Here is the design of a clinical trial:

Official Title: Interdependent Quality of Life in Parent-Child Dyads Adjusting to Eczema: Effects of a Randomized Controlled Trial of the Integrative Body-Mind-Spirit Group Intervention

Included conditions:
- Eczema
- Dermatitis, Atopic

Study Armgroups:
- {'label': 'Parent-child I-BMS intervention group', 'type': 'EXPERIMENTAL', 'description': 'Children with eczema and their parent caregivers will attend the six sessions simultaneously in a parallel group format. Parent caregivers will attend the parents group in the first 2.5 hours; while children will attend the children group in the first 2.5 hours. Both parents and children will later reunite in the joint group in the final 0.5 hours.', 'interventionNames': ['Behavioral: I-BMS for families with children suffering from eczema']}
- {'label': 'Parent only I-BMS intervention group', 'type': 'EXPERIMENTAL', 'description': 'Only parent caregivers of children with eczema will attend the six sessions. The content of the 2.5-hour parents group will be the same as the one in Arm 1 (Parent-child I-BMS intervention group), with an additional 0.5 hour of reflective discussion among group members. The children group will simultaneously attend a group activity class in a separate room for 3 hours.', 'interventionNames': ['Behavioral: I-BMS for families with children suffering from eczema']}
- {'label': 'Parent only health education active control group', 'type': 'ACTIVE_COMPARATOR', 'description': 'Only parent caregivers of children with eczema will attend the six sessions. Each session consists of teaching in the first 2.5 hours and Q\\&A in the final 0.5 hour. The children group will simultaneously attend a group activity class in a separate room for 3 hours.', 'interventionNames': ['Behavioral: Health education for parents whose children have eczema']}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'I-BMS for families with children suffering from eczema', 'description': 'It is a strength-based, family system approach to aid empowerment of individuals. It focuses on the interplay between physical and emotional well-being, the spiritual transformation of adverse life experiences, and the acceptance of adversity through reflection on the philosophical concepts of forgiveness and letting go. It integrates Western therapeutic techniques and Eastern philosophies to develop spiritual transformation through suffering and pain under a meaning-oriented framework. It consists of six three-hour consecutive weekly sessions: (1) awareness of body-mind connection; (2) regulation of emotion; (3) acknowledgement of the gains and losses in the caregiving or illness experience; (4) appreciation of self and others; (5) cultivation of acceptance; and (6) meaning reconstruction of caregiving or illness experience.', 'armGroupLabels': ['Parent only I-BMS intervention group', 'Parent-child I-BMS intervention group']}
- {'type': 'BEHAVIORAL', 'name': 'Health education for parents whose children have eczema', 'description': 'It focuses on practical eczema management. It serves as a control for group effect between conditions. It consists of six three-hour sessions: (1) information about the physiology of eczema and its health impact; (2) recognition and avoidance of trigger factors and daily skin care; (3) dealing with itching and scratching; (4) stage-related treatment of symptoms and unconventional therapies; (5) general child nutrition, food allergies in eczema, and different forms of diets; and (6) self-management plan and problems in integrating into daily routine.', 'armGroupLabels': ['Parent only health education active control group']}

Primary Outcomes:
- {'measure': 'Changes over the measurement points in the Family Dermatology Life Quality Index', 'description': 'It has 10 items. It measures how much a child with atopic dermatitis affects the quality of life of their parent caregivers. Scores range from 0 to 30, where a high score represents a greater effect on the life of the parent caregiver.', 'timeFrame': 'Baseline, post-intervention: 6 weeks after intervention initiation, 6-week follow up'}
- {'measure': "Changes over the measurement points in the Children's Dermatology Life Quality Index", 'description': "It has 10 items. It measures the impact of atopic dermatitis on the lives of children. Scores range from 0 to 30, where a higher score represents a greater impact on the child's life.", 'timeFrame': 'Baseline, post-intervention: 6 weeks after intervention initiation, 6-week follow up'}
- {'measure': 'Changes over the measurement points in the Cognitive Emotion Regulation Questionnaire - Short Version', 'description': 'It has 18 items. It measures the specific cognitive emotion regulation strategies parent caregivers have used when caring for their children. It has nine subscales, namely, self-blame, other-blame, rumination, catastrophizing, putting into perspective, positive refocusing, positive appraisal, acceptance and planning. Subscale scores range from 2 to 10, where a higher score represents more usage of a specific cognitive emotion strategy.', 'timeFrame': 'Baseline, post-intervention: 6 weeks after intervention initiation, 6-week follow up'}
- {'measure': 'Changes over the measurement points in the Short Version of the Cognitive Emotion Regulation Questionnaire for Spanish Kids', 'description': 'It has 18 items. It measures the specific cognitive emotion regulation strategies children have used to cope with their illness experience. It has nine subscales, namely, self-blame, other-blame, rumination, catastrophizing, putting into perspective, positive refocusing, positive appraisal, acceptance and planning. Subscale scores range from 2 to 10, where a higher score represents more usage of a specific cognitive emotion strategy.', 'timeFrame': 'Baseline, post-intervention: 6 weeks after intervention initiation, 6-week follow up'}

Please estimate the sample size based on the assumption: 
Alpha value set to 0.05, correlation among repeated measures set at 0.5, 80% power, and 25% attrition at each assessment point.
Sample size calculation
        The sample size calculation for each parentâs primary outcome (ie, QoL and emotional regulation) is conducted using G*Power V.3.1.9.4 âANOVA: Repeated measures, between factorsâ. The alpha value is set to 0.05. Correlation among repeated measures is set at 0.5. A minimum of 108 parents will be required to detect a small effect of 0.25 among the three arms across three assessment points with 80% power. Considering 25% attrition at each assessment point, a total sample of 192 parents is needed.
        Sample size calculation for each childâs primary outcome (ie, QoL and emotional regulation) is the same as that of the parents. A minimum of 108 children will be required to detect a small effect of 0.25 among the three arms across three assessment points with 80% power. Considering 25% attrition at each assessment point, a total sample of 192 children is needed. Taken together, the final target sample consists of 192 parentâchild dyads (64 dyads per arm).