Here is the design of a clinical trial:

Official Title: Effects of Photobiomodulation Therapy in Strength Training and Detraining in Humans

Included conditions:
- Muscle Strength

Study Armgroups:
- {'label': 'PBMT + training/ PBMT + detraining', 'type': 'EXPERIMENTAL', 'description': 'PBMT applied before the strength training sessions (12 weeks, 2 times a week) and PBMT applied during the detraining period (4 weeks, 2 times a week).', 'interventionNames': ['Device: PBMT']}
- {'label': 'PBMT + training/ placebo + detraining', 'type': 'EXPERIMENTAL', 'description': 'PBMT applied before the strength training sessions (12 weeks, 2 times a week) and placebo applied during the detraining period (4 weeks, 2 times a week).', 'interventionNames': ['Device: PBMT', 'Device: Placebo']}
- {'label': 'Placebo + training/ PBMT + detraining', 'type': 'EXPERIMENTAL', 'description': 'Placebo applied before the strength training sessions (12 weeks, 2 times a week) and PBMT applied during the detraining period (4 weeks, 2 times a week).', 'interventionNames': ['Device: PBMT', 'Device: Placebo']}
- {'label': 'Placebo + training/ placebo + detraining', 'type': 'PLACEBO_COMPARATOR', 'description': 'Placebo applied before the strength training sessions (12 weeks, 2 times a week) and placebo applied during the detraining period (4 weeks, 2 times a week).', 'interventionNames': ['Device: Placebo']}

Interventions:
- {'type': 'DEVICE', 'name': 'PBMT', 'description': 'PBMT will be applied bilaterally using the direct contact method with light pressure on the skin to 6 sites of the anterior thigh (2 medial, 2 lateral, and 2 central). A 12-diode cluster, with 4 905-nm laser diodes (12.5W peak power for each diode), 4 875-nm LED diodes (17.5 mW mean power for each diode), and 4 640-nm LED diodes (15 mW mean power for each diode), manufactured by Multi Radiance Medical® (Solon, OH, USA), will be used to apply the PBMT. The dose used for applications during the training and/or detraining periods will be 30 Joules (J) per site (180 J per thigh). PBMT will be applied before each workout and during the detraining period, depending on the group to which the volunteers are allocated.', 'armGroupLabels': ['PBMT + training/ PBMT + detraining', 'PBMT + training/ placebo + detraining', 'Placebo + training/ PBMT + detraining']}
- {'type': 'DEVICE', 'name': 'Placebo', 'description': 'Placebo PBMT will be applied bilaterally using the direct contact method with light pressure on the skin to 6 sites of the anterior thigh (2 medial, 2 lateral, and 2 central). The placebo PBMT will per performed using the dose of 0 J per diode. The sounds and signals emitted from the device as well as the information displayed on the screen will be identical, regardless of the type of treatment (active or placebo). Placebo PBMT will be applied before each workout and during the detraining period, depending on the group to which the volunteers are allocated.', 'armGroupLabels': ['PBMT + training/ placebo + detraining', 'Placebo + training/ PBMT + detraining', 'Placebo + training/ placebo + detraining']}

Primary Outcomes:
- {'measure': 'Peak Torque', 'description': 'The peak torque will be measured by Maximum Voluntary Contraction (MVC) test.', 'timeFrame': '16 weeks - 4 weeks after completing the training (detraining period).'}

Please estimate the sample size based on the assumption: 
A β value of 20% and an α of 5% were used to calculate the sample size. Predicting a 20% sample loss.
Subjects and sample size
        As far as we know there are no published studies assessing the effects of PBMT/sMF during the detraining period after a strength-training programme. Therefore, the number of participants per group in the present study was calculated based on a pilot study that was recently conducted by our research group that had five volunteers per group. A Î² value of 20% and an Î± of 5% were used to calculate the sample size.
        The pilot study showed that applying PBMT/sMF during the detraining period resulted in a peak torque (the primary outcome of this study) of 257.25âNm (SD: 33.73) during the maximum voluntary contraction (MVC) test, whereas applying the placebo during the detraining period resulted in a peak torque of 222.05âNm (SD: 29.87). We used the Researcherâs Toolkit to calculate the sample size (https://www.dssresearch.com/KnowledgeCenter/toolkitcalculators/samplesizecalculators.aspx).
        Based on the aforementioned parameters used to calculate the sample, we found an n of 10 volunteers per group, for a total of 40 volunteers, was required. Therefore, predicting a 20% sample loss, 48 healthy, male volunteers aged from 18 to 35 years will be recruited for the study (12 volunteers per group). The choice to recruit only male volunteers is to allow direct comparison with a previous study carried out by our research group.24 As previously demonstrated by Joensen et al
32 some PBMT devices can significantly increase skin temperature, promote discomfort and even lead to interruption of treatment/irradiation in patients with darker skin. However, since the PBMT/sMF device used in the study does not cause any significant increase in skin temperature nor harmful thermal effects in light, medium or dark human skin,33 volunteers of different skin colours will be recruited. Volunteers will be informed about all study procedures and asked to sign the informed consent form prior to their enrolment in the study.