Here is the design of a clinical trial:

Official Title: Effect of a Tailored Multidimensional Intervention on the Care Burden Among Family Caregivers of Stroke Survivors

Included conditions:
- Stroke
- Caregiver Burden
- Caregiver Burnout

Study Armgroups:
- {'label': 'Intervention Group', 'type': 'EXPERIMENTAL', 'description': 'Tailored Multidimensional Intervention', 'interventionNames': ['Behavioral: Tailored Multidimensional Intervention. the tailored intervention will be implemented through 6 months using a multidimensional approach (skill building, psychoeducation and peer support).']}
- {'label': 'Control Group', 'type': 'NO_INTERVENTION', 'description': 'Regarding the control group, the participants will receive a simple educational booklet through one home visit.'}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Tailored Multidimensional Intervention. the tailored intervention will be implemented through 6 months using a multidimensional approach (skill building, psychoeducation and peer support).', 'description': "Skill-building can be defined as training the family caregivers the following skills (1) hands-on training in such skills as positioning, transferring and mobility techniques and assistance with activities of daily living; (2) coping strategies and stress management (3) communicating with healthcare professionals. Psycho-education is teaching and provision the family caregivers the knowledge and information regarding stroke (stroke definition, types of stroke, risk factors, prevention of recurrent stroke, medication management, stroke complications and measures for prevention and management of these complications). Besides, family caregivers will be taught and given the knowledge and information regarding managing stroke survivors' emotions and behaviors. Peer support can be defined as engaging the family caregivers of stroke survivors in interactions with their peers for support and exchanging advices and experiences.", 'armGroupLabels': ['Intervention Group']}

Primary Outcomes:
- {'measure': 'Measuring the change of the Care burden among family caregivers of stroke survivors (Zarit Burden Interview)', 'description': 'Care burden can be defined in this context as the personal strain and role strain that the family caregiver experienced due to caring for one of the family. members having stroke. Consequently, the family caregivers will suffer from physical or psychological or emotional or social or financial complains. The Short version (12 items) of Zarit Burden Interview will be used. Items are rated on a 5-point Likert scale from 0 (never) to 4 (almost always). the validated Arabic version will be used.', 'timeFrame': 'baseline, 3 months, 6 months'}

Please estimate the sample size based on the assumption: 
Confidence level of 0.95, statistical power of 0.90, and an estimated dropout rate of 30%.
Sample size
        The sample size was estimated using G power software V.3.1.9.4 (Psychonomic Society, Madison, Wisconsin, USA)103 with an effect size of 0.72, which was based on a similar previous study on care burden among the family caregivers using ZBI.104 Assuming power analysis results for the difference between two independent means (two groups) and a confidence level of 0.95, statistical power of 0.90 and fair division, the sample size was required to be 84 caregivers. An additional 26 caregivers need to be recruited to compensate for an estimated dropout rate of 30%.105 106 The final sample size is 110 participants (55 in the IG and 55 in the CG).