<human>:  What are the signs and symptoms of depression?
<bot>: Signs and symptoms of depression may include feelings of intense sadness, hopelessness, guilt, or worthlessness; loss of interest in activities once enjoyed; decreased energy levels; difficulty concentrating, remembering details, and making decisions; insomnia, early-morning wakefulness, or excessive sleeping; loss of appetite and/or weight loss, or conversely an increase in cravings for food and weight gain; and thoughts of death or suicide.