Here is the design of a clinical trial:

Official Title: A Cluster Randomized Clinical Trial of Strategic AED Deployment in High-risk Residential Areas Combined With Activation of Local Residents

Included conditions:
- Out-Of-Hospital Cardiac Arrest

Study Armgroups:
- {'label': 'Control sites', 'type': 'NO_INTERVENTION', 'description': '* For all 1-1-2 calls with suspected cardiac arrest to the emergency dispatch center will activate a two-tiered response consisting of dispatch of an ambulance with an emergency medical technician, a physician-staffed mobile emergency care unit, and citizen first responders through the Heart Runner app.\n* The medical dispatcher offers telephone assisted cardiopulmonary resuscitation (CPR) to bystanders. Furthermore, if more than two bystanders are present and an AED is accessible within 1½ minute travel distance (depending on the type of terrain), then one bystander is guided to localize and retrieve the AED.'}
- {'label': 'Intervention sites', 'type': 'EXPERIMENTAL', 'description': 'As a supplement to the standard care as described in the control arm, the following will be supplied:\n\n* Strategical deployment of AEDs with 24:7 availability and 1½ minute walking distance to every residence within the area. The AEDs will be registered with the AED network and thus linked to the emergency dispatch center.\n* The emergency dispatch center will retrieve data from used AEDs.\n* For each interventional area, approximately 120 residents will receive a course in CPR and AED use and subsequently be recruited as citizen responders so that they can be activated through the HeartRunner app in case of a nearby cardiac arrest.', 'interventionNames': ['Device: Automated External Defibrillator (AED)', 'Other: Training in cardiopulmonary resuscitation and AED use', 'Other: Activation of citizen responders']}

Interventions:
- {'type': 'DEVICE', 'name': 'Automated External Defibrillator (AED)', 'description': 'Deployment of AEDs', 'armGroupLabels': ['Intervention sites']}
- {'type': 'OTHER', 'name': 'Training in cardiopulmonary resuscitation and AED use', 'description': 'Residents will undergo 30-minute courses at study start and if needed during the trial period. During the course they will also be recruited as citizen responders', 'armGroupLabels': ['Intervention sites']}
- {'type': 'OTHER', 'name': 'Activation of citizen responders', 'description': 'Citizen responders will be activated in case of suspected cardiac arrest through the heart runner app.', 'armGroupLabels': ['Intervention sites']}

Primary Outcomes:
- {'measure': 'Bystander defibrillation', 'description': 'Proportion of bystander defibrillation of witnessed cardiac arrests', 'timeFrame': 'Up to five years after implementation of the intervention'}

Please estimate the sample size based on the assumption: 
Desired power of 80%, significance level of 5%, varying ICCs and effect sizes, study duration of 5 years.
Sample size
        From 2016 to 2018, 167 witnessed OHCAs occurred within the areas in which one received bystander defibrillation. Based on prior evidence and assessed clinical relevance, we will strive to improve the proportion of patients with bystander-witnessed OHCA who receive bystander defibrillation from 1% to 10%.46 With the desired power of 80% and a significance level of 5%, power calculations were conducted with varying ICCs and effect sizes to determine a conservative sample size estimation (see online supplemental material B). We estimate study duration of 5âyears which should ensure 260 OHCAs.