FIGURE 2 | The hypothetical role of DNA epigenetics in addiction susceptibility. (Top) Factors related to addiction susceptibility that also have a DNA epigenetic basis. (Center) A schematic of DNA epigenetic dynamics. (Bottom) Addiction susceptibility is associated with DNA modi fi cation changes. Abbreviations: DNMT, DNA methyltransferase; TET, ten-eleven translocation methylcytosine dioxygenase; BER, base excision