Here is the design of a clinical trial:

Official Title: Pragmatic Randomized Controlled Multi Center Trial Comparing the Effectiveness of Antibacterial Therapeutic Clothing Based on Silver or Chitosan as Compared With Non-antibacterial Therapeutic Clothing in Patients With Moderate to Severe Atopic Dermatitis

Included conditions:
- Atopic Dermatitis

Study Armgroups:
- {'label': 'Control group', 'type': 'PLACEBO_COMPARATOR', 'description': 'This group will receive therapeutic clothing without antimicrobial agents', 'interventionNames': ['Device: Binamed® therapeutic clothing without antimicrobial agents']}
- {'label': 'Chitosan group', 'type': 'ACTIVE_COMPARATOR', 'description': 'This group will receive antimicrobial therapeutic clothing based on chitosan', 'interventionNames': ['Device: DermaCura® Chitosan based antimicrobial therapeutic clothing']}
- {'label': 'Silver group', 'type': 'ACTIVE_COMPARATOR', 'description': 'This group will receive antimicrobial clothing based on silver.', 'interventionNames': ['Device: Binamed® silver based antimicrobial therapeutic clothing']}

Interventions:
- {'type': 'DEVICE', 'name': 'DermaCura® Chitosan based antimicrobial therapeutic clothing', 'description': 'DermaCura® antimicrobial therapeutic clothing (D\\&M) consists of 98% TENCEL® and 2% elastane. 1% chitosan has been added to TENCEL®\n\nThe therapeutic clothing is to be worn at night during the 12-month intervention period and if needed during the day. Usual care including application of emollients, corticosteroid ointments or creams only if needed and/or antihistamines is continued, with standardized steroid ointments and treatment regimens for comparability purposes.', 'armGroupLabels': ['Chitosan group']}
- {'type': 'DEVICE', 'name': 'Binamed® silver based antimicrobial therapeutic clothing', 'description': 'The Binamed® antimicrobial therapeutic clothing (BAP Medical) consists of micro-modal, lycra and woven silver filaments as antibacterial agent.\n\nThe therapeutic clothing is to be worn at night during the 12-month intervention period and if needed during the day. Usual care including application of emollients, corticosteroid ointments or creams only if needed and/or antihistamines is continued, with standardized steroid ointments and treatment regimens for comparability purposes.', 'armGroupLabels': ['Silver group']}
- {'type': 'DEVICE', 'name': 'Binamed® therapeutic clothing without antimicrobial agents', 'description': 'The Binamed® therapeutic clothing without antimicriobial agents (BAP Medical) is therapeutic clothing made of micro-modal and lycra. Micro-madal is a semi-synthetic wood cellulose fiber. This fiber has a high strength hand elasticity, a high moisture-permeability and feels soft. Lycra ensures an optimal fit on the skin.\n\nThe therapeutic clothing is to be worn at night during the 12-month intervention period and if needed during the day. Usual care including application of emollients, corticosteroid ointments or creams only if needed and/or antihistamines is continued, with standardized steroid ointments and treatment regimens for comparability purposes.', 'armGroupLabels': ['Control group']}

Primary Outcomes:
- {'measure': 'Change in the Eczema Area and Severity Index (EASI)', 'description': 'Change in disease severity measured by the EASI between the clothing without antimicrobial agents (control group) and microbial growth reducing/ antimicrobial clothing based on chitosan or silver (intervention groups) over 12 months. Minimum score is 0, maximum score is 72. A higher score indicates more sever eczema', 'timeFrame': 'Two weeks for baseline, baseline, 1 month, 3 months 6 months and 12 months'}

Please estimate the sample size based on the assumption: 
An alpha of 0.05, a power of 0.80, and a 20% loss to follow-up were assumed. The study includes 3 groups, 5 measurements, and a 0.6 correlation between EASI scores.
Sample size
        The null hypothesis of this study is that there is no difference between the antimicrobial therapeutic clothing (based on silver and chitosan) and therapeutic clothing without antimicrobial agents.
        We used a standard deviation (SD) of 13 (based on the CLOTHES study [16]) and used the 6.6 minimal clinical important difference (MCID) for EASI as proposed by Schram et al. [17] resulting in an expected 0.51 Cohenâs D effect size. An alpha of 0.05 and a power of 0.80 were used.
        Based on the inclusion of 3 groups, 5 measurements (baseline, 1 month, 3 months, 6 months, 12 months) and a 0.6 correlation between EASI scores (correlation is based on the CLOTHES study), while assuming a 20% loss to follow-up, we will include 55 patients per group and 165 patients in total.