FIGURE 4 Analysis of genes and proteins that interact with DDR1. (A) The OncoPrint of DDR1 gene alterations in queried 777 samples of gastric cancer using cBioPortal database. Colors are used to highlight the various genetic alterations. (B) A PPI network of DDR1 and its related proteins using the Cytospace software and heatmaps of pathway enrichment using the Metascape. The p-value cutoff is 0.01. (C) The interaction network of genes and proteins that interact with DDR1 using PINA database. The yellow nodes represent genes related to poor prognosis (p <0.05, HR>1). The green nodes represent genes connected with good prognosis (p <0.05, HR<1). The red edges represent a positive correlation (FDR <0.05), while the blue edges represent a negative correlation (FDR <0.05). Edge width is relative to correlation coef fi cients. (D) Heatmap shows the correlation coef fi cients of mRNA expression (top row) and protein abundance (bottom row) among interacting proteins (DDR1-ERBB2 and DDR1-EPHA2) in each tumor