Fig. 7 Autophagy inhibitors signi fi cantly enhanced anti-cancer ef fi cacy of TNP-1-mediated PTT in the MCF7/MDR model. a Tumor-site temperature recorded after three minute of NIR irradiation, at the various time points after the intravenous injection of TNP-1. Mean± s.e.m. n = 3. Student ’ s t -test. b, c The body weight ( b ) and tumor volume ( c ) changes of mice in the various treatment groups during the 15-day therapeutic period. Dosing used: TNP-1 or TNP-2, 1.5 mg kg -1 ; CQ, 25 mg kg − 1 ; Dox, 15 mg kg − 1 . Mean ± s.e.m. n = 5. *** p < 0.001. Student ’ s t -test. d Photographs of the tumors excised on day 15. e Tumor weight of mice on day 15 in the various treatment groups. Mean± s.e.m. n = 5. ** p < 0.01, *** p < 0.001. Student ’ s t -test. f Tumor weight of mice in the various treatment groups after a 7-day PTT treatment regimen in a different study.Mean ± s.e.m. n = 6. *** p < 0.001. Student ’ s t