Here is the design of a clinical trial:

Official Title: The Effect of Elastic Bandage Compression on Pain and Function in Individuals With Knee Osteoarthritis - a Randomized Controlled Trial

Included conditions:
- Knee Osteoarthritis

Study Armgroups:
- {'label': 'Compression Group', 'type': 'EXPERIMENTAL', 'description': "The volunteer must remain supine on a stretcher, with both legs extended and relaxed. The intervention will be performed with elastic bandages (Selecta® of 13cm x 160 cm, composed of 45% cotton, 20% elastodiene and 27% polyamide) involving the entire knee surface, positioned considering anatomical aspects: covering the femoral condyles and the anterior tibial tuberosity). The bandage will involve the knee from the distal to the proximal, respecting the blood flow of the venous return. The level of compression was defined according to recommendations in the literature on compression interventions in lymphedema and venous changes, and should be kept between 30 mmHg and 60 mmHg. Variations on stipulated values may be interfered according to the volunteer's self-report, which should indicate a level of moderate, comfortable and pain-free compression. The intervention will be carried out for 20 minutes, once a day, for 4 consecutive days.", 'interventionNames': ['Other: Elastic bandage compression']}
- {'label': 'Sham Group', 'type': 'SHAM_COMPARATOR', 'description': 'For Sham application, the volunteer must remain supine on a stretcher, with both lower limbs extended and relaxed. Elastic bandages will be used (Selecta® of 13cm x 160 cm, composed of 45% cotton, 20% elastodiene and 27% polyamide) involving the entire knee surface, positioned considering anatomical aspects: covering the femoral condyles and the anterior tibial tuberosity) . The bandage will involve the knee from the distal (tibial tuberosity) to the proximal (femoral condyles), respecting the blood flow of the venous return. However, in this group, no compression force will be performed, maintaining the pressure at 00 mmHg according to a previous reliability study. The procedure will be carried out for 20 minutes, once a day, for 4 consecutive days.', 'interventionNames': ['Other: Elastic bandage compression']}
- {'label': 'Control Group', 'type': 'NO_INTERVENTION', 'description': "The Control group will be composed of individuals with knee osteoarthritis, who make up the study's waiting list and will carry out evaluations at the same time intervals as the other groups, but will not receive any type of intervention and will be instructed not to start another treatment during their participation."}

Interventions:
- {'type': 'OTHER', 'name': 'Elastic bandage compression', 'description': "The compression will be applied with the volunteer in the supine position on a stretcher, with both lower limbs extended and relaxed. The intervention in the Compression group will be with elastic bandages involving the entire surface of the knee, positioned considering anatomical aspects: femoral condyles and the anterior tibial tuberosity. The level of compression must be maintained between 30 mmHg and 60 mmHg, according to the researched literature. The variations within these values will be stipulated according to the volunteer's self-report (comfortable and painless compression). The Shan Group will have the bandage wrapped around the knee without any compression force being exerted. The intervention will be carried out for 20 minutes, once a day, for 4 consecutive days. The Control group will be composed of volunteers who make up a study waiting list and will carry out the evaluations at the same time intervals as the other groups, but will not receive any type of intervention.", 'armGroupLabels': ['Compression Group', 'Sham Group']}

Primary Outcomes:
- {'measure': 'Change from baseline - Visual Analog Scale (VAS)', 'description': 'The scale will be made available visually to the individual so that he can classify the intensity of the average pain relative to the last week, and also before and after the performance of each functional physical test. The scale will vary from 0 to 10 cm, with 0 being the complete absence of pain, and 10 being the maximum pain intensity reported by the individual. The 1.75cm reduction will be considered an MDCI.', 'timeFrame': 'Baseline, immediately after intervention and follow-up evaluations of 12 and 24 weeks.'}
- {'measure': 'Change from baseline WOMAC (Western Ontario e o McMaster Universities Osteoarthritis Index) - Pain scale', 'description': 'Self-report questionnaire, designed to assess problems experienced by individuals with lower limb OA, in the last 72 hours. The volunteer will be asked to answer 24 questions, which comprise three domains: pain, stiffness and physical function. The scores for the items are expressed using the Likert scale, classified as: none = 0, low = 25, moderate = 50, severe = 75 and very severe = 100. Higher scores indicate higher levels of pain, stiffness and physical dysfunction . The reduction of 8.74 points in the pain domain, from the baseline, will be considered an MDCI.', 'timeFrame': 'Baseline, immediately after intervention and follow-up evaluations of 12 and 24 weeks.'}

Please estimate the sample size based on the assumption: 
The significance level was set at 5%, the power was 95%, and a possible dropout rate of 20% was considered.
Sample size
        The sample size was preliminarily calculated using the G*Power software (V.3.1.3; University of Trier, Germany).54 Two calculations were performed: pain (assessed using the VAS) and function (assessed using the WOMAC questionnaire). The calculation was based on the application of an F-test for the difference between the three independent means (three groups). The effect size considered for this calculation, based on a previous study,17 were d=0.45 for EVA and d=0.39 for WOMAC, which after conversion represented f=0.225 and f=0.195, respectively.55 The f effect sizes were between small and moderate and coincided with the range of classification for the values of d presented. The significance level was set at 5%, and the power was 95%. The calculations indicated a total of 54 participants using the VAS and 72 participants using the WOMAC questionnaire. The calculation to be considered will be based on the WOMAC questionnaire, with 24 individuals per group, making a total of 72 individuals. Considering a possible dropout rate of 20%,17 29 participants should be allocated to each group; however, to facilitate calculations and randomisation, 30 participants will be allocated to each group (n=90).