Here is the design of a clinical trial:

Official Title: Adjunctive Inspiratory Muscle Training for Patients With COVID-19

Included conditions:
- Covid19
- Exercise

Study Armgroups:
- {'label': 'Intervention Group', 'type': 'EXPERIMENTAL', 'description': "The training volume will be 24 sessions. Training frequency will be 3 sessions per week. Duration of training sessions will be around 60min. Patients will perform endurance training or interval training at moderate to high intensities. IMT in both groups will be performed using the PowerBreathe KHP2 device (POWERbreatheKHP2, HaB, International, Southam, UK). Training intensity in the intervention group will be set initially at a load of 50% of patients' maximal inspiratory mouth pressure (MIP). This initial load will be continuously and gradually increased to the highest tolerable intensity during each of the supervised sessions.", 'interventionNames': ['Device: inspiratory muscle traiing']}
- {'label': 'Control group', 'type': 'ACTIVE_COMPARATOR', 'description': 'The training volume will be 24 sessions. Training frequency will be 3 sessions per week. Duration of training sessions will be around 60min. Patients will perform endurance training or interval training at moderate to high intensities. Sham IMT will be performed using the PowerBreathe KHP2 device (POWERbreatheKHP2, HaB, International, Southam, UK). Training intensity in the control group will be set at 10% baseline PImax and will be not modified throughout the intervention period.', 'interventionNames': ['Device: inspiratory muscle traiing']}

Interventions:
- {'type': 'DEVICE', 'name': 'inspiratory muscle traiing', 'description': 'The patients are encouraged to inhale against a load to increase the inspiratory muscle strength and endurance', 'armGroupLabels': ['Control group', 'Intervention Group'], 'otherNames': ['tapered flow resistive loading']}

Primary Outcomes:
- {'measure': 'Cardiopulmonary Exercise Testing Measurements', 'description': 'Peak VO2 is a measurement of oxygen consumption rate during exercise (milliliters of oxygen per minute). It is calculated by continuous measurement of oxygen consumed during exercise while patients breath through a mask/tube. To account for variability in patient size, the oxygen consumption is divided by patient body weight.The VE/VCO2 slope is calculated as the ratio of minute ventilation (VE) and carbon dioxide production (VCO2). Because these measurements share the same units, the resultant ratio is unitless.The ventilatory anaerobic threshold (VAT) will be determined by the V-slope method.', 'timeFrame': 'change from baseline in Peak VO2, VE/VCO2 slope and VAT at 8 weeks and 6 months'}

Please estimate the sample size based on the assumption: 
An α error probability of 0.05, power (1-β error probability) of 0.80, and a dropout rate of 15%.
Sample size
        Due to the lack of data on the effect of supervised IMT in a PR in patients with post-COVID-19, we performed a power analysis based on a previous meta-analysis of peak VO2 (in mL/kg/min) in patients with idiopathic pulmonary fibrosis.18 We used the software GPower to calculate sample size with a priori analysis with an intergroup difference of 1.46âmL/kg/min, an SD of 3.5âmL/kg/min, an Î± error probability of 0.05 and power (1-Î² error probability) of 0.80. Based on the results, it was decided that 138 patients will be divided into two groups, with a dropout rate of 15%.