FIGURE 3 | Spatial evolution of standardized R 0 yearly anomalies for (A) 2013, (B) 2014, and (C) 2015. (D) Average evolution of standardized R 0 anomalies (in units of standard deviations, s) for Latin America and the Caribbean [domain in panel (A) ] for the 1950–2015 period. Black empty curve and filled curve show the raw and linearly detrended standardized anomalies, respectively. A 12-month running average filter was applied to both curves to better capture the inter-annual variability. There is no data over the