Here is the design of a clinical trial:

Official Title: Comparison of Effects Between SMR/Delta Ratio and beta1/Theta Ratio Neurofeedback Trainings for Older Adults With Mild Cognitive Impairment: A Protocol for a Randomized Controlled Trial

Included conditions:
- Mild Cognitive Impairment

Study Armgroups:
- {'label': 'Sensorimotor/delta NF training group', 'type': 'EXPERIMENTAL', 'description': 'Three interventions will be administered:\n\n* An electroencephalography recording (EEG) for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system.\n* The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours.\n* The third intervention is the neurofeedback training sensorimotor/delta ratio that will be recorded at channel Cz according to the International 10-20 system.', 'interventionNames': ['Behavioral: Neurofeedback']}
- {'label': 'Beta1/theta NF training group', 'type': 'EXPERIMENTAL', 'description': 'Three interventions will be administered:\n\n* An electroencephalography recording (EEG) for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system.\n* The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours.\n* The third intervention is the neurofeedback training Beta1/theta ratio that will be recorded at channel Fz according to the International 10-20 system.', 'interventionNames': ['Behavioral: Neurofeedback']}
- {'label': 'Control group', 'type': 'NO_INTERVENTION', 'description': 'Three interventions will be administered:\n\n* An electroencephalography recording for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system.\n* The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours.\n* The psychopedagogical care : Each session will be organized using the same video material than for the NF training sessions.'}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Neurofeedback', 'description': 'Neurofeedback experiment will consist of 30 sessions of neurofeedback training, twice or three times a week during maximum 4 months. The two experimental groups will undergo questionnaires, EEG recording and neuropsychological assessments in three-time points, pre-training (T0), post-training (T1) and 3 months follow-up (T2). Electroencephalography will be recorded by a technician in EEGFor each participant, EEG power spectrum will be calculated in pre (T0) and post neurofeedback training/psycho-pedagogical care at T2 and T3.', 'armGroupLabels': ['Beta1/theta NF training group', 'Sensorimotor/delta NF training group'], 'otherNames': ['Electroencephalography']}

Primary Outcomes:
- {'measure': 'Change on attention test, TMTB-TMA', 'description': 'assessment of the Trail Making Test B and A, calculation of subtraction', 'timeFrame': 'Baseline Assessment in 2 weeks period before intervention, change from baseline at immediately after the end of the intervention and after 3-months follow-up'}

Please estimate the sample size based on the assumption: 
The total sample of 60 subjects has a power of 80% to detect differences between means using an F test with a significance level of 0.05.
Sample size
        The sample size calculation was estimated on the basis of our feasibility study evaluating the effects of NF training on cognitive performances in MCI subjects (registered at ClinicalTrials.gov under the identifier: NCT03526692, on 16 May 2018). In an analysis of covariance study (ANCOVA), sample sizes of 20 are obtained for each of the three groups whose expected averages of TMT B are 140 in the control group and 105âs in two intervention groups with a standard deviation of 45. The supposed R-squared of the model is 0.20. The total sample of 60 subjects has a power of 80% to detect differences between means using an F test with a significance level of 0.05.