Figure 9. Optimization algebraic ramps outlining the solution meeting the criteria of desired CQAs. The factor settings of Figure 9. Optimization algebraic ramps outlining the solution meeting the criteria of desired CQAs. The factor settings of Figure 9. Optimization algebraic ramps outlining the solution meeting the criteria of desired CQAs. The factor settings of ( a ) drug–stabilizer, ( b ) drug–mannitol ratios, ( c ) inlet temperature, are shown by the red dots and ( d ) the CQA selected ( a ) drug–stabilizer, ( b ) drug–mannitol ratios, ( c ) inlet temperature, are shown by the red dots and ( d ) the CQA selected ( a ) drug–stabilizer, ( b ) drug–mannitol ratios, ( c ) inlet temperature, are shown by the red dots and ( d ) the CQA selected response prediction particle size values are displayed in blue. response prediction particle size values are displayed in blue. response prediction particle size values are displayed in blue.