Here is the design of a clinical trial:

Official Title: A Multicenter Randomized Clinical Trial Comparing Surgical Site Infection After Intracorporeal Anastomosis and Extracorporeal Anastomosis for Left Colon Cancer (STARS)

Included conditions:
- Colon Cancer

Study Armgroups:
- {'label': 'laparoscopic assisted left colectomy (extracorporeal anastomosis group)', 'type': 'ACTIVE_COMPARATOR', 'description': 'All patients underwent laparoscopic dissection according to the left hemicolon cancer resection standard. lymph nodes and blood vessels, are completely trimmed and resected in an en bloc fashion. A small incision is made in the middle of the abdomen to trim the mesentery, remove the specimen, and complete the anastomosis. After completing the anastomosis, the incision will be sutured.', 'interventionNames': ['Procedure: laparoscopic assisted left colectomy (extracorporeal anastomosis group)']}
- {'label': 'total laparoscopic left colectomy (intracorporeal anastomosis group)', 'type': 'EXPERIMENTAL', 'description': 'All patients underwent laparoscopic dissection according to the left hemicolon cancer resection standard. lymph nodes and blood vessels, are completely trimmed and resected in an en bloc fashion. Mesentery resection is performed under laparoscopy, and anastomosis is completed under laparoscopy. A small incision is made to extract the specimen after the anastomosis is completed.', 'interventionNames': ['Procedure: total laparoscopic left colectomy (intracorporeal anastomosis group)']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'laparoscopic assisted left colectomy (extracorporeal anastomosis group)', 'description': "For patients in the control group, the surgeon uses wound edge protectors to exteriorize the colon through a small incision in the midline of the abdomen. A ruler and methylene blue solution are employed to mark the area for colon resection. This guarantees a 10-cm margin from the tumor. Guided by these markers, the marginal vessels and mesentery are divided outside the body. The method of anastomosis is at the surgeon's discretion. A side-to-side anastomosis (including antiperistaltic, isoperistaltic, or overlapping anastomosis) is recommended. Side-to-end or end-to-end anastomosis (sewn by hand or by inserting a circular stapler through the anus or proximal colon) is also allowed. After completing the anastomosis, the incision is sutured. An abdominal drainage tube is inserted at the end of the operation.", 'armGroupLabels': ['laparoscopic assisted left colectomy (extracorporeal anastomosis group)']}
- {'type': 'PROCEDURE', 'name': 'total laparoscopic left colectomy (intracorporeal anastomosis group)', 'description': 'In the experimental group, the surgeon will use a 10-cm medical suture and methylene blue solution to mark the resection margin. The marginal vessels and mesentery will be divided inside the body. The proximal and distal colons are resected using a 60mm linear laparoscopic stapler. Side-to-side intracorporeal anastomotic techniques like anti-peristaltic, iso-peristaltic, or overlap methods will be applied. Once the anastomosis is completed, the specimen is retrieved. The surgeon can place the specimen in a sterile plastic bag for retrieval. Alternatively, the surgeon can use a disposable incision retraction fixator to protect the wound. An abdominal drainage tube is inserted.', 'armGroupLabels': ['total laparoscopic left colectomy (intracorporeal anastomosis group)']}

Primary Outcomes:
- {'measure': 'The Count of Participants With Surgical Site Infection (SSI)', 'description': 'The primary outcome was the incidence of SSI based on the Definitions of CDC guidelines: superficial incisional, deep incisional, and organ/space infections . Infections involving both organ/space and the incisional site (superficial or deep) were categorized as organ/space infections. Surgeons and nurses assessed the presence of infection daily during hospitalization. After hospital discharge, all patients were followed up until 30 days after surgery at outpatient clinics to check the wound.', 'timeFrame': 'one month after surgery'}

Please estimate the sample size based on the assumption: 
One-sided level of significance is 0.025, power is 0.80, and dropout rate is 20%.
Sample size calculation
        This study is multicenter, randomized, controlled, non-inferiority trial for patients aged 18â80 years old with left-sided colon cancer. According to the previous data of our single center, the incidence of SSI after extracorporeal anastomosis left colon cancer surgery was 23.3%, and the incidence of SSI after intracorporeal anastomosis was 16.7%. Intracorporeal anastomosis is believed to be inferior to extracorporeal anastomosis when there is a difference in SSI rate of more than 5% 30 days after surgery [23]. Therefore, sample size is calculated based on non-inferiority with a difference of 5% with a one-sided level of significance of 0.025, a ratio of 1:1, a power of 0.80 and a 20% drop-out rate. A total of 354 patients is needed, 177 patients in the experiment group and 177 patients in the control group.