Here is the design of a clinical trial:

Official Title: Two-Armed Double-Blinded Registry-Based Randomized Control Trial Comparing Anterior Gastropexy to No Anterior Gastropexy for Paraesophageal Hernia Repair

Included conditions:
- Paraesophageal Hernia
- Hiatal Hernia Large

Study Armgroups:
- {'label': 'Intervention 1 (Control)', 'type': 'NO_INTERVENTION', 'description': 'No anterior gastropexy will be performed.'}
- {'label': 'Intervention 2 (Treatment)', 'type': 'EXPERIMENTAL', 'description': 'Anterior gastropexy will be performed.', 'interventionNames': ['Procedure: Anterior Gastropexy']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'Anterior Gastropexy', 'description': 'Two permanent sutures will be introduced into the abdomen and placed along the lesser curvature of the stomach. A suture passer will be used to grasp the ends of the sutures to externalize them at separate fascial punctures. At time of abdominal desufflation, the sutures will be tied and the incision closed per individual surgeon practice.', 'armGroupLabels': ['Intervention 2 (Treatment)']}

Primary Outcomes:
- {'measure': 'Paraesophageal Hernia Recurrence', 'description': 'Either radiographic evidence of hernia recurrence on an upper GI study or need for reoperation secondary to paraesophageal hernia recurrence', 'timeFrame': '1 year'}

Please estimate the sample size based on the assumption: 
20% rate of loss to follow-up, 80% power, two-sided chi-square test, alpha level of 5%, proportion of recurrences in the control group estimated to be 0.24.
Sample size {14}
        Assuming a 20% rate of loss to follow-up, enrollment of 240 participants with 120 participants in each arm will provide at least 80% power for showing superiority of anterior gastropexy to no anterior gastropexy for the primary endpoint of decreased recurrence rates by 15% at the 1-year postoperative visit using a two-sided chi-square test and an alpha level of 5%. For the purpose of calculating the power of this study, the proportion of recurrences in the control group (no anterior gastropexy) is estimated to be 0.24. This is based on the reported recurrence rates for paraesophageal hernia repair without gastropexy, ranging from 7 to 66% [3, 16, 21â24], with the majority falling between 13 and 42% [3, 16, 23, 24] at various time points after surgery.