Here is the design of a clinical trial:

Official Title: The Psycho-physiological & Social-spiritual Effects of Expressive Arts-based Intervention on Young and Pre-elderly Stroke Survivors: A Randomized Controlled Study

Included conditions:
- Stroke

Study Armgroups:
- {'label': 'Intervention', 'type': 'EXPERIMENTAL', 'description': 'This arm of participants will be receiving Expressive Arts Therapy as intervention', 'interventionNames': ['Behavioral: Expressive Arts Therapy']}
- {'label': 'Control', 'type': 'NO_INTERVENTION', 'description': 'This arm of participants will not receive any intervention and are allocated as a wait-list control group'}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Expressive Arts Therapy', 'description': 'The intervention brings together the strengths of different art modalities, such as visual art, music, movement, dance, drama and writing to assist reflect and response in individuals to their personal issues. Such variety of art forms multiplies the avenues by which a person in therapy may seek meaning, clarity, insight and healing.', 'armGroupLabels': ['Intervention']}

Primary Outcomes:
- {'measure': 'Change from Baseline Depression and Anxiety level at 2 months and 8 months', 'description': 'Administration of the Chinese translated version of Hospital Anxiety and Depression Scale\n\n* This scale is adopted to measure the level of Depression and Anxiety.\n* Two scores, Depression score and Anxiety score, are generated.\n* The minimum score is 0 and the maximum score is 21.\n* Scores ranging from "0-7" represents "Normal", ranging from "8-10" represents "Borderline abnormal", and ranging from "11-21" represents "Abnormal".', 'timeFrame': 'Baseline, Month 2, and Month 8'}
- {'measure': 'Change of Baseline Perceived Stress level at 2 months and 8 months', 'description': 'Administration of Chinese translated version of Perceived Stress Scale\n\n* This scale is adopted to measure the level of perceived stress\n* The total score of Perceived Stress Scale is summing all the scores from each item, with Q4, Q5, Q7, and Q8 are reverse items.\n* The minimum score is 0 and the maximum score is 40.\n* Scores ranging from "0-13" represents low stress, ranging from "14-26" represents moderate stress, and "27-40" represents high perceived stress.', 'timeFrame': 'Baseline, Month 2, and Month 8'}
- {'measure': 'Change of Baseline Perceived Social Support level at 2 months and 8 months', 'description': 'Administration of the Chinese version of the Multidimensional Scale of Perceived Social Support\n\n* This scale has adopted the measure the level of perceived social support from family, friends, or significant other.\n* The mean score of perceived social support from "family" is calculated by summing across Q3, Q4, Q8, and Q11, then divide by 4.\n* The mean score of perceived social support from "friends" is calculated by summing across Q6, Q7, Q9, and Q12, then divide by 4.\n* The mean score of perceived social support from "significant other" is calculated by summing across Q1, Q2, Q5, and Q10, then divide by 4.\n* The mean total score is calculated by summing across all 12 items, then divide by 12.\n* The minimum mean score of each sub-score and the total score is 1 and the maximum mean score is 7.', 'timeFrame': 'Baseline, Month 2, and Month 8'}
- {'measure': 'Change of Baseline Self-esteem at 2 months and 8 months', 'description': 'Administration of the Chinese version of the Rosenberg Self-esteem Scale\n\n* This scale is adopted to measure the level of self-esteem.\n* Q2, Q5, Q6, Q8, Q9 are reversed items.\n* Total self-esteem score is calculated by summing all items.\n* The minimum score is 10 and the maximum score is 40.\n* A higher score represents a higher level of self-esteem.', 'timeFrame': 'Baseline, Month 2, and Month 8'}
- {'measure': 'Change of Baseline Hope level at 2 months and 8 months', 'description': 'Administration of the Chinese version of the Adult State Hope Scale\n\n* This scale is adopted to measure the level of hope.\n* Pathways sub-scale score is calculated by summing across Q1, Q3, and Q5.\n* Agency sub-scale score is calculated by summing across Q2, Q4, and Q6.\n* Total hope score is calculated by summing all items.\n* The minimum score of the sub-scales is 3 and the maximum score of the sub-scales is 24.\n* The minimum score of the total score is 6 and the maximum score of the total score is 48.\n* The higher scores in sub-scales represent higher levels of pathways thinking or higher agency thinking respectively. The higher total score represents higher hope levels.', 'timeFrame': 'Baseline, Month 2, and Month 8'}
- {'measure': 'Change of Baseline Spiritual well-being level at 2 months and 8 months', 'description': 'Administration of the Chinese version of the 3-item spiritual care sub-scale of the Body-Mind-Spirit Holistic Well-being Scale\n\n* This sub-scale is adopted to measure the level of spiritual well-being.\n* The sub-scale score is calculated by summing across all three items.\n* The minimum score of this sub-scale is 3 and the maximum score of this sub-scale is 30.\n* A higher score represents a higher level of spiritual well-being.', 'timeFrame': 'Baseline, Month 2, and Month 8'}
- {'measure': 'Change of Baseline Stroke-specific quality of life at 2 months and 8 months', 'description': 'Administration of the Chinese version of the Stroke-specific Quality of Life Short Form\n\n* This scale is adopted to measure the level of stroke-specific Quality of Life.\n* Physical components of stroke-specific Quality of Life is calculated by summing across Q1, Q2, Q4, Q7, Q10, Q11, and Q12.\n* Psychosocial components of stroke-specific Qualify of life is calculated by summing across Q3, Q5, Q6, Q8, and Q9.\n* The minimum score of physical and psychosocial components is 7 and 5 respectively.\n* The maximum score of physical and psychosocial components is 35 and 25 respectively.\n* A higher score represents a higher level of stroke-specific quality of life.', 'timeFrame': 'Baseline, Month 2, and Month 8'}
- {'measure': 'Change of Baseline general quality of life at 2 months and 8 months', 'description': 'Administration of the Chinese version of the 12-item Short Form Health Survey\n\n* This scale is adopted to measure the level of health-related Quality of life.\n* Q1, Q8, Q9, and Q10 are reversed items.\n* Physical and Mental Health Composite Scale scores are calculated.', 'timeFrame': 'Baseline, Month 2, and Month 8'}
- {'measure': 'Change of Baseline Physical stress level and cortisol rhythm at 2 months and 8 months', 'description': 'Collection of saliva samples for analysis', 'timeFrame': 'Baseline, Month 2, and Month 8'}

Please estimate the sample size based on the assumption: 
statistical power of 80%, significance level of 0.05, attrition rate of 25%
Sample size estimates
        To achieve a statistical power of 80% with a medium effect size (Cohenâs dâ=â0.63) at a significance level of 0.05 in regression modelling (latent growth modelling) under the proposed two-arm, three-time point design, a sample size of 116 is needed according to Monte Carlo simulation. Assuming an attrition rate of 25% based on prior trials of arts-based therapies in stroke survivors [49], a total of 154 participants will be required (i.e. 77 per arm).