Here is the design of a clinical trial:

Official Title: Effectiveness and Cost-effectiveness of Improving Clinicians' Diagnostic and Communication Skills on Antibiotic Prescribing Appropriateness in Patients With Acute Cough in Primary Care in Catalonia.

Included conditions:
- Respiratory Tract Infections
- Cough

Study Armgroups:
- {'label': 'C-reactive protein rapid testing', 'type': 'EXPERIMENTAL', 'description': 'Continuous (workshop and monthly web-based training) disease-focused intervention with the use of C-reactive protein rapid testing.', 'interventionNames': ['Diagnostic Test: C-reactive protein rapid testing']}
- {'label': 'Enhancement of communication skills', 'type': 'EXPERIMENTAL', 'description': 'Continuous (on-site and monthly online training) illness-focused intervention with enhancement of communication skills to optimise doctor-patient consultations and share decision making with the aid of patient-centred leaflets.', 'interventionNames': ['Procedure: Communication skill enhancement']}
- {'label': 'C-reactive protein + communication skills', 'type': 'EXPERIMENTAL', 'description': 'Continuous (workshop and monthly web-based training) disease-focused intervention with C-reactive protein rapid testing and on-site and continuous (monthly online training illness-focused intervention) with enhancement of communication skills to optimise doctor-patient consultations and share decision making with the aid of patient-centred leaflets.', 'interventionNames': ['Diagnostic Test: C-reactive protein rapid testing', 'Procedure: Communication skill enhancement']}
- {'label': 'Usual care', 'type': 'NO_INTERVENTION', 'description': 'Usual care.'}

Interventions:
- {'type': 'DIAGNOSTIC_TEST', 'name': 'C-reactive protein rapid testing', 'description': 'Continuous (workshop and monthly web-based training) disease-focused intervention with the provision of CRP rapid testing in the primary care practices.', 'armGroupLabels': ['C-reactive protein + communication skills', 'C-reactive protein rapid testing'], 'otherNames': ['CRP']}
- {'type': 'PROCEDURE', 'name': 'Communication skill enhancement', 'description': 'Continuous (on-site and monthly online training) illness-focused intervention (enhancement of communication skills to optimise doctor-patient consultations and share decision making with the aid of patient-centred leaflets) in the primary care practices.', 'armGroupLabels': ['C-reactive protein + communication skills', 'Enhancement of communication skills'], 'otherNames': ['Leaflet provision']}

Primary Outcomes:
- {'measure': 'Antibiotic use', 'description': 'Number of antibiotics consumed (as documented in the CRFs and double-checked by the Pharmacy Unit of Institut Català de Salut that can track if the antibiotic has been dispensed at any of the Catalan pharmacies)', 'timeFrame': 'Day 42'}
- {'measure': 'Health status', 'description': 'Quality of life score obtained using the EuroQol questionnaire', 'timeFrame': 'Difference between baseline visit and day 42'}

Please estimate the sample size based on the assumption: 
Type I error of 5%, power of 80%, drop-out rate of 12%, intra-cluster correlation coefficient of up to 0.07.
Sample size calculation
        To calculate the sample size, we will use a type I error of 5% and a power of 80%, and we will assume that antibiotic prescribing will decrease by at least 15%, from 60% to 45%, in any one of the three intervention groups. We will also assume a drop-out rate of 12% and an intra-cluster correlation coefficient for antibiotic prescribing within practices of up to 0.07, based on two recent studies [14, 16]. We estimate that a sample of 788 (197âÃâ4) patients will be needed. Allowance for an inflation factor of 3.73 due to clustering and rounding of numbers for the four subgroups give an overall sample size of 2940 [17]. As a consequence, at least 147 patients will be recruited per centre.