Here is the design of a clinical trial:

Official Title: Effectiveness of the Integrated Care Model Salut+Social in Patients With Chronic Conditions: a Mixed Methods Study Protocol

Included conditions:
- Integrated Care

Study Armgroups:
- {'label': 'integrated-care-model benefiting group', 'type': 'EXPERIMENTAL', 'description': 'Chronic patients whose clinical and social data will be added in the integrated care model application software.', 'interventionNames': ['Other: integrated-care-model benefiting group']}

Interventions:
- {'type': 'OTHER', 'name': 'integrated-care-model benefiting group', 'description': 'Patients will be called for the ﬁrst interview of the study by the healthcare professional. Their data will be automatically entered in the Salut + Social app, they will be asked to respond to the study questionnaires (ad hoc questionnaire for sociodemographic data, EuroQol-5D, Zarit questionnaire and Morisky-Green test) and will take part in the future actions to be planned for them. Patients will receive an appointment to attend their PCC at 6, 9, and 12 months after their incorporation into the program. In those follow-up, the same questionnaires will be provided together with the IEXPAC questionnaire, which evaluates the experience of the chronic patient with the new care model.', 'armGroupLabels': ['integrated-care-model benefiting group']}

Primary Outcomes:
- {'measure': 'Change in life quality', 'description': 'to be evaluated with the EuroQol- 5 Dimension (EQ-5D). It will be measured by a scale Likert: 0 (worst) to 1 (best).', 'timeFrame': 'change from life quality at 6, 9 and 12 months after the beginning of the study.'}
- {'measure': 'Change in caregiver burden', 'description': 'to be evaluated with the Zarit Caregiver Burden Inventory. It will be measured by a scale Likert: 22 (best) to 110 (worst).', 'timeFrame': 'change from Zarit Caregiver Burden Inventory at 6, 9 and 12 months after the beginning of the study.'}
- {'measure': 'Change in adherence to treatment', 'description': 'be evaluated with the Morisky and Green test. It will be measured with a dichotomic variable: compliant (if response for the 4 questions is: No/Yes/No/No); noncompliant (if response for the 4 questions is different for: No/Yes/No/No).', 'timeFrame': 'change from Morisky and Green test at 6, 9 and 12 months after the beginning of the study.'}
- {'measure': 'Change in patient experience about his/her care', 'description': "Be evaluated with the IEXPAC (Instrument for the Evaluation of the Chronic Patient's Experience). Each of the 11 items will be measured with 5-point Likert scale. The global punctuation is an average of the score of the each of the items: 0 (worst experience) to 10 (best experience).", 'timeFrame': 'change from IEXPAC at 6, 9 and 12 months after the beginning of the study'}

Please estimate the sample size based on the assumption: 
95% confidence level, 80% power
2.2.1
          Study design and sample size
          We will carry out a single group clinical trial to evaluate the effect of the implementation of a new integrated care model. The principal dependent variable is quality of life. In order to detect a difference of at least 3 units in the EuroQol-5D questionnaire, with 95% confidence and a power of 80%, the sample size should be at least of 141 subjects. Convenience sampling will be used.