Here is the design of a clinical trial:

Official Title: A Randomized Control Trial to Compare the Euploid Rate of Blastocyst Between the Progestin-primed Ovarian Stimulation Protocol and the GnRH Antagonist Protocol in Patients Undergoing PGT-A

Included conditions:
- Preimplantation Genetic Testing
- Progestin-primed Ovarian Stimulation
- Euploid Rate
- GnRH Antagonist

Study Armgroups:
- {'label': 'Antagonist group', 'type': 'ACTIVE_COMPARATOR', 'description': 'Women will receive antagonist (Cetrotide 0.25mg) once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger.', 'interventionNames': ['Drug: GnRH antagonist']}
- {'label': 'PPOS group', 'type': 'EXPERIMENTAL', 'description': 'Women will receive oral Duphaston 10mg bd from Day 3 till the day of ovulation trigger.', 'interventionNames': ['Drug: oral Duphaston']}

Interventions:
- {'type': 'DRUG', 'name': 'GnRH antagonist', 'description': 'GnRH antagonist (Cetrorelix 0.25mg) once subcutaneously daily from day 6 of COH till the day of the ovulation trigger', 'armGroupLabels': ['Antagonist group'], 'otherNames': ['Cetrorelix']}
- {'type': 'DRUG', 'name': 'oral Duphaston', 'description': 'oral Duphaston 10mg bd from Day 3 of COH till the day of ovulation trigger.', 'armGroupLabels': ['PPOS group'], 'otherNames': ['Duphaston']}

Primary Outcomes:
- {'measure': 'euploidy rate', 'description': 'euploidy rate of blastocysts', 'timeFrame': '1 month after oocyte retrieval'}

Please estimate the sample size based on the assumption: 
Power of 0.8, type I error of 0.05, and a 10% drop-out rate.
Sample size estimation
          According to our data of the centre, in a group of 284âwomen (mean age 36.9 years and SD 3.5 years) undergoing PGT-A for advanced maternal age, recurrent pregnancy loss or repeated implantation failure, the mean euploid rate of blastocysts was 42.0% with SD of 34.0%. We hypothesise that a difference in the euploid rate of 10% between the PPOS versus GnRH antagonist group, the sample size required would be 182 in each arm to give a power of 0.8 and type I error of 0.05. Allowing 10% drop-out, 400âwomen or 200 in each arm will be needed.