Here is the design of a clinical trial:

Official Title: Effectiveness of an E-Health System Integrated in a Physical Recovery Program for the Treatment of Pain in the Oncological Population. PaiNEd Study.

Included conditions:
- Breast Cancer

Study Armgroups:
- {'label': 'Multimodal rehabilitation program + PNE (Therapeutic exercise, manual therapy and PNE)', 'type': 'EXPERIMENTAL', 'description': 'Physical recovery program (multimodal) with a duration of 8 weeks. Three weekly sessions on alternate days lasting 60 minutes each one. 4 individual manual therapy sessions (1 session every 2 weeks). Access to the PaiNEd system.', 'interventionNames': ['Other: Multimodal rehabilitation program + PNE (Therapeutic exercise, manual therapy and PNE)']}
- {'label': 'Multimodal rehabilitation program + traditional biomedical information', 'type': 'ACTIVE_COMPARATOR', 'description': 'Physical recovery program (multimodal) with a duration of 8 weeks. Three weekly sessions on alternate days lasting 60 minutes each one. 4 individual manual therapy sessions (1 session every 2 weeks). Dossier with traditional biomedical recommendations on the management of pain and disability.', 'interventionNames': ['Other: Multimodal rehabilitation program + traditional biomedical information']}
- {'label': 'Control group', 'type': 'ACTIVE_COMPARATOR', 'description': 'Information dossier with recommendations on pain control and dysfunction improvement.', 'interventionNames': ['Other: Control group']}

Interventions:
- {'type': 'OTHER', 'name': 'Multimodal rehabilitation program + PNE (Therapeutic exercise, manual therapy and PNE)', 'description': 'The sessions will consist of therapeutic exercise in groups: a) warm-up (10 minutes aerobic exercise), b) active mobilizations (cervical / shoulder) c) strength exercises of the cervical and shoulder muscles + general conditioning d) active postural control e) stretching and relaxation exercises.\n\n4 sessions of myofascial induction.\n\nFinally, patients will have access to the PaiNEd system before the start of the program (to prepare them for treatment sessions) and during the development of the treatment program in which they will introduce their pain levels and their characteristics and also receive a series of educational advice and recommendations for its improvement.', 'armGroupLabels': ['Multimodal rehabilitation program + PNE (Therapeutic exercise, manual therapy and PNE)']}
- {'type': 'OTHER', 'name': 'Multimodal rehabilitation program + traditional biomedical information', 'description': 'The sessions will consist of therapeutic exercise in groups: a) warm-up (10 minutes aerobic exercise), b) active mobilizations (cervical / shoulder) c) strength exercises of the cervical and shoulder muscles + general conditioning d) active postural control e) stretching and relaxation exercises.\n\n4 sessions of myofascial induction.\n\nPatients will receive a dossier with traditional biomedical recommendations on pain management and disability associated with the side effects of cancer treatment.', 'armGroupLabels': ['Multimodal rehabilitation program + traditional biomedical information']}
- {'type': 'OTHER', 'name': 'Control group', 'description': 'Waiting list of patients who have agreed to participate in the study. They will receive an information dossier with recommendations on pain control and improvement of dysfunction (similar to what was worked on in the experimental group). These recommendations will be distributed at the beginning of the study (initial assessment) and they will be summoned at 8 weeks for the next collection of variables. All patients will be invited to participate in the experimental phase at the end of the control phase.', 'armGroupLabels': ['Control group']}

Primary Outcomes:
- {'measure': 'Change from baseline in Pain on the Visual Analogue scale and Brief Pain Inventory at 2 and 6 months.', 'description': "The Visual Analogue Scale is used to assess the intensity of spontaneous neck, temporomandibular and shoulder pain. The VAS is a 100 mm line anchored with a '0' at one end representing no pain and '100' at the other end representing the worst pain imaginable.", 'timeFrame': 'Baseline, 2 and 6 months.'}

Please estimate the sample size based on the assumption: 
Differences of at least 5% can be detected with a statistical power of 90% and a significance level alpha of 0.05. A maximum monitoring loss of 20% will be allowed.
Calculation of the sample size
        The estimation of the sample size and statistical power for the trial were determined based on the main variable, pain measured through the VAS. Based on a previous study [26] and estimating that patients in the intervention group would have a difference of 15 mm or more in the VAS compared to the control group, differences of at least 5% can be detected with a statistical power of 90% and a significance level alpha Î± of 0.05. This will require a sample of 24 patients per group, which will result in a total of 72 participants. Therefore, a maximum monitoring loss of 20% will be allowed. To carry out this sample calculation, the G*Power v. 3.1 Software was used.