Figure 3. Effects of ECE and dieckol on the Murf1 , Atrogin-1 , and p53 modulation in the muscle of HF-fed mice. ( A – C ) The Figure 3. Effects of ECE and dieckol on the Murf1 , Atrogin-1 , and p53 modulation in the muscle of HF-fed mice. ( A – C ) The Murf1 ( A ), Atrogin-1 ( B ), and p53 ( C ) mRNA levels of the HF/saline groups were increased and decreased by ECE or Murf1 ( A ), Atrogin-1 ( B ), and p53 ( C ) mRNA levels of the HF/saline groups were increased and decreased by ECE or dieckol dieckol treatment. Data are presented as mean ± SD. **, p < 0.01 vs. Chow/saline; $$, p < 0.01 vs. HF/saline; #, p < 0.05 and treatment. Data are presented as mean ± SD. **, p < 0.01 vs. Chow/saline; $$, p < 0.01 vs. HF/saline; #, p < 0.05 and ##, ##, p < 0.01 vs. HF/ECE100 (Mann–Whitney U test). conc., concentration; ECE, Ecklonia cava extract; HF, high-fat diet; p < 0.01 vs. HF/ECE100 (Mann–Whitney U test). conc., concentration; ECE, Ecklonia cava extract; HF, high-fat diet; Murf1, Murf1, muscle RING-finger protein-1; p53, tumor protein P53. muscle RING-finger protein-1; p53, tumor protein P53.