Here is the design of a clinical trial:

Official Title: Comparative Effectiveness of Herb-partitioned Moxibustion Plus Lifestyle Modification Treatment for Patients With Simple Obesity: A Study Protocol for a Randomized Controlled Trial

Included conditions:
- Obesity

Study Armgroups:
- {'label': 'Heat application group', 'type': 'EXPERIMENTAL', 'description': 'Participants will receive heat application at acupoints plus lifestyle modification. Participants will receive heat application treatment once every other day, 3 times per week, for 4 consecutive weeks.', 'interventionNames': ['Device: Heat application at acupoints']}
- {'label': 'Medicated plaster group', 'type': 'EXPERIMENTAL', 'description': 'Participants will receive medicated plaster at acupoints plus lifestyle modification. Participants will receive medicated plaster at acupoints and lifestyle modification every once every other day, 3 times per week, for 4 consecutive weeks.', 'interventionNames': ['Device: Medicated plaster at acupoints']}
- {'label': 'Herb-partitioned moxibustion group', 'type': 'EXPERIMENTAL', 'description': 'Participants will receive herb-partitioned moxibustion at acupoints plus lifestyle modification. Participants will receive herb-partitioned moxibustion at acupoints and lifestyle modification every once every other day, 3 times per week, for 4 consecutive weeks.', 'interventionNames': ['Device: Herb-partitioned moxibustion at acupoints']}

Interventions:
- {'type': 'DEVICE', 'name': 'Heat application at acupoints', 'description': "1. The acupoints will be selected as Tianshu, Pishu, shenshu, zhongwan, and zusanli. The location of the acupoints were based on the national GB/T 12346-2006 acupoints standard. The hot sticker will be placed on the patient's acupoints for about 2 hours. This treatment will be applied once every other day, 3 times per week, for 4 consecutive weeks. The treatment will be delayed during the menstrual period.\n2. The following lifestyle modification are recommended to help to establish healthy habits:\n\nThe proportion of three nutrients in total calories comprises of 55%-65% from carbohydrates, 20%-30% from oils and 15% from protein, and the energy of the whole day distributed to three meals will follow the proportion of 30% for breakfast, 40% for lunch and 30% for dinner. Meanwhile, low-to-moderate intensity physical activities will be instructed to them for at least 5 days per week continually, 30%-50% of the maximum heart rate reserve value will be required.", 'armGroupLabels': ['Heat application group']}
- {'type': 'DEVICE', 'name': 'Medicated plaster at acupoints', 'description': "1. The acupoints will be selected as Tianshu, Pishu, shenshu, zhongwan, and zusanli. The location of the acupoints were based on the national GB/T 12346-2006 acupoints standard.The chinese traditional medicine(aconite root, dried ginger, evodia rutaecarpa, clove, cinnamon, etc)in moderation will be grinded into powder，and the powder will be added with a certain amount of flour, and finally they will be blended with ginger juice to the appearance of mud. Next, 10g of the kneaded medicine mud will be taked and applied to the bottom of the ordinary sticker. They will be placed on the patient's acupoints for about 2 hours. The sticker has the same shape as the hot sticker, but it does not have the effect of thermal stimulation and infrared radiation. This treatment will be applied once every other day, 3 times per week, for 4 consecutive weeks. The treatment will be delayed during the menstrual period.\n2. Lifestyle modification:It will be performed as the same as the heat application group.", 'armGroupLabels': ['Medicated plaster group']}
- {'type': 'DEVICE', 'name': 'Herb-partitioned moxibustion at acupoints', 'description': "1. The acupoints will be selected as Tianshu, Pishu, shenshu, zhongwan, and zusanli. The location of the acupoints were based on the national GB/T 12346-2006 acupoints standard\\[18\\]. The chinese traditional medicine(aconite root, dried ginger, evodia rutaecarpa, clove, cinnamon, etc)in moderation will be grinded into powder，and the powder will be added with a certain amount of flour, and finally they will be blended with ginger juice to the appearance of mud. Next, 10g of the kneaded medicine mud will be taked and applied to the bottom of the hot sticker. They will be placed on the patient's acupoints for about 2 hours. This treatment will be applied once every other day, 3 times per week, for 4 consecutive weeks. The treatment will be delayed during the menstrual period.\n2. Lifestyle modification:It will be performed as the same as the heat application group.", 'armGroupLabels': ['Herb-partitioned moxibustion group']}

Primary Outcomes:
- {'measure': 'the clinical effectiveness', 'description': 'The clinical effectiveness of 4 weeks of (A)Heat application group, (B)Medicated plaster group, and (C)Herb-partitioned moxibustion group for the improvement of simple obesity will be assessed and determined by the clinical evaluation of nimodipine:\n\n1. Healing: The clinical symptoms disappear or almost disappear, and the syndrome score is reduced by ≥85 percent;\n2. Significant effect: The clinical symptoms are obviously improved, and the syndrome score is reduced by \\<85 percent, but ≥50 percent;\n3. Effective: The clinical symptoms have improved, syndrome scores decreased by\\<50 percent, but ≥30 percent;\n4. Invalid: The clinical symptoms were not improved, even worse, and the syndrome score was reduced by\\<30 percent.\n\nIntegral variation formula(Nimodipine method: \\[(pre-treatment score-post-treatment score)/pre-treatment score\\]X100 percent.', 'timeFrame': 'week 4.'}

Please estimate the sample size based on the assumption: 
80% power to detect a significant difference with a significance level of 0.025 (1 sided) and a 10% withdrawal rate.
2.11
        Sample size calculation
        In a previous study, the effective rate of simple obesity in the herb-partitioned moxibustion group was P1â=â.80. The effective rate of the heat application group was P2â=â.65, and the effective rate of the medicated plaster group was P3â=â.6. PASS V.11 software (NCSS, Kaysville, UT) was used to calculate that, based on 80% power to detect a significant difference(Î±â=â0.025, 1 sided), 33 participants will be required for each group. Allowing for a 10% withdrawal rate, we plan to include a total of 108 participants with 36 participants in each group.