Fig 7. Connectedness of appetite-regulating genes and the feeding conditions based on the gene expression patterns. ( A ) Pairwise expression correlations of appetite regulating genes in the gut of wild-type and lepr mutant zebrafish. The blue and red colours respectively indicate positive and negative Pearson correlation coefficients and their light to dark shadings show significant levels of P < 0.05, P < 0.01 and P < 0.001, respectively. The gene specified with black background is an orexigenic gene whereas the rest are anorexigenic genes. Pairwise correlations delineated with black borders are similar between the two genotypes. ( B ) Clustering of the experimental conditions in each genotype based on similarities in expression patterns of the appetite regulating genes (the blue and yellow colors indicate higher and lower expression level, respectively).