Here is the design of a clinical trial:

Official Title: Effect of Antenatal Milk Expression on Breastfeeding Outcomes Among Overweight and Obese Women

Included conditions:
- Breastfeeding

Study Armgroups:
- {'label': 'Antenatal Milk Expression (AME) Intervention Group', 'type': 'EXPERIMENTAL', 'description': 'Weekly video interactions (weeks 37-40 of pregnancy) with International Board Certified Lactation Consultants (IBCLCs) to teach and reinforce antenatal milk expression. At-home practice of hand expression and collection of any expressed milk.', 'interventionNames': ['Behavioral: AME']}
- {'label': 'Video-based Infant Care Education Control Group', 'type': 'ACTIVE_COMPARATOR', 'description': 'Weekly video education (weeks 37-40 of pregnancy) on various topics related to infant care (e.g., safe sleep, car seat safety, etc.).', 'interventionNames': ['Behavioral: Video-based infant care education']}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'AME', 'description': 'Participants receive education on AME and feedback on technique with a remotely-based IBCLC via live streaming video.', 'armGroupLabels': ['Antenatal Milk Expression (AME) Intervention Group']}
- {'type': 'BEHAVIORAL', 'name': 'Video-based infant care education', 'description': 'Participants view a standard set of web-based streamed videos addressing evidence-based infant care, unrelated to feeding/breastfeeding.', 'armGroupLabels': ['Video-based Infant Care Education Control Group']}

Primary Outcomes:
- {'measure': 'Breastfeeding Exclusivity', 'description': 'Whether participant is feeding 100% breast milk at 2 weeks postpartum', 'timeFrame': '2 weeks postpartum'}
- {'measure': 'Breastfeeding Self-efficacy', 'description': 'Score on Breastfeeding Self-Efficacy Scale-SF (score range 14-70, with higher score represents better outcome)', 'timeFrame': '2 weeks postpartum'}

Please estimate the sample size based on the assumption: 
The study assumes a significance level of .017, power of .80, and an intervention drop-out/attrition rate of 25% by 2 weeks postpartum.
Sample size
        Our targeted enrollment sample size is 280 birthing parents. This sample size was based on an anticipated intervention drop-out/attrition by 2âweeks postpartum of 25%, current national breastfeeding exclusivity rates at 1â2âweeks postpartum, effects sizes for lactation support interventions in similar populations [19, 44], and anticipated challenges of recruitment within our eligiblity and geographical contraints. With a sample size of at least 210 (105 per group), we can detect with .80 power between-group differences in the prevalence of breastfeeding exclusivity at 2âweeks postpartum as small as .17 (medium effect size of ORâ=â2.55 using likelihood ratio chi-square test statistics) at an adjusted test-wise significance level of .017. In addition, with this sample size, we will be able to detect small to medium interaction effects between treatment groups over time as small as fÂ =â.32 when using repeated measures F-tests with at least four postpartum outcome time points.