Here is the design of a clinical trial:

Official Title: "Comparison of Two Methods of Securing Endotracheal Tubes in Intensive Care : Elastic Adhesive Strips vs Lace In A Protective Sheath. A Randomized Multicenter, Cluster and Crossover Controlled Study. FIXATUB"

Included conditions:
- Intubation Complication

Study Armgroups:
- {'label': 'Elastic Adhesive Strips', 'type': 'EXPERIMENTAL', 'description': "Endotracheal tube fixed by elastic adhesive tape (Tensoplast type adhesive tape):\n\nThe adhesive tape will be attached to the patient's face (opposite side to the endotracheal tube) and then two turns around the endotracheal tube will be made. The rest of the adhesive tape will be attached to the other side of the face (side of the endotracheal tube).\n\nThe laminated tape will be kept on the adhesive tape until it passes over the neck in order to avoid adhering to the hair.\n\nFinally, the end of the adhesive tape will be replaced on the part already attached to the patient.\n\nIt will be changed daily and after stain or examinations if necessary.", 'interventionNames': ['Device: Elastic Adhesive Strips']}
- {'label': 'Lace in A Protective Sheath', 'type': 'ACTIVE_COMPARATOR', 'description': 'A loop is made with the lace then the endotracheal tube is passed through the loop. The loop is tightened by pulling each side on the remaining cords and a knot is made on one side of the fastener.\n\nIt will be changed daily and after stain or examinations if necessary.', 'interventionNames': ['Device: Lace in A Protective Sheath']}

Interventions:
- {'type': 'DEVICE', 'name': 'Elastic Adhesive Strips', 'description': 'Securement of Endotracheal tube with Elastic Adhesive Strips', 'armGroupLabels': ['Elastic Adhesive Strips']}
- {'type': 'DEVICE', 'name': 'Lace in A Protective Sheath', 'description': 'Securement of Endotracheal tube with Lace in A Protective Sheath', 'armGroupLabels': ['Lace in A Protective Sheath']}

Primary Outcomes:
- {'measure': 'Peribuccal lesion', 'description': 'Appearance of at least one peribuccal lesion during the first 10 days of maintaining the endotracheal tube inserted orally.\n\nPresence of peribuccal lesion will be validated on picture by an independent review committee.\n\nThe picture will be taken daily without the visible fixing system (blind maintained for the adjudication committee) from J0 to J10 at the site of the endotracheal tube.', 'timeFrame': 'up to 10 days after intubation'}

Please estimate the sample size based on the assumption: 
Moderate intra-class correlation coefficient of 0.1, within-cluster between-period correlation coefficient of 0.05, 90% power, 5% alpha level.
Sample size calculation
          The study will take place in 16 centers (clusters) over two 12-month periods.
          According to the IDEFIX study (data not published, but provided during the French Intensive Care Congress in 2012, S1 Appendix), we hypothesize that 35% of patients with a "cord and sleeve" fixation system have a peri-oral lesion compared to 20% with the elastic adhesive tape system.
          The calculation of the number of subjects needed must take into account the design of the study and thus the two intra-class and inter-class correlation coefficients [18].
          As we have no data on the estimation of correlation coefficients, we have retained, for the calculation of the number of subjects, a "moderate" intra-class correlation coefficient and therefore defined at 0.1, and as recommended, a within-cluster between-period correlation coefficient equal to half of the intra-class correlation coefficient, i.e. 0.05 [19].
          With 90% power and 5% alpha level, we calculated that each of the 16 centers would need to include an average of 24 patients per period.
          A total of 768 patients are to be included.