Here is the design of a clinical trial:

Official Title: Effects of Cigar Flavors on Measures of Abuse Liability Among Young Adults

Included conditions:
- Tobacco Products

Study Armgroups:
- {'label': 'Own Brand Cigarette Condition', 'type': 'ACTIVE_COMPARATOR', 'interventionNames': ['Other: Tobacco product administration and assessment']}
- {'label': 'Original-flavor Black&Mild cigar', 'type': 'EXPERIMENTAL', 'interventionNames': ['Other: Tobacco product administration and assessment']}
- {'label': 'Apple-flavor Black&Mild cigar', 'type': 'EXPERIMENTAL', 'interventionNames': ['Other: Tobacco product administration and assessment']}
- {'label': 'Cream-flavor Black&Mild cigar', 'type': 'EXPERIMENTAL', 'interventionNames': ['Other: Tobacco product administration and assessment']}
- {'label': 'Wine-flavor Black&Mild cigar', 'type': 'EXPERIMENTAL', 'interventionNames': ['Other: Tobacco product administration and assessment']}

Interventions:
- {'type': 'OTHER', 'name': 'Tobacco product administration and assessment', 'description': 'two bouts of 10 puffs of a tobacco product with a 30-second interpuff interval separated by 60 minutes; preceded and followed by physiological, subjective and topography assessment', 'armGroupLabels': ['Apple-flavor Black&Mild cigar', 'Cream-flavor Black&Mild cigar', 'Original-flavor Black&Mild cigar', 'Own Brand Cigarette Condition', 'Wine-flavor Black&Mild cigar']}

Primary Outcomes:
- {'measure': 'Change in saliva nicotine concentration', 'description': 'Each participant will attend 5 study sessions, each study session will include two bouts of product administration. Product administration will consist of 10 puffs with a 30-second interpuff interval (IPI; puff number and IPI will be directed and monitored by staff).', 'timeFrame': 'Saliva will be collected at baseline before the first product administration, at 10 min following each product administration, and 55 min following the first product administration (baseline for the second product administration).'}
- {'measure': 'Change in breakpoint from two behavioral choice tasks (Cigarette Purchase Task, Multiple Choice Procedure)', 'description': 'Each participant will attend 5 study sessions, each study session will include two bouts of product administration. Product administration will consist of 10 puffs with a 30-second interpuff interval (IPI; puff number and IPI will be directed and monitored by staff).', 'timeFrame': 'A behavioral choice task (cigarette purchase cask) will be completed at baseline before the first product administration, 5, 15, 30, and 45 min following each bout. 45 min after the second bout, the multiple choice procedure will be administered.'}
- {'measure': 'Change in Addiction Research Center Inventory subjective abuse liability', 'description': 'Each participant will attend 5 study sessions, each study session will include two bouts of product administration. Product administration will consist of 10 puffs with a 30-second interpuff interval (IPI; puff number and IPI will be directed and monitored by staff).', 'timeFrame': 'Subjective measures of abuse liability will be collected at baseline before the first product administration, 5, 15, 30, and 45 min following each bout.'}
- {'measure': 'Change in Direct Effects of Nicotine and Tobacco Scale subjective abuse liability', 'description': 'Each participant will attend 5 study sessions, each study session will include two bouts of product administration. Product administration will consist of 10 puffs with a 30-second interpuff interval (IPI; puff number and IPI will be directed and monitored by staff).', 'timeFrame': 'Subjective measures of abuse liability will be collected at baseline before the first product administration, 5, 15, 30, and 45 min following each bout.'}
- {'measure': 'Change in Tobacco Abstinence Symptoms and Drug Effects subjective abuse liability', 'description': 'Each participant will attend 5 study sessions, each study session will include two bouts of product administration. Product administration will consist of 10 puffs with a 30-second interpuff interval (IPI; puff number and IPI will be directed and monitored by staff).', 'timeFrame': 'Subjective measures of abuse liability will be collected at baseline before the first product administration, 5, 15, 30, and 45 min following each bout.'}

Please estimate the sample size based on the assumption: 
power > 0.80, moderate correlation between measures (r > 0.50)
Sample size
          This study will recruit 25 young adults 18â25 years of age. This number was necessary to detect moderate within-subjects effects (ie, f=0.35) with powerÂ >0.80 between conditions for the primary outcome measures, assuming a moderate correlation between measures (r>0.50).