Here is the design of a clinical trial:

Official Title: Comparison of Continuous Versus Intermittent Enteral Nutrition in Critically Ill Patients. Effect on Energy and Protein Target Achievement, Tolerance and Incidence of Complications. Monocentric Prospective Randomised Study.

Included conditions:
- Nutrition Disorders

Study Armgroups:
- {'label': 'Intermittent', 'type': 'EXPERIMENTAL', 'description': 'enteral nutrition will be administered via enteral feeding pump as 30-60minutes lasting bolus 6 times per day volume of initial bolus will be 80ml. The volume of bolus will be increased gradually according to tolerance, till the estimated target rate will be reached', 'interventionNames': ['Other: enteral nutrition']}
- {'label': 'Continuous', 'type': 'EXPERIMENTAL', 'description': 'enteral nutrition will be administered via enteral feeding pump for at least 16 hours par day initial rate will be 25ml/hour. The rate will be increased gradually according to tolerance, till the estimated target rate will be reached', 'interventionNames': ['Other: enteral nutrition']}

Interventions:
- {'type': 'OTHER', 'name': 'enteral nutrition', 'description': 'administration of enteral nutrition', 'armGroupLabels': ['Continuous', 'Intermittent']}

Primary Outcomes:
- {'measure': 'Energy target', 'description': 'Daily assessment of energy intake in critically ill patients with enteral nutrition.Energy target will be achieved if at least 80% of calculated energy intake will be delivered.', 'timeFrame': '5 days from initiation of enteral nutrition'}

Please estimate the sample size based on the assumption: 
Alpha set to 5%, power set to 80%, and accounting for potential drop-out.
Sample size {14}
        Studies focused on the primary target of our study are lacking. However, we have identified several studies comparing bolus and continuous administration of enteral feeding. These studies included small numbers of patients, were conducted in different patient populations, and did not assess the time to reach the nutritional targets as a primary outcome. However, for calculation of the sample size, we hypothesized a difference of 1âday between groups (target being reached on day 2 and day 3, respectively). The alpha was set to 5%, and the power was set to 80%. The estimated sample size was 122 patients per arm. To account for potential drop-out, we increased the sample size to 300 participants in total, with 150 patients in each study arm.
Table 3Participant timelineStudy periodFollow-upTime pointScreeningD0D1D2D3D4D5D28Number of visits12345678Eligibility criteriaxInformed consentxAllocationxDemographic dataxAPACHE IIxSOFA scorexLaboratory tests (total serum protein, albumin, prealbumin)xxEstimation of energy and protein targetxAdministration of enteral nutritionxxxxxAssessment of tolerance (diarrhea, vomiting, GRV, postpyloric nutrition)xxxxxAssessment of complicationsxxxxxAssessment of energetic and protein targetsxxxxxAssessment of hospital LOS, ICU LOS, and mortalityx