Here is the design of a clinical trial:

Official Title: Efficacy of Myofascial Release Compared With Sham Therapy on Joint Range of Motion in Patients With Axial Spondyloarthritis.

Included conditions:
- Ankylosing Spondylitis

Study Armgroups:
- {'label': 'Myofascial release', 'type': 'EXPERIMENTAL', 'description': 'Myofascial release or induction (MFR) is a widely used manual therapy treatment involving specifically guided, low-load, long-lasting mechanical forces to manipulate the myofascial complex, aimed at restoring optimal length, decreasing pain, and improving function. Manual therapists often use their hands using their knuckles, elbows, or other instrumental tools to slowly penetrate the layers of the fascia, using applied pressure with a few kilograms of force that can strain the restricted fascia, this implies a guided gentle stretch.\n\nThe experimental group will receive 1 examination session and 6 myofascial release sessions carried out by a physiotherapist specialized in orthopedic manual therapy, superficial and deep techniques will be applied in the cervical region, for the spinal at the level of the quadratus lumborum, sacroiliac region and upper trapezius. 2 sessions per week over the course of 3 weeks.', 'interventionNames': ['Other: Myofascial release']}
- {'label': 'Sham Therapy', 'type': 'SHAM_COMPARATOR', 'description': 'The control group will receive 1 examination session and 6 simulated myofascial releasesessions, where a physiotherapist will apparently apply the same techniques and maneuvers of myofascial release, however, they will not follow the basic principles of technique execution, which does a procedure with a placebo effect.', 'interventionNames': ['Other: Sham therapy']}

Interventions:
- {'type': 'OTHER', 'name': 'Myofascial release', 'description': 'Myofascial release or induction (IMF) is a widely used manual therapy treatment involving specifically guided, low-load, long-lasting mechanical forces to manipulate the myofascial complex, aimed at restoring optimal length, decreasing pain, and improving function. The experimental group will receive 1 examination session and 6 myofascial induction sessions carried out by a physiotherapist specialized in orthopedic manual therapy, superficial and deep techniques will be applied in the cervical region, for spinal at the level of the lumbar square, sacroiliac region and upper trapezius. 2 sessions per week over the course of 3 weeks.', 'armGroupLabels': ['Myofascial release']}
- {'type': 'OTHER', 'name': 'Sham therapy', 'description': 'The control group will receive 1 examination session and 6 simulated myofascial induction sessions, where a physiotherapist will apparently apply the same techniques and maneuvers of myofascial induction, however, they will not follow the basic principles of technique execution, which does a procedure with a placebo effect.', 'armGroupLabels': ['Sham Therapy']}

Primary Outcomes:
- {'measure': 'Bath Ankylosing Spondylitis Metrology Index (BASMI)', 'description': 'Index that examines 4 axial measurements (cervical rotation, Schober test, lateral trunk flexion, tragus wall distance), also includes a measurement of peripheral mobility (intermaleolar distance), The measurement of these variables is carried out comparatively, in at least two attempts, obtaining the averages of the measurements to calculate the final score based on the 11-point table.', 'timeFrame': '3 weeks'}

Please estimate the sample size based on the assumption: 
loss of 20%, alpha one sided of 0.05%, power of 0.80, mean difference test for a clinical trial of superiority (repeated measures ANOVA)
Sample size
        The sample size was calculated in the program R Studio version 3.5.3, package of superiority clinical trials, based on a mean difference of 4.0 in the BASMI with a standard deviation of 2, an r (ratio) between groups of 1, and assuming a loss of 20%. An alpha one sided of 0.05% and a power of 0.80 were estimated based on mean difference test corresponding to a clinical trial of superiority (repeated measures ANOVA). The total number of people was 82 (42 per arm). Non probabilistic purposive sampling will be used.