Here is the design of a clinical trial:

Official Title: Bougie or Stylet In Patients Undergoing Intubation Emergently (BOUGIE): a Randomized, Multi-center Trial

Included conditions:
- Acute Respiratory Failure

Study Armgroups:
- {'label': 'BOUGIE', 'type': 'ACTIVE_COMPARATOR', 'description': 'For patients randomized to use of a bougie, the operator will use a bougie on the first attempt at intubation. If successful, an assistant will load an endotracheal tube over the bougie, and the operator (without removing the laryngoscope from the mouth) will guide the tube through the vocal cords to the desired depth in the trachea.\n\nIf the bougie is not successfully placed in the trachea or the endotracheal tube cannot be successfully advanced over the bougie on the first attempt at intubation, the operator may use any approach during subsequent attempts at tracheal intubation.', 'interventionNames': ['Other: Bougie']}
- {'label': 'Endotracheal Tube with Stylet', 'type': 'ACTIVE_COMPARATOR', 'description': 'For patients randomized to use of an endotracheal tube with stylet, the operator will use an endotracheal tube containing a removeable, malleable stylet, on the first attempt at intubation.\n\nManipulation of the shape/curve of the endotracheal tube with stylet is at the discretion of the operator, however a "straight-to-cuff" shape and a bend angle of 25° to 35° is encouraged. The stylet will be left in place until the tube is advanced to the trachea.\n\nIf the endotracheal tube with stylet is not successfully placed in the trachea on the first attempt at intubation, the operator may use any approach during subsequent attempts at tracheal intubation.', 'interventionNames': ['Other: Endotracheal Tube with Stylet']}

Interventions:
- {'type': 'OTHER', 'name': 'Bougie', 'description': 'disposable tracheal tube introducer of approximately 70 cm in length', 'armGroupLabels': ['BOUGIE']}
- {'type': 'OTHER', 'name': 'Endotracheal Tube with Stylet', 'description': 'endotracheal tube preloaded with a removable, malleable stylet', 'armGroupLabels': ['Endotracheal Tube with Stylet']}

Primary Outcomes:
- {'measure': 'Number of intubations with successful intubation on the first attempt', 'description': 'The primary outcome is successful intubation on the first attempt. Successful intubation on the first attempt is defined as placement of an endotracheal tube in the trachea (confirmed by standard means including capnography) following: (1) a single insertion of a laryngoscope blade into the mouth and (2) EITHER a single insertion of a bougie into the mouth followed by a single insertion of an endotracheal tube into the mouth OR a single insertion of an endotracheal tube with stylet into the mouth.', 'timeFrame': 'from induction to 2 minutes following tracheal intubation'}

Please estimate the sample size based on the assumption: 
Assuming 84% of patients in the endotracheal tube with stylet group experience successful intubation on the first attempt, the trial aims for 80% power at a two-sided alpha level of 0.05, with an anticipated missing data rate of 5% or less.
Sample size estimation
        There is no established minimum clinically important difference in successful intubation on the first attempt. A prior single-centre randomised trial reported an absolute difference of 11% in successful intubation on the first attempt between the bougie and endotracheal tube with stylet groups. Because this trial was performed in an ED where the majority of first intubation attempts used a bougie, we anticipated a potentially smaller difference between groups in this multicenter trial conducted in a broader range of clinical settings with a broader range of operators. Therefore, the current trial was designed to detect a 6% absolute difference between groups in the proportion of patients who experience successful intubation on the first attempt. For two inexpensive interventions already routinely available and used in practice, the minimally clinically significant difference that would be expected to change practice is unknown. However, an absolute difference of 6% in successful intubation on the first attempt is similar to or smaller than the difference considered to be clinically meaningful in the design of prior airway management trials.7 10 14 Assuming 84% of patients in the endotracheal tube with stylet group experience successful intubation on the first laryngoscopy attempt, detecting a 6% absolute increase in successful intubation on the first attempt with 80% power at a two-sided alpha level of 0.05 would require enrolment of 1050 patients (525 per group). Anticipating missing data for 5% of patients or less, we will plan to enrol a total of 1106 patients (553 per group).