Here is the design of a clinical trial:

Official Title: Aquablation vs. Holmium Laser Enucleation of the Prostate in the Treatment of Benign Prostatic Hyperplasia in Medium to Large Size Prostates: A Prospective Randomized Trial

Included conditions:
- Benign Prostatic Hyperplasia (BPH)

Study Armgroups:
- {'label': 'Aquablation', 'type': 'EXPERIMENTAL', 'interventionNames': ['Procedure: Aquablation']}
- {'label': 'HoLEP', 'type': 'ACTIVE_COMPARATOR', 'interventionNames': ['Procedure: HoLEP']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'Aquablation', 'description': 'By means of a high-pressure saline stream, parenchymal tissue of the prostate is removed endoscopically through a heat-free mechanism called hydrodissection. The intervention is supported by live ultrasound guidance and the required depth as well as the angle of the resection is planned out prior to the resection. The bladder is accessed using a 24-Fr hand-piece, which accommodates the scope. The handpiece is supported by an articulating arm attached to the operation table. Once placed in the optimal position, the system automatically adjusts the alignment as necessary.\n\nHemostasis is consecutively achieved through diathermy and post procedure, a threeway catheter is inserted and bladder irrigation is initiated.', 'armGroupLabels': ['Aquablation']}
- {'type': 'PROCEDURE', 'name': 'HoLEP', 'description': 'This is done endoscopically under general anesthesia the three lobes of the prostate that are cored out intact with the laser are pushed into the bladder before being morcellated by a special instrument inserted through the telescopic camera. A catheter is placed into the bladder to drain the urine while the raw surface heals, then left in place for around 24 hours before being removed on the day of discharge from hospital. Sterile saline fluid is also irrigated into the bladder through the catheter to dilute any blood in the urine and prevent clots from forming.', 'armGroupLabels': ['HoLEP']}

Primary Outcomes:
- {'measure': 'International Prostate Symptoms Score (IPSS)', 'description': 'The International Prostate Symptom Score (IPSS) can be utilized to measure the severity of lower urinary tract symptoms. The IPSS is made up of 7 questions related to voiding symptoms. A score of 0 to 7 indicates mild symptoms, 8 to 19 indicates moderate symptoms and 20 to 35 indicates severe symptoms.', 'timeFrame': '6 months'}

Please estimate the sample size based on the assumption: 
90% power, one-sided significance level of 5%, 10% dropout rate
Sample size
          Assuming a non-inferiority margin of 4 points, a true difference of 0 points, an SD of 6 points at each assessment and a correlation of 0.35 between assessments, 51 evaluable patients per group will provide 90% power to reject the null hypothesis in a t-test for non-inferiority at a one-sided significance level of 5%. To allow for 10% of dropouts, 114 patients need to be recruited. We aim to recruit 120 patients to allow for some uncertainty about the above assumptions.