Here is the design of a clinical trial:

Official Title: The Effects of Claudication Severity on Functional Outcomes in Patients With Intermittent Claudication

Included conditions:
- Intermittent Claudication

Study Armgroups:
- {'label': 'Pain Free Exercise (PF)', 'type': 'ACTIVE_COMPARATOR', 'description': 'Patients will be randomised to twice weekly for 24 weeks of pain free exercise in a supervised exercise programme', 'interventionNames': ['Other: Pain Free Exercise (PF)']}
- {'label': 'Moderate Claudication Pain Exercise (MOD-P)', 'type': 'ACTIVE_COMPARATOR', 'description': 'Patients will be randomised to twice weekly for 24 weeks of moderate claudication pain exercise in a supervised exercise programme', 'interventionNames': ['Other: Moderate Claudication Pain Exercise (MOD-P)']}
- {'label': 'Maximal Claudication Pain Exercise (MAX-P)', 'type': 'ACTIVE_COMPARATOR', 'description': 'Patients will be randomised to twice weekly for 24 weeks of maximal claudication pain exercise in a supervised exercise programme', 'interventionNames': ['Other: Maximal Claudication Pain Exercise (MAX-P)']}

Interventions:
- {'type': 'OTHER', 'name': 'Pain Free Exercise (PF)', 'description': 'Patients will exercise until the onset on claudication (1 on the rating scale)', 'armGroupLabels': ['Pain Free Exercise (PF)']}
- {'type': 'OTHER', 'name': 'Moderate Claudication Pain Exercise (MOD-P)', 'description': 'Patients will exercise until they experience moderate claudication pain (2 on the rating scale)', 'armGroupLabels': ['Moderate Claudication Pain Exercise (MOD-P)']}
- {'type': 'OTHER', 'name': 'Maximal Claudication Pain Exercise (MAX-P)', 'description': 'Patients will exercise until they experience maximal claudication pain (4 on the rating scale)', 'armGroupLabels': ['Maximal Claudication Pain Exercise (MAX-P)']}

Primary Outcomes:
- {'measure': 'Change in Maximal Walking Distance (MWD)', 'description': 'Metres walked until maximal claudication pain', 'timeFrame': '12 and 24 weeks'}

Please estimate the sample size based on the assumption: 
A power of 90%, a significance level of 5%, and a dropout rate of approximately 30%.
Sample size
        Power analysis performed in G*Power
31
 showed that 39 patients (total) would be needed to attain statistical
significance. Based on previously published data investigating a UK-based SEP
that adopted a similar exercise circuit
32
 and converting the interquartile range to standard deviation,
33
 a median change in MWD of 143 m and a pooled standard deviation of 111.3
m was calculated. A power of 90% and a significance level of 5% were assumed. A
drop-out of approximately 30% will be allowed, yielding a required sample size
of 51 patients (17 per group) to be randomised.