Here is the design of a clinical trial:

Official Title: Efficacy of Pre-operative Quadriceps Strength Training on Knee-extension Strength Before and Shortly Following Total Knee Arthroplasty: A Randomized Dose-response Trial (The QUADX-1 Trial)

Included conditions:
- Osteoarthritis, Knee

Study Armgroups:
- {'label': 'Group 2', 'type': 'ACTIVE_COMPARATOR', 'description': 'Two knee-extension exercise sessions per week. Each exercise session comprises a single strength training exercise; knee-extension, which is performed in 3 sets with 12 RM repetitions in each set.\n\nThe knee-extension resistance training exercise is performed with an elastic exercise band.', 'interventionNames': ['Other: Two knee-extension exercise sessions per week.']}
- {'label': 'Group 4', 'type': 'ACTIVE_COMPARATOR', 'description': 'Four knee-extension exercise sessions per week. Each exercise session comprises a single strength training exercise; knee-extension, which is performed in 3 sets with 12 RM repetitions in each set.\n\nThe knee-extension resistance training exercise is performed with an elastic exercise band.', 'interventionNames': ['Other: Four knee-extension exercise sessions per week.']}
- {'label': 'Group 6', 'type': 'ACTIVE_COMPARATOR', 'description': 'Six knee-extension exercise sessions per week. Each exercise session comprises a single strength training exercise; knee-extension, which is performed in 3 sets with 12 RM repetitions in each set.\n\nThe knee-extension resistance training exercise is performed with an elastic exercise band.', 'interventionNames': ['Other: Six knee-extension exercise sessions per week.']}

Interventions:
- {'type': 'OTHER', 'name': 'Two knee-extension exercise sessions per week.', 'description': 'Each exercise session comprises a single strength training exercise; knee-extension, which is performed in 3 sets with 12 RM repetitions in each set.\n\nThe knee-extension resistance training exercise is performed with an elastic exercise band.', 'armGroupLabels': ['Group 2']}
- {'type': 'OTHER', 'name': 'Four knee-extension exercise sessions per week.', 'description': 'Each exercise session comprises a single strength training exercise; knee-extension, which is performed in 3 sets with 12 RM repetitions in each set.\n\nThe knee-extension resistance training exercise is performed with an elastic exercise band.', 'armGroupLabels': ['Group 4']}
- {'type': 'OTHER', 'name': 'Six knee-extension exercise sessions per week.', 'description': 'Each exercise session comprises a single strength training exercise; knee-extension, which is performed in 3 sets with 12 RM repetitions in each set.\n\nThe knee-extension resistance training exercise is performed with an elastic exercise band.', 'armGroupLabels': ['Group 6']}

Primary Outcomes:
- {'measure': 'Isometric knee-extension strength at 60 degrees knee flexion measured as Nm/kg body mass', 'description': 'The measurement will be assessed using a computerized strength chair (Good Strength Chair, Metitur Oy, Jyvaskyla, Finland).', 'timeFrame': 'Change from 1) baseline to 2) after 12 weeks of exercise/just before surgery'}

Please estimate the sample size based on the assumption: 
Two-sided significance level of 0.05, power of 80%, and a dropout rate of 10%.
Sample size
        For a three-group-level One-way ANOVA of a normal mean difference with a two-sided significance level of 0.05, a common standard deviation of 0.22Â Nm/kg (isometric knee-extensor strength measurement) [51], and a minimal clinically important difference of 0.15Â Nm/kg (15%), a sample size of 126 (42 per group) patients is required to obtain a power of 80%. To allow for a dropout rate of 10%, we will include 140 patients in total for the intention-to-treat (ITT) analysis (3âÃâ42â+â14â=â140).