Here is the design of a clinical trial:

Official Title: Comparison of Posterior Muscle-preserving Selective Laminectomy and Laminectomy With Fusion for Treating Degenerative Cervical Myelopathy: Myelopathy Randomized Controlled Trial (MyRanC)

Included conditions:
- Cervical Spondylotic Myelopathy

Study Armgroups:
- {'label': 'Muscle preserving selective laminectomy (L-group)', 'type': 'EXPERIMENTAL', 'description': 'Muscle-preserving selective laminectomy with a posterior midline incision and dissection through the nuchal fascia. The spinous processes are split in the midline using a high-speed burr/ultrasound knife and without disturbing the deep extensor muscles on either side. Angulating away from the midline, the spinous processes are divided at their bases. Laminectomy is performed with a width no more than 2-3 mm wider than the dural borders. The facet joints are not exposed. Finally, the split spionous processes are sutured together. No collar or restrictions will be used in either group.', 'interventionNames': ['Procedure: Muscle preserving selective laminectomy']}
- {'label': 'Laminectomy with instrumented fusion (LF-group)', 'type': 'ACTIVE_COMPARATOR', 'description': 'Laminectomy with instrumented fusion with a midline incision over the appropriate levels defined as the same levels as the extension of laminectomy plus one level above and below but not extending beyond C3-C7. Soft tissue dissection and retraction is performed to identify osseous landmarks. Special care is taken to spare muscle attachments on C2 and C7. Spinal instrumentation is performed with lateral mass or pedicle screws (C3-C7) combined with rod fixation. Laminectomy is performed with a width not extending more than 2 mm outside the dural borders. Facet joint injury should be avoided. Special care is taken to spare the C7 spinous process and distal half of C7 lamina. The sagittal alignment is corrected before spinal fixation. No collar or restrictions will be used in either group.', 'interventionNames': ['Procedure: Laminectomy with instrumented fusion']}

Interventions:
- {'type': 'PROCEDURE', 'name': 'Muscle preserving selective laminectomy', 'description': 'Muscle-preserving selective laminectomy differ from traditional laminectomy by the spinous process split that preserves the deep extensor muscles. The bilateral facet joints are not exposed. After the laminectomy is finished the split fragments of the spinous process are sutured together so that the deep extensor muscles are restored.', 'armGroupLabels': ['Muscle preserving selective laminectomy (L-group)']}
- {'type': 'PROCEDURE', 'name': 'Laminectomy with instrumented fusion', 'description': 'A traditional laminectomy is complemented with lateral mass and/or pedicle screws connected with rods.', 'armGroupLabels': ['Laminectomy with instrumented fusion (LF-group)']}

Primary Outcomes:
- {'measure': 'The primary endpoint will be reoperation for any reason to reflect whether laminectomy alone or laminectomy with instrumented fusion results in fewer reoperations without increasing the frequency of complications.', 'description': 'Reoperation will be considered in case of:\n\n* Postoperative hematoma or reperfusion injury with neurologic deterioration within hours/days after the primary surgery.\n* Change in sagittal alignment (kyphosis, DJK of more than 40 mm cSVA and/or C2-C7 Cobb \\< -10°) with corresponding symptoms of camptocormia/increased pain/neurological deterioration.\n* ASP defined as degenerative changes on an adjacent level diagnosed with MRI and concomitant symptoms of myelopathy and/or radiculopathy.\n* Implant failure (clear radiolucency around \\>1 screw or rod breakage with increased neck pain and/or neurologic deterioration).\n* Postoperative infection that requires revision surgery.', 'timeFrame': 'Recorded at 5 years of follow-up'}

Please estimate the sample size based on the assumption: 
Significance level not explicitly stated; power of 86% based on simulation; 5% loss due to dropout and emigration.
Sample size {14}
        Based on data from the national Swedish spine registry on patients with CSM, reoperation was estimated to be 3.5% after stand-alone laminectomy and 7.4% after laminectomy and fusion. Five-year mortality was estimated to be 16.3% in the same population [31].
        We further determined that excluding a 5% excess rate of reoperation in the laminectomy group vs laminectomy and fusion was a clinically relevant target for the study and therefore set the non-inferiority margin at 5 percentage points (pp).
        With a planned sample size of 300 participants and with regard to mortality and an additional 5% loss due to dropout and emigration, we end up with 236 analyzable patients. This results in a power of 86% based on simulation using rerandomization. The reason for stopping at 300 patients was made on the calculation on how many patients it is reasonable for the four sites to include in 4â5 years. Ideally, we would have reached for 90% power but have agreed to compromise with a power over 85% if that means that we will finish the study in due time.
        All statistical analyses were performed in R [32], version 4.0.5 (R Foundation for Statistical Computing, Vienna, Austria), and the R code used in the sample size calculation may be received upon request.