<human>:  Who was the first to propose the theory of macro-mutation?
<bot>: The theory of macro-mutation was proposed by Gregor Mendel in 1865. Mendel was a monk who studied the inheritance of traits in pea plants. He discovered that traits are passed down from parents to offspring in a predictable way. He also discovered that there are two types of traits: dominant and recessive. Dominant traits are always expressed, while recessive traits are expressed only when they are present in both parents.