Figure 3. Metabolic characterisation of AD and PD subclasses. Flux balance analysis (FBA) was performed on iADPD1-3 Figure 3. Metabolic characterisation of AD and PD subclasses. Flux balance analysis (FBA) was performed on iADPD1-3 genome-scale metabolic models (GEMs), and flux values were compared with those of iADPDControl . Key metabolites genome-scale metabolic models (GEMs), and flux values were compared with those of iADPDControl . Key metabolites and reactions within the androgen metabolism pathway are shown and key dysregulations are displayed as coloured and reactions within the androgen metabolism pathway are shown and key dysregulations are displayed as coloured arrows: red indicates increased flux compared to iADPDControl ; blue indicates decreased flux compared to iADPDControl . arrows: red indicates increased flux compared to iADPDControl ; blue indicates decreased flux compared to iADPDControl . Dysregulations associated to each GEM are shown in coloured boxes. The dashed line indicates multiple reactions are Dysregulations associated to each GEM are shown in coloured boxes. The dashed line indicates multiple reactions are involved. Human Metabolic Reactions (HMR) identifiers are shown for androgen metabolism reactions with dysregulated involved. Human Metabolic Reactions (HMR) identifiers are shown for androgen metabolism reactions with dysregulated fluxes. For full data, refer to Supplementary Data fluxes. For full data, refer to Supplementary Data 2.