Here is the design of a clinical trial:

Official Title: Gestational Age Versus Nasal-tragus Length for Estimating Endotracheal Tube Insertion Depth in Newborns - A Randomised Trial

Included conditions:
- Endotracheal Tube Tip Position
- Bronchopulmonary Dysplasia
- Pneumothorax
- Death
- Duration, Ventilator

Study Armgroups:
- {'label': 'Gestational Age Chart Method', 'type': 'EXPERIMENTAL', 'description': 'In this method, the endotracheal tube insertion depth is obtained from the gestational age chart provided in the 7th edition textbook of neonatal resuscitation program (adapted from Kempley et al. PubMed identifier number: 18372092)', 'interventionNames': ['Other: Gestational Age Chart Method']}
- {'label': 'Nasal-Tragus Length Method', 'type': 'ACTIVE_COMPARATOR', 'description': 'In this method, the endotracheal tube insertion depth is calculated based on the formula-the distance from nasal septum tip to ear tragus+1 cm', 'interventionNames': ['Other: Nasal-Tragus Length Method']}

Interventions:
- {'type': 'OTHER', 'name': 'Gestational Age Chart Method', 'description': 'The endotracheal tube insertion depth is obtained by the gestational age chart', 'armGroupLabels': ['Gestational Age Chart Method']}
- {'type': 'OTHER', 'name': 'Nasal-Tragus Length Method', 'description': 'The endotracheal tube insertion depth is obtained by the nasal-tragus method formula', 'armGroupLabels': ['Nasal-Tragus Length Method']}

Primary Outcomes:
- {'measure': 'Proportion of infants with optimally positioned endotracheal tube tip on the chest X-ray', 'description': "Endotracheal tube tip is considered optimally positioned if the tip lies between upper border of first thoracic vertebra (T1) and the lower border of second thoracic vertebra (T2) on the chest X-ray. While obtaining the antero-posterior view chest X-ray in supine position, the infant's head, neck and chest is placed in the midline with no tension on the endotracheal tube and neck being in neutral position (i.e. neck neither flexed nor extended). Just before obtaining the film, the investigator/research assistant should re-confirm that the endotracheal tube is secured in a standardize manner at the estimated depth based on the treatment arm assigned.", 'timeFrame': 'within 4 hours of endotracheal intubation'}

Please estimate the sample size based on the assumption: 
Not specified
Sites and sample size
          The trial is aimed to recruit 454 infants over 3âyears across tertiary level NICUs.