Here is the design of a clinical trial:

Official Title: Efficacy of an Internet-based CBT Program for Adjustment Disorders: A Randomized Controlled Trial

Included conditions:
- Online Computerized Program Group
- Waiting List Control Group

Study Armgroups:
- {'label': 'Online Computerized Program group.', 'type': 'EXPERIMENTAL', 'description': 'Intervention group that uses "TAO" program.', 'interventionNames': ['Other: TAO']}
- {'label': 'Waiting list control group.', 'type': 'NO_INTERVENTION', 'description': 'Participants of this group are able to access the treatment program after 7 weeks of waiting period. After this waiting period of 7 weeks, those participants still interested in receiving assistance are randomly assigned to one of two intervention conditions (Online Computerized Program group or Bibliotherapy group).'}

Interventions:
- {'type': 'OTHER', 'name': 'TAO', 'description': '"TAO" is a self-applied online treatment program and consists on the computerized version of the traditional CBT protocol for Adjustment Disorders.\n\nThe treatment protocol comprises different therapeutic components (see section Intervention) which are presented to the patients through 7 modules (one of them introductory). The Internet platform allows audiovisual resources (videos, illustrations, music and exercises that provide quick feedback) to be included, that makes the program more interactive.', 'armGroupLabels': ['Online Computerized Program group.'], 'otherNames': ['TAO: Adjustment Disorders Online', 'Online Computerized CBT for Adjustment Disorders', 'Internet-based CBT for Adjustment Disorders']}

Primary Outcomes:
- {'measure': 'Change in Beck Depression Inventory - Second Edition (BDI-II) (Beck, Steer, & Brown, 1996; validated in Spanish population by Sanz, Navarro, & Vázquez, 2003) score from pre-intervention to post-intervention and 3, 6 and 12 months follow-ups.', 'description': "BDI-II is a self-report inventory that measures characteristic attitudes and symptoms of depression. The total score is obtained adding the 21 items which constitute the instrument and can be a maximum of 63 points. The instrument has good internal consistency (Cronbach's alpha of 0.76 to 0.95) and a test-retest reliability of around 0.8.", 'timeFrame': 'Up to 12 months'}
- {'measure': 'Change in Beck Anxiety Inventory (BAI) (Beck & Steer, 1990; validated in Spanish population by Magán, Sanz, & García-Vera, 2008) score from pre-intervention to post-intervention and 3, 6 and 12 months follow-ups.', 'description': "BAI measures the severity of both physiological and cognitive symptoms of anxiety. The 21 items are rated on a 4-point Likert-type scale (from 0 to 3) and the total score, which oscillates between 0 and 63, is obtained after directly adding the score of each item. Psychometric analysis carried out so far show excellent internal consistency (Cronbach's alpha ≥ 0.85).", 'timeFrame': 'Up to 12 months'}

Please estimate the sample size based on the assumption: 
A significance level of 5%, a power of 80%, and a dropout rate of around 30% were considered.
Sample size
        The sample size for the trial was calculated following the method described by Campbell, Julious, and Altman [37], and Freiman, Chalmers, Smith, and Kuebler [38]. G*Power 3 software [39] was used to facilitate power analysis.
        Because there is no published research on the effectiveness of ICBT for the treatment of AjD, the sample size was calculated taking into account outcomes found in trials that used the BAI and BDI-II as measures of clinical change after an ICBT intervention in patients with clinical depression or anxiety disorder [40â42]. After reviewing the literature and adopting a more conservative approach, an effect size of .70 was assumed in the present study. Considering a significance level of 5% and a power of 80%, 26 participants in each group would be enough to detect the assumed difference. However, because the literature reveals dropout rates from ICBTs of around 30% [43], a sample of 68 participants will be recruited (34 per group).