Here is the design of a clinical trial:

Official Title: Effect of Topical Anesthesia Combined With Intravenous Induction on Hemodynamics During the Induction Period in Patients Undergo Cardiac Surgery: a Randomized Controlled Study

Included conditions:
- Coronary Artery Disease
- Valvular Heart Disease
- Arrhythmia
- Myocardial Disease

Study Armgroups:
- {'label': 'The combined topical anesthesia induction group', 'type': 'EXPERIMENTAL', 'description': 'The superior glottic mucosa would be anesthetized 3 times with a vaporizer before intravenous anesthesia. After the intravenous induction, a catheter would be inserted to provide the subglottic anesthesia，3-5ml 2% lidocaine would be used for supraglottic anesthesia, and 3ml 1% tetracaine would be used for subglottic anesthesia.', 'interventionNames': ['Procedure: The combined topical anesthesia induction group']}
- {'label': 'The routine induction group', 'type': 'NO_INTERVENTION', 'description': 'The superior glottic mucosa would be anesthetized 3 times with a vaporizer before intravenous anesthesia. After the intravenous induction, a catheter would be inserted to provide the subglottic anesthesia.In the routine induction group，all procedures will be the same as those of the topical anesthesia group, The drug will be replaced with constant volume saline.'}

Interventions:
- {'type': 'PROCEDURE', 'name': 'The combined topical anesthesia induction group', 'description': 'The superior glottic mucosa would be anesthetized 3 times with a vaporizer before intravenous anesthesia. After the intravenous induction, a catheter would be inserted to provide the subglottic anesthesia，3-5ml 2% lidocaine would be used for supraglottic anesthesia, and 3ml 1% tetracaine would be used for subglottic anesthesia.', 'armGroupLabels': ['The combined topical anesthesia induction group']}

Primary Outcomes:
- {'measure': 'The area under the curve of baseline blood pressure', 'description': 'The area under the curve (AUC) of blood pressure below baseline from the beginning of general anesthesia induction to the surgery beginning.', 'timeFrame': 'From the beginning of general anesthesia induction(T1) to the surgery beginning(T2). T1 is when induction drug (midazolam) is administered. T2 is defined as the time of the skin incision. It will take up to 1hour or 2hours.'}

Please estimate the sample size based on the assumption: 
The significance level (alpha) is set at 0.025. The power is 80%. The potential dropout rate is estimated at 20%.
Sample size calculation
        This is a superiority, parallel-group, randomised controlled trial and the ratio of the participants in the two groups is 1:1. A one-sided, two-sample t-test with a sample size of 39 in each group achieves 80% power to detect a ratio of 0.700 when the ratio under the null hypothesis is 1.000. The coefficient of variation in the original scale is 0.6. The significance level (alpha) is set at 0.025. According to references, we identified a coefficient of variation of 60% for the AUC MAP of topical airway anaesthesia as clinically significant.14 We defined a clinically relevant effect as a between-group difference in the AUC (reduction from baseline MAP over 30 min after induction) of â¥33.3%. For this effect size, we estimated that 39 patients per study arm would be needed to demonstrate superiority (a<0.025, one-sided) with 80% power. It is estimated that the potential dropout due to various reasons is 20%, and 48 patients in each group would be calculated, resulting in a total of 96 patients.15