Here is the design of a clinical trial:

Official Title: HVPG-guided Laparoscopic Versus Endoscopic Therapy for Variceal Rebleeding in Portal Hypertension: A Multicenter Randomized Controlled Trial (CHESS1803)

Included conditions:
- Portal Hypertension
- Variceal Rebleeding

Study Armgroups:
- {'label': 'Experimental group', 'type': 'EXPERIMENTAL', 'description': 'Procedure: Laparoscopic splenectomy and pericardial devascularization Drug: Propranolol', 'interventionNames': ['Drug: Propranolol', 'Procedure: Laparoscopic splenectomy and pericardial devascularization']}
- {'label': 'Control group', 'type': 'ACTIVE_COMPARATOR', 'description': 'Procedure: Endoscopic therapy Drug: Propranolol', 'interventionNames': ['Drug: Propranolol', 'Procedure: Endoscopic therapy']}

Interventions:
- {'type': 'DRUG', 'name': 'Propranolol', 'description': 'Propranolol was administrated orally while keeping monitoring heart rate and blood pressure daily.', 'armGroupLabels': ['Control group', 'Experimental group']}
- {'type': 'PROCEDURE', 'name': 'Laparoscopic splenectomy and pericardial devascularization', 'description': 'Including splenectomy and pericardial devascularizaion under laparoscopy', 'armGroupLabels': ['Experimental group']}
- {'type': 'PROCEDURE', 'name': 'Endoscopic therapy', 'description': 'Either endoscopic variceal ligation (EVL) or cyanoacrylate injection was applied according to the condition of varices', 'armGroupLabels': ['Control group']}

Primary Outcomes:
- {'measure': 'Variceal rebleeding', 'description': 'The occurrence rate of gastroesophageal varices rebleeding within 1-year follow-up', 'timeFrame': '1 year'}

Please estimate the sample size based on the assumption: 
Type I error rate (α) of 5%, Type II error rate (1−β) of 20%, and a dropout rate of 10%.
Sample size estimation
        No study has yet compared the outcome between cirrhotic patients with gastro-oesophageal variceal bleeding receiving either laparoscopic therapy or endoscopic therapy. Also, because of the lack of study restricting HVPG baseline level and studies about laparoscopic therapy plus propranolol oral administration, the sample size is determined based on pooled data of variceal rebleeding rate of several studies including endoscopic therapy plus propranolol oral administration or laparoscopic therapy. The variceal rebleeding rate of endoscopic therapy plus propranolol oral administration is estimated by six randomised controlled trials (table 2).22â27 The variceal rebleeding rate of laparoscopic therapy is estimated by six retrospective studies (table 2).20 28â32 Pooled rates of variceal rebleeding for the endoscopic group and laparoscopic group are 44% and 6%, respectively. Considering a type I error rate (Î±) of 5% and a type II error rate (1âÎ²) of 20% and a dropout rate of 10%, the calculated sample size for this trial is 40.
        
          Table 2
          
            Variceal rebleeding rates in cirrhotic patients with portal hypertension bleeding treated by endoscopic therapy plus propranolol or laparoscopic therapy: a review of 12 studies
          
          
            
              
                Laparoscopic therapy
                Endoscopic therapy plus propranolol
              
              
                First author, year
                Patients (n)
                Rebleeding, n (%)
                First author, year
                Patients (n)
                Rebleeding, n (%)
              
            
            
              
                Zheng, 201829
                250
                9 (3.6)
                Lv, 201822
                25
                13 (52)
              
              
                Bai, 201728
                40
                2 (5)
                Holster, 201623
                35
                10 (28.6)
              
              
                Bao, 201730
                76
                19 (25)
                Luo, 201524
                36
                21 (58.3)
              
              
                Cheng, 201420
                204
                7 (3.4)
                Hung, 201225
                47
                22 (46.8)
              
              
                Jiang, 200931
                26
                0 (0)
                Sauer, 200226
                40
                12 (30)
              
              
                Wang, 200832
                22
                0 (0%)
                RÃ¶ssle, 199727
                62
                29 (46.8)