Here is the design of a clinical trial:

Official Title: Dynamic Supported Mobility for Infants and Toddlers With Cerebral Palsy

Included conditions:
- Cerebral Palsy

Study Armgroups:
- {'label': 'Conventional Therapy', 'type': 'EXPERIMENTAL', 'description': 'The conventional treatment group will receive traditional, therapist-directed pediatric physical therapy. Therapy will focus on early gait training strategies and encouragement of "normal" movement patterns for walking and other age-appropriate movements, with manual guidance or correction of atypical movements from the therapist. This group may use assistive devices, orthoses, and may receive static body weight support for gait training. Therapy activities will be performed in blocks of practice, with the specific activities and level of therapist assistance tailored to each child.', 'interventionNames': ['Other: Conventional Therapy']}
- {'label': 'Dynamic Supported Mobility', 'type': 'EXPERIMENTAL', 'description': "Children will receive dynamic weight support during all DSM treatment time. The environment will be arranged to encourage active motor exploration, somewhat similar to a play gym for toddlers, to promote the motor variability, engagement, and error experiences that characterize the typical development of upright motor skills and walking. The floor area within 3 feet below either side of the overhead track for a distance of 20 feet (approximately 120 ft2 total) will be defined with colorful thin rubber interlocking mats and arranged with pediatric toys and activities, tailored to the child's interests and to encourage motor skills just beyond his/her current ability. The therapist will minimally assist the child as needed to perform the movements he/she initiates.", 'interventionNames': ['Other: Dynamic Supported Mobility']}

Interventions:
- {'type': 'OTHER', 'name': 'Dynamic Supported Mobility', 'description': "Dynamic weight support; Child-directed; No assistive devices, limited use of orthoses, no treadmill; Encourage high degree of error with reduced physical assistance; Encourage frequent variability in motor tasks (no redirection when moving from one activity to another); Physical therapist expertise is focused on designing a salient and challenging environment for the child's specific interests and ability level to encourage engagement, variability, challenge, and error experience, and on determining the appropriate amount of weight assistance", 'armGroupLabels': ['Dynamic Supported Mobility']}
- {'type': 'OTHER', 'name': 'Conventional Therapy', 'description': 'No or static weight support; Therapist-directed (therapist initiates); Traditional early gait training methods: use of assistive devices/orthoses and may use treadmill; Focus on producing "typical" movement patterns with extensive manual guidance/correction from therapist, prevention of falls; Therapy activities grouped into blocks of practice (i.e. repeated floor to stand practice followed by gait training); Physical therapist expertise is focused on designing and directing the specific practice activities each session, tailored to the individual child', 'armGroupLabels': ['Conventional Therapy']}

Primary Outcomes:
- {'measure': 'Change in Gross Motor Function Measure (GMFM-66) During Treatment Phase', 'description': "Computation of the GMFM-66 score involves statistical weighting of the raw item scores for difficulty. This score will also be used with the patient's age to determine Gross Motor Function Classification System (GMFCS) percentile rank. Scores range from 0 (no volitional movement) to 100 (gross motor function of an average 5 year old). Higher scores reflect better outcomes.", 'timeFrame': 'Baseline and 12 weeks'}

Please estimate the sample size based on the assumption: 
A uniform attrition rate of 20% is assumed, and a 2-sided 95% confidence interval for the estimated difference in GMFM-66 between the two interventions will extend +/- 6 units from the observed difference, assuming a conservative standard deviation of 9.
Sample size estimation
        Predicted change in the iMOVE group was estimated from data collected from four children (pilot study data) who would meet the proposed inclusion criteria. A mean GMFM-66 [47] increase of 5.3 was observed after 6Â weeks of treatment. We estimated that a change of 10.6 would be expected within 24Â weeks of treatment. Predicted change in the CONV group was determined from published GMFM-66 percentile scores for average change over six monthsâ time [48]. We are planning to recruit a total of 42 participants (21 per treatment group). We estimated a uniformed attrition rate of 20% by the end of the study, therefore, evaluable data from 34 participants (17 per group) will be available. With a sample size of 34, a 2-sided 95% confidence interval for the estimated difference in GMFM-66 between the two interventions will extend +/ââ6Â units from the observed difference assuming a conservative standard deviation of 9.