Here is the design of a clinical trial:

Official Title: Comparison of an Opioid-Free Anesthesia Protocol Versus Standard Practices on Early and Late Post-operative Recovery

Included conditions:
- Anesthesia
- Anesthesia; Adverse Effect
- Opioid Analgesic Adverse Reaction
- Post-Op Complication

Study Armgroups:
- {'label': 'Opioid free anesthesia (OFA) protocol', 'type': 'EXPERIMENTAL', 'interventionNames': ['Drug: Opioid Free Anaesthesia protocol']}
- {'label': 'standard practice protocol based on the use of opioids (sufentanil or remifentanil)', 'type': 'SHAM_COMPARATOR', 'interventionNames': ['Drug: standard practice protocol based on the use of opioids (sufentanil or remifentanil)']}

Interventions:
- {'type': 'DRUG', 'name': 'Opioid Free Anaesthesia protocol', 'description': 'The OFA protocol begins with a systematic preoperative premedication with clonidine, continues with an adapted intraoperative management without opioid administration, but associating several molecules (clonidine, magnesium, lidocaine, ketamine) and ends with a continued administration of xylocaine up to 1 hour postoperatively in PACU. The use of an opioid in preoperative or intraoperative phases is considered as a deviation from the protocol.\n\nTo these different molecules, the use of hypnotic molecules left to the choice of the practitioner and a curare will be systematically associated.', 'armGroupLabels': ['Opioid free anesthesia (OFA) protocol']}
- {'type': 'DRUG', 'name': 'standard practice protocol based on the use of opioids (sufentanil or remifentanil)', 'description': 'Standard anesthetic practices can be summed up as the combination of a hypnotic, a morphinic (sufentanil or remifentanil) and a curare. The use of ketamine is allowed.', 'armGroupLabels': ['standard practice protocol based on the use of opioids (sufentanil or remifentanil)']}

Primary Outcomes:
- {'measure': 'FQoR-15 score at 24 hours', 'description': 'Value of the French Quality of Recovery-15 score (minimum value of 0 and maximum value of 150, with a higher score for a better outcome).\n\nThe QoR-15 questionnaires will be completed by the patient himself whenever possible, who could be helped by a nurse blinded to the assignment group, or by phone if the patient has returned home.', 'timeFrame': '24 hours after surgery'}

Please estimate the sample size based on the assumption: 
Type I error risk of 0.05 in a two-sided test, power of 0.8, and a 10% dropout rate.
Sample size
        According to the database used to assess the French version of the QoR-15 that included 72 patients undergoing gynecologic, digestive, or urologic major surgery, the mean QoR-15 score was 97 at 24âh after the surgery, with a standard deviation of 16. A difference of at least 8.0 points in the score is considered clinically significant [30]. The OFA will thus be superior to the standard of care if the mean QoR-15 is at least 105. Considering a type I error risk of 0.05 in two-sided test and a power of 0.8, the estimated number of patients needed is 126 (63 patients in both groups). Considering that data will not be available for ten percent of the patients (e.g., surgery canceled, lost in follow-up, consent withdrawal) regarding the primary outcome, we plan to include 140 patients.