Here is the design of a clinical trial:

Official Title: In Vitro Maturation Versus Standard in Vitro Fertilization in Infertile Patients Diagnosed With Polycystic Ovaries Syndrome: a Study Protocol for a Single-center Prospective, Randomized Controlled Clinical Trial

Included conditions:
- PCOS

Study Armgroups:
- {'label': 'standard IVF', 'type': 'ACTIVE_COMPARATOR', 'description': 'On the Day2/3 of the menstrual cycle, qualified participants will be randomized into either of two groups. Participants in group A will receive standard IVF procedure. Other standard assisted reproductive treatments are similar and parallel between two groups.', 'interventionNames': ['Procedure: standard IVF']}
- {'label': 'In vitro maturation', 'type': 'ACTIVE_COMPARATOR', 'description': 'On the Day2/3 of the menstrual cycle, qualified participants will be randomized into either of two groups. Participants in group B will receive IVM procedure.Other standard assisted reproductive treatments are similar and parallel between two groups.', 'interventionNames': ['Drug: In vitro maturation']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'standard IVF', 'description': 'Ovarian stimulation will be performed by a standard protocol using gonadotrophin-releasing hormone antagonist (GnRH-ant) in association with recombinant FSH (rFSH) and human chorionic gonadotrophin (hCG).Oocyte retrieval is scheduled for 36 (±2) after hCG injection.The retrieved cumulus oocyte complexes (COC) will be inseminated using ICSI or conventional IVF according to the seman analysis. All embryos will be cultured to blastocyst stage and be vitrified.', 'armGroupLabels': ['standard IVF']}
- {'type': 'DRUG', 'name': 'In vitro maturation', 'description': 'Controlled ovarian stimulation protocol will not performed in this group patients. Transvaginal ultrasound scanning was examined on natural cycle to monitor the follicle size in group B participants. Oocyte retrieval was scheduled once the endometrium had reached at least 6 mm in thickness and there was no follicle larger than 10 mm. After oocyte retrieval, the COCs will be cultured for 28-32h in special IVM media in order to get the matured oocytes. All the metaphase II (MII) oocytes were inseminated by means of intracytoplasmic sperm injection (ICSI). All embryos will be cultured to blastocyst stage and be vitrified.', 'armGroupLabels': ['In vitro maturation'], 'otherNames': ['IVM']}

Primary Outcomes:
- {'measure': 'the proportion of ongoing pregnancy leading to live birth', 'description': 'number of ongoing pregnancy leading to live birth resulting from the first oocyte retrieval cycle after the randomization ( 6 month) divided by the number of patients with oocyte retrieval', 'timeFrame': 'after 22 weeks of gestation'}

Please estimate the sample size based on the assumption: 
Power of 80%, one-sided significance level (α) of 0.025, and a dropout rate of 10%.
Sample size calculation
          The primary hypothesis of this study is that the experimental group (IVM) is non-inferior to the control group (IVF) in terms of ongoing pregnancy leading to live birth. On the basis of actual data on the women with PCOS who underwent IVM or IVF-ET in our reproductive medicine centre, we assume that after IVF the proportions of ongoing pregnancy leading to live birth for the PCOS women are 35% per transferred cycle.22 23 With a non-inferiority margin of 15%, power of 80% and one-sided Î± 0.025, we will need to enrol 159 participants in each group (the ratio between groups will be 1:1). Taking consideration of dropout rate as 10% (such as cancellation during trial procedures), each group will include 175 participants (a total of 350 participants).