Here is the design of a clinical trial:

Official Title: Estimated Oxygen Extraction Versus Dynamic Parameters for Perioperative Hemodynamic Optimization of Patients Undergoing Non-cardiac Surgery: a Non-inferiority Randomized Controlled Trial

Included conditions:
- Perioperative/Postoperative Complications
- Morality

Study Armgroups:
- {'label': 'Estimated Oxygen Extraction', 'type': 'EXPERIMENTAL', 'interventionNames': ['Diagnostic Test: Estimated oxygen extraction protocol']}
- {'label': 'Dynamic Parameters', 'type': 'ACTIVE_COMPARATOR', 'interventionNames': ['Diagnostic Test: Dynamic parameters of fluid responsiveness protocol']}

Interventions:
- {'type': 'DIAGNOSTIC_TEST', 'name': 'Dynamic parameters of fluid responsiveness protocol', 'description': 'Dynamic parameter of fluid responsiveness (pulse pressure variation/stroke volume variation) are used to optimize hemodynamics intraoperatively and during the first 6 hours postoperatively when appropriate. A cutoff of 12% is used to predict an increase of stroke volume \\>10% after fluid administration.', 'armGroupLabels': ['Dynamic Parameters']}
- {'type': 'DIAGNOSTIC_TEST', 'name': 'Estimated oxygen extraction protocol', 'description': 'Oxygen extraction is estimated by the difference of arterial oxygen saturation and central venous oxygen saturation divided by arterial oxygen saturation. A cutoff of 27% is used as a marker of inadequate tissue perfusion requiring hemodynamic optimization.', 'armGroupLabels': ['Estimated Oxygen Extraction']}

Primary Outcomes:
- {'measure': 'Complications rate', 'description': 'Evaluate the difference of postoperative complications rate between the two groups', 'timeFrame': 'From date of randomization until the date of hospital discharge assessed up to 90 days'}

Please estimate the sample size based on the assumption: 
Power: 80%, significance level (alpha): 0.05, dropout rate: 10%
Sample size calculation
        From literature analysis, we estimate a complication rate for control and experimental group of 28 and 35% respectively [2, 15]. With a non-inferiority margin of 10%, 184 patients (92 for each group) are needed to have a power of 80% and an alfa error of 0.05 [16]. Considering a 10% losing in follow-up, we enroll 200 patients (100 for each group).