but not TNP-2. Notably again, autophagy inhibition helped TNP- 1-mediated PTT to achieve a level of cell death unattainable under TNP-2-mediated PTT, as near complete killing was achieved with the combined treatment of TNP-1, irradiation and 3-MA (>92%, with the lower-right and the upper-right quadrants combined, which included both early apoptotic and late apoptotic/necrotic cells), while much less killing (55%) was observed for the combined treatment of TNP-2, irradiation and 3-MA. NATURE COMMUNICATIONS| (2018) 9:4236 |DOI: