Figure 8. Response surface and contour plots of the particle size versus: ( a ) drug–diluent and drug–stabilizer ratio, ( b ) inlet Figure 8. Response surface and contour plots of the particle size versus: ( a ) drug–diluent and drug–stabilizer ratio, ( b ) inlet temperature and drug–stabilizer ratio, ( c ) operating temperature and drug–mannitol ratio. temperature and drug–stabilizer ratio, ( c ) operating temperature and drug–mannitol ratio.