Here is the design of a clinical trial:

Official Title: Effect of Mental Stress on Myocardial Perfusion and Myocardial Blood Flow in Women With Chest Pain and Coronary Artery Stenosis Less Than 50%

Included conditions:
- Non-Obstructive Coronary Atherosclerosis

Study Armgroups:
- {'label': 'women with chest pain', 'type': 'EXPERIMENTAL', 'description': 'women with chest pain and coronary artery stenosis less than 50%', 'interventionNames': ['Diagnostic Test: Mental Stress Test']}
- {'label': 'healthy women', 'type': 'SHAM_COMPARATOR', 'description': 'women without chest pain and coronary artery stenosis less than 50%', 'interventionNames': ['Diagnostic Test: Mental Stress Test']}

Interventions:
- {'type': 'DIAGNOSTIC_TEST', 'name': 'Mental Stress Test', 'description': 'In this study, we compare MSIMI prevalence in the two groups (chest pain group and no chest pain group). Each subject in both groups receive the same mental stress test process, and the mental stress test process have 3 consecutive stress tests, which including: Stroop Color-Word test; Public speaking with anger recall test and Mental arithmetic test.', 'armGroupLabels': ['healthy women', 'women with chest pain']}

Primary Outcomes:
- {'measure': 'MSIMI (Measures as perfusion deficit with mental stress test via PET-CT) prevalence in chest pain women with coronary artery stenosis less than 50%, as compared to age matched healthy women.', 'description': 'Percentage of participants wih an presence of mental stress-induced myocardial ischemia (MSIMI) during the 3 mental stressors.\n\nMSIMI is defined by the following: compared to rest, 1) Each myocardial segment was scored from 0 to 4, with 0 being normal, 1 possibly normal, 2 definitely abnormal, 3 severely abnormal, and 4 no perfusion. The investigators calculated summed scores in a conventional fashion, including a summed stress score, a summed rest score, and a summed difference score. A summed difference score ≥3 is typically used as evidence of MSIMI.', 'timeFrame': 'half an hour'}
- {'measure': 'The MBF change during mental stress test', 'description': 'The MBF change during mental stress test', 'timeFrame': 'half an hour'}

Please estimate the sample size based on the assumption: 
2:1 ratio of women with ANOCA to healthy controls, 0.80 power, p=0.05, precision of 5%, using χ2 test and analysis of variance.
Sample size considerations
        Using pilot data, we estimate the incidence of MSIMI in women with ANOCA to be ~25%. With a 2:1 ratio of women with ANOCA and healthy controls, and assuming MSIMI incidence at 25% and a precision of 5%, a total of 126 patients (84 with ANOCA and 42 controls) will be required to achieve 0.80 power at p=0.05 using theÏ2 test. To maximise the power to detect group differences, we will also use analysis of variance to compare continuous perfusion scores or MBF changes between the two groups of patients.