Here is the design of a clinical trial:

Official Title: HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial

Included conditions:
- Traumatic Brain Injury
- Transfusion

Study Armgroups:
- {'label': 'Liberal Transfusion Strategy', 'type': 'EXPERIMENTAL', 'description': 'Patients will receive red blood cells transfusion if Hb ≤ 100 g/L.', 'interventionNames': ['Procedure: Red Blood Cells Transfusion']}
- {'label': 'Restrictive Transfusion Strategy', 'type': 'EXPERIMENTAL', 'description': 'Patients will receive red blood cells transfusion if Hb ≤ 70 g/L.', 'interventionNames': ['Procedure: Red Blood Cells Transfusion']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'Red Blood Cells Transfusion', 'description': 'Transfusion of packed red blood cells unit(s).', 'armGroupLabels': ['Liberal Transfusion Strategy', 'Restrictive Transfusion Strategy']}

Primary Outcomes:
- {'measure': 'extended Glasgow Outcome Scale (GOSe)', 'description': 'Assessment of neurological outcome by the extended Glasgow Outcome Scale (GOSe)', 'timeFrame': '6 months'}

Please estimate the sample size based on the assumption: 
The study is designed with a power of 80% and a type 1 error of 5%. A 2% dropout rate is also considered.
Sample size
        Our sample size was calculated based on the proportion of patients who will experience an unfavourable outcome (GOSe â¤4).24 27 28 Assuming a 40% risk of unfavourable outcome in the control group,27 28 a sample size of 712âpatients will allow us to detect an absolute risk reduction of 10% with a power of 80% and a type 1 error of 5%. Our sample size is conservative as it was based on the simple dichotomous cut-off and most used definition of an unfavourable outcome in TBI using the GOSe. Based on simulated data, a sliding dichotomy approach will increase our ability to observe the planned effect size with 95% power. To account for an estimated 2% dropout rate (consent withdrawals and losses to follow-up) based on observed aggregate rates at the interim analysis, the final sample size was increased to 742.40