Here is the design of a clinical trial:

Official Title: Implementation of a Community Intervention to Improve Asthma Self-Management Practices in Peru

Included conditions:
- Asthma
- Asthma in Children

Study Armgroups:
- {'label': 'Intervention', 'type': 'EXPERIMENTAL', 'description': 'The intervention arm will receive a multi-faceted self-management intervention package.', 'interventionNames': ['Behavioral: Self-management Intervention Package']}
- {'label': 'Enhanced care', 'type': 'NO_INTERVENTION', 'description': 'The control arm will receive usual care plus basic asthma education from a trained nurse educator.'}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Self-management Intervention Package', 'description': 'Children will receive basic asthma education, based on the National Heart, Lung, and Blood Institute "A Breath of Life" asthma education program. Children/caregivers in the intervention arm will also be assigned a designated nurse case manager who will provide home visits and be available via text message and phone-based support throughout follow-up. Intervention components:\n\n* Interactive education and support on use of an asthma action plan\n* Locally adapted patient-provider communication tool\n* Child-oriented educational materials in comic book format\n* Modeling and hands-on practice of inhaler technique (written instructions, in person, video)\n* Education regarding environmental trigger abatement\n* Patient navigation, home visits, and goal setting support from nurse manager', 'armGroupLabels': ['Intervention']}

Primary Outcomes:
- {'measure': 'Change in Asthma Control as assessed by Childhood Asthma Control Test (cACT) Score', 'description': 'cACT (5-11 years of age) will be administered at baseline and monthly during the follow-up period. The cACT is scored by summing the scores for all items. Overall scores ranges from 0 to 27. Lower scores indicate poorer asthma control and higher scores indicate better asthma control. Scores 19 and below suggest impaired asthma control.', 'timeFrame': 'Baseline, then monthly up to 6 months'}
- {'measure': 'Change in Asthma Control as assessed by Asthma Control Test (ACT) Score', 'description': 'ACT (12-17 years of age) will be administered at baseline and monthly during the follow-up period. The ACT is scored by summing the scores for all items. Overall score ranges from 5 to 25. Lower scores indicate poorer asthma control and higher scores indicate better asthma control. Scores 19 and below suggest impaired asthma control.', 'timeFrame': 'Baseline, then monthly up to 6 months'}
- {'measure': 'Number of participants with at least one asthma-related ED or urgent care visit during the six-month follow-up period', 'description': 'Number with asthma-related emergency department (ED) or urgent care visits will be used to assess healthcare utilization.', 'timeFrame': '6 months'}

Please estimate the sample size based on the assumption: 
Standard deviation of 3.6, type II error of 5%, 80% power, 9% attrition
Sample size
          The primary objective of this pilot trial is to assess the feasibility, acceptability, and preliminary effectiveness of the intervention package in the Peruvian context. With a sample size of 100 participants, assuming a standard deviation of 3.6 and a type II error of 5%, we will be able to detect a difference of 2 in ACT score with 80% power. These calculations were based on preliminary data from a prior epidemiological study of children with asthma in this setting, in which the standard deviation of the ACT score was 3.6 [17]. In order to account for approximately 9% attrition, we arrived at a final sample size of 110 individuals.