text:
Patent US7018620 - Delivery of beta-blockers through an inhalation route - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe present invention relates to the delivery of atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route. Specifically, it relates to aerosols containing atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a method aspect of the...http://www.google.com/patents/US7018620?utm_source=gb-gplus-sharePatent US7018620 - Delivery of beta-blockers through an inhalation routeAdvanced Patent SearchPublication numberUS7018620 B2Publication typeGrantApplication numberUS 10/775,583Publication dateMar 28, 2006Filing dateFeb 9, 2004Priority dateMay 24, 2001Fee statusLapsedAlso published asCA2446904A1, CA2446916A1, CA2446916C, CA2446917A1, CA2446917C, CA2446990A1, CA2446990C, CA2447099A1, CA2447099C, CA2447166A1, CA2447166C, CA2447521A1, CA2447521C, DE60220909D1, DE60220909T2, DE60228232D1, DE60235851D1, DE60235852D1, EP1389094A1, EP1389094B1, EP1389095A1, EP1389096A1, EP1389096B1, EP1389096B9, EP1389097A1, EP1389097B1, EP1389098A1, EP1389098B1, EP1389099A1, EP1390021A1, EP1390021B1, EP1392257A1, EP1392257B1, EP1392259A2, EP1392259B1, EP1392261A2, EP1392261B1, EP1392262A1, EP1392264A1, EP1392264B1, EP1987823A1, EP1987823B1, EP1990046A1, EP1990046B1, US6716415, US6716416, US6716417, US6737042, US6740307, US6740308, US6740309, US6743415, US6776978, US6780399, US6780400, US6783753, US6797259, US6803031, US6805854, US6814954, US6814955, US6855310, US6884408, US6994843, US7005121, US7005122, US7008615, US7008616, US7011820, US7014840, US7014841, US7022312, US7029658, US7033575, US7045118, US7048909, US7052679, US7052680, US7060254, US7063830, US7063831, US7063832, US7067114, US7070761, US7070762, US7070763, US7070764, US7070765, US7070766, US7078017, US7078018, US7078019, US7078020, US7087216, US7087217, US7094392, US7108847, US7115250, US7169378, US7442368, US7445768, US7449172, US7449174, US7449175, US7465435, US7465436, US7465437, US7468179, US7485285, US7491047, US7507397, US7507398, US7510702, US7524484, US7601337, US7988952, US8173107, US20030000518, US20030005924, US20030007933, US20030007934, US20030012737, US20030012740, US20030015189, US20030015190, US20030017114, US20030017115, US20030017116, US20030017117, US20030017118, US20030017119, US20030017120, US20030021753, US20030021754, US20030021755, US20030206869, US20040126326, US20040126327, US20040126328, US20040126329, US20040127481, US20040156788, US20040156789, US20040156790, US20040156791, US20040161385, US20040167228, US20040170569, US20040170573, US20040184996, US20040184997, US20040184998, US20040184999, US20040185000, US20040185001, US20040185002, US20040185004, US20040185005, US20040185006, US20040185007, US20040185008, US20040186130, US20040191179, US20040191180, US20040191181, US20040191182, US20040191183, US20040191184, US20040191185, US20040202617, US20040228807, US20050075273, US20050089479, US20060153779, US20060177382, US20060216243, US20060216244, US20060233719, US20060239936, US20060246011, US20060246012, US20060251587, US20060251588, US20060257329, US20060269487, US20060280692, US20060286042, US20060286043, US20070014737, US20070178052, US20080175796, US20090246147, WO2002094236A1, WO2002094236A9Publication number10775583, 775583, US 7018620 B2, US 7018620B2, US-B2-7018620, US7018620 B2, US7018620B2InventorsJoshua D. Rabinowitz, Alejandro C. ZaffaroniOriginal AssigneeAlexza Pharmaceuticals, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (103), Non-Patent Citations (79), Referenced by (5), Classifications (147), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetDelivery of beta-blockers through an inhalation route
US 7018620 B2Abstract
The present invention relates to the delivery of atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route. Specifically, it relates to aerosols containing atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a method aspect of the present invention, atenolol, pindolol, esmolol, propranolol, or metoprolol is administered to a patient through an inhalation route. The method comprises: a) heating a composition of atenolol, pindolol, esmolol, propranolol, or metoprolol, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route is provided which comprises: a) a thin coating of an atenolol, pindolol, esmolol, propranolol, or metoprolol composition and b) a device for dispensing said thin coating as a condensation aerosol.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3219533Nov 29, 1962Nov 23, 1965Merck & Co IncAerosol solid medicament in propellant and low-level ethanol avoiding higher-level ethanol dispersed-solid reflocculationUS3560607Jul 5, 1968Feb 2, 1971Fisons Pharmaceuticals LtdAerosol formulations of finely divided solid medicaments with anionic surface-active agentsUS3949743Sep 6, 1974Apr 13, 1976Schick IncorporatedMedicated vapor production method and apparatusUS3982095Oct 4, 1973Sep 21, 1976Searle Cardio-Pulmonary Systems Inc.Respiratory humidifierUS4141369Jan 24, 1977Feb 27, 1979Burruss Robert PNoncombustion system for the utilization of tobacco and other smoking materialsUS4303083Oct 10, 1980Dec 1, 1981Burruss Jr Robert PDevice for evaporation and inhalation of volatile compounds and medicationsUS4474191Sep 30, 1982Oct 2, 1984Steiner Pierre GTar-free smoking devicesUS4484576Oct 3, 1983Nov 27, 1984Dragerwerk AktiengesellschaftApparatus for admixing liquid anesthetics and respiratory gasUS4566451Jul 1, 1983Jan 28, 1986Plantorgan Werk Heinrich G. E. Christensen KgVapor inhalation deviceUS4708151Mar 14, 1986Nov 24, 1987R. J. Reynolds Tobacco CompanyPipe with replaceable cartridgeUS4734560Jan 20, 1987Mar 29, 1988Medical Enterprises, Ltd.Vaporizing unitUS4735217Aug 21, 1986Apr 5, 1988The Procter & Gamble CompanyDosing device to provide vaporized medicament to the lungs as a fine aerosolUS4819665Jan 23, 1987Apr 11, 1989R. J. Reynolds Tobacco CompanyAerosol delivery articleUS4848374Jun 10, 1988Jul 18, 1989Chard Brian CSmoking deviceUS4853517Mar 28, 1988Aug 1, 1989John G. BowenVaporizing unitUS4895719Mar 6, 1987Jan 23, 1990Liposome Technology, Inc.Suspension, encapsulation, drug deliveryUS4906417May 3, 1989Mar 6, 1990Associated Mills Inc.HumidifierUS4917119Nov 30, 1988Apr 17, 1990R. J. Reynolds Tobacco CompanyDrug delivery articleUS4924883Mar 6, 1987May 15, 1990R. J. Reynolds Tobacco CompanySmoking articleUS4941483Sep 18, 1989Jul 17, 1990R. J. Reynolds Tobacco CompanyAerosol delivery articleUS4963289Jun 8, 1989Oct 16, 1990The United States Of America As Represented By The United States Department Of EnergyNebulizing, vaporizing, cooling a mixture of aqueous and organic solutionsUS5042509Aug 21, 1987Aug 27, 1991R. J. Reynolds Tobacco CompanyMethod for making aerosol generating cartridgeUS5049389Dec 1, 1989Sep 17, 1991Liposome Technology, Inc.Novel liposome composition for the treatment of interstitial lung diseasesUS5060671Dec 1, 1989Oct 29, 1991Philip Morris IncorporatedFlavor generating articleUS5099861Feb 27, 1990Mar 31, 1992R. J. Reynolds Tobacco CompanyAerosol delivery articleUS5135009Mar 9, 1990Aug 4, 1992B.A.T. Cigarettenfabriken GmbhSmokable articleUS5144962Dec 1, 1989Sep 8, 1992Philip Morris IncorporatedFlavor-delivery articleUS5146915Jan 8, 1991Sep 15, 1992The Boc Group PlcAnesthetic vaporizersUS5224498Dec 5, 1991Jul 6, 1993Philip Morris IncorporatedElectrically-powered heating elementUS5345951Aug 12, 1992Sep 13, 1994Philip Morris IncorporatedSmoking articleUS5366770Sep 13, 1993Nov 22, 1994Xingwu WangCoating nickel substrate with zirconium, calcium and yttrium compounds using ultrasonic waves; radio frequency radiation; vaporizationUS5388574Jul 29, 1993Feb 14, 1995Ingebrethsen; Bradley J.Aerosol delivery articleUS5456247Aug 26, 1993Oct 10, 1995Iowa State University Research Foundation, Inc.Method for delivering drugs soluble in a vaporization vehicleUS5511726Feb 23, 1993Apr 30, 1996Battelle Memorial InstituteNebulizer deviceUS5544646May 20, 1994Aug 13, 1996Aradigm CorporationSystems for the intrapulmonary delivery of aerosolized aqueous formulationsUS5564442Nov 22, 1995Oct 15, 1996Angus Collingwood MacDonaldBattery powered nicotine vaporizerUS5592934Jun 22, 1994Jan 14, 1997The Boc Group PlcAnaesthetic vaporizerUS5605146Nov 29, 1994Feb 25, 1997Instrumentarium OyMethod and an arrangement in connection with vaporizing an anaestheticUS5649554Oct 16, 1995Jul 22, 1997Philip Morris IncorporatedElectrical lighter with a rotatable tobacco supplyUS5655523May 22, 1995Aug 12, 1997Minnesota Mining And Manufacturing CompanyDry powder inhalation device having deagglomeration/aerosolization structure responsive to patient inhalationUS5666977Dec 23, 1994Sep 16, 1997Philip Morris IncorporatedElectrical smoking article using liquid tobacco flavor medium delivery systemUS5694919Oct 27, 1995Dec 9, 1997Aradigm CorporationHand-held, portable, self-contained aerosol drug delivery systemUS5735263Apr 15, 1996Apr 7, 1998Aradigm CorporationLockout device for controlled release of drug from patient-activated dispenserUS5738865Dec 30, 1996Apr 14, 1998Edward Mendell Co., Inc.Controlled release insufflation carrier for medicamentsUS5743251May 15, 1996Apr 28, 1998Philip Morris IncorporatedAerosol and a method and apparatus for generating an aerosolUS5758637Feb 21, 1996Jun 2, 1998Aerogen, Inc.Apparatus for nebulizing a liquidUS5819756Aug 17, 1994Oct 13, 1998Mielordt; SvenSmoking or inhalation deviceUS5840246Aug 6, 1996Nov 24, 1998Reckitt & Colman Inc.Oil lamp with fragrance emanatorUS5855913Jan 16, 1997Jan 5, 1999Massachusetts Instite Of TechnologyParticles incorporating surfactants for pulmonary drug deliveryUS5874481Jun 7, 1995Feb 23, 1999Alliance Pharmaceutical Corp.Fluorochemical solutions for the delivery of lipophilic pharmaceutical agentsUS5894841Jun 28, 1994Apr 20, 1999Ponwell Enterprises LimitedDispenserUS5915378Oct 27, 1995Jun 29, 1999Aradigm CorporationCreating an aerosolized formulation of insulinUS5918595Dec 20, 1996Jul 6, 1999Siemens-Elema AbMethod for vaporizing an anesthetic liquid and vaporizer operating according to the methodUS5934272Oct 27, 1995Aug 10, 1999Aradigm CorporationDevice and method of creating aerosolized mist of respiratory drugUS5957124Sep 27, 1995Sep 28, 1999Aradigm CorporationDynamic particle size control for aerosolized drug deliveryUS5960792Oct 27, 1995Oct 5, 1999Aradigm CorporationDevice for aerosolized delivery of peptide drugsUS5993805Jun 7, 1995Nov 30, 1999Quadrant Healthcare (Uk) LimitedSpray-dried microparticles and their use as therapeutic vehiclesUS6041777 *Dec 1, 1995Mar 28, 2000Alliance Pharmaceutical Corp.Methods and apparatus for closed-circuit ventilation therapyUS6051566Mar 2, 1998Apr 18, 2000B.S.D. Bio Science Development Snc Di Omini C. & Zuccari G.Anti-reactive anti-asthmatic activity of non-steroidal anti-inflammatory drugs by inhalationUS6090212Aug 15, 1997Jul 18, 2000Micro C Technologies, Inc.Substrate platform for a semiconductor substrate during rapid high temperature processing and method of supporting a substrateUS6095134Apr 24, 1997Aug 1, 2000The Board Of Regents Of The University Of CoMethods and apparatus for fine particle formationUS6095153Jun 19, 1998Aug 1, 2000Kessler; Stephen B.Vaporization of volatile materialsUS6102036Jul 30, 1998Aug 15, 2000Smoke-StopBreath activated inhalerUS6131570Jun 30, 1998Oct 17, 2000Aradigm CorporationTemperature controlling device for aerosol drug deliveryUS6136295Dec 15, 1998Oct 24, 2000Massachusetts Institute Of TechnologyBiocompatible particles for delivery of a therapeutic, prophylactic or diagnostic agent to the pulmonary system comprising a therapeutic, prophylactic or diagnostic agentUS6155268Jul 23, 1998Dec 5, 2000Japan Tobacco Inc.Flavor-generating deviceUS6158431Feb 13, 1998Dec 12, 2000Tsi IncorporatedPortable systems and methods for delivery of therapeutic material to the pulmonary systemUS6234167Oct 14, 1998May 22, 2001Chrysalis Technologies, IncorporatedAerosol generator and methods of making and using an aerosol generatorUS6241969Jun 26, 1998Jun 5, 2001Elan Corporation PlcAqueous compositions containing corticosteroids for nasal and pulmonary deliveryUS6255334Sep 1, 1999Jul 3, 2001Pfizer Inc5HT 1 receptor agonists and metoclopramide for the treatment of migraineUS6306431Apr 7, 2000Oct 23, 2001Zars, Inc.Dermal drug delivery systemUS6506762Sep 29, 2000Jan 14, 2003Neurogen CorporationCertain alkylene diamine-substituted heterocyclesUS6514482 *Sep 19, 2000Feb 4, 2003Advanced Inhalation Research, Inc.Pulmonary delivery in treating disorders of the central nervous systemUS6591839Mar 28, 2001Jul 15, 2003Dieter MeyerFilter material for reducing harmful substances in tobacco smokeUS6632047Apr 16, 2001Oct 14, 2003Board Of Regents, The University Of Texas SystemHeater element for use in an in situ thermal desorption soil remediation systemUS6701922Dec 20, 2001Mar 9, 2004Chrysalis Technologies IncorporatedMouthpiece entrainment airflow control for aerosol generatorsUS6740307 *May 20, 2002May 25, 2004Alexza Molecular Delivery CorporationDelivery of β-blockers through an inhalation routeUS6772756Feb 9, 2002Aug 10, 2004Advanced Inhalation Revolutions Inc.Method and system for vaporization of a substanceUS20010020147Feb 26, 2001Sep 6, 2001John StaniforthDelivery of oral drugsUS20020037828Jun 21, 2001Mar 28, 2002Wilson Leland F.Pretreatment sexual intercourseUS20020058009Jun 8, 2001May 16, 2002Advanced Inhalation Research, Inc.Pulmonary delivery in treating disorders of the central nervous systemUS20020086852May 23, 2001Jul 4, 2002Cantor Jerome O.Method for treating respiratory disorders associated with pulmonary elastic fiber injuryUS20020112723Sep 20, 2001Aug 22, 2002Schuster Jeffrey A.Temperature controlling device for aerosol drug deliveryUS20020117175Oct 29, 2001Aug 29, 2002Kottayil S. GeorgeThermal vaporizing device for drug deliveryUS20020176841Mar 19, 2002Nov 28, 2002Praecis Pharmaceuticals Inc.Pharmaceutical formulations for sustained releaseUS20030000518May 23, 2002Jan 2, 2003Rabinowitz Joshua D.Delivery of nonsteroidal antiinflammatory drugs through an inhalation routeUS20030004142Apr 17, 2002Jan 2, 2003Prior Christopher P.In situ supplying; anticancer, antitumor agentsUS20030005924May 20, 2002Jan 9, 2003Rabinowitz Joshua D.Delivery of beta-blockers through an inhalation routeUS20030005925May 22, 2002Jan 9, 2003Hale Ron L.Delivery of rizatriptan or zolmitriptan through an inhalation routeUS20030007933May 15, 2002Jan 9, 2003Rabinowitz Joshua D.Delivery of muscle relaxants through an inhalation routeUS20030007934May 15, 2002Jan 9, 2003Rabinowitz Joshua D.Delivery of stimulants through an inhalation routeUS20030012737May 21, 2002Jan 16, 2003Rabinowitz Joshua D.Delivery of diphenhydramine through an inhalation routeUS20030012738May 22, 2002Jan 16, 2003Rabinowitz Joshua D.Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation routeUS20030012740May 20, 2002Jan 16, 2003Rabinowitz Joshua D.Aerosols especially containing benzotropine, pergolide, ropinerole, amantadine or deprenyl.US20030015189May 21, 2002Jan 23, 2003Rabinowitz Joshua D.Delivery of antihistamines through an inhalation routeUS20030015190May 23, 2002Jan 23, 2003Rabinowitz Joshua D.Delivery of compounds for the treatment of migraine through an inhalation routeUS20030015196May 13, 2002Jan 23, 2003Hodges Craig C.Aerosol forming device for use in inhalation therapyUS20030017114May 23, 2002Jan 23, 2003Rabinowitz Joshua D.Aerosol comprises particles of chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine.US20030017115May 13, 2002Jan 23, 2003Rabinowitz Joshua D.Aerosol comprises particles comprising at least 10 percent by weight of a drug ester.US20030017116May 17, 2002Jan 23, 2003Rabinowitz Joshua D.Delivery of sedative-hypnotics through an inhalation routeUS20030017117May 16, 2002Jan 23, 2003Rabinowitz Joshua D.Delivery of analgesics through an inhalation routeUS20040016427 *Mar 24, 2003Jan 29, 2004Byron Peter R.Method and apparatus for generating an aerosolUSRE30285Feb 4, 1977May 27, 1980 Spraying devices, in particular nebulizing devices* Cited by examinerNon-Patent CitationsReference1Bennett, R.L. et al. (1981). "Patient-Controlled Analgesia: A New Concept of Postoperative Pain Relief," Annual Surg. 195(6):700-705.2Carroll, M.E. et al. (1990), "Cocaine-base smoking in rhesus monkeys: reinforcing and physiological effects," Psychopharmacology (Berl). 102:443-450.3Clark, A. and Byron, P. (1986). "Dependence of Pulmonary Absorption Kinetics on Aerosol Particle Size," A. Erkrank. 166:13-24.4Darquenne, C. et al. (1997). "Aerosol Dispersion in Human Lung: Comparison Between Numberical Simulations and Experiments for Bolus Tests," American Physiological Society, 966-974.5Davies, C.N. et al. (May 1972). "Breathing of Half-Micron Aerosols," Journal of Applied Physiology. 32(5):591-600.6Dershwitz, M., M.D., et al. (Sep. 2000). "Pharmacokinetics and Pharmacodynamics of Inhaled versus Intravenous Morphine in Healthy Volunteers," Anesthesiology. 93(3): 619-628.7Finlay, W.H. (2001). "The Mechanics of Inhaled Pharmaceutical Aerosols", Academic Press: San Diego Formula 2.39. pp. 3-14 (Table of Contents). pp. v-viii.8Gonda,I. (1991). "Particle Deposition in the Human Respiratory Tract," Chapter 176, The Lung: Scientific Foundations. Crystal R.G. and West, J.B. (eds.), Raven Publishers, New York. pp. 2289-2294.9Hatsukami D, et al. (May 1990) "A method for delivery of precise doses of smoked cocaine-base to humans." Pharmacology Biochemistry & Behavior. 36(1):1-7.10Heyder, J. et al. (1986). "Deposition of Particles in the Human Respiratory Tract in the Size Range 0.005-15 mum," J. Aerosol Sci. 17(5):811-822.11Huizer, H., "Analytical studies on illicit heron. V. Efficacy of volatilization during heroin smoking." Pharmaceutisch Weekblad Scientific Edition (1987). 9(4):203-211.12Hurt, R.D., MD and Robertson, C.R., PhD, (Oct. 1998). "Prying Open the Door to the Tobacco Industry's Secrets About Nicotine: The Minnesota Tobacco Trial," JAMA 280(13):1173-1181.13Lichtman, A.H. et al. (1996). "Inhalation Exposure to Volatilized Opioids Produces Antinociception in Mice," Journal of Pharmacology and Experimental Therapeutics, 279(1):69-76.14Martin, B.R. and Lue, L.P. (May/Jun. 1989). "Pyrolysis and Volatilization of Cocaine," Journal of Analytical Toxicology 13:158-162.15Mattox, A.J. and Carroll, M.E., (1996). "Smoked heroin self-administration in rhesus monkeys," Psychopharmacology, 125:195-201.16Meng, Y. et al. Inhalation Studies With Drugs of Abuse, NIDA Research Monograph, (1997) 173:201-224.17Meng, Y., et al. (1999). "Pharmacological effects of methamphetamine and other stimulants via inhalation exposure," Drug and Alcohol Dependence, 53:111-120.18Pankow, J. (Mar. 2000). ACS Conference-San Francisco-Mar. 26, 2000. Chemistry of Tobacco Smoke. pp. 1-8.19Pankow, J.F. et al. (1997). "Conversion of Nicotine in Tobacco Smoke to Its Volatile and Available Free-Base Form Through the Action of Gaseous Ammonia," Envron. Sci. Technol. 31:2428-2433.20Seeman, J. et al. (1999). "The Form of Nicotine in Tobacco. Thermal Transfer of Nicotine and Nicotine Acid Salts to Nicotine in the Gas Phase," J. Agric. Food Chem. 47(12):5133-5145.21Sekine, H. and Nakahara, Y. (1987). "Abuse of Smoking Methamphetamine Mixed with Tobacco: 1. Inhalation Efficiency and Pyrolysis Products of Methamphetamine," Journal of Forensic Science 32(5):1271-1280.22U.S. Appl. No. 10/057,197 filed Oct. 26, 2001, "Aerosol Generating Device And Method".23U.S. Appl. No. 10/057,198 filed Oct. 26, 2001 "Method And Device For Delivering A Physiologically Active Compound".24U.S. Appl. No. 10/057,198, filed Oct. 26, 2001, Lloyd et al.25U.S. Appl. No. 10/146,080 filed May 13, 2002, "Aerosol Forming Device For Use In Inhalation Therapy".26U.S. Appl. No. 10/146,088, filed May 13, 2002, Hale et al.27U.S. Appl. No. 10/153,313 filed May 21, 2002 "Delivery of Benzodiazepines Through an Inhalation Route".28U.S. Appl. No. 10/280,315, filed Oct. 25, 2002, Shen.29U.S. Appl. No. 10/302,614, filed Nov. 21, 2002, Lu.30U.S. Appl. No. 10/322,227, filed Dec. 17, 2002, Novack et al.31U.S. Appl. No. 10/442,385, filed May 20, 2003, Cross et al.32U.S. Appl. No. 10/633,876, filed Aug. 4, 2003, Hale et al.33U.S. Appl. No. 10/633,877, filed Aug. 4, 2003, Hale et al.34U.S. Appl. No. 10/719,540, filed Nov. 20, 2003, Hale et al.35U.S. Appl. No. 10/749,537, filed Dec. 30, 2003, Rabinowitz et al.36U.S. Appl. No. 10/749,539, filed Dec. 30, 2003, Rabinowitz et al.37U.S. Appl. No. 10/766,149, filed Jan. 27, 2004, Rabinowitz et al.38U.S. Appl. No. 10/766,279, filed Jan. 27, 2004, Rabinowitz et al.39U.S. Appl. No. 10/766,566, filed Jan. 27, 2004, Rabinowitz et al.40U.S. Appl. No. 10/766,574, filed Jan. 27, 2004, Rabinowitz et al.41U.S. Appl. No. 10/766,634, filed Jan. 27, 2004, Rabinowitz et al.42U.S. Appl. No. 10/766,647, filed Jan. 27, 2004, Rabinowitz et al.43U.S. Appl. No. 10/767,115, filed Jan. 28, 2004, Rabinowitz et al.44U.S. Appl. No. 10/768,205, filed Jan. 29, 2004, Rabinowitz et al.45U.S. Appl. No. 10/768,220, filed Jan. 29, 2004, Rabinowitz et al.46U.S. Appl. No. 10/768,281, filed Jan. 29, 2004, Rabinowitz et al.47U.S. Appl. No. 10/768,293, filed Jan. 29, 2004, Rabinowitz et al.48U.S. Appl. No. 10/769,046, filed Jan. 30, 2004, Rabinowitz et al.49U.S. Appl. No. 10/769,051, filed Jan. 30, 2004, Rabinowitz et al.50U.S. Appl. No. 10/769,157, filed Jan. 29, 2004, Rabinowitz et al.51U.S. Appl. No. 10/769,197, filed Jan. 29, 2004, Rabinowitz et al.52U.S. Appl. No. 10/775,586, filed Feb. 9, 2004, Rabinowitz et al.53U.S. Appl. No. 10/791,915, filed Mar. 3, 2004, Hale et al.54U.S. Appl. No. 10/792,001, filed Mar. 3, 2004, Rabinowitz et al.55U.S. Appl. No. 10/792,012, filed Mar. 3, 2003, Hale et al.56U.S. Appl. No. 10/792,013, filed Mar. 3, 2004, Rabinowitz et al.57U.S. Appl. No. 10/792,096, filed Mar. 3, 2004, Hale et al.58U.S. Appl. No. 10/792,239, filed Mar. 3, 2004, Hale et al.59U.S. Appl. No. 10/813,721, filed Mar. 31, 2004, Rabinowitz et al.60U.S. Appl. No. 10/813,722, filed Mar. 31, 2004, Rabinowitz et al.61U.S. Appl. No. 10/814,690, filed Mar. 31, 2004, Rabinowitz et al.62U.S. Appl. No. 10/814,998, filed Mar. 31, 2004, Rabinowitz et al.63U.S. Appl. No. 10/815,527, filed Apr. 1, 2004, Rabinowitz et al.64U.S. Appl. No. 10/816,407, filed Apr. 1, 2004, Rabinowitz et al.65U.S. Appl. No. 10/816,492, filed Apr. 1, 2004, Rabinowitz et al.66U.S. Appl. No. 10/816,567, filed Apr. 1, 2004, Rabinowitz et al.67U.S. Appl. No. 10/850,895, filed May 20, 2004, Damani et al.68U.S. Appl. No. 10/851,018, filed May 20, 2004, Hale et al.69U.S. Appl. No. 10/851,429, filed May 20, 2004, Hale et al.70U.S. Appl. No. 10/851,432, filed May 20, 2004, Hale et al.71U.S. Appl. No. 10/851,883, filed May 20, 2004, Hale et al.72U.S. Appl. No. 10/861,554, filed Jun. 3, 2004, Cross et al.73U.S. Appl. No. 10/912,417, filed Aug. 4, 2004, Bennett et al.74U.S. Appl. No. 10/912,462, filed Aug. 4, 2004, Hale et al.75U.S. Appl. No. 10/917,720, filed Aug. 12, 2004, Hale et al.76U.S. Appl. No. 10/917,735, filed Aug. 12, 2004, Hale et al.77Vapotronics, Inc. (1998) located at http://www.vapotronics.com.au/banner.htm., 11 pages, (visited on Jun. 5, 2000).78Ward, M.E. MD, et al. (Dec. 1997). "Morphine Pharmacokinetics after Pulmonary Administration from a Novel Aerosol Delivery System," Clinical Pharmacology & Therapeutics 62(6):596-609.79Wood, R.W. et al. (1996). "Generation of Stable Test Atmospheres of Cocaine Base and Its Pyrolyzate, Methylecgonidine, and Demonstration of Their Biological Activity." Pharmacology Biochemistry & Behavior, 55(2):237-248.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS7445768 *Aug 7, 2006Nov 4, 2008Alexza Pharmaceuticals, Inc.Delivery of sedative-hypnotics through an inhalation routeUS7449174 *Jun 30, 2006Nov 11, 2008Alexza Pharmaceuticals, Inc.Delivery of analgesics through an inhalation routeUS7449175 *Jul 5, 2006Nov 11, 2008Alexza Pharmaceuticals, Inc.Delivery of erectile dysfunction drugs through an inhalation routeUS7488469Jul 18, 2006Feb 10, 2009Alexza Pharmaceuticals, Inc.Delivery of caffeine through an inhalation routeUS7766013 *Oct 26, 2001Aug 3, 2010Alexza Pharmaceuticals, Inc.Aerosol generating method and device* Cited by examinerClassifications U.S. Classification424/45, 128/203.15, 424/46, 128/200.14, 424/489, 424/499, 128/200.24, 514/958International ClassificationA61K31/421, A61K31/495, A61K31/4545, A61K31/439, A61K31/5513, A61M11/00, A61K9/72, A61P31/04, A61P21/02, A61K31/407, A61P43/00, A61P25/18, C07D471/04, A61K31/4985, A61K31/19, A61P25/24, A61K31/192, A61K31/4402, A61K31/405, A61P15/10, A61K31/167, A61K31/13, A61K31/4418, A61K31/4045, A61K31/437, A61K31/403, A61K31/53, A61P25/16, A61P25/08, A61K31/505, A61P37/08, A61P29/00, A61K31/46, A61K31/48, A61P25/20, A61P25/06, C07D487/04, A61P25/22, A61K31/40, A61K31/55, A61K31/4525, A61P25/32, A61K45/00, A61K31/5415, A61K31/519, A61K31/485, A61K31/137, A61K9/00, A61K47/48, A61K31/138, A61K31/27, A61K9/14, F24J1/00, A61K31/551, A61K31/216, A61K31/4196, A61K31/49, A61K9/12, A61K31/423, A61K31/422, A61K31/404, A61K31/501, A61K31/496, A61K31/473, A61K31/00, A61K31/165, A61K31/5517, A61M15/00Cooperative ClassificationY10S514/923, Y10S514/958, A61K9/0073, F24J1/00, A61K31/53, A61K31/437, A61K31/404, A61K31/192, A61K31/138, A61K9/12, A61K31/519, A61K31/195, A61K31/5517, A61K9/007, A61K31/407, A61K31/422, A61K31/137, A61K31/551, A61K31/495, A61K47/48023, A61K31/4985, A61K31/165, A61K31/423, A61K31/216, A61K31/49, A61K31/421, A61K31/19, A61K31/27, A61K31/405, A61K31/496, A61K31/00, A61K31/4196, A61K31/501, A61K31/485, A61K31/473, A61M11/042, A61M2205/8206, A61M15/06European ClassificationA61K31/00, A61K31/53, A61K31/195, A61K31/19, A61K31/485, A61K31/404, A61K31/421, A61K31/496, A61K31/27, A61K31/5517, F24J1/00, A61K31/165, A61K31/407, A61K9/12, A61K31/437, A61K31/422, A61K31/192, A61K9/00M20B, A61K31/501, A61K31/519, A61K47/48H4, A61K31/4196, A61K31/49, A61K31/405, A61K31/473, A61K31/4985, A61K31/137, A61K31/216, A61K31/495, A61K31/138, A61K31/551, A61K31/423, A61K9/00M20Legal EventsDateCodeEventDescriptionMay 18, 2010FPExpired due to failure to pay maintenance feeEffective date: 20100328Mar 28, 2010LAPSLapse for failure to pay maintenance feesNov 2, 2009REMIMaintenance fee reminder mailedOct 18, 2005ASAssignmentOwner name: ALEXZA PHARMACEUTICALS, INC., CALIFORNIAFree format text: CHANGE OF NAME;ASSIGNOR:ALEXZA MOLECULAR DELIVERY CORPORATION;REEL/FRAME:016926/0674Effective date: 20050720RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services

value: This website is a search engine provided by Google. Handling over 3.5 billion searches per day, it has a 92% share of the global search engine market.


text:
Exeter, PA Plumbing Contractors
789 Exeter, PA Plumbing Contractors
(570) 842-4678	Moscow, PA, 18444, United States14 miles from Exeter
(570) 587-4933	South Abington Township, PA, 18411, United States15 miles from Exeter
(570) 969-2221	South Abington Township, PA, 18411, United States15 miles from Exeter
(570) 256-6297	Hunlock Creek, PA, 18621, United States15 miles from Exeter
(570) 256-7472	Hunlock Creek, PA, 18621, United States15 miles from Exeter
(570) 945-3479	Factoryville, PA, 18419, United States16 miles from Exeter
(570) 842-6445	Spring Brook Township, PA, 18444, United States16 miles from Exeter
(570) 836-2772	Tunkhannock, PA, 18657, United States16 miles from Exeter
(570) 489-9366	Peckville, PA, 18452, United States16 miles from Exeter
(570) 307-0949	Jessup, PA, 18434, United States16 miles from Exeter
(570) 646-0113	Tunkhannock, PA, 18657, United States17 miles from Exeter
(570) 489-0039	Peckville, PA, 18452, United States17 miles from Exeter
(570) 836-5411	Tunkhannock, PA, 18657, United States17 miles from Exeter
(570) 996-0750	Tunkhannock, PA, 18657, United States17 miles from Exeter
(570) 489-7690	Peckville, PA, 18452, United States17 miles from Exeter
List your business here for free - Learn More 56789101112131415Next Page Plumbing Contractors near Exeter
Scranton Plumbing Contractors · Wilkes-Barre Plumbing Contractors · Back Mountain Plumbing Contractors · Dunmore Plumbing Contractors · Kingston Plumbing Contractors · Nanticoke Plumbing Contractors · Blakely Plumbing Contractors · Plymouth Plumbing Contractors · Moosic Plumbing Contractors · Swoyersville Plumbing Contractors · Duryea Plumbing Contractors · West Pittston Plumbing Contractors · Edwardsville Plumbing Contractors · Jessup Plumbing Contractors · Larksville Plumbing Contractors · Plains Plumbing Contractors · Forty Fort Plumbing Contractors · Throop Plumbing Contractors · Wyoming Plumbing Contractors · Ashley Plumbing Contractors	· more...
· West Wyoming Plumbing Contractors · Dupont Plumbing Contractors · Avoca Plumbing Contractors · Jermyn Plumbing Contractors · Trucksville Plumbing Contractors · Chinchilla Plumbing Contractors · Inkerman Plumbing Contractors · Laflin Plumbing Contractors · Clarks Green Plumbing Contractors · Hudson Plumbing Contractors · Browntown Plumbing Contractors · Hughestown Plumbing Contractors · Hilldale Plumbing Contractors · Dalton Plumbing Contractors · Sugar Notch Plumbing Contractors · Pringle Plumbing Contractors · Chase Plumbing Contractors · Glenburn Plumbing Contractors · Silkworth Plumbing Contractors · West Nanticoke Plumbing Contractors · Lake Winola Plumbing Contractors · Courtdale Plumbing Contractors · Upper Exeter Plumbing Contractors · Nuangola Plumbing Contractors · Sheatown Plumbing Contractors · Wanamie Plumbing Contractors · Laurel Run Plumbing Contractors · West Falls Plumbing Contractors · Penn Lake Park Plumbing Contractors	Professional Categories in Exeter
Exeter Residential Contractors · Exeter Custom Design-build Firms · Exeter Decorators · Exeter Architectural Designers · Exeter Custom Kitchen And Bath Designers · Exeter Kitchen & Bath Remodelers · Exeter Custom Builders · Exeter Landscape Architects & Designers · Exeter Licensed Landscape Contractors · Exeter Tile, Stone & Countertops · Exeter Cabinets & Cabinetry · Exeter Home Furnishers · Exeter Wood Flooring Installer · Exeter Painters · Exeter Decks, Patios & Outdoor Enclosures · Exeter Pools and Spas · Exeter Custom Stairs · Exeter Doors · Exeter Garage Doors · Exeter Home Organizers	· more...
· Exeter Lighting · Exeter Custom Curtains · Exeter Windows · Exeter Architectural Photographers · Exeter Roofing & Gutters · Exeter Siding & Exterior Contractors · Exeter Custom Mosaic Art · Exeter Appliances · Exeter Bed Products · Exeter Building Supplies · Exeter Carpenters · Exeter Driveways & Paving · Exeter Electrical Contractors · Exeter Environmental Services & Restoration · Exeter Fencing & Gates · Exeter Fireplaces · Exeter Yard Maintenance · Exeter HVAC Contractors · Exeter Residential Home Media Design & Installation · Exeter Residential Home Stagers · Exeter Ironwork · Exeter Nursery Designers · Exeter Custom Cabinets · Exeter Lawn & Sprinklers · Exeter Design Bloggers · Exeter Outdoor Audio/Visual · Exeter Outdoor Play Systems · Exeter Plumbing Contractors · Exeter Rubbish Removal · Exeter Septic Tanks and Systems · Exeter Solar Energy Contractors · Exeter Sport Courts · Exeter Staircases · Exeter Stone, Pavers & Concrete · Exeter Tree Services · Exeter Real Estate Agents · Exeter Upholstery · Exeter Wine Cellars	Professional Metro Areas

type: global

value: This website is an American website, online community and software for architecture; interior design and decorating; landscape design and home improvement. It was founded in 2009 and is based in Palo Alto, California.


text:
What's your favourite ReSharper's plugins, what is still missing in? - Stack Overflow
What's your favourite ReSharper's plugins, what is still missing in? [closed]
I'm new in ReSharper - I found it very useful but also noticed some gaps I'd like to fill.
1) what ReSharper's plugins you use.
2) what missing functionalities you are extremely interested to have in inside?
A) spell check my XML comments (have to use Agent Smith)
a) numbered bookmarking (Deplhi-like) (forced to use DPack)
b) right align variables / operands (as described here)
c) possibility to collapse all projects in solution browser (again need use DPack)
resharper share|improve this question edited Aug 21 '09 at 7:56
asked Aug 19 '09 at 9:19
closed as primarily opinion-based by Sahuagin, Paul Hicks, Pang, Shankar Damodaran, Constantin Oct 8 '15 at 4:28
Perhaps make this wiki ? :)
@Binary Worrier: I dont think this is duplication of question you edited! I've asked about favourite plugins which fills R# gaps (NOT EXISTING functionality) - quoted question asked about favourite (EXISTING) functinoality
Aug 19 '09 at 10:04
There's one plugin for R# that is completely different from any other plugins. It's called WhySharper and it dovetails R# and this very site, stackoverflow.
Quite often, people ask questions as "why R# recommends this" and "why R# suggests that". With WhySharper installed, you can quickly get complete and detailed explanations to pretty much anything - directly from your Visual Studio! - or ask for an explanation if it's missing.
A bit more details at my blog here.
share|improve this answer answered Sep 1 '09 at 13:37
6,46722234
Looks like they implemented this as a feature in R# 6
Yeah, great news - they will provide much better support than I could have ever hoped for!
StyleCop for ReSharper provides Alt + Return correction of StyleCop guideline violations.
share|improve this answer edited Aug 19 '09 at 13:26
answered Aug 19 '09 at 9:41
5,80612234
AgentJohnson and AgentSmith provide lots of goodies to R#; I tried also a plugin for NHibernate HBMs but is not that good.
numbered bookmarking -- will be in ReSharper 5
right align variables / operands -- unlikely
possibility to collapse all projects in solution browser -- available since ReSharper 4.5
share|improve this answer answered Oct 11 '09 at 22:21
6,9752139
Thanks for response - re collapsing - I've really missed it! Thanks Re ver 5 - what's your release time estimation? And - is it somewhere planned features list available?
Oct 12 '09 at 7:12

value: This website is a question and answer website for professional and enthusiast programmers. It is the flagship site of the Stack Exchange Network, created in 2008 by Jeff Atwood and Joel Spolsky.


text:
Advertisementad feedback	ad feedback	Researcher (#46902961)	member for 9 years, 2 months, 23 days
Search Contributor's Records First NameLast NameVirtual CemeteriesPHILADELPHIA POLICE OFFIC... (327)Section 204 Mount Moriah ... (139)Find A Grave FriendsAutistic Wonder..., Big Ern, Bonnie Fortney-..., cathy313, Denise Petersen, Donna Bobb, Donna Di Giacom..., Donnamarie, Grave Hunters, Jenn O., Jennifer M., Joan Pacitti, L. M. Arrigale, Lisa Frankel, Lori D, Mark Maxwell, New York Histor..., PhillyJDM, RestoreByTim, sr/ks, [View all Find A Grave Friends...]Messages left for Researcher (157)[Leave Message]
Jack LutherSarah TreonMy email is jackluther1@aol.com. Thank you.Added by Jack Luther on May 23, 2016 6:57 PMJack LutherSarah Treon LoseThank you for your work on the Treon families. Do you have any info on Sarah Treon, b. 1823 I believe in either Northumberland or Lycoming counties? She married Levi Lose. Thank you.Added by Jack Luther on May 20, 2016 8:20 PMPhyllisElizabeth MarksYour story and research on Elizabeth and her family is wonderful. I read all of her bio and find it very interesting. I also do a lot of family research and appreciate your work.Added by Phyllis on May 09, 2016 2:16 PMJosh RichardRE Willie WilliamsJust transferred Willie Williams to you.Added by Josh Richard on May 06, 2016 6:42 PMJoan (Wyatt) BradleyThanks you for transferring Martha PattersonI appreciate your removing the erroneous parent links and transferring Martha E. (Mattie) Patterson's memorial to me. After I sent you my request, I did a little looking around for the Martha Patterson who matches those parents, Matthew and Margaret Patterson (per 1870 census). I found the following death certificate which could be "your" Martha, as her father is listed as Matthew Patterson:Name: Mrs Mattie Mackey[Mrs Mattie Patterson] Gender: FemaleRace: WhiteAge: 64Birth Date: 30 Jul 1867Birth Place: PennsylvaniaDeath Date: 4 Oct 1931Death Place: Pennsylvania, USAFather: Matthew Patterson <--------------Spouse: Wm R MackeyCertificate Number: 91949This Martha/Mattie (Patterson) Mackey lived in Philadelphia from birth to 1930 per censuses. She married William Robert Mackey in 1899. She is buried in Arlington Cemetery, Delware County, Pennsylvania (Find A Grave memorial 124418505).Added by Joan (Wyatt) Bradley on May 04, 2016 1:36 PMsr/ksRe: Sam'l F Kiehl d. 1906I just sent a note to the memorial creator and don't know if she will incorporate it or not, but I think of you as my go-to Kiehl guy and thought I should share. Not sure how deep your interest runs on this gent, but...A 1937 WPA survey of this cemetery said Samuel's stone said "Son of Felix and Lydia Kiehl, adopted son of F H Wetzel and wife, died December 6, 1906. Aged 23 years, 3 months, 11 days."Added by sr/ks on Mar 25, 2016 9:50 AMP. EadieWilliam MilesGood Morning! You are very welcome . When I photographed Williams headstone, I also took photos of other family members. Jake (1925), Marie (1970), Vincent( 1938) and Mary Schultz(1958). If you would post memorial sites for them, I would be happy to upload stone pictures for them . Please advise. PatAdded by P. Eadie on Mar 03, 2016 6:15 AMJerseymanHollis KosterIt appears you have accessed manuscript material related to Hollis Koster. Can you provide me with where that material might be located? I am researching Hollis for the poetry he wrote.Added by Jerseyman on Jan 28, 2016 5:51 PMP. EadieRE: Police Officer George FreemanYou are very welcome. The inscription picture was difficult to take as it was hidden behind bushes. I am happy to assist and wish you luck with your research. PatAdded by P. Eadie on Jan 17, 2016 6:03 AMKathryn DunlapGeorge Edward Congleton2 additional childrenIrvin W. Congleton born abt 1886Leroy E. Congleton born abt 1894I can't figure how to put them on the list.Added by Kathryn Dunlap on Dec 25, 2015 9:28 AM[View all messages...] Privacy Statement and Terms of Service ad feedback

value: This website is a website that allows the public to search and add to an online database of cemetery records. It is owned by Ancestry.com.


text:
9781555873684: Mirages of Development: Science and Technology for the Third Worlds - AbeBooks - Jean-Jacques Salomon; Andre Lebeau: 1555873685
Jean-Jacques Salomon; Andre Lebeau Mirages of Development: Science and Technology for the Third Worlds
ISBN 13: 9781555873684
Jean-Jacques Salomon; Andre Lebeau
ISBN 10: 1555873685 ISBN 13: 9781555873684
Publisher: Lynne Rienner Pub, 1993
This work looks at the issues of development in terms that attack both the earlier idealism and the current mood of cynicism about the Third World. Salomon and Lebeau consider why the great majority of Third World countries have failed to solve the problems of underdevelopment by relying on science and technology, while a very few of them - the newly industrialised countries - have at least partially succeeded. Opposed to the smug optimism of scientific enthusiasts (though equally opposed to the dismal prophecies of others), the authors argue that, while technological advances may speed the process of modernisation in isolated instances, they cannot induce the social transformations that are a prerequisite of development. Scientific research and technological innovation can be effective, they conclude, only where social structures, institutions and habits have first eliminated the "blocking factors" that are characteristic of traditional societies. It is also essential to recognise that less advanced technologies still have much to contribute to improving productivity and living standards and should not be neglected in the search for solutions.
1. Mirages of Development: Science and Technology for the Third Worlds
Salomon, Jean-Jacques, Lebeau, Andre
Book Description Lynne Rienner Pub. Book Condition: Good. Ex-library, so some stamps and wear, but in good overall condition. May contain underlining and/or highlighting. Bookseller Inventory # Z1-G-034-00615
2. Mirages of Development: Science and Technology for the Third Worlds
Book Description Lynne Rienner Pub, 1993. Hardcover. Book Condition: Used: Good. Bookseller Inventory # SONG1555873685

value: This website is an e-commerce global online marketplace with seven websites that offer books, fine art, and collectables from sellers in over 50 countries. Launched in 1996, it specialises in used, rare and out-of-print books.