Here is the design of a clinical trial:

Official Title: A Prospective Randomised Control Trial Comparing the Effect of Functional Alignment With Mechanical Axis Alignment on Outcomes After Total Knee Arthroplasty.

Included conditions:
- Osteoarthritis
- Osteo Arthritis Knee

Study Armgroups:
- {'label': 'Functionally aligned Total Knee Arthroplasty', 'type': 'ACTIVE_COMPARATOR', 'description': 'Knee arthroplasty performed using a functional alignment theory', 'interventionNames': ['Procedure: Functionally Aligned Total Knee Arthroplasty']}
- {'label': 'Mechanical axis aligned Total Knee Arthroplasty', 'type': 'ACTIVE_COMPARATOR', 'description': 'Knee arthroplasty performed using a mechanical alignment theory', 'interventionNames': ['Procedure: Mechanically Aligned Total Knee Arthroplasty']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'Functionally Aligned Total Knee Arthroplasty', 'description': "Femoral + tibial osteotomy planned for equal resection of femoral condyles to replicate patient anatomy. In coronal plane, distal femoral resection of 6.5mm subchondral bone from medial + lateral condyles, adjusted 1-3mm for compensation of wear. Proximal tibia, 7mm resection from subchondral bone from medial + lateral tibial plateau. Sagittal plane, resection angle determined intraoperatively to closely match native femoral flexion + tibial slope. Axial plane: posterior femoral resection 6.5mm from the subchondral bone of medial and lateral posterior condyles. Tibial rotation aligned to Akagi's line. Adjustments will be made to bony alignment to balance soft tissues within boundaries of 6° varus/3° valgus HKA alignment. Femoral component alignment limited to 6° valgus/3° varus in coronal plane. Tibial alignment limited 6° varus/3° valgus in coronal plane. Combined flexion of components limited to 10° flexion. Soft tissue release if balance within boundaries not achieved.", 'armGroupLabels': ['Functionally aligned Total Knee Arthroplasty']}
- {'type': 'PROCEDURE', 'name': 'Mechanically Aligned Total Knee Arthroplasty', 'description': "Tibial and femoral osteotomies in the coronal plane will be planned perpendicular to the tibial and femoral mechanical axes respectively to achieve neutral overall alignment. Soft tissue balance will be assessed and minor adjustments to bony alignment made to balance the knees with a maximal adjustment of two degrees valgus and two degrees varus of coronal alignment from neutral. Femoral rotation will be planned to surgical epicondylar axis and adjustments to rotation made to allow equal flexion and extension balance (to within 1mm). If balance can not be achieved within these boundaries then soft tissue release will be undertaken. In the sagittal plane, 0-3° degrees of posterior tibial slope and 0-5° of femoral component flexion will be used to optimise implant sizing whilst preventing notching. In the axial plane, the tibial component aligned to Akagi's line, which connects the medial border of the patellar tendon attachment to the middle of the posterior cruciate ligament.", 'armGroupLabels': ['Mechanical axis aligned Total Knee Arthroplasty']}

Primary Outcomes:
- {'measure': 'Difference in Forgotten Joint Score after 2 years', 'description': 'Difference in relative change in Forgotten joint score between FA and MA patients 2 years post-operatively compared to preoperatively. Scale 0-100 with higher scores being a better outcome', 'timeFrame': 'Preoperatively and 2 years postoperatively'}
- {'measure': 'Difference in Oxford Knee Score after 2 years', 'description': 'Difference in relative change in Oxford Knee Score (OKS) between FA and MA patients 2 years post-operatively compared to preoperatively. Scale 0-48 with higher scores being a better outcome.', 'timeFrame': 'Preoperatively and 2 years postoperatively'}
- {'measure': 'Relative change in range of motion between FA and MA patients post-operatively compared to preoperatively.', 'description': 'Difference in range of motion via goniometry preoperatively and postoperatively at 2 years', 'timeFrame': 'Preoperatively and 2 years postoperatively'}

Please estimate the sample size based on the assumption: 
The study aims to have at least 45 patients in each treatment group completing the study, implying considerations for dropout or missing data.
Sample size {14}
          In total, 100 patients will be enrolled in a 1:1 ratio between the two treatment groups. This will ensure that the minimum of 90 patients required to answer the study question are followed up for the duration of the study. The enrolment goal is to have at least 45 patients in each of the two treatment groups completing the study.