Here is the design of a clinical trial:

Official Title: Child Health, Agriculture and Integrated Nutrition (CHAIN): a Randomized Trial to Close the Nutrient Gap in Rural Zimbabwe

Included conditions:
- Stunting

Study Armgroups:
- {'label': 'IYCF-Only', 'type': 'ACTIVE_COMPARATOR', 'description': 'Infants in the IYCF-only arm will receive white maize and SQ-LNS daily from 6 months of age, and the primary caregiver will receive a series of behaviour-change modules delivered by village health workers.', 'interventionNames': ['Dietary Supplement: Small-quantity lipid-based nutrient supplement', 'Dietary Supplement: White maize meal']}
- {'label': 'IYCF-Plus', 'type': 'EXPERIMENTAL', 'description': 'Infants in the IYCF-plus arm will receive orange provitamin A-fortified maize and SQ-LNS daily from 6 months of age, plus powdered NUA-45 sugar beans, moringa leaf powder, and powdered whole egg; and the primary caregiver will receive a series of behaviour-change modules delivered by village health workers.', 'interventionNames': ['Dietary Supplement: Small-quantity lipid-based nutrient supplement', 'Dietary Supplement: Provitamin A biofortified maize', 'Dietary Supplement: NUA-45 biofortified sugar beans', 'Dietary Supplement: Moringa oleifera', 'Dietary Supplement: Whole egg powder']}

Interventions:
- {'type': 'DIETARY_SUPPLEMENT', 'name': 'Small-quantity lipid-based nutrient supplement', 'description': 'Small Quantity Lipid-based Nutrient Supplement (SQ-LNS) is a food supplement rich in both macro and micronutrients (calories, proteins, fat and multivitamin mix). SQ-LNS is not considered a regulated drug product in Zimbabwe, or by the United States Food and Drug Administration (FDA). It is commercially available for prevention of chronic malnutrition, produced by Nutriset (https://www.nutriset.fr/products/en/enov-nutributter2). Each child will receive a daily sachet of 20g SQ-LNS between 6-12 months of age, consumed directly from the sachet or mixed with porridge.', 'armGroupLabels': ['IYCF-Only', 'IYCF-Plus']}
- {'type': 'DIETARY_SUPPLEMENT', 'name': 'Provitamin A biofortified maize', 'description': 'Provitamin A Maize Meal is orange maize-meal processed from provitamin A-rich orange maize. PVA maize meal will be sourced from International Maize and Wheat Improvement Centre (CIMMYT). Children in the intervention arm will consume 13g - 128g of pro-vitamin A (PVA) maize meal, with added powders. Each family will receive a monthly ration of 5kg PVA maize and this ration takes into consideration of household sharing. Families with children in the IYCF arm will receive white maize meal.', 'armGroupLabels': ['IYCF-Plus'], 'otherNames': ['Orange maize']}
- {'type': 'DIETARY_SUPPLEMENT', 'name': 'NUA-45 biofortified sugar beans', 'description': 'NUA 45 bean powder is ground from roasted iron and zinc-rich biofortified sugar beans. NUA 45 bean powder will be sourced from Sky Brands Ltd Company. Children will consume a daily dose of 5g - 15g of NUA 45 bean powder added to complementary foods.', 'armGroupLabels': ['IYCF-Plus']}
- {'type': 'DIETARY_SUPPLEMENT', 'name': 'Moringa oleifera', 'description': 'Moringa oleifera is an edible plant abundant in dry tropic regions including Zimbabwe. It is known to be rich in micronutrients and has been widely used in Zimbabwe and around the world both as a food and a herb. Moringa oleifera leaf powder, is a dried and ground powder produced from Moringa oleifera leaves using traditional methods. It has been widely used to fortify complementary foods in the African region with the aim of improving micronutrient status. Moringa oleifera leaf powder will be sourced from Lemex Products Company. Children will receive a daily dose of 5g - 15g of Moringa leaf powder added to complementary foods.', 'armGroupLabels': ['IYCF-Plus'], 'otherNames': ['Moringa leaf powder']}
- {'type': 'DIETARY_SUPPLEMENT', 'name': 'Whole egg powder', 'description': 'Egg Powder is hydrolysed non-genetically modified organism (GMO), fine and unflavoured whole egg powder. It is processed with no additives, preservatives, lecithin, added sugar, soy or monosodium glutamate. Egg powder will be sourced from France (A \\& D Food Ingredients - distributor in South Africa). Children in the IYCF-plus arm will receive a daily dose of 14g egg powder. A 15% extra amount of egg powder will be provided to families taking into consideration of household sharing. Egg powder will be provided in sealed plastic jars similar to that of peanut butter and households will receive promotion messages to store the powder in a cool, dry place and avoiding contact with water or moisture during use.', 'armGroupLabels': ['IYCF-Plus']}
- {'type': 'DIETARY_SUPPLEMENT', 'name': 'White maize meal', 'description': 'Commercial white maize meal will be provided monthly. Infants age 6-8 months will receive 45g (3 tablespoons) daily; infants aged 9-12 months will receive 71g (4.5 tablespoons) daily.', 'armGroupLabels': ['IYCF-Only']}

Primary Outcomes:
- {'measure': 'Energy intake', 'description': 'Percentage of infants meeting daily energy requirements, measured by multi-pass 24-hour dietary recall,', 'timeFrame': '9 months of age (window 9-11 months)'}

Please estimate the sample size based on the assumption: 
86% power at 5% significance level, with a 10% lost to follow-up rate; 80% power if lost to follow-up is 15%.
Sample size
      The sample size of 192 infants assumes 10% lost to follow-up due to withdrawal and infant deaths, meaning there will be an estimated 86 evaluable infants per group at endline. This sample size provides 86% power at 5% significance to detect a 20% increase in the proportion of infants achieving their recommended energy intake (by 24-hour dietary recall) in the IYCF-plus arm, assuming that only 65% of infants are meeting requirements in the IYCF (standard-of-care) arm based on SHINE data. If lost to follow-up is as high as 15%, we will still have 80% power to detect a 20% increase in the proportion reaching their daily energy intake (study primary outcome).