Figure 1. Effects of ECE and dieckol on the CD36, PPAR- α , and PLIN2 modulation in the muscle Figure 1. Effects of ECE and dieckol on the CD36, PPAR- α , and PLIN2 modulation in the muscle of HF-fed mice. ( A ) The protein levels of CD36, PPAR- α , PLIN2 and β -actin were determined by of HF-fed mice. ( A ) The protein levels of CD36, PPAR- α , PLIN2 and β -actin were determined by western blotting. The β -actin was used for comparison for equal amount of protein level, and rela- western blotting. The β -actin was used for comparison for equal amount of protein level, and relative tive comparisons were mad for the Chow/saline group. ( B ) The CD36 protein level of the HF/sa- comparisons were mad for the Chow/saline group. ( B ) The CD36 protein level of the HF/saline line groups were increased and decreased by ECE or dieckol treatment. ( C ) The PPAR- α protein groups were increased and decreased by ECE or dieckol treatment. ( C ) The PPAR- α protein level of level of the HF/saline groups were decreased and increased by ECE or dieckol treatment. ( D ) The the HF/saline groups were decreased and increased by ECE or dieckol treatment. ( D ) The PLIN2 PLIN2 protein level of the HF/saline groups was increased and decreased by ECE or dieckol treat- protein level of the HF/saline groups was increased and decreased by ECE or dieckol treatment. ment. Data are presented as mean ± SD. **, p < 0.01 vs. Chow/saline; $, p < 0.05 and $$, p < 0.01 vs. Data are presented as mean ± SD. **, p < 0.01 vs. Chow/saline; $, p < 0.05 and $$, p < 0.01 vs. HF/saline; ##, p < 0.01 vs. HF/ECE100 (Mann–Whitney U test). CD36, cluster of differentiation 36; conc., concentration; ECE, Ecklonia cava extract; HF, high-fat diet; PLIN2, Perilipin-2; PPAR- α , pe- HF/saline; ##, p < 0.01 vs. HF/ECE100 (Mann–Whitney U test). CD36, cluster of differentiation roxisome proliferator-activated receptor alpha. 36; conc., concentration; ECE, Ecklonia cava extract; HF, high-fat diet; PLIN2, Perilipin-2; PPAR- α , peroxisome proliferator-activated receptor