Figure 1. ( A ) Chemical structure of UPAR415, on the left; the main interactions derived from X-ray Figure 1. ( A ) Chemical structure of UPAR415, on the left; the main interactions derived from X-ray studies of UPAR415 with the active site are shown in the middle; and the general structure of studies of UPAR415 with the active site are shown in the middle; and the general structure of UPAR415 derivatives are on the right, with the substituents of the most active compounds being shown. ( B ) Cartoon representation of the StOASS-A active site in complex with UPAR415 (PDB code: 6Z4N). Highlighted with a dashed black line is the H-bond interaction of the ligand carboxylic function