Here is the design of a clinical trial:

Official Title: A Randomized, Controlled Trial Comparing Wound COmplications in Elective Midline Laparotomies After FAscia Closure Using Two Different Techniques of Running Sutures: COFACTOR-trial

Included conditions:
- Wound Complication

Study Armgroups:
- {'label': 'Standard arm', 'type': 'NO_INTERVENTION', 'description': 'In the standard arm, an average of one suture will be placed at each cm length of the wound, thus the number of sutures placed should be equal to the length of the wound in cm.'}
- {'label': 'Intervention arm', 'type': 'EXPERIMENTAL', 'description': 'The intervention arm will undergo the alternative/new closure technique with small and close fascia sutures, where each suture will be placed only 5 mm away from the fascia edge and 5 mm apart from the adjacent fascia suture.', 'interventionNames': ['Procedure: New closure technique']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'New closure technique', 'description': 'In the intervention arm, an average of two sutures will be placed at each cm length of the wound, thus the number of sutures placed should be equal to at least double the length of the wound in cm.The aim is to have a ratio of 4:1 between the overall lengths of the suture to the length of the wound being closed', 'armGroupLabels': ['Intervention arm'], 'otherNames': ['Alternative closure technique']}

Primary Outcomes:
- {'measure': 'Incisional hernia', 'description': 'We will define incisional hernia according to the European Society of Hernia: "any abdominal wall gap with or without bulge in the area of a postoperative scar perceptible or palpable by clinical examination or imaging". (7) Using both clinical exam and imaging if performed, these hernias will be described according to their location along the midline, size of the defect using vertical and transverse measurements, and reducibility of any protruding viscera upon lying down or following gentle pressure by the examining hand. Also, we will collect information whether the hernia is causing any pain, discomfort, decrease in mobility, or any incidence of incarceration where the hernia contents protrude and does not reduce to the abdomen upon gentle pressure.', 'timeFrame': '1 year'}

Please estimate the sample size based on the assumption: 
Alpha of 5%, power of 80%, and a 30% loss to follow-up rate.
Sample size {14}
        Millbourn et al. compared long to short continuous stitches and found a drop in incisional hernia rate at 1âyear from 18 to 6% and a drop of SSI from 10 to 5% [6].
        In order to detect a drop of 12% in the incidence of incisional hernia, with an alpha of 5%, we will need to recruit 114 patients per arm to detect this difference with anÂ 80% power thus a total of 228 patientsÂ need to be recruited into the trial. We are expecting a 30% loss to follow-up, so our adjusted target recruitment will be 274 subjects in total.
        After a thorough discussion with our institutionâs admitting officers as well as clinicians and surgeons regarding follow-up visit rate, we reached the conclusion that approximately 30% of patients do not present for follow-up by 12âmonths.