Here is the design of a clinical trial:

Official Title: Can a Serious Game-based Cognitive Training Attenuate Cognitive Decline Related to Alzheimer's Disease

Included conditions:
- Alzheimer Disease
- Dementia
- Mild Cognitive Impairment

Study Armgroups:
- {'label': 'Study Intervention', 'type': 'EXPERIMENTAL', 'description': 'The study intervention consists of a tablet-based cognitive training, targeting the cognitive domains mostly affected by AD. This training will be performed for three months (each day for 20 minutes). After three months this group will continue the training at home for six months and meet monthly for group sessions (i.e. booster sessions) on site.', 'interventionNames': ['Device: Computerized Cognitive Training']}
- {'label': 'Active Control Group', 'type': 'ACTIVE_COMPARATOR', 'description': 'This control study arm will watch documentaries at home for three months (each day for 20 minutes) , instead of performing the CCT and serve as active control group. This group will also train with the CCT tasks after these three months.', 'interventionNames': ['Device: Documentaries with delayed Computerized Cognitive Training']}
- {'label': 'Wait-List Control', 'type': 'OTHER', 'description': 'This control study arm will start with the CCT with a delay of three months and serve as wait-list control group.', 'interventionNames': ['Device: Computerized Cognitive Training']}

Interventions:
- {'type': 'DEVICE', 'name': 'Computerized Cognitive Training', 'description': 'The study intervention consists of a tablet-based cognitive training, targeting the cognitive domains mostly affected by Alzheimer Disease.', 'armGroupLabels': ['Study Intervention', 'Wait-List Control']}
- {'type': 'DEVICE', 'name': 'Documentaries with delayed Computerized Cognitive Training', 'description': 'The active control group watches documentaries for three months before starting with the CCT.', 'armGroupLabels': ['Active Control Group']}

Primary Outcomes:
- {'measure': 'Change in AD specific component score', 'description': 'The outcome is quantified by an AD component score including measures of EM (auditory verbal learning), SM (verbal fluency, naming task) and spatial abilities (Rey-Osterrieth complex figure test). These scores will be assessed four times, before the training as well as after three, six and nine months by tablet-based cognitive tests. A short follow-up assessment will be performed after a total of 12 months which does not include primary outcome measure.', 'timeFrame': 'The primary endpoint will be assessed four times, with breaks of three months in between. Primary outcome will be assessed up to 9 months.'}

Please estimate the sample size based on the assumption: 
Significance level (α) = 5%, Power = 80%, Non-sphericity correction factor = 0.75
Sample size
          For our primary analysis (âDoes change in performance on the three typical AD domains 3 months after the start of the training differ between groups?â), a repeated- measures ANOVA is planned (3 groups with 2 time points). We computed the necessary sample size using G*Power [66] to ensure a power of 80% to detect an assumed moderate effect (i.e. effect size: Î·2â=â0.06, fâ=â0.25) with Î± of 5%. The power analysis revealed a total sample size of 162 (54 participants per group). Moreover, we performed a power analysis for testing the interaction between the groups and all four time points within a repeated-measures ANOVA using the same parameters as before (Î±â=â5%, powerâ=â80%, Î·2â=â0.06) as well as a non-sphericity correction factor of 0.75. According to this power analysis a total sample size of 96 (32 participants per group) is needed.