Here is the design of a clinical trial:

Official Title: Comparison of the Effectiveness of 3 Teaching Methods in Oral Hygiene in Adolescent Orthodontic Patients: Prospective Randomized Controlled Clinical Study

Included conditions:
- Orthodontic Appliance

Study Armgroups:
- {'label': 'Control group', 'type': 'ACTIVE_COMPARATOR', 'description': 'oral hygiene advice given orally', 'interventionNames': ['Behavioral: Control group']}
- {'label': 'Group with active participation', 'type': 'ACTIVE_COMPARATOR', 'description': 'oral hygiene advice given orally and demonstration of brushing methods in the sink with active participation', 'interventionNames': ['Behavioral: Group with active participation']}
- {'label': 'Group with video and quizz', 'type': 'EXPERIMENTAL', 'description': 'oral hygiene advice given orally and an additional appointment between the device bonding appointment and the first check-up. This is a 15-minute session dedicated to teaching oral hygiene. This session will include watching of an educational video followed by a quiz, as well as the application of the methods taught in the sink (using plate developer and the Oral B electric toothbrush with special orthodontic head).', 'interventionNames': ['Behavioral: Group with video and quizz']}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Control group', 'description': 'oral hygiene advice given orally in the chair during the bonding appointment and at each check-up appointment.', 'armGroupLabels': ['Control group']}
- {'type': 'BEHAVIORAL', 'name': 'Group with active participation', 'description': 'oral hygiene advice given orally in the chair during the bonding appointment and at each check-up appointment with a demonstration of brushing methods in the sink with active participation (use of plate developer and then the Oral B electric toothbrush with special orthodontic head) during the bonding appointment as well than at each check-up appointment.', 'armGroupLabels': ['Group with active participation']}
- {'type': 'BEHAVIORAL', 'name': 'Group with video and quizz', 'description': 'oral hygiene advice given orally in the chair during the bonding appointment and at each check-up appointment with have an additional appointment between the device bonding appointment and the first check-up. This is a 15-minute session dedicated to teaching oral hygiene. This session will include watching of an educational video followed by a quiz, as well as the application of the methods taught in the sink (using plate developer and the Oral B electric toothbrush with special orthodontic head).', 'armGroupLabels': ['Group with video and quizz']}

Primary Outcomes:
- {'measure': 'Compare the effectiveness of 3 methods of teaching oral hygiene in terms of controlling biofilm formation: MOP (Modified Orthodnotic Plaque Index) classification', 'description': "The average plaque index at six months after inclusion according to the MOP (Modified Orthodnotic Plaque Index) classification. It is evaluated on macro photography in a standardized manner by a blind examiner of the patient's randomization arm. The values range from 0 to 4 for each tooth, which makes an average score of 0 to 48 for the maxillary arch. 0 is the absence of plaque while 48 is an abundance of plaque on all teeth, the worst situation. The score is expressed in absolute value without unit.", 'timeFrame': '6 months of intervention'}

Please estimate the sample size based on the assumption: 
risk alpha = 5%, power of 80%, ANOVA type analysis, 3 groups, possible dropouts
Sample size {14}
        The sample size calculation is based on the primary outcome: comparison of the mean MOP between the 3 experimental groups after 6âmonths of treatment. For a risk alphaâ=â5%, a power of 80%, an effect size of 0.35, with an ANOVA type analysis and 3 groups, a total of 81 subjects is necessary (27 per group). To consider possible dropouts, we plan to recruit 30 patients per group, i.e., 90 patients in total.