Here is the design of a clinical trial:

Official Title: The Effects of the Laparoscopic Roux-en-Y Gastric Bypass and the Laparoscopic Mini Gastric Bypass on the Remission of Type II Diabetes Mellitus and the Pathophysiological Mechanisms That Drive the Conversion of Malign to Benign Obesity

Included conditions:
- Obesity, Morbid
- Type 2 Diabetes Mellitus

Study Armgroups:
- {'label': 'Laparoscopic Roux-en-Y gastric bypass', 'type': 'ACTIVE_COMPARATOR', 'description': 'Laparoscopic Roux-en-Y gastric bypass', 'interventionNames': ['Procedure: laparoscopic Roux-en-Y gastric bypass']}
- {'label': 'Laparoscopic Mini Gastric Bypass', 'type': 'EXPERIMENTAL', 'description': 'laparoscopic Mini gastric bypass', 'interventionNames': ['Procedure: laparoscopic Mini gastric bypass']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'laparoscopic Roux-en-Y gastric bypass', 'description': 'laparoscopic Roux-en-Y gastric bypass with a 50 cm biliary limb and a 150 cm alimentary limb', 'armGroupLabels': ['Laparoscopic Roux-en-Y gastric bypass'], 'otherNames': ['gastric bypass']}
- {'type': 'PROCEDURE', 'name': 'laparoscopic Mini gastric bypass', 'description': 'laparoscopic Mini gastric bypass with a gastrojejunostomy at 200 centimeters measured from the ligament of Treitz', 'armGroupLabels': ['Laparoscopic Mini Gastric Bypass'], 'otherNames': ['One anastomosis gastric bypass, omega loop gastric bypass']}

Primary Outcomes:
- {'measure': 'glycaemic control', 'description': 'as measured by the difference in HBa1C', 'timeFrame': '12 months FU'}

Please estimate the sample size based on the assumption: 
Two-sided significance level of P < 0.05, power of 80%, and a 10% dropout rate.
Power calculation and sample size
          Sample size calculation was performed based on a retrospective analysis of patients after RYGB (nâ=â90) and OAGB (nâ=â37). Patients were matched in a 3:1 ratio on baseline age, BMI, and gender. The mean pre-operative Hba1c in the RYGB group was 7.5âÂ±â1.4% and 7.5âÂ±â1.5% in the OAGB group (pâ=â0.97). Null hypothesis is as follows: there is no difference in decrease of Hba1c at 12 months after RYGB or OAGB in patients with T2DM. Alternative hypothesis: the decrease in Hba1c after OAGB is higher than after RYGB in patients with T2DM at 12 months after surgery. For sample size calculation, the mean Hba1c of both groups was compared with a two-sided significance level of P < 0.05 and a power of 80%. Based on the retrospective results, 100 subjects per group will be required. Considering a 10% dropout rate, 220 patients are needed.