Here is the design of a clinical trial:

Official Title: TICS: Transcranial Magnetic Stimulation for Intervening in Children With Tourette's Syndrome

Included conditions:
- Tic Disorders

Study Armgroups:
- {'label': 'rTMS + CBIT', 'type': 'EXPERIMENTAL', 'description': 'Repetitive transcranial magnetic stimulation (rTMS) and Comprehensive Behavioural Intervention for Tics (CBIT)', 'interventionNames': ['Device: rTMS + CBIT', 'Behavioral: Sham rTMS + CBIT']}
- {'label': 'Sham rTMS + CBIT', 'type': 'ACTIVE_COMPARATOR', 'description': 'Sham repetitive transcranial magnetic stimulation (rTMS) and Comprehensive Behavioural Intervention for Tics (CBIT)', 'interventionNames': ['Behavioral: Sham rTMS + CBIT']}

Interventions:
- {'type': 'DEVICE', 'name': 'rTMS + CBIT', 'description': 'Repetitive Transcranial Magnetic Stimulation (rTMS) parameters are: intensity 100% resting motor threshold (RMT), frequency 1Hz, duration = 30 minutes (1800 stimulations; 900 per side), target - the supplementary motor area (SMA). Treatments occur on weekdays (T - F) for four weeks (20 total).\n\nThe Comprehensive Behavioral Intervention for Tics (CBIT) will be completed over eight sessions that will average 60 minutes in duration. First, participants will undergo awareness training. Participants will then be introduced to competing response training, which involves performing a voluntary behaviour designed to disrupt the execution of the tic. The eight sessions will occur on Mondays, once a week for six weeks and then on weeks 8 and 10.', 'armGroupLabels': ['rTMS + CBIT']}
- {'type': 'BEHAVIORAL', 'name': 'Sham rTMS + CBIT', 'description': 'Sham rTMS (sham coil) will be paired with CBIT. Sham rTMS will be delivered over the same time-frame as above. CBIT will be identical to the above.', 'armGroupLabels': ['Sham rTMS + CBIT', 'rTMS + CBIT']}

Primary Outcomes:
- {'measure': 'Yale Global Tic Severity Scale Total Tic score (YGTSS)', 'description': '30% reduction in Yale Global Tic Severity Scale Total Tic score (YGTSS) (\\~9 point reduction).\n\nA higher score on all scales suggests a more severe tics.\n\nThe YGTSS provides two tic severity scores:\n\n1. Total Motor (0 to 25)\n2. Total Phonic (0 to 25)\n\nThese are summed to form the Total Tic Severity Score (0 to 50). This is the measure for the primary outcome variable.\n\nThere is also the separate Impairment Dimension Score (0 to 50).\n\nThe total score is hence 0 to 100 (sum of Total Tic Severity Score and Impairment Dimension Score).', 'timeFrame': 'Baseline to week 7'}

Please estimate the sample size based on the assumption: 
Significance level adjusted using Benjamini-Hochberg approach with a false discovery rate of 5%, minimum power of 80%, and a potential data loss of 20%.
Sample size
        The sample size was estimated with G*Power (V.3.1.9.4).55 Prior pilot rTMS data (n=10) and a previous randomised controlled CBIT study (n=126) informed the estimates of effect size. Piacentini et al37 reported a mean difference of 4.1 (95% CI, 2.0 to 6.2) and a standardised mean difference of 0.7 in total YGTSS scores between a CBIT and control group.37 We expect the added effect of rTMS to be of the same magnitude, and thus we expect to see a difference in change of at least 4.1 between rTMS plus CBIT compared with CBIT alone. We estimate the SD of change to be 5.85 based on the reported Cohenâs d of 0.7. We will use the Benjamini-Hochberg approach to adjust alpha, with a false discovery rate of 5% and a minimum power of 80%. We assume a potential data loss of 20% due to withdrawal, loss of follow-up, data acquisition failures/errors and so on. With this difference of 4.1 and SD of 5.85 our ideal sample size calculation is 31 per group (62 total), 80% power. However, the funding received for this study allows for n=25 per group (50 total): with 25 per group, as long as the SD of pre to post change is not bigger than 5.31 (alpha (Î±)=0.033 as per Benjamini-Hochberg), we will still be powered to detect a desired 4.1 change. In addition, 20 participants per group (due to potential data loss/drop out) is still powered to detect a 4.1 difference as long as the SD of the pre to post change is not bigger than 4.73 (Î±=0.033).
        Participants will be recruited through the Calgary Touretteâs Syndrome Clinic (ACH, Calgary, Albertaâled by TP), a network of paediatricians, TS families and advertisements.