Here is the design of a clinical trial:

Official Title: Feasibility of Two Novel Interactive Software Modules for the Rehabilitation of Patients With Neuromuscular Upper Limb Impairments Using the YouGrabber Training System - the KAYO Study Protocol

Included conditions:
- Stroke
- Parkinson Disease
- Traumatic Brain Injury
- Guillain-Barre Syndrome

Study Armgroups:

Interventions:
- {'type': 'OTHER', 'name': 'VR-based training including AO and MI', 'description': 'Virtual Reality-based training intervention including Action Observation and Motor Imagery using the YouGrabber® training device'}

Primary Outcomes:
- {'measure': 'cARAT', 'description': 'Score on the conventional Action Research Arm Test', 'timeFrame': '17 weeks'}
- {'measure': 'dARAT', 'description': 'score on the digital ARAT', 'timeFrame': '17 weeks'}
- {'measure': 'SUS', 'description': 'System Usability Scale questionnaire', 'timeFrame': '15 weeks'}

Please estimate the sample size based on the assumption: 
Project 1 assumes a sample size of 75 patients to check for validity and other objectives. Project 2 does not apply confirmatory statistics and does not conduct a power analysis.
Determination of sample size
        
          Project 1
          In order to determine an adequate sample size for testing the psychometrics, we assessed the available literature on the ARAT. It has been reported to be valid,13 32 56â58 reliable13 31 32 57 and sensitive to change.59â61 The number of included patients for the estimation of the validity coefficients varies between the cited publications from 12 to 59. However, Hobart et al found that validity estimates would generally be stable in samples nâ¥80, for 75% of scales in samples of 40 subjects and for 50% of scales in samples of 20.62 They also stated that sample sizes of a minimum of 20 for reliability provided highly representative estimates.62 Thus, after consideration of the available literature and project constraints, we decided to include 75 patients in order to check for the validity of the d-ARAT module and the other objectives of project 1 (table 1). OfÂ these 75 patients,Â 30 are planned to additionally practise on the AO-MI module in project 2.
        
        
          Project 2
          Further, as it is not intended in the course of this study to apply confirmatory statistics for the evaluation of the AO-MI module a sample size calculation by conducting a power analysis is also not envisaged for project 2. Substantial and reliable data on the effect of BMT practice in adults have not yet been published. Therefore, the sample size determination for project 2 had to rely on according available literature on pilot and feasibility study methodology.63â70 We decided on that basis to include 30 patients into project 2 which aims to evaluate the practice on the AO-MI module.