Fig. 6 BRD1389 is a novel dual-site inhibitor of Plasmodium cFRS. a Catalytic pocket in Pv cFRS:BRD1389 complex while it is superimposed on Hs cFRS-L-Phe (Purple; PDB “ 3L4G [https://www.rcsb.org/structure/ 3l4g] ” ) and on Tt FRS-L-Phe-AMP-tRNA (Yellow; PDB “ 2IY5 [https://www. rcsb.org/structure/2IY5] ” ). BRD1389 occupies L-Phe and auxiliary sites and its methoxymethyl group (arrow; green) is proximal to ATP binding site. b Schematic map showing BRD1389 occupancy in the enzyme