Here is the design of a clinical trial:

Official Title: Effect of Electroacupuncture on Symptoms of Female Pelvic Organ Prolapse(Level II - III )

Included conditions:
- Pelvic Organ Prolapse

Study Armgroups:
- {'label': 'electroacupuncture group', 'type': 'EXPERIMENTAL', 'description': 'patients will receive electroacupuncture at 3 acupoints(Bladder meridian of foot-taiyang 33 and 35#BL33 and BL35), and Spleen meridian of foot-taiyin 33(SP6)) 3 times/week for 4 weeks, then 3 times/week for 4 weeks, and then once/week for 4 weeks(24 times in total in 3 months), and be followed up for 6 months after treatment. Disposable acupuncture needles with size of 0.30 × 75 mm will be used at BL 33 and BL 35, and needles with size of 0.30 ×40 mm at SP 6. Standardized electroacupuncture apparatuses will be used, and the stimulation will last for 30 minutes with a continuous wave of 20 Hz, and a current intensity of 2 to 6.5 mA at BL33 and BL 35, and 1 to 3.5 mA at SP6.', 'interventionNames': ['Other: electroacupuncture']}
- {'label': 'sham electroacupuncture group', 'type': 'SHAM_COMPARATOR', 'description': 'patient will receive sham electroacupuncture with the same frequency and amount as applied in the electroacupuncture group, as well as the follow-up period. Disposable acupuncture needles with size of 0.30 × 40 mm will be applied and penetrate the skin of patients for 2 to 3mm at sham acupoints to the 3 acupoints mentioned above. The stimulation will only last for 30-second with a very weak currency intensity and a continuous wave of 20 Hz.', 'interventionNames': ['Other: sham electroacupuncture']}

Interventions:
- {'type': 'OTHER', 'name': 'electroacupuncture', 'description': 'the same as described in experimental arm.', 'armGroupLabels': ['electroacupuncture group']}
- {'type': 'OTHER', 'name': 'sham electroacupuncture', 'description': 'the same as described in sham comparator.', 'armGroupLabels': ['sham electroacupuncture group']}

Primary Outcomes:
- {'measure': 'the change from baseline on the score of the Pelvic Floor Distress Inventory-short form 20 (PFDI-20)', 'description': 'Data will be collected via the the Pelvic Floor Distress Inventory-short form 20 (PFDI-20) . The questionnaire consists of three sections, pelvic organ prolapse distress inventory 6 (POPDI-6), colorectal-anal distress inventory 8 (CRADI-8), and urinary distress inventory 6 (UDI-6). Each section has 6-8 questions with 5 answers rated from 0-4 in each, and mean score of each section is the total score of this section divided by number of questions in this session. Then the sum of the mean scores of the three section timing 25 will come to the total score of the questionnaire(0-300). The higher the total score is, the severer the symptoms are.', 'timeFrame': 'at baseline, and 3 months when the treatment is completed.'}

Please estimate the sample size based on the assumption: 
80% power, 5% significance level (two-tailed), and 10% loss of follow-up rate.
Sample size calculation
        In this study change of PFDI-20 score from baseline will be used as the basis for primary sample size estimation. As there is no consensus on the minimal clinically important difference (MCID) of PFDI-20 score,27 and few RCT on acupuncture was identified, the study decided to use 15 points as MCID based on previous studies on conservative therapies for POP.9â28 Assuming a PDFI-20 baseline score of 60 points, it is estimated that 160 patients (80 per group) are needed to provide 80% power for detection of a difference of 15 points between groups at 12 weeks since randomisation, using a SD of 27 points,9 22 29 a two-tailed 5% level of significance and 10% loss of follow-up rate. PASS V.15 software was used for sample size calculation.