Here is the design of a clinical trial:

Official Title: Effect of High-volume Online hemodiafiLtration on Intra-diaLytic hemodynAmic (iN)sTability and Cardiac Function in Chronic Hemodialysis Patients (the HOLLANT Study)

Included conditions:
- End Stage Renal Disease (ESRD)
- Hemodialysis
- Hemodiafiltration
- Intradialytic Hypotension
- Diastolic Dysfunction

Study Armgroups:
- {'label': 'standard hemodialysis', 'type': 'ACTIVE_COMPARATOR', 'description': 'prescription of dialysate temperature: 36.5 degrees celsius prescription of convection volume: 0 Liters (L)', 'interventionNames': ['Device: cool hemodialysis', 'Device: low volume hemodiafiltration', 'Device: high volume hemodiafiltration']}
- {'label': 'cool hemodialysis', 'type': 'ACTIVE_COMPARATOR', 'description': 'prescription of dialysate temperature: 35.5 degrees celsius prescription of convection volume: 0 L', 'interventionNames': ['Device: standard hemodialysis', 'Device: low volume hemodiafiltration', 'Device: high volume hemodiafiltration']}
- {'label': 'low volume hemodiafiltration', 'type': 'ACTIVE_COMPARATOR', 'description': 'prescription of dialysate temperature: 36.5 degrees celsius prescription of convection volume: 15 L', 'interventionNames': ['Device: standard hemodialysis', 'Device: cool hemodialysis', 'Device: high volume hemodiafiltration']}
- {'label': 'high volume hemodiafiltration', 'type': 'ACTIVE_COMPARATOR', 'description': 'prescription of dialysate temperature: 36.5 degrees celsius prescription of convection volume: 25 L', 'interventionNames': ['Device: standard hemodialysis', 'Device: cool hemodialysis', 'Device: low volume hemodiafiltration']}

Interventions:
- {'type': 'DEVICE', 'name': 'standard hemodialysis', 'description': 'hemodialysis with high-flux dialyzer; prescription of dialysate temperature: 36.5 degrees Celsius; convection volume: not applicable', 'armGroupLabels': ['cool hemodialysis', 'high volume hemodiafiltration', 'low volume hemodiafiltration']}
- {'type': 'DEVICE', 'name': 'cool hemodialysis', 'description': 'hemodialysis with high-flux dialyzer; prescription of dialysate temperature: 35.5 degrees Celsius; convection volume: not applicable', 'armGroupLabels': ['high volume hemodiafiltration', 'low volume hemodiafiltration', 'standard hemodialysis']}
- {'type': 'DEVICE', 'name': 'low volume hemodiafiltration', 'description': 'hemodiafiltration; prescription of dialysate temperature: 36.5 degrees celsius prescription of convection volume: 15 L', 'armGroupLabels': ['cool hemodialysis', 'high volume hemodiafiltration', 'standard hemodialysis']}
- {'type': 'DEVICE', 'name': 'high volume hemodiafiltration', 'description': 'hemodiafiltration; prescription of dialysate temperature: 36.5 degrees celsius prescription of convection volume: 25 L', 'armGroupLabels': ['cool hemodialysis', 'low volume hemodiafiltration', 'standard hemodialysis']}

Primary Outcomes:
- {'measure': 'intradialytic hypotension', 'description': 'nadir in systolic blood pressure (SBP) of 90 mmHg for patient with predialysis SBP \\<160mmHg and a nadir of 100 mmHg for patients with predialysis SBP ≥160 mmHg during treatment (blood pressure will be measured before and every 15 minutes after the start of dialysis during the treatment)', 'timeFrame': 'up to 4 hours (= one dialysis treatment); assessed during 3 treatments on each modality'}

Please estimate the sample size based on the assumption: 
significance level (α) = 0.05, power (β) = 0.80, loss to follow-up = 20%
Sample size considerations
          We plan to include 40 patients. Loss to follow-up (due to an event) is expected to be about 20%. The number of patients with complete follow-up will be sufficient to detect a 40% lower risk (relative risk of 0.60, Î±â=â0.05, Î²â=â0.80) in the occurrence of the primary endpoint. The power calculation applied was designed for cross-over studies [60].