Here is the design of a clinical trial:

Official Title: Protocolised Early De-Resuscitation in Septic Shock (REDUCE) - a Randomised Controlled Multi-centre Feasibility Study

Included conditions:
- Septic Shock

Study Armgroups:
- {'label': 'Intervention: REDUCE Protocol', 'type': 'EXPERIMENTAL', 'description': 'Fluid resuscitation and de-resuscitation is based on the REDUCE fluid management protocol.', 'interventionNames': ['Other: Fluid management according to the REDUCE Fluid Protocol']}
- {'label': 'Standard of Care', 'type': 'ACTIVE_COMPARATOR', 'description': 'Fluid resuscitation and de-resuscitation according to the standard of care', 'interventionNames': ['Other: Standard of care']}

Interventions:
- {'type': 'OTHER', 'name': 'Fluid management according to the REDUCE Fluid Protocol', 'description': 'Fluid management according to the protocol will be guided by pre-defined clinical signs for impaired perfusion and fluid overload.', 'armGroupLabels': ['Intervention: REDUCE Protocol'], 'otherNames': ['REDUCE protocol']}
- {'type': 'OTHER', 'name': 'Standard of care', 'description': 'Fluid resuscitation and de-resuscitation will be managed according to the standard of care', 'armGroupLabels': ['Standard of Care']}

Primary Outcomes:
- {'measure': 'Proportion of patient with a negative fluid balance on day 3', 'description': 'Proportion of patients with a negative cumulative fluid balance on day 3', 'timeFrame': 'Up to day 3 after ICU admission'}

Please estimate the sample size based on the assumption: 
Power of 0.8, 15% dropout rate, Pearson's χ2 test, significance level not explicitly stated
Determination of sample size
          We intend to enrol 170 patients to show an increase in the proportion of patients with a negative fluid balance on day 3 after ICU admission from 30% to 50% (power of 0.8), including a 15% dropout rate. The estimation is based on previous trials, as well as data from our ICU, which has shown that about one-third of patients with septic shock achieve a negative cumulative fluid balance on day 3.18 41 We have chosen day 3, as previous studies have shown a better survival in patients with septic shock with achieving a negative cumulative fluid balance on day 3 after ICU admission.18 42 The sample size calculation was performed by the CTU of the University of Bern and was computed using Stata, V.16.1, applying Pearsonâs Ï2 test.