Here is the design of a clinical trial:

Official Title: Central Venous Catheter Insertion Site and Catheter Colonization and Bloodstream Infection in Pediatric Cardiac Surgery

Included conditions:
- Central Line-associated Bloodstream Infection (CLABSI)
- Central Venous Catheter Associated Bloodstream Infection
- Heart; Surgery, Heart, Functional Disturbance as Result
- Congenital Heart Disease
- Newborn; Infection

Study Armgroups:
- {'label': 'Jugular', 'type': 'EXPERIMENTAL', 'description': 'CVC insertion in the left or right internal jugular vein', 'interventionNames': ['Procedure: Internal jugular vein CVC insertion']}
- {'label': 'Femoral', 'type': 'ACTIVE_COMPARATOR', 'description': 'CVC insertion in the right or left femoral vein', 'interventionNames': ['Procedure: Internal jugular vein CVC insertion']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'Internal jugular vein CVC insertion', 'description': 'Double lumen CVC insertion in the internal jugular vein', 'armGroupLabels': ['Femoral', 'Jugular']}

Primary Outcomes:
- {'measure': 'CVC colonization', 'description': 'CVC positive culture after removal', 'timeFrame': '14 days'}
- {'measure': 'CRBSI', 'description': 'Positive CVC culture and blood stream infection for the same organism', 'timeFrame': '14 days'}
- {'measure': 'CLABSI', 'description': 'A laboratory-confirmed bloodstream infection where central line was in place for more than 48h.', 'timeFrame': 'More than 48 hours'}

Please estimate the sample size based on the assumption: 
The study assumed an alpha error value of 5%, a power of 80%, and a dropout rate of 4%.
Sample size
        The power analysis was conducted on the basis of the endpoint of catheter colonization. Previous observational data on catheter lineâassociated bloodstream infections (CLABSIs) in a non-surgical neonatal intensive care showed that the femoral line was associated with a CLABSI rate of 10.2% but that the jugular site had a CLABSI rate of 2.7% [11]. We assumed a 2:1 ratio between catheter colonization rate and CLABSI rate and therefore hypothesized colonization rates of 20.4% for the femoral line and 5.4% for the jugular line. With an alpha error value of 5% and a power of 80%, 77 patients are required for each group. Considering a dropout rate of 4%, we increased this number to 80 subjects for each group.