Here is the design of a clinical trial:

Official Title: Comparative Effectiveness and Cost-effectiveness of Chuna Manual Therapy for Chronic Neck Pain: A Multi-center Randomized Controlled Trial

Included conditions:
- Chronic Neck Pain

Study Armgroups:
- {'label': 'Chuna manual therapy', 'type': 'EXPERIMENTAL', 'description': 'The Chuna manual therapy group will receive Chuna manual therapy alone. Chuna manual therapy will employ a semi-standardized treatment plan of Chuna manual therapy through Chuna technique selection based on physician judgement of techniques from Chuna Medicine (Korean Society of Chuna Manual Medicine for Spine \\& Nerves: Chuna Medicine: Seoul: Korean Society of Chuna Manual Medicine for Spine \\& Nerves; 2017) and osteopathic manipulative medicine. The Chuna techniques employed in this study are divided into cervical, thoracic and rib cage, lumbar, pelvic, sacral, pubic, and hip joint area techniques. Chuna manual therapy sessions will be administered 2 sessions/week over a period of 5 weeks (total 10 sessions). The time duration of 1 Chuna manual therapy session will consist of approximately 10-20 minutes of diagnosis and approximately 10 minutes of treatment.', 'interventionNames': ['Procedure: Chuna manual therapy']}
- {'label': 'Usual care', 'type': 'ACTIVE_COMPARATOR', 'description': 'The usual care group will receive usual care alone. Usual care will be limited to physical therapy and conventional medication in this study. Usual care will be provided with reference to a list of most frequently used treatments in neck pain-related patients from Korean Health Insurance Review and Assessment (HIRA) 2014 statistics. Frequency and types of physical therapy used will be recorded in a separate electronic case report form for outcome assessor blinding purposes.', 'interventionNames': ['Drug: Conventional medication', 'Procedure: Physical therapy']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'Chuna manual therapy', 'description': 'Chuna is a Korean manual therapy that has absorbed and incorporated aspects of osteopathic manipulative medicine. Chuna manual therapy utilizes spinal manipulation techniques for joint mobilization including high-velocity, low amplitude thrusts to joints slightly beyond the passive range of motion and gentle force to joints within the passive range of movement, muscle energy, and fascial techniques.', 'armGroupLabels': ['Chuna manual therapy'], 'otherNames': ['Chuna manipulation']}
- {'type': 'DRUG', 'name': 'Conventional medication', 'description': 'Conventional drugs will be prescribed in an individually-tailored, pragmatic method with reference to most frequently used treatments in patients with a primary diagnosis of cervical sprain/strain group, cervical disc disorder with radiculopathy group, or cervicalgia according to Korean Health Insurance Review and Assessment (HIRA) 2014 statistics.', 'armGroupLabels': ['Usual care'], 'otherNames': ['Conventional medicine', 'Conventional drugs']}
- {'type': 'PROCEDURE', 'name': 'Physical therapy', 'description': 'Physical therapy will be prescribed in an individually-tailored, pragmatic method with reference to most frequently used treatments in patients with a primary diagnosis of cervical sprain/strain group, cervical disc disorder with radiculopathy group, or cervicalgia according to Korean Health Insurance Review and Assessment (HIRA) 2014 statistics.', 'armGroupLabels': ['Usual care'], 'otherNames': ['Physiotherapy']}

Primary Outcomes:
- {'measure': 'Difference between visual analogue scale (VAS) of neck pain for the past 3 days at 5 weeks post-baseline and baseline', 'description': "VAS uses a 10cm line labeled at each end with scale anchors. In pain measurement using VAS, patients are asked to mark a point that represents their pain between the anchors of 'no pain' and 'worst pain possible' (labels may vary by study). Scores are recorded in millimeters with a total range of 0-100 millimeters.", 'timeFrame': 'Week 5 post-baseline (screening)'}

Please estimate the sample size based on the assumption: 
Level of significance (α) is 0.05; Type II error (β) is 0.2 with a power of 80%; Compliance rate is set at 85%; 15% dropout rate is considered.
Sample size
        
Calculation of number of participants requiredÂ for the clinical trial: for calculation of significant number of participants, the following is hypothesized based on theÂ previous literature:Level of significance, Î±â=â0.05;Type II error (Î²) is set at 0.2 with power of the test set at 80%;According to a previous clinical study using VAS as the main assessment tool for Chuna manual therapy in neck pain patients, the effect size of Chuna manual therapy in comparison to the control can be considered to be 1.03 [30], andÂ 1.49 [31], respectively;Compliance rate will be set at 85% (theÂ predicted rate of receiving â¥Â 6 sessions of treatment during the five-week treatment period);For calculation of sample size, G*Power 3.1.7 was used. With evidence from item (3), application of meanâÂ±âSD resulted in conservatively hypothesizing theÂ effect size of this clinical trial as 0.6 because of the high clinical heterogeneity of manual therapies such as Chuna. Application of items (1) and (2) and the effect size resulted in the calculation of a sample size of 90 participants (45 in each group).The mean comparison of pain requires a total of 90 participants (45 in each group), which is the minimum number of participants needed for testing the abovementioned hypothesis. Considering that 15% of participants received <â6 sessions of treatment within the five-week treatment period, a total of 108 participants, 54 in each group, will be extracted for the study.