Here is the design of a clinical trial:

Official Title: the Effect of Opioid-free General Anesthesia on the Recovery Quality After Gynecological Laparoscopy

Included conditions:
- Gynecologic Disease

Study Armgroups:
- {'label': 'opioid-free anesthesia', 'type': 'EXPERIMENTAL', 'description': 'The study group receives the dexmedetomidine and lidocaine infusion with general anesthesia for gynecological laparoscopy.', 'interventionNames': ['Drug: Dexmedetomidine Hydrochloride', 'Drug: Lidocaine Hydrochloride']}
- {'label': 'opioid anesthesia', 'type': 'ACTIVE_COMPARATOR', 'description': 'The control group receives the remifentanil infusion with general anesthesia for gynecological laparoscopy.', 'interventionNames': ['Drug: Remifentanil Hydrochloride']}

Interventions:
- {'type': 'DRUG', 'name': 'Dexmedetomidine Hydrochloride', 'description': 'dexmedetomidine iv bolus followed by the infusion of 0.1-1 ug/kg/hr during general anesthesia', 'armGroupLabels': ['opioid-free anesthesia'], 'otherNames': ['precedex']}
- {'type': 'DRUG', 'name': 'Lidocaine Hydrochloride', 'description': 'lidocaine iv bolus followed by the infusion of 1.5 mg/kg/hr during general anesthesia', 'armGroupLabels': ['opioid-free anesthesia'], 'otherNames': ['lidocaine']}
- {'type': 'DRUG', 'name': 'Remifentanil Hydrochloride', 'description': 'remifentanil iv infusion of 0.5-5 ng/ml (effect site concentration using TCI) during general anesthesia', 'armGroupLabels': ['opioid anesthesia'], 'otherNames': ['remifentanil']}

Primary Outcomes:
- {'measure': 'the quality of recovery', 'description': 'The quality of recovery is assessed using questionnaire. This questionnaire includes 40 items. The score range is from 40 to 200. The higher score means the better quality of recovery after surgery.', 'timeFrame': 'at 24 hour after the completion of surgery'}

Please estimate the sample size based on the assumption: 
power of 80%, type 1 error of 0.05, 15% loss to follow-up
Sample size
        The primary outcome is the QoR-40 score on POD 1. Based on a previous study that reported a 13-point difference in QoR-40 scores between different anesthetic techniques [13], a sample size of 34 was calculated to be as necessary to achieve a power of 80% with a type 1 error of 0.05. An additional 15% of participants are added to account for possible loss to follow-up. Thus, the final sample size will be 78 participants (39 in each group).