Here is the design of a clinical trial:

Official Title: Hospital-home Linkage Short-term Rehabilitation Therapy Using Real-time Interactive Digital Healthcare System in Frozen Shoulder; Randomized Controlled Trial, Assessor Blinding, Multi-center Study

Included conditions:
- Frozen Shoulder

Study Armgroups:
- {'label': 'Exercise using Uincare Homeplus', 'type': 'EXPERIMENTAL', 'description': 'Uincare Homeplus', 'interventionNames': ['Device: Uincare Homeplus']}
- {'label': 'Exercise using brochure', 'type': 'ACTIVE_COMPARATOR', 'description': 'brochure', 'interventionNames': ['Other: Brochure']}

Interventions:
- {'type': 'DEVICE', 'name': 'Uincare Homeplus', 'description': 'Interactive digital healthcare system', 'armGroupLabels': ['Exercise using Uincare Homeplus'], 'otherNames': ['digital healthcare']}
- {'type': 'OTHER', 'name': 'Brochure', 'description': 'Brochure', 'armGroupLabels': ['Exercise using brochure']}

Primary Outcomes:
- {'measure': 'Range of motion (ROM) in affected shoulder', 'description': 'Evaluation of change of ROM in the affected shoulder from baseline to 12 weeks', 'timeFrame': 'Enrollment, 4 week, 8 week, 12 week, 18 weeks, 24 weeks'}

Please estimate the sample size based on the assumption: 
Significance level of 5% (0.05/4 for each hypothesis), 80% statistical power, and an expected dropout rate of 25%.
Sample size calculation
        The target sample size was calculated through consultation with an in-hospital statistics team. The primary hypothesis was that there would be a significant difference in the amount of change in PROM before and after 3âmonths for the digital health care and control groups. The ROM consists of flexion, abduction, external rotation, and internal rotation of the shoulder joint. When the standard deviation of the variation is 18.64, 16.79, 11.22, and 11.65, respectively, and the difference between the two groups variation is expected to be 15, 15, 10, 10, or more, respectively, based on the results of the existing studies [21â25], 35 people per group are required for a significance level of 5% (a significant level of 0.05/4*100% of each hypothesis) and 80% statistical power. Assuming an expected dropout rate of 25%, we require at least 47 participants per group.