Here is the design of a clinical trial:

Official Title: Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Premature Ventricular Contractions

Included conditions:
- Premature Ventricular Contraction

Study Armgroups:
- {'label': 'Experimental Group', 'type': 'EXPERIMENTAL', 'description': 'Low-level tragus stimulation', 'interventionNames': ['Device: Low-level tragus stimulation']}
- {'label': 'Control Group', 'type': 'SHAM_COMPARATOR', 'description': 'Sham stimulation', 'interventionNames': ['Device: Sham stimulation']}

Interventions:
- {'type': 'DEVICE', 'name': 'Low-level tragus stimulation', 'description': 'Frequency: 20Hz; Pulse width: 0.2 ms; Current is based on the following: Determine the perception threshold (feeling tingling) at the time of baseline information assessment. Because of sensory adaptation, ask the patient 5 minutes later to increase the current by 1-5 mA. Try to find the current level below the discomfort level and above the perception threshold; Stimulation spot: ear tragus; Stimulation time: 30 min in the morning (from 6:00 a.m. to 9:00 a.m.) and 30 min in the evening (from 20:00 p.m. to 23:00 p.m.)', 'armGroupLabels': ['Experimental Group']}
- {'type': 'DEVICE', 'name': 'Sham stimulation', 'description': 'Frequency: 20 Hz; Pulse width: 0.2 ms; Current is based on the following: Determine the perception threshold (feeling tingling) at the time of baseline information assessment. Because of sensory adaptation, ask the patient 5 minutes later to increase the current by 1-5 mA. Try to find the current level below the discomfort level and above the perception threshold; Stimulate spot: ear lobe. Stimulation time: 30 min in the morning (from 6:00 a.m. to 9:00 a.m.) and 30 min in the evening (from 20:00 p.m. to 23:00 p.m.)', 'armGroupLabels': ['Control Group']}

Primary Outcomes:
- {'measure': 'PVC burden', 'description': 'Patients underwent noninvasive continuous ECG monitoring using an adhesive continuous ECG patch for 10 days to evaluate their PVC burden which is deﬁned as the percentage of premature ventricular beats in total heart beats.', 'timeFrame': '3 months follow-up'}
- {'measure': 'PVC burden', 'description': 'Patients underwent noninvasive continuous ECG monitoring using an adhesive continuous ECG patch for 10 days to evaluate their PVC burden which is deﬁned as the percentage of premature ventricular beats in total heart beats.', 'timeFrame': '6 months follow-up'}

Please estimate the sample size based on the assumption: 
80% power, two-sided significance alpha level of 0.05, and a potential drop-out rate of 10%.
Sample size calculation
        Based on the 11 patients who underwent 1 month of stimulation, the average burden at baseline was 21.7% and the relative reduction after stimulation was 16.4%. We assume a baseline burden of 15% and expect a reduction of 40% at the end of 6 months. A sample size of 90 patients would provide at least 80% power to detect the specified effect sizes at a two-sided significance alpha level of 0.05. The sample size was calculated by using online statistic system (STATBOX, http://www.cnstat.org/statbox/; last access 9/19/2023). The exact formula used for sample size was as follows.\documentclass[12pt]{minimal}
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				\begin{document}$$1-{\varvec{\beta}}={\varvec{P}}{\varvec{\upgamma}}[{\varvec{F}}(1,{\varvec{N}}-2,{\varvec{N}}\{\left({{\varvec{\upomega}}}_{1}{{\varvec{\upomega}}}_{2}\right)[\frac{{{\varvec{\mu}}}_{1}-{{\varvec{\mu}}}_{2}}{{\varvec{\sigma}}}{]}^{2}\})\ge {{\varvec{F}}}_{\boldsymbol{\alpha }}]$$\end{document}1-Î²=PÎ³[F(1,N-2,N{Ï1Ï2[Î¼1-Î¼2Ï]2})â¥FÎ±]\documentclass[12pt]{minimal}
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				\begin{document}$${{\varvec{n}}}_{1}={{\varvec{N}}}^{\boldsymbol{*}}{{\varvec{\omega}}}_{1},\boldsymbol{ }{{\varvec{n}}}_{2}=\boldsymbol{ }{{\varvec{N}}}^{\boldsymbol{*}}{{\varvec{\omega}}}_{2}$$\end{document}n1=NâÏ1,n2=NâÏ2
        To account for a potential drop-out rate of 10%, 50 patients in each group and 100 patients in total are planned to be recruited.