Figure 4. Effects of ECE and dieckol on the weight, muscle atrophy, and grip strength modulation in the livers of HF-fed Figure 4. Effects of ECE and dieckol on the weight, muscle atrophy, and grip strength modulation in the livers of HF-fed mice. ( A ) Bodyweight was increased by HF/saline and decreased by ECE or dieckol treatment. ( B ) Fat mass was increased mice. ( A ) Bodyweight was increased by HF/saline and decreased by ECE or dieckol treatment. ( B ) Fat mass was increased by HF/saline and decreased by dieckol treatment. ( C ) Lean mass was decreased by HF/saline but not increased by ECE or by HF/saline and decreased by dieckol treatment. ( C ) Lean mass was decreased by HF/saline but not increased by ECE or dieckol treatment. ( D , E ) The CSA of the muscle fiber by hematoxylin and eosin (H&E) staining was decreased by HF/saline dieckol treatment. ( D , E ) The CSA of the muscle fiber by hematoxylin and eosin (H&E) staining was decreased by HF/saline and increased by ECE or dieckol treatment. ( F ) The grip strength was decreased by HF/saline and increased by ECE or and increased by ECE or dieckol treatment. ( F ) The grip strength was decreased by HF/saline and increased by ECE dieckol treatment. ( G ) The schematic summary of the effect of ECE or dieckol in high fat diet muscle. Scale bar = 100 µm. Data are presented as mean ± SD. *, p < 0.05, **, p < 0.01 and ***, p < 0.001 vs. Chow/saline; $, p < 0.05 and $$, p < 0.01 vs. HF/saline; #, p < 0.05 and ##, p < 0.01 vs. HF/ECE100 (Mann–Whitney U test). conc., concentration; ECE, Ecklonia cava extract; HF, high-fat diet.