Figure 14. Numeric optimization ramps investigating the optimal solution meeting the criteria of the desired CQAs (right Figure 14. Numeric optimization ramps investigating the optimal solution meeting the criteria of the desired CQAs (right lower corner blue circle indications). The optimal factor settings of inlet temperature, drug–stabilizer and drug–mannitol lower corner blue circle indications). The optimal factor settings of inlet temperature, drug–stabilizer and drug–mannitol ratios are shown with red dots, while the optimal response prediction values are displayed in blue: ( a ) average particle ratios are shown with red dots, while the optimal response prediction values are displayed in blue: ( a ) average particle size size was set at 887.6 nm; ( b ) algebraic ζ -potential corresponding at − 16.49 mV and set inlet temperature 77 °C ( c ) temper- was set at 887.6 nm; ( b ) algebraic ζ -potential corresponding at − 16.49 mV and set inlet temperature 77 ◦ C ( c ) temperature ature corresponding at − 16,49 mV and set inlet temperature 77 °C ( d ) ζ -potential outlier values ( e ) particle size outlier corresponding at − 16,49 mV and set inlet temperature 77 ◦ C ( d ) ζ -potential outlier values ( e ) particle size outlier values