Here is the design of a clinical trial:

Official Title: A Multicenter Noninferior Randomized Controlled Study Comparing the Efficacy of Laparoscopic Versus Abdominal Radical Hysterectomy for Cervical Cancer(Stage IB3,IIA2)

Included conditions:
- Cervical Cancer

Study Armgroups:
- {'label': '1', 'type': 'EXPERIMENTAL', 'description': 'the group of LRH', 'interventionNames': ['Other: Total Laparoscopic or Robotic Radical Hysterectomy']}
- {'label': '2', 'type': 'ACTIVE_COMPARATOR', 'description': 'the group of ARH', 'interventionNames': ['Other: Total Abdominal Radical Hysterectomy']}

Interventions:
- {'type': 'OTHER', 'name': 'Total Laparoscopic or Robotic Radical Hysterectomy', 'description': 'Radical hysterectomy with bilateral pelvic lymph node dissection is performed as standard type C RH by Q-M classification, including cardinal ligaments divided at pelvic sidewall and uterosacral ligaments divided at near the sacral origin and the upper 1/4 to 1/3 of the vagina.', 'armGroupLabels': ['1']}
- {'type': 'OTHER', 'name': 'Total Abdominal Radical Hysterectomy', 'description': 'Radical hysterectomy with bilateral pelvic lymph node dissection is performed as standard type C RH by Q-M classification, including cardinal ligaments divided at pelvic sidewall and uterosacral ligaments divided at near the sacral origin and the upper 1/4 to 1/3 of the vagina.', 'armGroupLabels': ['2']}

Primary Outcomes:
- {'measure': 'the rate of OS at 5 years', 'description': 'Compare between groups(Cox proportional hazards model will be used to estimate the hazard ratio and 95% CI for the effect of treatment on the 5-year OS rate.)', 'timeFrame': '5 years from surgery'}

Please estimate the sample size based on the assumption: 
80% power, a one-sided alpha of 0.025, and a 10% drop-out rate.
Sample size calculation
        This study is a non-inferiority trial, with the primary outcome of 5-year OS rate. The sample size is calculated based on the difference between the two groups of 5-year OS rate. According to clinical data from our hospital, the 5-year OS rate of the open surgery group is estimated to be 72%. Based on the assumptions of (i) the 5-year OS rate of 72% in the open surgery group, (ii) a non-inferiority margin of 8%, (iii) 80% power, and (iv) a one-sided alpha of 0.025, the sample size estimation resulted in 495 subjects per group (SAS software, version 9.4). Assuming a 10% drop-out rate and considering the randomization scheme with a block size of 6, the final sample size is 1104 patients (552 for each group).