Here is the design of a clinical trial:

Official Title: Impact on Mortality of an Oxygenation Strategy Including Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial.

Included conditions:
- Acute Respiratory Failure
- Hypoxemic Respiratory Failure

Study Armgroups:
- {'label': 'standard oxygen group', 'type': 'ACTIVE_COMPARATOR', 'description': 'In order to maintain SpO2 between 92 and 96%', 'interventionNames': ['Other: Standard oxygen']}
- {'label': 'high-flow nasal cannula oxygen group', 'type': 'EXPERIMENTAL', 'description': 'At least 50 L/min adjusted in order to maintain SpO2 between 92 and 96 %', 'interventionNames': ['Other: High-flow nasal oxygen therapy']}

Interventions:
- {'type': 'OTHER', 'name': 'Standard oxygen', 'description': 'Standard low flow oxygen therapy through facemask or non-rebreathing mask at least 10 L/min.', 'armGroupLabels': ['standard oxygen group']}
- {'type': 'OTHER', 'name': 'High-flow nasal oxygen therapy', 'description': 'Humidified and heated oxygen with a gas flow at least 50 l/min through nasal cannula and inspired fraction of oxygen adjusted in order to maintain a SpO2 between 92 and 96%', 'armGroupLabels': ['high-flow nasal cannula oxygen group']}

Primary Outcomes:
- {'measure': 'Mortality at 28 days after randomization', 'description': 'Death between randomization and 28 days after randomization', 'timeFrame': 'Day 28'}

Please estimate the sample size based on the assumption: 
Power of 80% (beta risk of 0.2) and a two-sided alpha level of 0.05.
Sample size
        In accordance with the literature and our previous study,1 18 we determined that randomisation of 1110 patients would provide a power of 80% (beta risk of 0.2) to show an absolute difference of 6% in rate of mortality at day 28, between the control groups using standard oxygen (mortality rate estimated at 18%) and the experimental group using high-flow nasal oxygen (mortality rate estimated at 12%), at two-sided alpha level of 0.05.