Here is the design of a clinical trial:

Official Title: Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With Endovascular Thrombectomy on Long-term Prognosis in Patients With Acute Ischemic Stroke (PPDET)

Included conditions:
- Acute Ischemic Stroke

Study Armgroups:
- {'label': 'Intervention group', 'type': 'EXPERIMENTAL', 'description': 'Dexmedetomidine 0.1\\~1.0 μg/kg/h for 24h after patients finished endovascular thrombectomy and returned to ICU. Maintain Ramsay score 2-3.', 'interventionNames': ['Drug: Dexmedetomidine prolonged sedation']}
- {'label': 'Control group', 'type': 'PLACEBO_COMPARATOR', 'description': 'An equal dose of saline 24h after patients finished endovascular thrombectomy and returned to ICU. If the Ramsay sedation score is 1, propofol will be administrated to maintain the Ramsay sedation score at 2 to 3.', 'interventionNames': ['Drug: 0.9% saline']}

Interventions:
- {'type': 'DRUG', 'name': 'Dexmedetomidine prolonged sedation', 'description': 'Dexmedetomidine for 24h after patients finished endovascular thrombectomy and returned to ICU.', 'armGroupLabels': ['Intervention group']}
- {'type': 'DRUG', 'name': '0.9% saline', 'description': 'An equal dose of 0.9% saline 24h after patients finished endovascular thrombectomy and returned to ICU.', 'armGroupLabels': ['Control group']}

Primary Outcomes:
- {'measure': 'The favorable functional outcome of stroke-related disability rate', 'description': 'Modified Rankin Scale ≤ 2 points. mRS range from 0 to 6, higher scores mean a worse outcome.', 'timeFrame': '90 ± 14 days after thrombectomy'}

Please estimate the sample size based on the assumption: 
A power of 80%, a two-sided significance level (alpha) of 0.05, and a 10% dropout rate were assumed.
Sample size {14}
          According to previous studies, the functional independence rate at 90 days after EVT for AIS is about 40 to 55% [7, 8]. Given the risk and benefit of infusion with DEX after EVT, at least an increase of 15% in the proportion of mRS 0â2 in the AIS patients with postoperative prolonged sedation is considered clinically meaningful. Thus, we assume 50% of participants in the control group could achieve mRS 0â2 and an increase of 15% in the intervention group. With a power of 80% and 2-side Î± = .05, 167 patients per group are required. Considering a 10% dropout rate and random block length, the total sample size is 368 (184 patients per group). The sample size calculation was conducted on PASS software, version 14.0 (Number Cruncher Statistical Software).