Here is the design of a clinical trial:

Official Title: Optimizing Tobacco Dependence Treatment in the Emergency Department

Included conditions:
- Tobacco Use Disorder

Study Armgroups:
- {'label': 'BNI+NRT+QL+Text', 'type': 'EXPERIMENTAL', 'description': 'Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text)', 'interventionNames': ['Behavioral: Brief Negotiated Interview (BNI)', 'Drug: Nicotine replacement therapy (NRT)', 'Other: CT Smokers Quitline (QL)', 'Other: SmokefreeText (Text)']}
- {'label': 'BNI+NRT+QL', 'type': 'EXPERIMENTAL', 'description': 'Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL)', 'interventionNames': ['Behavioral: Brief Negotiated Interview (BNI)', 'Drug: Nicotine replacement therapy (NRT)', 'Other: CT Smokers Quitline (QL)']}
- {'label': 'BNI+NRT+Text', 'type': 'EXPERIMENTAL', 'description': 'Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text)', 'interventionNames': ['Behavioral: Brief Negotiated Interview (BNI)', 'Drug: Nicotine replacement therapy (NRT)', 'Other: SmokefreeText (Text)']}
- {'label': 'BNI+NRT', 'type': 'EXPERIMENTAL', 'description': 'Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply', 'interventionNames': ['Behavioral: Brief Negotiated Interview (BNI)', 'Drug: Nicotine replacement therapy (NRT)']}
- {'label': 'BNI+QL+Text', 'type': 'EXPERIMENTAL', 'description': 'Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text)', 'interventionNames': ['Behavioral: Brief Negotiated Interview (BNI)', 'Other: CT Smokers Quitline (QL)', 'Other: SmokefreeText (Text)']}
- {'label': 'BNI+QL', 'type': 'EXPERIMENTAL', 'description': 'Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL)', 'interventionNames': ['Behavioral: Brief Negotiated Interview (BNI)', 'Other: CT Smokers Quitline (QL)']}
- {'label': 'BNI+Text', 'type': 'EXPERIMENTAL', 'description': 'Brief Negotiated Interview (BNI) Registration in SmokefreeText (Text)', 'interventionNames': ['Behavioral: Brief Negotiated Interview (BNI)', 'Other: SmokefreeText (Text)']}
- {'label': 'BNI only', 'type': 'EXPERIMENTAL', 'description': 'Brief Negotiated Interview (BNI)', 'interventionNames': ['Behavioral: Brief Negotiated Interview (BNI)']}
- {'label': 'NRT+QL+Text', 'type': 'EXPERIMENTAL', 'description': 'Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text)', 'interventionNames': ['Drug: Nicotine replacement therapy (NRT)', 'Other: CT Smokers Quitline (QL)', 'Other: SmokefreeText (Text)']}
- {'label': 'NRT+QL', 'type': 'EXPERIMENTAL', 'description': 'Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL)', 'interventionNames': ['Drug: Nicotine replacement therapy (NRT)', 'Other: CT Smokers Quitline (QL)']}
- {'label': 'NRT+Text', 'type': 'EXPERIMENTAL', 'description': 'Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text)', 'interventionNames': ['Drug: Nicotine replacement therapy (NRT)', 'Other: SmokefreeText (Text)']}
- {'label': 'NRT only', 'type': 'EXPERIMENTAL', 'description': 'Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply', 'interventionNames': ['Drug: Nicotine replacement therapy (NRT)']}
- {'label': 'QL+Text', 'type': 'EXPERIMENTAL', 'description': 'Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text)', 'interventionNames': ['Other: CT Smokers Quitline (QL)', 'Other: SmokefreeText (Text)']}
- {'label': 'QL only', 'type': 'EXPERIMENTAL', 'description': 'Referral to CT Smokers Quitline (QL)', 'interventionNames': ['Other: CT Smokers Quitline (QL)']}
- {'label': 'Text only', 'type': 'EXPERIMENTAL', 'description': 'Registration in SmokefreeText (Text)', 'interventionNames': ['Other: SmokefreeText (Text)']}
- {'label': 'Control', 'type': 'NO_INTERVENTION', 'description': 'Control arm, no intervention'}

Interventions:
- {'type': 'BEHAVIORAL', 'name': 'Brief Negotiated Interview (BNI)', 'description': 'Brief motivational interview on smoking behavior', 'armGroupLabels': ['BNI only', 'BNI+NRT', 'BNI+NRT+QL', 'BNI+NRT+QL+Text', 'BNI+NRT+Text', 'BNI+QL', 'BNI+QL+Text', 'BNI+Text']}
- {'type': 'DRUG', 'name': 'Nicotine replacement therapy (NRT)', 'description': '6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece.', 'armGroupLabels': ['BNI+NRT', 'BNI+NRT+QL', 'BNI+NRT+QL+Text', 'BNI+NRT+Text', 'NRT only', 'NRT+QL', 'NRT+QL+Text', 'NRT+Text']}
- {'type': 'OTHER', 'name': 'CT Smokers Quitline (QL)', 'description': 'Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling.', 'armGroupLabels': ['BNI+NRT+QL', 'BNI+NRT+QL+Text', 'BNI+QL', 'BNI+QL+Text', 'NRT+QL', 'NRT+QL+Text', 'QL only', 'QL+Text']}
- {'type': 'OTHER', 'name': 'SmokefreeText (Text)', 'description': "Enrollment in a version of NCI's SmokefreeTxt, tailored for the study.", 'armGroupLabels': ['BNI+NRT+QL+Text', 'BNI+NRT+Text', 'BNI+QL+Text', 'BNI+Text', 'NRT+QL+Text', 'NRT+Text', 'QL+Text', 'Text only']}

Primary Outcomes:
- {'measure': 'Tobacco Abstinence', 'description': 'Abstinence self reported and verified by exhaled carbon monoxide', 'timeFrame': '3 months'}

Please estimate the sample size based on the assumption: 
A two-sided 0.05 significance level, 80% power, and a 15% dropout rate by 3 months.
2.11. Justification of sample size
        The goal of this proposal is to identify individual tobacco dependence treatment intervention components which show clinical efficacy, subject to constraints of cost effectiveness and acceptability. As each component is allocated to half the participants, the sample size to detect main effects in a full factorial MOST design depends not on the number of components evaluated, but rather the smallest clinically important difference between the presence and absence of a component. In our previous trial, we found a difference of 7.3% in biochemically confirmed abstinence between the control and intervention arms at 3 months. It is reasonable to expect that, in this factorial trial, the effect of individual components will be less than that seen in the multi-component trial [17,44]. Therefore, we have chosen an absolute difference of 5% for the main effects of each component. (We considered a narrower difference of 4%, but the sample size and resources needed become unfeasible.) With a two-sided 0.05 significance level, and an average abstinence proportion of 4.9% in the absence of a component, a total sample size of 860 participants will provide 80% power to detect a 5% increase in the abstinence rate. We will enroll 1056 participants to account for a 15% dropout rate by 3 months. We will investigate whether the effect of a component is dependent on the levels of other components (i.e. interactions), but our trial is not powered with the intent to detect these interactions.