Here is the design of a clinical trial:

Official Title: Efficacy and Safety of Hourly Titrated Misoprostol Versus Vaginal Dinoprostone and Misoprostol for Cervical Ripening and Labor Induction: Randomized Clinical Trial

Included conditions:
- Labor, Induced

Study Armgroups:
- {'label': 'Oral misoprostol', 'type': 'EXPERIMENTAL', 'description': 'Administration of oral misoprostol according to a "3x1" diagram, that is,3 oral doses (1 per hour) and then 1 hour without treatment', 'interventionNames': ['Drug: Oral misoprostol']}
- {'label': 'Vaginal misoprostol', 'type': 'ACTIVE_COMPARATOR', 'description': 'vaginal misoprostol, 25 microgs every 4 hours', 'interventionNames': ['Drug: Vaginal misoprostol']}
- {'label': 'Vaginal dinoprostone', 'type': 'ACTIVE_COMPARATOR', 'description': 'vaginal dinoprostone, 10 mg during 24 hours (maximum)', 'interventionNames': ['Drug: Vaginal dinoprostone']}

Interventions:
- {'type': 'DRUG', 'name': 'Oral misoprostol', 'description': 'hourly titrated misoprostol', 'armGroupLabels': ['Oral misoprostol']}
- {'type': 'DRUG', 'name': 'Vaginal misoprostol', 'description': 'Administration of 25 microgs every 6 hours, maximum 150 microgr', 'armGroupLabels': ['Vaginal misoprostol']}
- {'type': 'DRUG', 'name': 'Vaginal dinoprostone', 'description': 'Vaginal delivery system of 10mg of dinoprostone', 'armGroupLabels': ['Vaginal dinoprostone']}

Primary Outcomes:
- {'measure': 'Compare the percentage of women in each group who achieved vaginal delivery within 24 hours after the beginning of administration in each group (oral misoprostol, vaginal misoprostol and intravaginal dinoprostone)', 'timeFrame': '24 hours'}

Please estimate the sample size based on the assumption: 
power of 90%, confidence level of 95%, 10% rate of losses during follow-up
Sample size calculation
        Taking data in the scientific literature on the rate of vaginal delivery within 24âh after the administration of the study drugs (70% for oral misoprostol [12], 55% for dinoprostone [12] and 54% of vaginal misoprostol [24]) as a reference, we will need to analyse 333 women (111 per arm) to detect significant differences between the groups with a power of 90% and a confidence level of 95%. Assuming a 10% rate of losses during the follow-up period, we will therefore need to recruit a total of 372 women (124 per arm).