Here is the design of a clinical trial:

Official Title: Parents as Pain Management in Swedish Family-centred Neonatal Care. A Mixed Methods Approach

Included conditions:
- Infant Pain Management
- Parent-driven Pain Management

Study Armgroups:
- {'label': 'Standard care with glucose', 'type': 'NO_INTERVENTION', 'description': "Control Group with standard care comprises facilitated tucking done by a nurse or the parent, oral glucose (300 mg/ml) and the opportunity to suck on a pacifier or on a parent's or a nurse's plastic gloved finger. The infant is placed on an examination table for the venipuncture."}
- {'label': 'Skin-to-skin contact', 'type': 'EXPERIMENTAL', 'description': "Skin-to-skin contact is a method widely used in neonatal care globally. The infant is placed naked (except for a diaper and possibly a hat) on the parents' bare chest.", 'interventionNames': ['Behavioral: Parent-driven pain management with skin-to-skin contact']}
- {'label': 'Skin-to-skin contact/breastfeeding/parental singing', 'type': 'EXPERIMENTAL', 'description': 'Parent-driven interventions are skin-to-skin care, breastfeeding and multi-sensory stimulation like vocalisation. They are all a combination of multiple sensory inputs comprising auditory, tactile and olfactory recognition. Research has started to investigate breastfeeding in combination with Kangaroo-mother- care for example, which has shown to be an effective mix. A multimodal approach that includes a combination of non-pharmacological approaches is considered more effective during venipuncture than single strategies and provides greater pain relief.', 'interventionNames': ['Behavioral: Parent-driven pain management with skin-to-skin contact/breastfeeding/parental singing']}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Parent-driven pain management with skin-to-skin contact', 'description': "The infant is placed naked (except for a diaper and possibly a hat) on the parents' bare chest.", 'armGroupLabels': ['Skin-to-skin contact']}
- {'type': 'BEHAVIORAL', 'name': 'Parent-driven pain management with skin-to-skin contact/breastfeeding/parental singing', 'description': 'Live parental infant-directed lullaby singing is an individually tailored, non-verbal, multisensory, multimodal and affective tool to regulate the infant before, during and after venipuncture. Direct breast-feeding has demonstrated efficacy that is equal to, or greater than, sweet taste interventions in reducing behavioral and physiological responses to pain in full-term infants undergoing venipuncture with no demonstrated adverse outcomes. Direct breast-feeding should be considered the preferred first-line analgesic intervention for painful procedures performed on full-term infants.', 'armGroupLabels': ['Skin-to-skin contact/breastfeeding/parental singing']}

Primary Outcomes:
- {'measure': 'Pain in infants', 'description': 'The primary outcome in the randomized controlled trial is pain in infants measured with the Premature Infant Pain Profile Revised (PIPP-R). The PIPP-R evaluates three behavioral facial actions (brow bulge, eye squeeze and nasolabial furrow), two physiological items (heart rate, transcutaneous oxygen saturation), and two contextual items (gestational age and behavioral state). The PIPP is weighted for younger gestational age and sleep state. Scores can range from 0 to 21, and a difference of two points between conditions can be considered clinically important.', 'timeFrame': 'Through study completion, an average of 1 year.'}

Please estimate the sample size based on the assumption: 
A power of 0.8 and a significance level set to 0.05. To compensate for possible dropouts and incomplete data, 75 infants per group will be enrolled.
Sample size
        No previous RCT has examined the effects of parent-driven pain management in newborn infants by combining SSC, breastfeeding and live parental lullaby singing. Based on previous studies using PIPP-R or its predecessor PIPP in pain alleviation projects, a difference of two PIPP-R points between standard care (group 1) and the full parent driven pain management (group 3) is considered clinically important. Based on those studies we also assume a standard deviation around 2 points. A power calculation sets the number of infants to include in the study to 63 in each group, with a power of 0.8 and a significance level set to 0.05 (www.clincalc.com). To compensate for possible dropouts, incomplete data, such as equipment malfunction or blood sample collection failure, 75 infants per group will be enrolled, making a total of 225 infants.