Here is the design of a clinical trial:

Official Title: Multimodal Neuronavigation Guiding Precision Bypass in Adult Ischemic Patients With Moyamoya Disease

Included conditions:
- Moyamoya Disease

Study Armgroups:
- {'label': 'Precision bypass group', 'type': 'ACTIVE_COMPARATOR', 'description': 'Using ICG with Flow800 software and multimodal neuronavigation to choose the recipient vessel', 'interventionNames': ['Procedure: Precision bypass group']}
- {'label': 'Empirical group', 'type': 'NO_INTERVENTION', 'description': "choosing the recipient vessel by the surgeon's own experience"}

Interventions:
- {'type': 'PROCEDURE', 'name': 'Precision bypass group', 'description': 'With the brain cortex exposed after craniotomy, an initial ICG fluorescence angiography will be performed. ICG fluorescence angiography using Flow800 software to determine blood flow velocity and cortical perfusion in different candidate receptors. And electromagnetic neuronavigation system is used to evaluate the cerebral flow under different candidate recipient vessels. The treatment planning station will be situated based on the multimodal neuronavigation data. The vessel was chose as the receptor with lower flow velocity and lower cerebral perfusion area to perform anastomosis. Then a direct bypass surgery will be performed just like in the empirical direct bypass surgery group.', 'armGroupLabels': ['Precision bypass group']}

Primary Outcomes:
- {'measure': 'ischemic events', 'description': 'All strokes \\& death within 30 days post-surgery and ipsilateral infarctions afterwards', 'timeFrame': '30 days'}

Please estimate the sample size based on the assumption: 
Prospective, exploratory, randomised controlled trial
Sample size
        Because this trial is a prospective, exploratory, randomised controlled trial, there is no previous data for multimodal neuronavigation-guided precise bypass procedure, the sample size for this trial canât be calculated from the formula. Finally, 100 patients are randomised (1:1) to two groups, 50 of them will undergo direct bypass guided by multimodal neuronavigation, while others will undergo empirical direct bypass procedure.