Here is the design of a clinical trial:

Official Title: Supporting Parenting at Home: Empowering Rehabilitation Through Engagement (SPHERE)

Included conditions:
- Neurodevelopmental Disorders

Study Armgroups:
- {'label': 'Telemedicine Video Feedback Arm', 'type': 'EXPERIMENTAL', 'description': "Mother-child dyads will take part into a 6 video-conference sessions of Video Feedback (vVF). The vVF will be standardized according to previously published RCTs. Specifically, the 6 vVFI sessions will be organized in two subsequent phases: 4 sessions based on sharing the focus on different relational themes, and 2 sessions of interactive integration. In more specific terms, during the first set of 4 sessions the psychologist will review with mothers' segments of the videotapes obtained during the baseline assessment and will focus on four different relational themes: responsiveness, physical stimulation, teaching, and parenting experience. During the interactive integration session, the insights developed from the first 4 videoconferences will be applied to the real-time interaction between the parent and his/her infant under the guidance of the psychologist.", 'interventionNames': ['Other: Telemedicine Video Feedback Intervention']}
- {'label': 'Psychoeducational booklet arm', 'type': 'ACTIVE_COMPARATOR', 'description': 'Mothers assigned to condition B will receive an informative booklet addressing the same themes discussed in the experimental intervention (i.e., responsiveness, physical stimulation, teaching, and parenting experience), but not tailored on their own infant or specific parenting challenges.', 'interventionNames': ['Other: Psychoeducational Booklet Intervention']}

Interventions:
- {'type': 'OTHER', 'name': 'Telemedicine Video Feedback Intervention', 'description': "Mother-child dyads will take part into a 6 video-conference sessions of Video Feedback (vVF). The vVF will be standardized according to previously published RCTs. Specifically, the 6 vVFI sessions will be organized in two subsequent phases: 4 sessions based on sharing the focus on different relational themes, and 2 sessions of interactive integration. In more specific terms, during the first set of 4 sessions the psychologist will review with mothers' segments of the videotapes obtained during the baseline assessment and will focus on four different relational themes: responsiveness, physical stimulation, teaching, and parenting experience. During the interactive integration session, the insights developed from the first 4 videoconferences will be applied to the real-time interaction between the parent and his/her infant under the guidance of the psychologist.", 'armGroupLabels': ['Telemedicine Video Feedback Arm']}
- {'type': 'OTHER', 'name': 'Psychoeducational Booklet Intervention', 'description': 'Mothers of this condition will receive an informative booklet addressing the same themes included in the experimental intervention (responsiveness, physical stimulation, teaching, and parenting experience), but not tailored on their own infant status.', 'armGroupLabels': ['Psychoeducational booklet arm']}

Primary Outcomes:
- {'measure': 'Maternal sensitivity', 'description': 'The maternal sensitivity will be coded through the Global Rating Scales (Murray, Fiori-Cowley, Hooper, \\& Cooper, 1996). The score will range from 1 (low) to 5 (high).', 'timeFrame': 'Immediate post-intervention (6 weeks after the intervention started)'}

Please estimate the sample size based on the assumption: 
alpha=0.05, beta=0.05, power=0.95, attrition rate of 20% for each phase
Statistical power and sample size estimation
        The sample size was estimated for what pertains the first specific aim, that is, the effect of an early VFI intervention on maternal sensitivity. A minimum sample size of 59 subjects per group (alpha=0.05, beta=0.05, power=0.95, effect size, d=0.67) was estimated using G*Power software on the basis of meta-analytical evidence of online interventions focused on parenting.37 Moreover, due to the longitudinal nature of the study, attrition rate of 20% for each phase was considered, therefore a starting sample size of 84 infants for each group (total sample size=168) has been estimated.