Here is the design of a clinical trial:

Official Title: HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial

Included conditions:
- Hip Fractures

Study Armgroups:
- {'label': 'Accelerated medical clearance and surgery', 'type': 'EXPERIMENTAL', 'description': 'Rapid medical clearance with targeted arrival to the operating room within 6 hours of diagnosis of a hip fracture requiring surgical repair.', 'interventionNames': ['Other: Accelerated medical clearance and surgery']}
- {'label': 'Standard surgical care', 'type': 'NO_INTERVENTION', 'description': 'Surgical hip fracture repair according to the standard timing.'}

Interventions:
- {'type': 'OTHER', 'name': 'Accelerated medical clearance and surgery', 'description': 'Rapid medical clearance with targeted arrival to the operating room within 6 hours of diagnosis of a hip fracture requiring surgical repair.', 'armGroupLabels': ['Accelerated medical clearance and surgery']}

Primary Outcomes:
- {'measure': 'Composite - major perioperative complication', 'description': 'Composite of mortality, nonfatal myocardial infarction, nonfatal pulmonary embolism, nonfatal pneumonia, nonfatal sepsis, nonfatal stroke, and nonfatal life-threatening and major bleeding', 'timeFrame': '90 days'}
- {'measure': 'Mortality', 'description': 'All-cause mortality', 'timeFrame': '90 days'}

Please estimate the sample size based on the assumption: 
Significance level (two-sided α) of 0.05, over 80% power, and accounting for 4% missing AKI status.
Sample size
          The main HIP ATTACK trial enrolled 3001 patients, and more than 90% of these patients were enrolled after the initiation of the renal substudy protocol. We expect that approximately 74% of these patients will be eligible for inclusion in the kidney substudy. A sample of 1998 patients will provide over 80% power to detect a relative risk (RR) reduction of 30% for the primary outcome of AKI (two-sided Î±=0.05), comparing the accelerated approach to usual care, assuming the incidence of AKI is 14% in the usual-care group, after accounting for 4% missing AKI status. Approximately 10%â12% of patients develop postoperative AKI.17 18 In hip fracture patients, AKI incidence is even higher, around 15%â20%.10â12 With these data in mind, we used a conservative 14% AKI incidence for the usual care group to perform the sample size calculation to ensure we would have adequate statistical power to detect a 30% RR reduction in the primary outcome, if it in truth exists.