Here is the design of a clinical trial:

Official Title: Rotator Cuff Related Shoulder Pain: Does The Type of Exercise Influence Outcome? - A Randomized Controlled Trial

Included conditions:
- Shoulder Pain
- Rotator Cuff Injury
- Rotator Cuff Tendinitis
- Rotator Cuff Impingement Syndrome

Study Armgroups:
- {'label': 'Strengthening exercises program', 'type': 'EXPERIMENTAL', 'interventionNames': ['Other: Strengthening exercises program']}
- {'label': 'Motor control exercises program', 'type': 'EXPERIMENTAL', 'interventionNames': ['Other: Motor control exercises program']}
- {'label': 'Education and advice', 'type': 'ACTIVE_COMPARATOR', 'interventionNames': ['Other: Education and advice']}

Interventions:
- {'type': 'OTHER', 'name': 'Strengthening exercises program', 'description': 'Participants from this group will be given a progressive shoulder strengthening exercises program based on 1 RM that will involve isometric, concentric and eccentric contractions. The exercises will target shoulder internal/external rotators and abductors and the scapular muscles. They will have to exercise every other day for 12 weeks. At each session with the therapist (6 over a 12 week period), strength will be reassessed and the program will be progressed accordingly. Any questions or concerns will also be addressed and participants will be requested to complete a paper based or digital record of their exercise participation.', 'armGroupLabels': ['Strengthening exercises program']}
- {'type': 'OTHER', 'name': 'Motor control exercises program', 'description': "Each session will start with a series of clinical tests that will look at the influence of different corrections to alleviate symptoms during upper limb movements.The tests will be performed in a sequential format through four key areas: thoracic repositioning, scapula facilitation, humeral head procedures and neuromodulatory techniques. If a correction reduces pain, that technique will then be performed as exercises and incorporated into the participant's functional movement. In addition, motor control exercises during arm elevation, progressed through a standardized 6-phase retraining sequence, will be executed. Retraining phases will be graded according to: 1) resistance applied on the shoulder; and 2) use or non-use of feedback. Once participants reach pain free execution, the program will be progressed into re-education exercises according to the participants' work, sport and activities of daily living and will incorporate activities involving the upper and lower limbs.", 'armGroupLabels': ['Motor control exercises program']}
- {'type': 'OTHER', 'name': 'Education and advice', 'description': "Each participant will be given written information about the shoulder (anatomy and function), basic pain science and will be directed to the Internet to watch a series of carefully selected educational videos. Comprehensive written advice will include: Information about the shoulder and the condition; Pain neuroscience; Activity modification (when to increase and decrease); Pain management (night and day); A series of educational videos to watch with 2 questions to answer per video: a) what was the most important message? and b) was there anything you didn't understand in the video?", 'armGroupLabels': ['Education and advice']}

Primary Outcomes:
- {'measure': 'Change in symptoms and functional limitations from baseline to 3 weeks: QuickDASH', 'description': 'The QuickDASH is a self-reported questionnaire that includes 11 items measuring physical disability and symptoms. This tool uses a 5-point (1-5) Likert scale. The total out of 55 is then reported to a score from 0 to 100. Score ranges from 0 (no disability) to 100 (most severe disability).', 'timeFrame': '0 and 3 weeks'}
- {'measure': 'Change in symptoms and functional limitations from baseline to 6 weeks: QuickDASH', 'description': 'The QuickDASH is a self-reported questionnaire that includes 11 items measuring physical disability and symptoms. This tool uses a 5-point (1-5) Likert scale. The total out of 55 is then reported to a score from 0 to 100. Score ranges from 0 (no disability) to 100 (most severe disability).', 'timeFrame': '0 and 6 weeks'}
- {'measure': 'Change in symptoms and functional limitations from baseline to 12 weeks: QuickDASH', 'description': 'The QuickDASH is a self-reported questionnaire that includes 11 items measuring physical disability and symptoms. This tool uses a 5-point (1-5) Likert scale. The total out of 55 is then reported to a score from 0 to 100. Score ranges from 0 (no disability) to 100 (most severe disability).', 'timeFrame': '0 and 12 weeks'}
- {'measure': 'Change in symptoms and functional limitations from baseline to 24 weeks: QuickDASH', 'description': 'The QuickDASH is a self-reported questionnaire that includes 11 items measuring physical disability and symptoms. This tool uses a 5-point (1-5) Likert scale. The total out of 55 is then reported to a score from 0 to 100. Score ranges from 0 (no disability) to 100 (most severe disability).', 'timeFrame': '0 and 24 weeks'}

Please estimate the sample size based on the assumption: 
α=0.05, power=0.95, SD=13 DASH points, expected lost at follow-up=15%
Participants and sample size
        Adults presenting with RCRSP will be recruited using the following inclusion criteria: (1) 18â75 years of age, (2) symptoms lasting longer than 3 months, (3) presence of a painful arc in flexion or abduction, (4) presence of a positive Neer sign or Hawkins-Kennedy Test, (5) presence of pain when resisting humeral external rotation or abduction, or positive Jobe Test, and (6) ability to speak English or French. A positive cluster of criteria 3, 4 and 5 represents an adequate diagnostic tool for RCRSP (sensitivity: 0.75, specificity: 0.74).25 Participants will be excluded if they present any of the following criteria: (1) clinical signs of massive rotator cuff tears as defined by presence of gross weakness in the absence of limited pain, (2) other shoulder disorders, for example, adhesive capsulitis (restriction of passive glenohumeral movement of at least 30% for two or more directions), severe osteoarthritis, fracture, dislocation, severe acromioclavicular joint pathology, (3) previous shoulder surgery, (4) presence of significant comorbidity, for example, neurological disorders, rheumatoid arthritis, (5) current or past carcinoma, (6) unlikely to be able to perform required clinical assessment tasks or attend the required evaluation and intervention sessions, (7) symptomatic cervical spine pathology, defined as reproduction of symptoms with active physiological cervical spine movements, and (8) corticosteroid injection in the last 6 weeks. All recruited participants will be evaluated by a physiotherapist (PT) in order to confirm their eligibility.
        Based on our sample size calculation, calculated for our primary outcome (abbreviated version of the Disabilities of the Arm, Shoulder and Hand Questionnaire (QuickDASH)), 41 participants are required per group (G*Power V.3.1.9; effect size: 0.80, Î±=0.05, power=0.95, SD=13âDASH points, clinically important difference (CID)=11âDASH points, expected lost at follow-up=15%). Therefore, 123 participants with RCRSP will be recruited. This sample size should be sufficient to detect a CID between groups.
        Potential participants will be recruited in outpatient physiotherapy clinics of hospitals and in private physiotherapy clinics in the Quebec City region, and through electronic mailing lists of employees and students at UniversitÃ© Laval (>52â000 individuals). Since our research team has performed studies evaluating the same population in the same metropolitan area, we are confident to recruit the targeted population.26â28 With an average rate of seven new participants per month, we estimate that 18 months will be ample time to reach our goal of 123 participants.