Here is the design of a clinical trial:

Official Title: Randomized Controlled Trial of Dopamine, Adrenaline, and Blood Transfusion for Treatment of Fluid Refractory Shock in Children With Severe Acute Malnutrition or Severe Underweight and Cholera or Other Dehydrating Diarrheas

Included conditions:
- Shock Hypovolemic
- Shock, Septic
- Blood Transfusion
- Adrenaline
- Dopamine

Study Armgroups:
- {'label': 'Dopamine arm', 'type': 'EXPERIMENTAL', 'description': 'Children in the dopamine arm (Treatment plan A) will receive dopamine, 8 microgram/kg/min (increasing the dose after 15 minutes to 12 microgram/kg/min to a maximum of 15 microgram/kg/min)', 'interventionNames': ['Drug: Dopamine']}
- {'label': 'Adrenaline arm', 'type': 'EXPERIMENTAL', 'description': 'Children in the adrenaline arm (Treatment plan B) will receive adrenaline, 0.1 microgram/kg/min (increasing the dose after 15 minutes to 0.2 microgram/kg.min to a maximum of 0.3 microgram/kg.min)', 'interventionNames': ['Drug: adrenaline']}
- {'label': 'Blood transfusion arm', 'type': 'ACTIVE_COMPARATOR', 'description': 'Children in the blood transfusion arm (Treatment plan C) will receive a transfusion of whole human blood in a dose of 10 mL/kg over 2-3 hours. While the blood transfusion is being arranged, IV fluid would be given @ of 3 ml per kg per hour', 'interventionNames': ['Drug: Blood Transfusion']}

Interventions:
- {'type': 'DRUG', 'name': 'Dopamine', 'description': 'Children will receive dopamine, 8 microgram/kg.min (increasing the dose after 15 minutes to 12 microgram/kg/min to a maximum of 15 microgram/kg/min)', 'armGroupLabels': ['Dopamine arm']}
- {'type': 'DRUG', 'name': 'adrenaline', 'description': 'Children will receive adrenaline, 0.1 microgram/kg/min (increasing the dose after 15 minutes to 0.2 microgram/kg.min to a maximum of 0.3 microgram/kg.min)', 'armGroupLabels': ['Adrenaline arm'], 'otherNames': ['Epinephrine']}
- {'type': 'DRUG', 'name': 'Blood Transfusion', 'description': 'Children will receive a transfusion of whole human blood in a dose of 10 mL/kg over 2-3 hours. While the blood transfusion is being arranged, IV fluid would be given @ of 3 ml per kg per hour', 'armGroupLabels': ['Blood transfusion arm'], 'otherNames': ['Blood']}

Primary Outcomes:
- {'measure': 'Case fatality rate', 'description': 'Number of mortalities among SAM or severe underweight children presenting with diarrhea and fluid refractory shock who would receive WHO standard fluid therapy followed by dopamine or adrenaline, compared to those receiving blood transfusion after WHO standard fluid therapy', 'timeFrame': '28 days (± 3 days)'}

Please estimate the sample size based on the assumption: 
80% power (20% type II error) and 0.05 type I error, with around 10% drop-outs after enrolment.
Sample size
        The 2010â2011 data from the ICU of the Dhaka Hospital of the icddr, b (the proposed study site) revealed that among the 36 severely malnourished children with shock, 22 died, that is, mortality rate among SAM children with septic shock was 61% (22/36). We assumed that the proposed interventions would reduce the case fatality rate by 50%, that is, the rate will decrease from 61% to 31%.
        To detect this magnitude of difference in the death rate, with 80% power (20% type II error) and 0.05 type I error, the required sample size is 40 children in each of the three groups. Considering around 10% drop-outs after enrolment, the total sample size would be 45 children at least in each of the three groups, that is, a total of 135 childrenâthe final sample size of our study.