Fig. 4 BRD1389-bound Plasmodium cFRS adopts unique conformations. a Superimposition of Hs cFRS (grey; PDB “ 3L4G [https://www.rcsb.org/ structure/3l4g] ” ) and Tt FRS (orange; PDB “ 2IY5 [https://www.rcsb.org/structure/2IY5] ” ) structures on Pv cFRS:BRD1389 complex (corn fl ower blue). b Opening of Loop 1 (residues 443 – 453) of Pv cFRS for BRD1389 binding to accommodate its methoxymethyl group and adoption of a possible open conformation. c Closing of Loop 2 (residues 507 – 515) in Pv cFRS:BRD1389 complex. d Open conformation of the Arg548 in Pv cFRS:BRD1389 complex accommodates its [6.2.0]-diazabicyclodecane core as compared to its orthologue residue in Hs cFRS (Arg463) and Tt FRS (Arg321) which in its closed conformation may clash with this