FIGURE 4 | Kaplan – Meier curves for PFS (A) and OS (B) according to baseline PIV in external validation group. Yellow lines indicate patients with low PIV (<581.95), and blue lines indicate patients with high PIV ( ≥ 581.95). mOS, median overall survival; mPFS, median progression-free survival; m month; PIV, Pan- Immune-In fl ammation