Fig. 5 Histopathologic section of liver (400 X) with hema- toxylin and eosin staining the cell nucleus and cytoplasm with extracellular matrix with purple blue and pink colours, respectively: a Showing nor- mal arrangement of hepato- cytes in the liver lobule. b Showing hepatocyte necrosis, inflammation, biliary cirrhosis, microvesicular steatosis, broad infiltration of Kupffer cells around the central vein and vacuolation in CCl treated 4 wistar rats. c Animal treated with CCl and 100 mg/kg 4 RoMi showing mild sinusoidal dialatation in centrizonal area, necrosis recovery around the central vein and hepatocytes showing regenerative activity. d Animal treated with CCl 4 and 200 mg/kg RoMi show- ing no centrilobular necrosis, hepatocytes with normal texture around the central vein and proper sinusoid texture. e CCl and silymarin (25 mg/kg) 4 treated animals showing nor- mal hepatocytes and proper central vein. (NB: CV: Central vein, BC: Biliary cirrhosis, V: vacuolation, II: Inflammatory infiltration, MS: Microvesicular steatosis, MN: Mild necrosis and RH: Regenerating hepato-