Figure 15. Contour overall plots are presented showing the desirability as function of factorial functions guiding the Figure 15. Contour overall plots are presented showing the desirability as function of factorial functions guiding the ex- exploration of the design interaction space: ( a ) Fenofibrate to Pharmacoat and Fenofibrate to mannitol w / w ratios, ( b ) ploration of the design interaction space: ( a ) Fenofibrate to Pharmacoat and Fenofibrate to mannitol w / w ratios, ( b ) Feno- Fenofibrate to mannitol w / w ratio and inlet temperature, ( c ) Fenofibrate to Pharmacoat w / w ratio and inlet temperature. fibrate to mannitol w / w ratio and inlet temperature, ( c ) Fenofibrate to Pharmacoat w / w ratio and inlet temperature. For For each graph on the left column the optimum of ζ -potential and Z-size responses are flagged in the medium and the left each graph on the left column the optimum of ζ -potential and Z-size responses are flagged in the medium and the left column, respectively. Inner red to perimeter blue face contours define the operational CQA area of column, respectively. Inner red to perimeter blue face contours define the operational CQA area of interest.