<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> What is Causality and explain in detail? [/INST] Causality (also referred to as causation, or cause and effect) is influence by which one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly responsible for the effect, and the effect is partly dependent on the cause. In general, a process has many causes, which are also said to be causal factors for it, and all lie in its past. An effect can in turn be a cause of, or causal factor for, many other effects, which all lie in its future. Some writers have held that causality is metaphysically prior to notions of time and space.Causality is an abstraction that indicates how the world progresses. As such a basic concept, it is more apt as an explanation of other concepts of progression than as something to be explained by others more basic. The concept is like those of agency and efficacy. For this reason, a leap of intuition may be needed to grasp it. Accordingly, causality is implicit in the logic and structure of ordinary language.In English studies of Aristotelian philosophy, the word "cause" is used as a specialized technical term, the translation of Aristotles term αἰτία, by which Aristotle meant "explanation" or "answer to a why question". Aristotle categorized the four types of answers as material, formal, efficient, and final "causes". In this case, the "cause" is the explanans for the explanandum, and failure to recognize that different kinds of "cause" are being considered can lead to futile debate. Of Aristotles four explanatory modes, the one nearest to the concerns of the present article is the "efficient" one.
David Hume, as part of his opposition to rationalism, argued that pure reason alone cannot prove the reality of efficient causality; instead, he appealed to custom and mental habit, observing that all human knowledge derives solely from experience.
The topic of causality remains a staple in contemporary philosophy.

Concept
Metaphysics
The nature of cause and effect is a concern of the subject known as metaphysics. Kant thought that time and space were notions prior to human understanding of the progress or evolution of the world, and he also recognized the priority of causality. But he did not have the understanding that came with knowledge of Minkowski geometry and the special theory of relativity, that the notion of causality can be used as a prior foundation from which to construct notions of time and space.

Ontology
A general metaphysical question about cause and effect is what kind of entity can be a cause, and what kind of entity can be an effect.
One viewpoint on this question is that cause and effect are of one and the same kind of entity, with causality an asymmetric relation between them. That is to say, it would make good sense grammatically to say either "A is the cause and B the effect" or "B is the cause and A the effect", though only one of those two can be actually true. In this view, one opinion, proposed as a metaphysical principle in process philosophy, is that every cause and every effect is respectively some process, event, becoming, or happening. An example is his tripping over the step was the cause, and his breaking his ankle the effect. Another view is that causes and effects are states of affairs, with the exact natures of those entities being less restrictively defined than in process philosophy.Another viewpoint on the question is the more classical one, that a cause and its effect can be of different kinds of entity. For example, in Aristotles efficient causal explanation, an action can be a cause while an enduring object is its effect. For example, the generative actions of his parents can be regarded as the efficient cause, with Socrates being the effect, Socrates being regarded as an enduring object, in philosophical tradition called a substance, as distinct from an action.

Epistemology
Since causality is a subtle metaphysical notion, considerable intellectual effort, along with exhibition of evidence, is needed to establish knowledge of it in particular empirical circumstances. According to David Hume, the human mind is unable to perceive causal relations directly. On this ground, the scholar distinguished between the regularity view on causality and the counterfactual notion. According to the counterfactual view, X causes Y if and only if, without X, Y would not exist. Hume interpreted the latter as an ontological view, i.e., as a description of the nature of causality but, given the limitations of the human mind, advised using the former (stating, roughly, that X causes Y if and only if the two events are spatiotemporally conjoined, and X precedes Y) as an epistemic definition of causality. Having an epistemic concept of causality is needed to distinguish between causal and noncausal relations. The contemporary philosophical literature on causality can be divided into five big approaches to causality. These include the (mentioned above) regularity, probabilistic, counterfactual, mechanistic, and manipulationist views. The five approaches can be shown to be reductive, i.e., define causality in terms of relations of other types. According to this reading, they define causality in terms of, respectively, empirical regularities (constant conjunctions of events), changes in conditional probabilities, counterfactual conditions, mechanisms underlying causal relations, and invariance under intervention.

Geometrical significance
Causality has the properties of antecedence and contiguity. These are topological, and are ingredients for space-time geometry. As developed by Alfred Robb, these properties allow the derivation of the notions of time and space. Max Jammer writes "the Einstein postulate ... opens the way to a straightforward construction of the causal topology ... of Minkowski space." Causal efficacy propagates no faster than light.Thus, the notion of causality is metaphysically prior to the notions of time and space. In practical terms, this is because use of the relation of causality is necessary for the interpretation of empirical experiments. Interpretation of experiments is needed to establish the physical and geometrical notions of time and space.

Volition
The deterministic world-view holds that the history of the universe can be exhaustively represented as a progression of events following one after as cause and effect. The incompatibilist version of this holds that there is no such thing as "free will". Compatibilism, on the other hand, holds that determinism is compatible with, or even necessary for, free will.

Necessary and sufficient causes
Causes may sometimes be distinguished into two types: necessary and sufficient. A third type of causation, which requires neither necessity nor sufficiency in and of itself, but which contributes to the effect, is called a "contributory cause".

Necessary causes
If x is a necessary cause of y, then the presence of y necessarily implies the prior occurrence of x. The presence of x, however, does not imply that y will occur.
Sufficient causes
If x is a sufficient cause of y, then the presence of x necessarily implies the subsequent occurrence of y. However, another cause z may alternatively cause y. Thus the presence of y does not imply the prior occurrence of x.
Contributory causes
For some specific effect, in a singular case, a factor that is a contributory cause is one among several co-occurrent causes. It is implicit that all of them are contributory. For the specific effect, in general, there is no implication that a contributory cause is necessary, though it may be so. In general, a factor that is a contributory cause is not sufficient, because it is by definition accompanied by other causes, which would not count as causes if it were sufficient. For the specific effect, a factor that is on some occasions a contributory cause might on some other occasions be sufficient, but on those other occasions it would not be merely contributory.J. L. Mackie argues that usual talk of "cause" in fact refers to INUS conditions (insufficient but non-redundant parts of a condition which is itself unnecessary but sufficient for the occurrence of the effect). An example is a short circuit as a cause for a house burning down. Consider the collection of events: the short circuit, the proximity of flammable material, and the absence of firefighters. Together these are unnecessary but sufficient to the houses burning down (since many other collections of events certainly could have led to the house burning down, for example shooting the house with a flamethrower in the presence of oxygen and so forth). Within this collection, the short circuit is an insufficient (since the short circuit by itself would not have caused the fire) but non-redundant (because the fire would not have happened without it, everything else being equal) part of a condition which is itself unnecessary but sufficient for the occurrence of the effect. So, the short circuit is an INUS condition for the occurrence of the house burning down.

Contrasted with conditionals
Conditional statements are not statements of causality. An important distinction is that statements of causality require the antecedent to precede or coincide with the consequent in time, whereas conditional statements do not require this temporal order. Confusion commonly arises since many different statements in English may be presented using "If ..., then ..." form (and, arguably, because this form is far more commonly used to make a statement of causality). The two types of statements are distinct, however.
For example, all of the following statements are true when interpreting "If ..., then ..." as the material conditional:

If Barack Obama is president of the United States in 2011, then Germany is in Europe.
If George Washington is president of the United States in 2011, then ⟨arbitrary statement⟩.The first is true since both the antecedent and the consequent are true. The second is true in sentential logic and indeterminate in natural language, regardless of the consequent statement that follows, because the antecedent is false.
The ordinary indicative conditional has somewhat more structure than the material conditional. For instance, although the first is the closest, neither of the preceding two statements seems true as an ordinary indicative reading. But the sentence:

If Shakespeare of Stratford-on-Avon did not write Macbeth, then someone else did.intuitively seems to be true, even though there is no straightforward causal relation in this hypothetical situation between Shakespeares not writing Macbeth and someone elses actually writing it.
Another sort of conditional, the counterfactual conditional, has a stronger connection with causality, yet even counterfactual statements are not all examples of causality. Consider the following two statements:

If A were a triangle, then A would have three sides.
If switch S were thrown, then bulb B would light.In the first case, it would not be correct to say that As being a triangle caused it to have three sides, since the relationship between triangularity and three-sidedness is that of definition. The property of having three sides actually determines As state as a triangle. Nonetheless, even when interpreted counterfactually, the first statement is true. An early version of Aristotles "four cause" theory is described as recognizing "essential cause". In this version of the theory, that the closed polygon has three sides is said to be the "essential cause" of its being a triangle. This use of the word cause is of course now far obsolete. Nevertheless, it is within the scope of ordinary language to say that it is essential to a triangle that it has three sides.
A full grasp of the concept of conditionals is important to understanding the literature on causality. In everyday language, loose conditional statements are often enough made, and need to be interpreted carefully.

Questionable cause
Fallacies of questionable cause, also known as causal fallacies, non-causa pro causa (Latin for "non-cause for cause"), or false cause, are informal fallacies where a cause is incorrectly identified.

Theories
Counterfactual theories
Counterfactual theories define causation in terms of a counterfactual relation. These theories can often be seeing as "floating" their account of causality on top of an account of the logic of counterfactual conditionals. This approach can be traced back to David Humes definition of the causal relation as that "where, if the first object had not been, the second never had existed." More full-fledged analysis of causation in terms of counterfactual conditionals only came in the 20th century after development of the possible world semantics for the evaluation of counterfactual conditionals. In his 1973 paper "Causation," David Lewis proposed the following definition of the notion of causal dependence:
An event E causally depends on C if, and only if, (i) if C had occurred, then E would have occurred, and (ii) if C had not occurred, then E would not have occurred.Causation is then defined as a chain of causal dependence. That is, C causes E if and only if there exists a sequence of events C, D1, D2, ... Dk, E such that each event in the sequence depends on the previous. This chain may be called a mechanism.
Note that the analysis does not purport to explain how we make causal judgements or how we reason about causation, but rather to give a metaphysical account of what it is for there to be a causal relation between some pair of events. If correct, the analysis has the power to explain certain features of causation. Knowing that causation is a matter of counterfactual dependence, we may reflect on the nature of counterfactual dependence to account for the nature of causation. For example, in his paper "Counterfactual Dependence and Times Arrow," Lewis sought to account for the time-directedness of counterfactual dependence in terms of the semantics of the counterfactual conditional. If correct, this theory can serve to explain a fundamental part of our experience, which is that we can only causally affect the future but not the past.

Probabilistic causation
Interpreting causation as a deterministic relation means that if A causes B, then A must always be followed by B. In this sense, war does not cause deaths, nor does smoking cause cancer or emphysema. As a result, many turn to a notion of probabilistic causation. Informally, A ("The person is a smoker") probabilistically causes B ("The person has now or will have cancer at some time in the future"), if the information that A occurred increases the likelihood of Bs occurrence. Formally, P{B|A}≥ P{B} where P{B|A} is the conditional probability that B will occur given the information that A occurred, and P{B} is the probability that B will occur having no knowledge whether A did or did not occur. This intuitive condition is not adequate as a definition for probabilistic causation because of its being too general and thus not meeting our intuitive notion of cause and effect. For example, if A denotes the event "The person is a smoker," B denotes the event "The person now has or will have cancer at some time in the future" and C denotes the event "The person now has or will have emphysema some time in the future," then the following three relationships hold: P{B|A} ≥ P{B}, P{C|A} ≥ P{C} and P{B|C} ≥ P{B}. The last relationship states that knowing that the person has emphysema increases the likelihood that he will have cancer. The reason for this is that having the information that the person has emphysema increases the likelihood that the person is a smoker, thus indirectly increasing the likelihood that the person will have cancer. However, we would not want to conclude that having emphysema causes cancer. Thus, we need additional conditions such as temporal relationship of A to B and a rational explanation as to the mechanism of action. It is hard to quantify this last requirement and thus different authors prefer somewhat different definitions.

Causal calculus
When experimental interventions are infeasible or illegal, the derivation of a cause-and-effect relationship from observational studies must rest on some qualitative theoretical assumptions, for example, that symptoms do not cause diseases, usually expressed in the form of missing arrows in causal graphs such as Bayesian networks or path diagrams. The theory underlying these derivations relies on the distinction between conditional probabilities, as in

        P
        (
        c
        a
        n
        c
        e
        r

          |

        s
        m
        o
        k
        i
        n
        g
        )

    {\displaystyle P(cancer|smoking)}
  , and interventional probabilities, as in

        P
        (
        c
        a
        n
        c
        e
        r

          |

        d
        o
        (
        s
        m
        o
        k
        i
        n
        g
        )
        )

    {\displaystyle P(cancer|do(smoking))}
  . The former reads: "the probability of finding cancer in a person known to smoke, having started, unforced by the experimenter, to do so at an unspecified time in the past", while the latter reads: "the probability of finding cancer in a person forced by the experimenter to smoke at a specified time in the past". The former is a statistical notion that can be estimated by observation with negligible intervention by the experimenter, while the latter is a causal notion which is estimated in an experiment with an important controlled randomized intervention. It is specifically characteristic of quantal phenomena that observations defined by incompatible variables always involve important intervention by the experimenter, as described quantitatively by the observer effect. In classical thermodynamics, processes are initiated by interventions called thermodynamic operations. In other branches of science, for example astronomy, the experimenter can often observe with negligible intervention.
The theory of "causal calculus" (also known as do-calculus, Judea Pearls Causal Calculus, Calculus of
Actions) permits one to infer interventional probabilities from conditional probabilities in causal Bayesian networks with unmeasured variables. One very practical result of this theory is the characterization of confounding variables, namely, a sufficient set of variables that, if adjusted for, would yield the correct causal effect between variables of interest. It can be shown that a sufficient set for estimating the causal effect of

        X

    {\displaystyle X}
   on

        Y

    {\displaystyle Y}
   is any set of non-descendants of

        X

    {\displaystyle X}
   that

        d

    {\displaystyle d}
  -separate

        X

    {\displaystyle X}
   from

        Y

    {\displaystyle Y}
   after removing all arrows emanating from

        X

    {\displaystyle X}
  . This criterion, called "backdoor", provides a mathematical definition of "confounding" and helps researchers identify accessible sets of variables worthy of measurement.

Structure learning
While derivations in causal calculus rely on the structure of the causal graph, parts of the causal structure can, under certain assumptions, be learned from statistical data. The basic idea goes back to Sewall Wrights 1921 work on path analysis. A "recovery" algorithm was developed by Rebane and Pearl (1987) which rests on Wrights distinction between the three possible types of causal substructures allowed in a directed acyclic graph (DAG):

        X
        →
        Y
        →
        Z

    {\displaystyle X\rightarrow Y\rightarrow Z}

        X
        ←
        Y
        →
        Z

    {\displaystyle X\leftarrow Y\rightarrow Z}

        X
        →
        Y
        ←
        Z

    {\displaystyle X\rightarrow Y\leftarrow Z}
  Type 1 and type 2 represent the same statistical dependencies (i.e.,

        X

    {\displaystyle X}
   and

        Z

    {\displaystyle Z}
   are independent given

        Y

    {\displaystyle Y}
  ) and are, therefore, indistinguishable within purely cross-sectional data. Type 3, however, can be uniquely identified, since

        X

    {\displaystyle X}
   and

        Z

    {\displaystyle Z}
   are marginally independent and all other pairs are dependent. Thus, while the skeletons (the graphs stripped of arrows) of these three triplets are identical, the directionality of the arrows is partially identifiable. The same distinction applies when

        X

    {\displaystyle X}
   and

        Z

    {\displaystyle Z}
   have common ancestors, except that one must first condition on those ancestors. Algorithms have been developed to systematically determine the skeleton of the underlying graph and, then, orient all arrows whose directionality is dictated by the conditional independencies observed.Alternative methods of structure learning search through the many possible causal structures among the variables, and remove ones which are strongly incompatible with the observed correlations. In general this leaves a set of possible causal relations, which should then be tested by analyzing time series data or, preferably, designing appropriately controlled experiments. In contrast with Bayesian Networks, path analysis (and its generalization, structural equation modeling), serve better to estimate a known causal effect or to test a causal model than to generate causal hypotheses.
For nonexperimental data, causal direction can often be inferred if information about time is available. This is because (according to many, though not all, theories) causes must precede their effects temporally. This can be determined by statistical time series models, for instance, or with a statistical test based on the idea of Granger causality, or by direct experimental manipulation. The use of temporal data can permit statistical tests of a pre-existing theory of causal direction. For instance, our degree of confidence in the direction and nature of causality is much greater when supported by cross-correlations, ARIMA models, or cross-spectral analysis using vector time series data than by cross-sectional data.

Derivation theories
Nobel laureate Herbert A. Simon and philosopher Nicholas Rescher claim that the asymmetry of the causal relation is unrelated to the asymmetry of any mode of implication that contraposes. Rather, a causal relation is not a relation between values of variables, but a function of one variable (the cause) on to another (the effect). So, given a system of equations, and a set of variables appearing in these equations, we can introduce an asymmetric relation among individual equations and variables that corresponds perfectly to our commonsense notion of a causal ordering. The system of equations must have certain properties, most importantly, if some values are chosen arbitrarily, the remaining values will be determined uniquely through a path of serial discovery that is perfectly causal. They postulate the inherent serialization of such a system of equations may correctly capture causation in all empirical fields, including physics and economics.

Manipulation theories
Some theorists have equated causality with manipulability. Under these theories, x causes y only in the case that one can change x in order to change y. This coincides with commonsense notions of causations, since often we ask causal questions in order to change some feature of the world. For instance, we are interested in knowing the causes of crime so that we might find ways of reducing it.
These theories have been criticized on two primary grounds. First, theorists complain that these accounts are circular. Attempting to reduce causal claims to manipulation requires that manipulation is more basic than causal interaction. But describing manipulations in non-causal terms has provided a substantial difficulty.
The second criticism centers around concerns of anthropocentrism. It seems to many people that causality is some existing relationship in the world that we can harness for our desires. If causality is identified with our manipulation, then this intuition is lost. In this sense, it makes humans overly central to interactions in the world.
Some attempts to defend manipulability theories are recent accounts that do not claim to reduce causality to manipulation. These accounts use manipulation as a sign or feature in causation without claiming that manipulation is more fundamental than causation.

Process theories
Some theorists are interested in distinguishing between causal processes and non-causal processes (Russell 1948; Salmon 1984). These theorists often want to distinguish between a process and a pseudo-process. As an example, a ball moving through the air (a process) is contrasted with the motion of a shadow (a pseudo-process). The former is causal in nature while the latter is not.
Salmon (1984) claims that causal processes can be identified by their ability to transmit an alteration over space and time. An alteration of the ball (a mark by a pen, perhaps) is carried with it as the ball goes through the air. On the other hand, an alteration of the shadow (insofar as it is possible) will not be transmitted by the shadow as it moves along.
These theorists claim that the important concept for understanding causality is not causal relationships or causal interactions, but rather identifying causal processes. The former notions can then be defined in terms of causal processes.

A subgroup of the process theories is the mechanistic view on causality. It states that that causal relations supervene on mechanisms. While the notion of mechanism is understood differently, the definition put forward by the group of philosophers referred to as the New Mechanists dominate the literature.

Fields
Science
For the scientific investigation of efficient causality, the cause and effect are each best conceived of as temporally transient processes.
Within the conceptual frame of the scientific method, an investigator sets up several distinct and contrasting temporally transient material processes that have the structure of experiments, and records candidate material responses, normally intending to determine causality in the physical world. For instance, one may want to know whether a high intake of carrots causes humans to develop the bubonic plague. The quantity of carrot intake is a process that is varied from occasion to occasion. The occurrence or non-occurrence of subsequent bubonic plague is recorded. To establish causality, the experiment must fulfill certain criteria, only one example of which is mentioned here. For example, instances of the hypothesized cause must be set up to occur at a time when the hypothesized effect is relatively unlikely in the absence of the hypothesized cause; such unlikelihood is to be established by empirical evidence. A mere observation of a correlation is not nearly adequate to establish causality. In nearly all cases, establishment of causality relies on repetition of experiments and probabilistic reasoning. Hardly ever is causality established more firmly than as more or less probable. It is most convenient for establishment of causality if the contrasting material states of affairs are precisely matched, except for only one variable factor, perhaps measured by a real number.

Physics
One has to be careful in the use of the word cause in physics. Properly speaking, the hypothesized cause and the hypothesized effect are each temporally transient processes. For example, force is a useful concept for the explanation of acceleration, but force is not by itself a cause. More is needed. For example, a temporally transient process might be characterized by a definite change of force at a definite time. Such a process can be regarded as a cause. Causality is not inherently implied in equations of motion, but postulated as an additional constraint that needs to be satisfied (i.e. a cause always precedes its effect). This constraint has mathematical implications such as the Kramers-Kronig relations.
Causality is one of the most fundamental and essential notions of physics. Causal efficacy cannot propagate faster than light. Otherwise, reference coordinate systems could be constructed (using the Lorentz transform of special relativity) in which an observer would see an effect precede its cause (i.e. the postulate of causality would be violated).
Causal notions appear in the context of the flow of mass-energy. Any actual process has causal efficacy that can propagate no faster than light. In contrast, an abstraction has no causal efficacy. Its mathematical expression does not propagate in the ordinary sense of the word, though it may refer to virtual or nominal velocities with magnitudes greater than that of light. For example, wave packets are mathematical objects that have group velocity and phase velocity. The energy of a wave packet travels at the group velocity (under normal circumstances); since energy has causal efficacy, the group velocity cannot be faster than the speed of light. The phase of a wave packet travels at the phase velocity; since phase is not causal, the phase velocity of a wave packet can be faster than light.Causal notions are important in general relativity to the extent that the existence of an arrow of time demands that the universes semi-Riemannian manifold be orientable, so that "future" and "past" are globally definable quantities.

Engineering
A causal system is a system with output and internal states that depends only on the current and previous input values. A system that has some dependence on input values from the future (in addition to possible past or current input values) is termed an acausal system, and a system that depends solely on future input values is an anticausal system. Acausal filters, for example, can only exist as postprocessing filters, because these filters can extract future values from a memory buffer or a file.

Biology, medicine and epidemiology
Austin Bradford Hill built upon the work of Hume and Popper and suggested in his paper "The Environment and Disease: Association or Causation?" that aspects of an association such as strength, consistency, specificity, and temporality be considered in attempting to distinguish causal from noncausal associations in the epidemiological situation. (See Bradford-Hill criteria.) He did not note however, that temporality is the only necessary criterion among those aspects. Directed acyclic graphs (DAGs) are increasingly used in epidemiology to help enlighten causal thinking.

Psychology
Psychologists take an empirical approach to causality, investigating how people and non-human animals detect or infer causation from sensory information, prior experience and innate knowledge.

AttributionAttribution theory is the theory concerning how people explain individual occurrences of causation. Attribution can be external (assigning causality to an outside agent or force—claiming that some outside thing motivated the event) or internal (assigning causality to factors within the person—taking personal responsibility or accountability for ones actions and claiming that the person was directly responsible for the event). Taking causation one step further, the type of attribution a person provides influences their future behavior.
The intention behind the cause or the effect can be covered by the subject of action. See also accident; blame; intent; and responsibility.

Causal powersWhereas David Hume argued that causes are inferred from non-causal observations, Immanuel Kant claimed that people have innate assumptions about causes. Within psychology, Patricia Cheng attempted to reconcile the Humean and Kantian views. According to her power PC theory, people filter observations of events through an intuition that causes have the power to generate (or prevent) their effects, thereby inferring specific cause-effect relations.

Causation and salienceOur view of causation depends on what we consider to be the relevant events. Another way to view the statement, "Lightning causes thunder" is to see both lightning and thunder as two perceptions of the same event, viz., an electric discharge that we perceive first visually and then aurally.

Naming and causalityDavid Sobel and Alison Gopnik from the Psychology Department of UC Berkeley designed a device known as the blicket detector which would turn on when an object was placed on it. Their research suggests that "even young children will easily and swiftly learn about a new causal power of an object and spontaneously use that information in classifying and naming the object."
Perception of launching eventsSome researchers such as Anjan Chatterjee at the University of Pennsylvania and Jonathan Fugelsang at the University of Waterloo are using neuroscience techniques to investigate the neural and psychological underpinnings of causal launching events in which one object causes another object to move. Both temporal and spatial factors can be manipulated.See Causal Reasoning (Psychology) for more information.

Statistics and economics
Statistics and economics usually employ pre-existing data or experimental data to infer causality by regression methods. The body of statistical techniques involves substantial use of regression analysis. Typically a linear relationship such as

          y

            i

        =

          a

            0

        +

          a

            1

          x

            1
            ,
            i

        +

          a

            2

          x

            2
            ,
            i

        +
        ⋯
        +

          a

            k

          x

            k
            ,
            i

        +

          e

            i

    {\displaystyle y_{i}=a_{0}+a_{1}x_{1,i}+a_{2}x_{2,i}+\dots +a_{k}x_{k,i}+e_{i}}
  is postulated, in which

          y

            i

    {\displaystyle y_{i}}
   is the ith observation of the dependent variable (hypothesized to be the caused variable),

          x

            j
            ,
            i

    {\displaystyle x_{j,i}}
   for j=1,...,k is the ith observation on the jth independent variable (hypothesized to be a causative variable), and

          e

            i

    {\displaystyle e_{i}}
   is the error term for the ith observation (containing the combined effects of all other causative variables, which must be uncorrelated with the included independent variables). If there is reason to believe that none of the

          x

            j

    {\displaystyle x_{j}}
  s is caused by y, then estimates of the coefficients

          a

            j

    {\displaystyle a_{j}}
   are obtained. If the null hypothesis that

          a

            j

        =
        0

    {\displaystyle a_{j}=0}
   is rejected, then the alternative hypothesis that

          a

            j

        ≠
        0

    {\displaystyle a_{j}\neq 0}
   and equivalently that

          x

            j

    {\displaystyle x_{j}}
   causes y cannot be rejected. On the other hand, if the null hypothesis that

          a

            j

        =
        0

    {\displaystyle a_{j}=0}
   cannot be rejected, then equivalently the hypothesis of no causal effect of

          x

            j

    {\displaystyle x_{j}}
   on y cannot be rejected. Here the notion of causality is one of contributory causality as discussed above: If the true value

          a

            j

        ≠
        0

    {\displaystyle a_{j}\neq 0}
  , then a change in

          x

            j

    {\displaystyle x_{j}}
   will result in a change in y unless some other causative variable(s), either included in the regression or implicit in the error term, change in such a way as to exactly offset its effect; thus a change in

          x

            j

    {\displaystyle x_{j}}
   is not sufficient to change y. Likewise, a change in

          x

            j

    {\displaystyle x_{j}}
   is not necessary to change y, because a change in y could be caused by something implicit in the error term (or by some other causative explanatory variable included in the model).
The above way of testing for causality requires belief that there is no reverse causation, in which y would cause

          x

            j

    {\displaystyle x_{j}}
  . This belief can be established in one of several ways. First, the variable

          x

            j

    {\displaystyle x_{j}}
   may be a non-economic variable: for example, if rainfall amount

          x

            j

    {\displaystyle x_{j}}
   is hypothesized to affect the futures price y of some agricultural commodity, it is impossible that in fact the futures price affects rainfall amount (provided that cloud seeding is never attempted). Second, the instrumental variables technique may be employed to remove any reverse causation by introducing a role for other variables (instruments) that are known to be unaffected by the dependent variable. Third, the principle that effects cannot precede causes can be invoked, by including on the right side of the regression only variables that precede in time the dependent variable; this principle is invoked, for example, in testing for Granger causality and in its multivariate analog, vector autoregression, both of which control for lagged values of the dependent variable while testing for causal effects of lagged independent variables.
Regression analysis controls for other relevant variables by including them as regressors (explanatory variables). This helps to avoid false inferences of causality due to the presence of a third, underlying, variable that influences both the potentially causative variable and the potentially caused variable: its effect on the potentially caused variable is captured by directly including it in the regression, so that effect will not be picked up as an indirect effect through the potentially causative variable of interest. Given the above procedures, coincidental (as opposed to causal) correlation can be probabilistically rejected if data samples are large and if regression results pass cross-validation tests showing that the correlations hold even for data that were not used in the regression. Asserting with certitude that a common-cause is absent and the regression represents the true causal structure is in principle impossible.Apart from constructing statistical models of observational and experimental data, economists use axiomatic (mathematical) models to infer and represent causal mechanisms. Highly abstract theoretical models that isolate and idealize one mechanism dominate microeconomics. In macroeconomics, economists use broad mathematical models that are calibrated on historical data. A subgroup of calibrated models, dynamic stochastic general equilibrium (DSGE) models are employed to represent (in a simplified way) the whole economy and simulate changes in fiscal and monetary policy.

Management
For quality control in manufacturing in the 1960s, Kaoru Ishikawa developed a cause and effect diagram, known as an Ishikawa diagram or fishbone diagram. The diagram categorizes causes, such as into the six main categories shown here. These categories are then sub-divided. Ishikawas method identifies "causes" in brainstorming sessions conducted among various groups involved in the manufacturing process. These groups can then be labeled as categories in the diagrams. The use of these diagrams has now spread beyond quality control, and they are used in other areas of management and in design and engineering. Ishikawa diagrams have been criticized for failing to make the distinction between necessary conditions and sufficient conditions. It seems that Ishikawa was not even aware of this distinction.

Humanities
History
In the discussion of history, events are sometimes considered as if in some way being agents that can then bring about other historical events. Thus, the combination of poor harvests, the hardships of the peasants, high taxes, lack of representation of the people, and kingly ineptitude are among the causes of the French Revolution. This is a somewhat Platonic and Hegelian view that reifies causes as ontological entities. In Aristotelian terminology, this use approximates to the case of the efficient cause.
Some philosophers of history such as Arthur Danto have claimed that "explanations in history and elsewhere" describe "not simply an event—something that happens—but a change". Like many practicing historians, they treat causes as intersecting actions and sets of actions which bring about "larger changes", in Dantos words: to decide "what are the elements which persist through a change" is "rather simple" when treating an individuals "shift in attitude", but "it is considerably more complex and metaphysically challenging when we are interested in such a change as, say, the break-up of feudalism or the emergence of nationalism".Much of the historical debate about causes has focused on the relationship between communicative and other actions, between singular and repeated ones, and between actions, structures of action or group and institutional contexts and wider sets of conditions. John Gaddis has distinguished between exceptional and general causes (following Marc Bloch) and between "routine" and "distinctive links" in causal relationships: "in accounting for what happened at Hiroshima on August 6, 1945, we attach greater importance to the fact that President Truman ordered the dropping of an atomic bomb than to the decision of the Army Air Force to carry out his orders." He has also pointed to the difference between immediate, intermediate and distant causes. For his part, Christopher Lloyd puts forward four "general concepts of causation" used in history: the "metaphysical idealist concept, which asserts that the phenomena of the universe are products of or emanations from an omnipotent being or such final cause"; "the empiricist (or Humean) regularity concept, which is based on the idea of causation being a matter of constant conjunctions of events"; "the functional/teleological/consequential concept", which is "goal-directed, so that goals are causes"; and the "realist, structurist and dispositional approach, which sees relational structures and internal dispositions as the causes of phenomena".

Law
According to law and jurisprudence, legal cause must be demonstrated to hold a defendant liable for a crime or a tort (i.e. a civil wrong such as negligence or trespass). It must be proven that causality, or a "sufficient causal link" relates the defendants actions to the criminal event or damage in question. Causation is also an essential legal element that must be proven to qualify for remedy measures under international trade law.

History
Hindu philosophy
Vedic period (c. 1750–500 BCE) literature has karmas Eastern origins. Karma is the belief held by Sanatana Dharma and major religions that a persons actions cause certain effects in the current life and/or in future life, positively or negatively. The various philosophical schools (darshanas) provide different accounts of the subject. The doctrine of satkaryavada affirms that the effect inheres in the cause in some way. The effect is thus either a real or apparent modification of the cause. The doctrine of asatkaryavada affirms that the effect does not inhere in the cause, but is a new arising. See Nyaya for some details of the theory of causation in the Nyaya school. In Brahma Samhita, Brahma describes Krishna as the prime cause of all causes.Bhagavad-gītā 18.14 identifies five causes for any action (knowing which it can be perfected): the body, the individual soul, the senses, the efforts and the supersoul.
According to Monier-Williams, in the Nyāya causation theory from Sutra I.2.I,2 in the Vaisheshika philosophy, from causal non-existence is effectual non-existence; but, not effectual non-existence from causal non-existence. A cause precedes an effect. With a threads and cloth metaphors, three causes are:

Co-inherence cause: resulting from substantial contact, substantial causes, threads are substantial to cloth, corresponding to Aristotles material cause.
Non-substantial cause: Methods putting threads into cloth, corresponding to Aristotles formal cause.
Instrumental cause: Tools to make the cloth, corresponding to Aristotles efficient cause.Monier-Williams also proposed that Aristotles and the Nyayas causality are considered conditional aggregates necessary to mans productive work.

Buddhist philosophy
Karma is the causality principle focusing on 1) causes, 2) actions, 3) effects, where it is the minds phenomena that guide the actions that the actor performs. Buddhism trains the actors actions for continued and uncontrived virtuous outcomes aimed at reducing suffering. This follows the Subject–verb–object structure.The general or universal definition of pratityasamutpada (or "dependent origination" or "dependent arising" or "interdependent co-arising") is that everything arises in dependence upon multiple causes and conditions; nothing exists as a singular, independent entity. A traditional example in Buddhist texts is of three sticks standing upright and leaning against each other and supporting each other. If one stick is taken away, the other two will fall to the ground.Causality in the Chittamatrin Buddhist school approach, Asangas (c. 400 CE) mind-only Buddhist school, asserts that objects cause consciousness in the minds image. Because causes precede effects, which must be different entities, then subject and object are different. For this school, there are no objects which are entities external to a perceiving consciousness. The Chittamatrin and the Yogachara Svatantrika schools accept that there are no objects external to the observers causality. This largely follows the Nikayas approach.The Vaibhashika (c. 500 CE) is an early Buddhist school which favors direct object contact and accepts simultaneous cause and effects. This is based in the consciousness example which says, intentions and feelings are mutually accompanying mental factors that support each other like poles in tripod. In contrast, simultaneous cause and effect rejectors say that if the effect already exists, then it cannot effect the same way again. How past, present and future are accepted is a basis for various Buddhist schools causality viewpoints.All the classic Buddhist schools teach karma. "The law of karma is a special instance of the law of cause and effect, according to which all our actions of body, speech, and mind are causes and all our experiences are their effects."

Western philosophy
Aristotelian
Aristotle identified four kinds of answer or explanatory mode to various "Why?" questions. He thought that, for any given topic, all four kinds of explanatory mode were important, each in its own right. As a result of traditional specialized philosophical peculiarities of language, with translations between ancient Greek, Latin, and English, the word cause is nowadays in specialized philosophical writings used to label Aristotles four kinds. In ordinary language, the word cause has a variety of meanings, the most common of which refers to efficient causation, which is the topic of the present article.

Material cause, the material whence a thing has come or that which persists while it changes, as for example, ones mother or the bronze of a statue (see also substance theory).
Formal cause, whereby a things dynamic form or static shape determines the things properties and function, as a human differs from a statue of a human or as a statue differs from a lump of bronze.
Efficient cause, which imparts the first relevant movement, as a human lifts a rock or raises a statue. This is the main topic of the present article.
Final cause, the criterion of completion, or the end; it may refer to an action or to an inanimate process. Examples: Socrates takes a walk after dinner for the sake of his health; earth falls to the lowest level because that is its nature.Of Aristotles four kinds or explanatory modes, only one, the efficient cause is a cause as defined in the leading paragraph of this present article. The other three explanatory modes might be rendered material composition, structure and dynamics, and, again, criterion of completion. The word that Aristotle used was αἰτία. For the present purpose, that Greek word would be better translated as "explanation" than as "cause" as those words are most often used in current English. Another translation of Aristotle is that he meant "the four Becauses" as four kinds of answer to "why" questions.Aristotle assumed efficient causality as referring to a basic fact of experience, not explicable by, or reducible to, anything more fundamental or basic.
In some works of Aristotle, the four causes are listed as (1) the essential cause, (2) the logical ground, (3) the moving cause, and (4) the final cause. In this listing, a statement of essential cause is a demonstration that an indicated object conforms to a definition of the word that refers to it. A statement of logical ground is an argument as to why an object statement is true. These are further examples of the idea that a "cause" in general in the context of Aristotles usage is an "explanation".The word "efficient" used here can also be translated from Aristotle as "moving" or "initiating".Efficient causation was connected with Aristotelian physics, which recognized the four elements (earth, air, fire, water), and added the fifth element (aether). Water and earth by their intrinsic property gravitas or heaviness intrinsically fall toward, whereas air and fire by their intrinsic property levitas or lightness intrinsically rise away from, Earths center—the motionless center of the universe—in a straight line while accelerating during the substances approach to its natural place.
As air remained on Earth, however, and did not escape Earth while eventually achieving infinite speed—an absurdity—Aristotle inferred that the universe is finite in size and contains an invisible substance that held planet Earth and its atmosphere, the sublunary sphere, centered in the universe. And since celestial bodies exhibit perpetual, unaccelerated motion orbiting planet Earth in unchanging relations, Aristotle inferred that the fifth element, aither, that fills space and composes celestial bodies intrinsically moves in perpetual circles, the only constant motion between two points. (An object traveling a straight line from point A to B and back must stop at either point before returning to the other.)
Left to itself, a thing exhibits natural motion, but can—according to Aristotelian metaphysics—exhibit enforced motion imparted by an efficient cause. The form of plants endows plants with the processes nutrition and reproduction, the form of animals adds locomotion, and the form of humankind adds reason atop these. A rock normally exhibits natural motion—explained by the rocks material cause of being composed of the element earth—but a living thing can lift the rock, an enforced motion diverting the rock from its natural place and natural motion. As a further kind of explanation, Aristotle identified the final cause, specifying a purpose or criterion of completion in light of which something should be understood.
Aristotle himself explained,

Cause means
(a) in one sense, that as the result of whose presence something comes into being—e.g., the bronze of a statue and the silver of a cup, and the classes which contain these [i.e., the material cause];
(b) in another sense, the form or pattern; that is, the essential formula and the classes which contain it—e.g. the ratio 2:1 and number in general is the cause of the octave—and the parts of the formula [i.e., the formal cause].
(c) The source of the first beginning of change or rest; e.g. the man who plans is a cause, and the father is the cause of the child, and in general that which produces is the cause of that which is produced, and that which changes of that which is changed [i.e., the efficient cause].
(d) The same as "end"; i.e. the final cause; e.g., as the "end" of walking is health. For why does a man walk? "To be healthy", we say, and by saying this we consider that we have supplied the cause [the final cause].

(e) All those means towards the end which arise at the instigation of something else, as, e.g., fat-reducing, purging, drugs, and instruments are causes of health; for they all have the end as their object, although they differ from each other as being some instruments, others actions [i.e., necessary conditions].
Aristotle further discerned two modes of causation: proper (prior) causation and accidental (chance) causation. All causes, proper and accidental, can be spoken as potential or as actual, particular or generic. The same language refers to the effects of causes, so that generic effects are assigned to generic causes, particular effects to particular causes, and actual effects to operating causes.
Averting infinite regress, Aristotle inferred the first mover—an unmoved mover. The first movers motion, too, must have been caused, but, being an unmoved mover, must have moved only toward a particular goal or desire.

Pyrrhonism
While the plausibility of causality was accepted in Pyrrhonism, it was equally accepted that it was plausible that nothing was the cause of anything.

Middle Ages
In line with Aristotelian cosmology, Thomas Aquinas posed a hierarchy prioritizing Aristotles four causes: "final > efficient > material > formal". Aquinas sought to identify the first efficient cause—now simply first cause—as everyone would agree, said Aquinas, to call it God. Later in the Middle Ages, many scholars conceded that the first cause was God, but explained that many earthly events occur within Gods design or plan, and thereby scholars sought freedom to investigate the numerous secondary causes.

After the Middle Ages
For Aristotelian philosophy before Aquinas, the word cause had a broad meaning. It meant answer to a why question or explanation, and Aristotelian scholars recognized four kinds of such answers. With the end of the Middle Ages, in many philosophical usages, the meaning of the word cause narrowed. It often lost that broad meaning, and was restricted to just one of the four kinds. For authors such as Niccolò Machiavelli, in the field of political thinking, and Francis Bacon, concerning science more generally, Aristotles moving cause was the focus of their interest. A widely used modern definition of causality in this newly narrowed sense was assumed by David Hume </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> What is Ischemic cardiomyopathy and explain in detail? [/INST] Ischemic cardiomyopathy is a type of cardiomyopathy caused by a narrowing of the coronary arteries which supply blood to the heart. Typically, patients with ischemic cardiomyopathy have a history of acute myocardial infarction, however, it may occur in patients with coronary artery disease, but without a past history of acute myocardial infarction. This cardiomyopathy is one of the leading causes of sudden cardiac death. The adjective ischemic means characteristic of, or accompanied by, ischemia — local anemia due to mechanical obstruction of the blood supply.

Signs and symptoms
Signs and symptoms of ischemic cardiomyopathy include sudden fatigue, shortness of breath, dizziness, and palpitations.

Cause
Ischemic cardiomyopathy is the cause of more than 60% of all cases of systolic congestive heart failure in most countries of the world. A chest radiograph that demonstrates coronary artery calcification is a probable indication of ischemic cardiomyopathy. The following are causes of ischemic cardiomyopathy:
Diabetes
Atherosclerosis
Vasospasm
Inflammation of arteries

Pathophysiology
Ischemic cardiomyopathy is caused by too little blood flow and hence oxygen reaching the muscular layer of the heart due to a narrowing of coronary arteries in turn causing cell death. This can cause different levels of tissue injury and affect large and intermediate arteries alike.

Diagnosis
Ischemic cardiomyopathy can be diagnosed via magnetic resonance imaging (MRI) protocol, imaging both global and regional function. Also the Look-Locker technique is used to identify diffuse fibrosis; it is therefore important to be able to determine the extent of the ischemic scar. Some argue that only left main- or proximal-left anterior descending artery disease is relevant to the diagnostic criteria for ischemic cardiomyopathy. Myocardial imaging usually demonstrates left ventricular dilation, severe ventricular dysfunction, and multiple infarctions. Signs include congestive heart failure, angina edema, weight gain and fainting, among others.

Management
Restoring adequate blood flow to the heart muscle in people with heart failure and significant coronary artery disease is strongly associated with improved survival, some research showing up to 75% survival rates over 5 years. A stem cell study indicated that using autologous cardiac stem cells as a regenerative approach for the human heart (after a heart attack) has great potential.American Heart Association practice guidelines recommend implantable cardioverter-defibrillator (ICD)  use in those with ischemic cardiomyopathy (40 days post-MI) that are (NYHA) New York Heart Association functional class I. A LVEF measurement (simply called LVEF alone among cardiologists) of greater than (>) 30% is often used to differentiate primary from ischemic cardiomyopathy, and as a prognostic indicator.A 2004 study showed the patients in that study who underwent ventricular restoration as well as a coronary artery bypass achieved greater postoperative LVEF than with the latter surgery alone. Severe cases are treated with heart transplantation.

Prognosis
One of the most important features differentiating ischemic cardiomyopathy from the other forms of cardiomyopathy is the shortened, or worsened all-cause mortality in patients with ischemic cardiomyopathy. According to several studies, coronary artery bypass graft surgery has a survival advantage over medical therapy (for ischemic cardiomyopathy) across varied follow-ups.

References
Further reading
Likoff, Jessup Mariell, Chandler Sheryl L., Kay Harold R. (1987). "Clinical determinants of mortality in chronic congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy". The American Journal of Cardiology. 59 (6): 634–638. doi:10.1016/0002-9149(87)91183-0. PMID 3825904.{{cite journal}}:  CS1 maint: multiple names: authors list (link)
Carmeliet Peter;  et al. (1999). "Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188". Nature Medicine. 5 (5): 495–502. doi:10.1038/8379. PMID 10229225. S2CID 7536458.
Menasché Philippe;  et al. (2008). "The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial first randomized Placebo-controlled study of myoblast transplantation" </s>