Here is the design of a clinical trial:

Official Title: The Efficacy and Neural Mechanism of Acupuncture Treatment in Older Adults With Subjective Cognitive Decline: a Randomized Controlled Trial

Included conditions:
- Subjective Cognitive Decline
- Subjective Cognitive Complaint

Study Armgroups:
- {'label': 'Acupuncture group', 'type': 'EXPERIMENTAL', 'interventionNames': ['Device: Acupuncture group']}
- {'label': 'Sham acupuncture group', 'type': 'PLACEBO_COMPARATOR', 'interventionNames': ['Device: Sham acupuncture group']}

Interventions:
- {'type': 'DEVICE', 'name': 'Acupuncture group', 'description': 'Acupuncture needles were placed at acupoints Baihui (DU20), Shenting (DU24), Fengfu (DU16), Fengchi (GB20), Danzhong (RN17), Zhongwan (RN12), Qihai (RN6), Neiguan (PC6), Zusanli (ST36), Xuehai (SP10), Xinshu (BL15), Yixi (BL45), Tongli (HT5), and Zhaohai(KI6). Electrodes were attached the needle holders of the Baihui (DU20) and Shenting (DU24). The acupuncture needles are inserted through the adhesive pads and are retained for 20 minutes in every course. Treatment will be conducted over a period of 3 months, at a frequency of two times per week.', 'armGroupLabels': ['Acupuncture group']}
- {'type': 'DEVICE', 'name': 'Sham acupuncture group', 'description': 'Sham acupoint (SA) 1 located in the midpoint of Shuaigu and Touwei. SA2 located in the midpoint of Touwei and Yangbai. SA3 located in the midpoint of Tianyou and Tianrong. SA4 located in 4 cun above umbilicus and 1 cun right of umbilical midline (UM). SA5 located in 2 cun below umbilicus and 1 cun right of UM. SA6 1 cun outside the point 1/4 of the line between Shenmen and Shaohai. SA7 located in 1 cun outside the midpoint of Shaohai and Tongli. SA8 located in 6 cun above mediosuperior border of the patella. SA9 located in 3 cun below the Yanglingquan and middle of the gallbladder and bladder channels. SA10 located in midpoint between Jiexi and Qiuxu. SA11 and SA12 located in 2 cun from the lower border of spinous process of fifth or sixth thoracic vertebra. Electrodes were attached the needle holders of the bilateral SA 2. Procedures, and other treatment settings were the same in the acupuncture group but with no skin penetration, electricity output, or needle manipulation for de qi.', 'armGroupLabels': ['Sham acupuncture group']}

Primary Outcomes:
- {'measure': 'Change in cognitive function', 'description': 'A composite score will be computed by averaging z-scores from Animal Fluency Test, Digit Symbol Substitution Test, Trail-Making Test Parts A and B, Stroop Color Word Test C, Digit Span Test, Boston Naming Test, Clock Drawing Test and Auditory Verbal Learning Test delayed recall and delayed recognition.', 'timeFrame': 'Changes from baseline at 12 weeks'}

Please estimate the sample size based on the assumption: 
80% power, significance level (alpha) of 0.05 for single voxel level, stricter alpha of 0.000002, type I error of alpha=0.005, estimated dropout rate and loss of data due to head motion.
Sample size and blinding
        Task fMRI studies characteristically include small sample size41 and thus have a low statistical power. The statistically underpowered study by definition means that a study will have less of a chance for detecting significant effects.42 Therefore, power-based sample size will be calculated prior to fMRI data collection.43 Fortunately, approaches for sample size calculations in studies using fMRI have been developed.
        By using the non-central random field theory, Hayasaka et al estimated that at least 12 subjects would be required to detect signals in either of the auditory cortices with at least 80% power.44 They also found that approximately 13 subjects would be required to detect signals in the auditory cortices with 80% power, when generated a sample size map based on the mock pilot analysis.44 Adopting a simulation-based method to calculate statistical power for group-level fMRI studies, Desmond and Glover found a minimum of 12 subjects are required to achieve 80% power at Î±=0.05 at the single voxel level.45 For a more realistic threshold, twice as many subjects are recommended to maintain this level of power after correcting for multiple comparisons. For a stricter alpha of 0.000002, approximately 25 subjects are needed. Mumford and Nichols recommended 20 subjects and a type I error of Î±=0.005 should probably be used, and this power calculation is based on a non-central T or F distribution.46 We used the largest sample size of 25 for each group with an estimated dropout rate and loss of data due to head motion, then we planned to enrol 60 participants in the two groups.
        Eligible patients will be randomly assigned into either the acupuncture or sham acupuncture group after signing written informed consent forms via a randomisation digital table with a 1:1 ratio. Blocked randomisation with a block size of 6 will be employed to ensure balance within the two groups. The randomisation sequence will be generated by a third-party professional statistician using computer-generated randomisation digital table by using SAS V.9.2 (SAS Institute). The randomisation list will be stored by a non-involved investigator and out of reach and sight of the involved investigators. The allocation schedule will be using a telephone randomisation procedure. The randomisation list was restricted to this research coordinator and was concealed from other study personnel. The patients, outcome assessors and statisticians will be blinded to treatment allocation. Patients are told that they will receive one of two effective interventions randomised after enrolment. During the acupuncture treatment, the adhesive pads are pasted on the acupoints or sham acupoints after skin disinfection. The true or sham needles with a blunt tip will be placed in the adhesive pads. Patients in different groups will be assigned into separate cubicles to refrain from communication.