Here is the design of a clinical trial:

Official Title: SEnsitive Care: Understanding and REsponding - Promoting Sensitivity in Center-based Childcare of 0-2 Year Old Children (the SECURE Project)

Included conditions:
- Caregiver Interactive Skills

Study Armgroups:
- {'label': 'COSC', 'type': 'EXPERIMENTAL', 'description': 'Eight weekly manualized sessions of Circle of Security Classroom (COSC), delivered in groups, two hours per session, 5-10 childcare providers per group.\n\nCOSC is facilitated by a psychologist who is a registered COSP facilitator and who has completed the an additional COSC online training.', 'interventionNames': ['Other: COSC']}
- {'label': 'Control', 'type': 'NO_INTERVENTION', 'description': 'Usual care control condition, i.e., standard practice in the participating childcare centers.\n\nTeams of childcare providers are allocated to either COSC or waitlist in clusters, and baseline and follow-up measures are collected parallel in both groups. Childcare providers allocated to the waitlist will receive COSC after the follow-up data have been collected.'}

Interventions:
- {'type': 'OTHER', 'name': 'COSC', 'description': "COSC is professional development program for early childcare providers adapted from the Circle of Security-Parenting (COSP) model. It is a manualized intervention that leverages research on attachment relationships combining psycho-education with a mentalization-based approach. The model uses pre-produced video vignettes of secure and problematic caregiver-child interactions to illustrate how caregivers' may struggle in meeting children's' attachment needs.\n\nParticipants are invited to reflect on how they meet and perhaps still not meet the needs of the children in their care with a particular focus on the challenging or 'difficult' children.\n\nThe COSP manual has been translated into Danish (Cooper, Hoffman and Powel, 2020, translated by Pedersen, Kronendorf von Wowern, Lier, \\& Smith-Nielsen), and the additional COSC material has been translated into Danish for the purpose of this study.", 'armGroupLabels': ['COSC']}

Primary Outcomes:
- {'measure': 'Caregiver Interactive Profile (CIP-scales), Sensitive responsiveness scale.', 'description': 'Coding of sensitive responsiveness is based on video-recorded caregiver-child interactions and sensitivity is rated on a 7-point scale with higher ratings reflecting higher levels of sensitivity', 'timeFrame': '12-16 weeks'}

Please estimate the sample size based on the assumption: 
Two-sided alpha of 0.05, 80% power, correlation between baseline and post-intervention of 0.5, ICC of 0.1.
Sample size and power
        The primary outcome for the study is the childcare providersâ sensitive responsiveness using the CIP-Scales [52]. Therefore, sample size was determined as the number of participants required to achieve min. 80% power for detecting a change in this measure with a two-sided alpha of 0.05. Two previous RCTs have examined interventions aiming at increasing professional caregiversâ sensitive responsiveness using the CIP-Scales. These studies find medium (dâ=â0.55) to large (dâ=â0.72) effects of the interventions on caregiversâ sensitive responsiveness post intervention. For normally distributed outcomes, a sample of 29Â day care centers (15 intervention, 14 control corresponding to 110 caregivers) with each 3.4 caregivers yields a statistical power of 81% to detect an effect size of dâ=â0.55 using a two-sided alpha of 0.05, a correlation between baseline and post-intervention of 0.5 and an ICC of 0.1. This is the conservative estimate using the lowest effect size. If the effect size is 0.72 the statistical power rises to 96%.