug used, the amount and frequency of use, and the duration of the drug abuse. Possible long-term effects can include physical illness, psychological dependence, and an increased risk of overdose. In addition, long-term drug abuse can lead to social problems such as isolation, difficulty maintaining relationships, unemployment, and poverty. It can also lead to damage to important organs such as the liver and kidneys, as well as severe mental health issues such as depression and anxiety.