Here is the design of a clinical trial:

Official Title: Behavioral Economic and Wellness-based Approaches for Reducing Alcohol Use and Consequences Among Diverse Non-student Emerging Adults

Included conditions:
- Alcohol Abuse

Study Armgroups:
- {'label': 'Brief Alcohol Intervention (BAI) + Substance Free Activity Session (SFAS)', 'type': 'EXPERIMENTAL', 'description': "Participants first receive a 50-minute standard brief motivational intervention designed to reduce alcohol use. A week later, they will receive the Substance-free activity session (SFAS), a 50-minute counseling session designed to increase the salience of the individual's goals, to highlight the connection between their current patterns of behavior (including drinking and substance-free activities) and the attainment of these goals, and to increase future orientation and engagement in enjoyable and goal-directed activities that are inconsistent with substance use (even if the participant has no desire to change their use).", 'interventionNames': ['Behavioral: Brief Alcohol Intervention (BAI)', 'Behavioral: Substance-free Activity Session (SFAS)']}
- {'label': 'Relaxation Training (RT) + Substance Free Activity Session (SFAS)', 'type': 'EXPERIMENTAL', 'description': "Participants will complete a relaxation training session that will include a clinician leading them through a diaphragmatic breathing exercise, a progressive muscle relaxation protocol, and then a brief breath-counting (mindfulness) exercise. A week later, the participant will receive the SFAS, a 50-minute counseling session designed to increase the salience of the individual's goals, to highlight the connection between their current patterns of behavior (including drinking and substance-free activities) and the attainment of these goals, and to increase future orientation and engagement in enjoyable and goal-directed activities that are inconsistent with substance use (even if the participant has no desire to change their use).", 'interventionNames': ['Behavioral: Substance-free Activity Session (SFAS)', 'Behavioral: Relaxation Training (RT)']}
- {'label': 'Education Control', 'type': 'ACTIVE_COMPARATOR', 'description': 'This minimal contact control condition will include a brief (2-3 minute) discussion where the research assistant (RA) who completed the assessment session will describe the educational handout. This condition is meant to approximate a public health-level approach to providing referral information and some of the content included in the BAI+SFAS condition but without any of the personalized information or motivational interviewing. Participants will receive information on risks associated with alcohol/drug misuse, strategies for reducing alcohol problems, managing stress, and goal-setting. The handout will also include links to hotlines, websites, and apps related to these domains. This condition will not include booster contact', 'interventionNames': ['Other: Education Control']}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Brief Alcohol Intervention (BAI)', 'description': "This session includes a discussion related to harm reduction and the participant's autonomy to make decisions about the information provided in the session; an alcohol use decisional balance exercise; personalized alcohol-related feedback, and goal-setting. Elements included in the feedback are: (a) comparison of the participant's perception of how much he or she drinks and actual norms, (b) a comparison of the participant's alcohol consumption vs. norms, (c) an estimate of the participant's peak blood alcohol content in the past month, (d) alcohol-related problems experienced, (e) money spent on alcohol, and (f) calories consumed from alcohol. Participants discuss the personalized feedback with the clinician and review protective behavioral strategies if he or she indicates interest.", 'armGroupLabels': ['Brief Alcohol Intervention (BAI) + Substance Free Activity Session (SFAS)']}
- {'type': 'BEHAVIORAL', 'name': 'Substance-free Activity Session (SFAS)', 'description': "The SFAS session includes : a) discussion of life goals, b) discussion of associations between alcohol and drug use, goals, and substance-free activities; c) a graph depicting the participant's ratings of the relative importance of various aspects of their life and how their actions in the past week have been consistent with these priorities; d) personalized feedback on recent time allocation to activities across life domains, and a discussion of any changes the participant would like to make; e) feedback on symptoms of stress, anxiety and discussion of adaptive coping strategies; f) discussion of enjoyable substance-free activities and hobbies and substance-free recreational activity suggestions tailored to individual's interests and neighborhood; g) a goal setting exercise for specific behavior change plans; h) a Future Thinking Writing Exercise. Participants will receive weekly text-message based booster prompts for four weeks after their SFAS session.", 'armGroupLabels': ['Brief Alcohol Intervention (BAI) + Substance Free Activity Session (SFAS)', 'Relaxation Training (RT) + Substance Free Activity Session (SFAS)']}
- {'type': 'BEHAVIORAL', 'name': 'Relaxation Training (RT)', 'description': 'The clinician will begin by establishing the credibility of the session by providing the participant with the rationale that developing relaxation or mindfulness training strategies can reduce stress and enhance wellness. The clinician will then lead the participant through a diaphragmatic breathing exercise, followed by a progressive muscle RT protocol, and then a brief breath-counting (mindfulness) exercise. The session will conclude with a brief discussion of additional stress and anxiety management strategies (e.g., apps to monitor heartrate and breathing). Participants will be asked about their reaction to the techniques and, if interested, encouraged to commit to a specific plan for practicing these techniques.', 'armGroupLabels': ['Relaxation Training (RT) + Substance Free Activity Session (SFAS)']}
- {'type': 'OTHER', 'name': 'Education Control', 'description': 'This condition will not include any clinical contact other than a brief (2-3 minute) discussion with the research assistant (RA) who completed the assessment session and who will describe the educational handout. This condition is meant to approximate a low-threshold public health-level approach to providing referral information and some of the content included in the BAI+SFAS condition but without any of the personalized information or MI/clinical contact. Thus, participants will receive information on risks associated with alcohol and drug misuse, strategies for reducing use/problems, and strategies for managing stress and setting and follow-through with achievable goals. The handout will also include links to hotlines, websites, and apps related to these domains. This condition will not include booster contact.', 'armGroupLabels': ['Education Control']}

Primary Outcomes:
- {'measure': 'Change from Baseline Alcohol Consumption and Drug Use at 1-month', 'description': 'At each assessment point, participants will complete a computer administered Daily Drinking Questionnaire (DDQ) concerning their daily drinking during a typical week in the past month, an interval found sufficiently long to characterize drinking patterns.', 'timeFrame': 'Enrollment, 1-month post intervention'}
- {'measure': 'Change from Baseline Alcohol Consumption and Drug Use at 3-months', 'description': 'At each assessment point, participants will complete a computer administered Daily Drinking Questionnaire (DDQ) concerning their daily drinking during a typical week in the past month, an interval found sufficiently long to characterize drinking patterns.', 'timeFrame': 'Enrollment, 3-months post intervention'}
- {'measure': 'Change from Baseline Alcohol Consumption and Drug Use at 6-months', 'description': 'At each assessment point, participants will complete a computer administered Daily Drinking Questionnaire (DDQ) concerning their daily drinking during a typical week in the past month, an interval found sufficiently long to characterize drinking patterns.', 'timeFrame': 'Enrollment, 6-months post-intervention'}
- {'measure': 'Change from Baseline Alcohol Consumption and Drug Use at 12-months', 'description': 'At each assessment point, participants will complete a computer administered Daily Drinking Questionnaire (DDQ) concerning their daily drinking during a typical week in the past month, an interval found sufficiently long to characterize drinking patterns.', 'timeFrame': 'Enrollment, 12-months post intervention'}
- {'measure': 'Change from Baseline Alcohol-related Consequences at 1-month', 'description': 'The Brief Young Adult Alcohol Consequences Questionnaire (BYAACQ) questionnaire asks about negative events over the past month (e.g., neglected obligations, driving after drinking). Research has shown that the BYAACQ is reliable yet sensitive to changes in alcohol use, has high internal consistency, and includes common but less severe consequences.', 'timeFrame': 'Enrollment, 1-month'}
- {'measure': 'Change from Baseline Alcohol-related Consequences at 3-months', 'description': 'The Brief Young Adult Alcohol Consequences Questionnaire (BYAACQ) questionnaire asks about negative events over the past month (e.g., neglected obligations, driving after drinking). Research has shown that the BYAACQ is reliable yet sensitive to changes in alcohol use, has high internal consistency, and includes common but less severe consequences.', 'timeFrame': 'Enrollment, 3-months'}
- {'measure': 'Change from Baseline Alcohol-related Consequences at 6-months', 'description': 'The Brief Young Adult Alcohol Consequences Questionnaire (BYAACQ) questionnaire asks about negative events over the past month (e.g., neglected obligations, driving after drinking). Research has shown that the BYAACQ is reliable yet sensitive to changes in alcohol use, has high internal consistency, and includes common but less severe consequences.', 'timeFrame': 'Enrollment, 6-months'}
- {'measure': 'Change from Baseline Alcohol-related Consequences at 12-months', 'description': 'The Brief Young Adult Alcohol Consequences Questionnaire (BYAACQ) questionnaire asks about negative events over the past month (e.g., neglected obligations, driving after drinking). Research has shown that the BYAACQ is reliable yet sensitive to changes in alcohol use, has high internal consistency, and includes common but less severe consequences.', 'timeFrame': 'Enrollment, 12-months'}

Please estimate the sample size based on the assumption: 
The significance level is set at alpha=0.05. Power estimates for various effects are: treatment effect of BAI+SFAS vs. control=1.00/1.00; mediation via proportionate substance-free reinforcement=0.90/0.99; mediation via negative affect=0.85/0.93; mediation via alcohol demand=1.00/1.00. The dropout/missing data rates are assumed to be similar to the previous trial: 69% complete cases, 18% missing one data point, 7% missing two data points, 4% missing three data points, and 2% missing four data points.
Sample size and power
      We have focused our power analysis using Monte Carlo simulations [64] with population estimates and patterns of missingness from our previous trial [24]. These models from our previous trial used generalized mixed models which covaried gender and race/ethnicity, taking into account clustering by individual and therapist. Based on the Monte Carlo estimates comparing BAIâ+âSFAS to control (within dâ=â0.83/0.71, between dâ=â0.33/0.32), we are proposing to recruit 525 subjects (175 per group) for the study. Assuming a similar pattern of attrition as our previous trial will result in nâ=â362 (69%) complete cases, nâ=â95 (18%) cases missing one data point; nâ=â37 (7%) cases missing two data points; nâ=â21 (4%) cases missing three data points; and nâ=â11 (2%) cases missing four data points. We calculated power via Monte Carlo simulations by determining the proportion of 1000 replications for which the null hypothesis that a parameter was equal to zero was rejected for each parameter at alphaâ=â0.05 (i.e., probability of rejecting the null hypothesis when it is false). This resulted in the following power estimates for typical drinks/problems: treatment effect of BAIâ+âSFAS vs. controlâ=â1.00/1.00; mediation via proportionate substance-free reinforcementâ=â0.90/0.99; mediation via negative affectâ=â0.85/0.93; mediation via alcohol demand: 1.00/1.00. While our proposed sample size would not be sufficient to detect very small effects, we believe such small effects are likely to have little clinical meaning in terms of the variables we are assessing in the present trial, and the necessary sample size to detect such effects would be very large (>â1000).