Fig 6. Histological changes in the epididymal white adipose tissue. eWAT wet weight ( A ), representative eWAT images stained with hematoxylin and eosin ( B ), distribution of adipocyte diameter ( C ), and number of crown-like structures ( D ). eWAT, epididymal white adipose tissue; wo, week-old. Black arrows indicate crown-liked structure. Data are illustrated as mean ± SEM. � and † show significantly different from age-matched LETO rats and age-matched the OLETF Sed group, respectively, P < 0.05, one way ANOVA. n = 5–6 per group. https://doi.org/10.1371/journal.pone.0270330.g006