Here is the design of a clinical trial:

Official Title: Opening the Conversation for Couples With Reproductive Health Concerns

Included conditions:
- Breast Cancer
- Gynecologic Cancer

Study Armgroups:
- {'label': 'Program #1', 'type': 'EXPERIMENTAL', 'description': 'Participants attend 5 sessions (1.5 hours each) consisting of education and skills training to address cancer-related reproductive and sexual health concerns. Sessions occur via videoconference.', 'interventionNames': ['Behavioral: Opening the Conversation']}
- {'label': 'Program #2', 'type': 'ACTIVE_COMPARATOR', 'description': 'Participants attend 4 sessions (1.5 hours each) consisting of education and skills training to address cancer-related concerns. Sessions occur via videoconference.', 'interventionNames': ['Behavioral: Side by Side']}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Opening the Conversation', 'description': 'The intervention includes 5 weekly sessions (1.5 hours each), plus participant educational materials, and is delivered to couples via videoconference by a trained interventionist. Participants are asked to complete home activities between sessions. Sessions focus on development of communication and coping skills, with a focus on reproductive and sexual health distress.', 'armGroupLabels': ['Program #1']}
- {'type': 'BEHAVIORAL', 'name': 'Side by Side', 'description': 'The intervention includes 4 weekly sessions (1.5 hours each), plus participant educational materials, and is delivered to couples via videoconference by a trained interventionist. Participants are asked to complete home activities between sessions. Sessions focus on development of communication and coping skills, with a focus on general cancer-related distress.', 'armGroupLabels': ['Program #2']}

Primary Outcomes:
- {'measure': 'Change in reproductive distress', 'description': 'Relationship concern domain of the Fertility Problem Inventory (FPI) scale. 10 items. Range 10-60. Higher score indicates more reproductive distress.', 'timeFrame': 'Baseline to 3 months post-intervention'}
- {'measure': 'Change in sexual distress', 'description': 'Sexual and relationship distress (SaRDS). 30 items. Range 1-30. Higher score indicates more sexual distress.', 'timeFrame': 'Baseline to 3 months post-intervention'}

Please estimate the sample size based on the assumption: 
The study assumes a significance level that provides 90% power without attrition and 80% power with 20% attrition. It also assumes a cross-dyad correlation of r = .4.
Sample size estimate/ power calculations
          A sensitivity power analysis was conducted using the program G*Power and anticipating an initial sample of 100 couples (N = 200 individuals), and an attrition rate of 20% at the final assessment. Given that the design has two levels of the treatment and three assessments, for outcomes that are assessed on only survivors (or only partners), the study has 90% power to detect small to moderate effects (i.e., d = .32) if there is no attrition. With the expected 20% attrition, the study has 80% power to detect effects greater than d = .36. Because both partners will complete most of the same outcomes, for these outcomes the effective sample size is larger than the number of dyads but smaller than the number of individuals. Specifically, assuming a cross-dyad correlation of r = .4 (e.g., the correlation between the two partnersâ distress), the effective sample size to test the treatment by time interaction is 142 without attrition and 114 with attrition. Thus, for these outcomes, without attrition the study will have 90% power to detect effects of d > .27 and with attrition it will have 90% power to detect effects of d > .30.