Here is the design of a clinical trial:

Official Title: Flow Controlled Ventilation in ARDS Associated With COVID-19

Included conditions:
- ARDS Associated With COVID-19

Study Armgroups:
- {'label': 'Group A', 'type': 'EXPERIMENTAL', 'description': 'This is the treatment group. Patients will be ventilated using the new device (Evone) applying flow controlled ventilation for 48 hours. Ventilation parameters will be assessed every 6-8 hours. All other treatment will be unchanged and according to institutional standards.', 'interventionNames': ['Device: Flow controlled ventilation (Evone-ventilator)']}
- {'label': 'Group B', 'type': 'NO_INTERVENTION', 'description': 'These patients will be treated according to institutional standards. Only data will be collected. This is the control group.'}

Interventions:
- {'type': 'DEVICE', 'name': 'Flow controlled ventilation (Evone-ventilator)', 'description': 'The new ventilation technique will be applied', 'armGroupLabels': ['Group A']}

Primary Outcomes:
- {'measure': 'arterial oxygen partial pressure (PaO2)', 'timeFrame': 'during 48 hours of treatment'}

Please estimate the sample size based on the assumption: 
intended power of 80%, an alpha error of 5%, and an equal sample ratio
Numbers to be randomised (sample size)
          The sample size calculation based on the assumption of an effect size (change in PaO2) of 1.5 SDS in the primary endpoint (PaO2), an intended power of 80%, an alpha error of 5% and an equal sample ratio results in n=7 patients needed to treat. However, to compensate for dropouts we will include 10 patients in each group, which means in total 20 patients.