Here is the design of a clinical trial:

Official Title: Early Care, Therapeutic Education, and Psychological Intervention for the Management of Post-intensive Care Syndrome and Chronic Pain After Coronavirus Disease 2019 Infection. Simple-blind, Controlled, Randomized Trial.

Included conditions:
- Post ICU Syndrome
- Chronic Pain
- Covid-19

Study Armgroups:
- {'label': 'Intervention arm', 'type': 'EXPERIMENTAL', 'description': 'The intervention is a program that includes early patient care, therapeutic education, and psychological intervention. It will be performed through three medical visits and a psychological intervention that requires seven face-to-face sessions.', 'interventionNames': ['Behavioral: Intervention program']}
- {'label': 'Standard care arm', 'type': 'NO_INTERVENTION', 'description': 'Standard medical practice: patient follow-up is carried out by their referring physicians (primary care physicians or specialists) who are outside the study.'}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Intervention program', 'description': "Medical visits:\n\nThere will be three medical visits stipulated as follows:\n\n* Visit 1 Intervention Group, four weeks after hospital discharge.\n* Visit 2 Intervention Group, eight weeks after hospital discharge.\n* Visit 3 Intervention Group, 18 weeks after hospital discharge.\n\nComponents of visits:\n\n* Interview and physical examination.\n* Therapeutic education about the intensive care syndrome orally and with a specific document that will be delivered at the end of the visit.\n* Therapeutic education around pain. If the patient reports pain, a specific document will be prepared that will be delivered at the end of the visit.\n\nPsychological intervention:\n\nInclusion criteria for psychological intervention: Patients with a score higher than 8 on the HAD (hospital anxiety and depression) test depression subscale.\n\nDescription :\n\nThe intervention protocol consists of 7 weekly sessions lasting one hour and a half. The intervention in depression is based on Rehm's model of self-control.", 'armGroupLabels': ['Intervention arm']}

Primary Outcomes:
- {'measure': 'Impact of intervention program on health-related quality of life (VAS)', 'description': 'Health-related quality of life reported by the patient assessed through the visual analogue scale of the EQoL 5D/5L questionnaire at six months after discharge.\n\n\\[European quality of life 5 dimensions/5 levels ; from 0 (the worst imaginable health) to 100 (the best imaginable health) \\]', 'timeFrame': 'Six months after discharge'}

Please estimate the sample size based on the assumption: 
Type I error of 0.05, power of 80%, and a loss to follow-up rate of 20%.
Sample size
          To calculate the sample size of the PAIN COVID clinical trial with an assumed average of 50 points on the visual analog scale of the EuroQOL-5D-5L for the control group, and a clinically relevant difference between the groups of 20%, for distribution of a tail with a type I error of 0.05 and a power of 80%, the sample size has been calculated as 84 patients, 42 for each arm. Assuming a loss to follow-up of 20%, the sample size needed is 102 patients (51 in each group).