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User Profile PUSH_FotoGrafik
Listed below are comments made by PUSH_FotoGrafik between Saturday, 4th June 2011 and Saturday, 4th June 2011.
Ideal: Not just about drugs
12:10pm on 04 Jun 2011
When Ideal first hit the screens, I used to tell my mates that it was a comedy about a drug dealer. After watching the first couple of series and each character became more familiar, I realised it is much more than that and exactly what you're saying above Graham. It's an honest (albeit with weird and wonderfully twisted humour) account of every day life in 21st century sub culture Britain. There is nothing I look forward to watching more. Pure genius. «Newer

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The Cycle of Leadership: How Great Leaders Teach Their Companies to Win by Noel M. Tichy, Nancy Cardwell |, Paperback | Barnes & Noble
Noel M. Tichy, Nancy CardwellNoel M. Tichy, Nancy Cardwell
In The Leadership Engine, Noel Tichy showed how great companies strive to create leaders at all levels of the organization, and how those leaders actively develop future generations of leaders. In this new book, he takes the theme further, showing how great companies and their leaders develop their business knowledge into "teachable points of
In The Leadership Engine, Noel Tichy showed how great companies strive to create leaders at all levels of the organization, and how those leaders actively develop future generations of leaders. In this new book, he takes the theme further, showing how great companies and their leaders develop their business knowledge into "teachable points of view" depend a great portion of their time giving their learnings to others, sharing best practices, and how they in turn learn and receive business ideas/knowledge from the employees they are teaching.Calling this exchange a virtuous teaching cycle, Professor Tichy shows how business builders from Jack Welch at GE to Joe Liemandt at Trilogy create organizations that foster this knowledge exchange and how their efforts result in smarter, more agile companies, and winning results. Some of these ideas were showcased in Tichy's recent Harvard Business Review article entitled, ⍯ Ordinary Boot Camp."Using examples from GE, Ford, Dell, Southwest Airlines and many others, Tichy presents and analyzes these principles in action and shows how managers can begin to transform their own businesses into teaching organizations and, consequently, better-performing companies Read More
5.18(w) x 7.94(h) x 1.14(d)

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Selling arms to the Saudis was always immoral. Now it is unlawful, too | Andrew Smith | Opinion | The Guardian
Thu 20 Jun 2019 07.05 EDT Last modified on Thu 20 Jun 2019 12.03 EDT
Campaigners outside the court of appeal in London today after the result. Photograph: Simon Dawson/Reuters
A Saudi-led airstrike on the outskirts of Yemen’s capital, Sanaa, in 2016. Photograph: Hani Mohammed/AP
The assault on the factory was not an isolated event. Since the war began, weddings, funerals and school bus trips have all been turned into massacres. Schools, hospitals, homes and even a refugee camp have been bombed. The EU and national arms export licensing criteria, which govern UK arms exports, are very clear in saying that if there is a “clear risk” that a weapon “might” be used in a serious breach of international humanitarian law (IHL) then an arms sale should not go ahead. Despite repeated reports from reputable sources that Saudi-led forces have been responsible for consistent and serious IHL breaches, the government continued to offer its uncritical political and military support for the war.
Many of the killings have been painstakingly documented by organisations such as Mwatana for Human Rights, a Yemeni organisation that this year published an exceptionally detailed report that linked UK-made bombs to specific attacks on civilian targets. The evidence of war crimes has been overwhelming, but the government has refused to listen.
• Andrew Smith is a spokesman for Campaign Against Arms Trade. @CAATuk

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Amazon.co.uk: S. Scarsbrook "S.J.S. Veteran"'s review of Complete 1950 - 54 Studio Issued Recording...
A "must" read, 15 Mar 2009
By S. Scarsbrook "S.J.S. Veteran"
This review is from: Complete 1950 - 54 Studio Issued Recordings [Spanish Import] (Audio CD)
It's amazing how these modern day Historians don't even Know aboutimportant British victory's which took place in WW2 and this was the FIRSTland victory against Nazi Germany. Interested in WW2 ?,Then read this book. SJS.
Complete 1950 - 54 Studio Issued Recordings [Spanish Import] B0001J3VJC
Complete 1950 - 54 Studio Issued Recordings [Spanish Import]
S. Scarsbrook "S.J.S. Veteran"
Initial post: 13 Aug 2012 21:52:58 BDT
This is the most random, Unconnected review I've ever read. I think Amazon's database has blown a gasket. Or you are completely pilchard.
Top Reviewer Ranking: 346,864

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Light Wood (799)
Backsplash Material Ceramic Tile (150)
Find out if your remodeling dreams fit your budget reality.Try the Real Cost Finder 799 blue hutch Kitchen Design Photos
Ideabooks2,460	Questions6	What color is the blue cabinet?Did you find out blue color of cabinet.?partial blue cabinets with light topsThe blue of the up board is closelove the colors, two islands and the hutch that looks like a piece of furniturehave the kitchen wall look like a hutch on the full lengthNice looking blue hutchcabinets/ built in hutch lookAmber and blue kitchenCurvy hutch top...Hutch color...Like Hutch...Hutch is separate...grey blue...Blue for trunk?...dining hutchp[ainted different color — sorkhurt Embed
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$20.95 4" x 6" Sample - Bliss Iceland Random Strip Glass and Marble Mosaic Tiles
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$34.99 SaveEmail	Don F. Wong
Ideabooks2,664	Questions7	where can i get blue [emndant lightsThe Cone Pendant by Tech Lighting is available in all of the colors shown here, including cobalt blue:
-NissaPendants, blue countertops, offsetting wood cabinetspendants (maybe red or blue for pop of color)this is pretty much what I said I wanted, blue cntr, wood cabs. but not wood floor. This is not it thoughI like this blue counter even more.5. Light fixtures. The designer kept the rest of the space monotone and natural but emphasized the island with multi-colored lamp shades, a deep blue counter and comfy brown bar stools.Johnston casuals stools — janetmdc Embed
10 Reviews	revfremont - Rosichelli Design has provided us with three beautiful models. Prospects are...
8 Reviews	Dawn Wilkinson - Organized Spaces has done an excellent job on several projects that Six Walls...
Ideabooks2,657	Questions5	I'm looking for blue hanging lights. Where can I find these?It's likely the Icicle pendant by LBL, available in blue, amber, white or clear. We are an LBL dealer, let me know if I can assist.Have you heard of Tech lighting? They do some beautiful blues! All the glass is hand blown in Italy.
Littmanbros.comBlue lights in pop up ceiling, cool!Cool lighting - blue - basementFloor and cab — jackisalonblonde Embed
Ideabooks5,862	Questions12	3467 Blue Storm 180fx® By Formica GroupBold and graceful, 3467 Blue Storm 180fx® Formica® brand laminate incorporates black, brown, and blue and is stunning in a kitchen installation! Innovative and appealing, 180fx® patterns only repeat after 5 feet! Get your free sample, now! ...I am doing black kitchen cabinets and love the Blue Storm Formica.Black cabinets, with Blue storm formica - what should I use for a backsplash or paint color in my kitchen?A subway tile in a lighter color found in the Blue Storm could work for either contemporary or traditional – white, light gray and even the gold might look nice with black cabinets. Just be mindful of other backsplash options getting too busy with the Blue Storm … glass tile could easily do this, especiallylove the color of the floor — andysglassofmontana Embed
Ideabooks290	Questions2	built-in hutchHutch around ovencountertops — Fleetwood Jacobs Embed
Ideabooks3,175	Questions5	The perimeter is "Lagos Blue" Honed Caesarstone and the island is "Azul Aran" granite polished.The counter on the perimeter is Lagos Blue Honed from Caesarstone. The island is natural granite, called Azul Aran.Light cabinets and Llagos blue countertopslagos blue caesarstone and white maple cabinetsLagos blue counters with ceramic tile backsplash from Stone Source. Contrasting island with Azul Aran granite counter.lagos blue, cs, looks more brown in personSize of tile for backsplash — ckadz Embed
Ideabooks11,651	Questions11	what type of glass has been used on the ceiling? how was the blue led installed to the glass?love the blue glass and the light that is admittedlighted blue counters, backsplash, and ceilingBlue and clear counters w blue lightingColor-changing strip lighting in this kitchen casts a soft blue glow behind theColor-changing strip lighting in this kitchen casts a soft blue glow behind the custom glass backsplash. The lighting shifts between various colors throughout the day and night.The average cost for a decent-quality LED color-changing system is $500 for 17 feet with a controller and driver.blue lighting — colleenkeener Embed
Ideabooks2,594	Questions7	I have been putting off finishing my laundry room for 6 months because I can't find any fun colored countertops! With cobalt blue tile on the floor, mustard and salmon colored cabinets, red washer/dryer and lime green walls these look like the answer! Please tell me how do I getanywhere!! again - i have been ALL OVER green goods' site- no product number - no price- no info on HOW - H O W - to accomplish the purchase of the 3x6 blue tile in THIS picture!!! i get email responses " Green Goods said:
" and we can ship it anywhere. :)" and "Green GoodsYou can find it at Green Goodspurple cabinets & blue/purple combocontemporary kitchen with purple base cabinets and watery blue glass tiles. How about a few bright green niches to add even more color power?The floor — kathleenmmalloy Embed

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Waltons Motor Court Motel (Mount Isa, Australia) - Lodge Reviews - TripAdvisor
Mount Isa Luxury Hotels
Hotels near Hard Times Underground Mine Tour
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South Pacific›Australia›Queensland›Mount Isa›Mount Isa Specialty Lodging›Mount Isa Lodges
#8 of 9 Specialty Lodging in Mount Isa 23 Camooweal St, Mount Isa, Queensland 4825, Australia Hotel amenities
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Save Rooms & rates for Waltons Motor Court Motel We're finding you the best rooms at the lowest prices from our partner.Book on Check In Check Out 1 room 1 room 2 adults 2 adults 0 children 0 children Ages of Children: change Please provide ages Child 1 Age Age Update Search Update 4Standard Room Getting you more information on this room See More Free Cancellation Best Price /night taxes & fees Select Show available rooms for Waltons Motor Court Motel We’re sorry, there are no available rooms for this property on TripAdvisor. Please change dates or see offers from our partners.
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reviews Clear all Start your review of Waltons Motor Court Motel Click to rate
86 helpful votes “Nothing Flash, but clean and comfortable.”
Waltons sits just over the road from the Mt Isa Hospital. and I suspect many of its guests are in from the bush seeking treatment, or specialist's appointments.
Our unit was clean, basic - but with TV, reverse cycle a/c, refrigerator and easily accessible parking. The manager greeted us with cupcakes, and checked to make sure we were OK with...
Thank obione980 Report 648Rosie
1 review 4 helpful votes “Don't even consider it!”
We were told the accommodation was basic but clean & so we booked to stay - worst accommodation we've ever experienced. Cockroaches everywhere, filthy walls, used & dirty sheets, mattress protector even dirtier & the mattress had squashed cockroaches, cigarette burns & marked mattress! Soap had been opened & used in a dirty shower alcove that still had a used...
Thank 648Rosie Report Travelers are raving about these Mount Isa hotels Copper City Motel
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Level Contributor 3 reviews “terribly disappointed”
the walls were dirty, the ensuite was dirty with no handtowel, floor mat or soap
the toilet seat was not fitted the shower floor was dirty as was the room floor and the phone didn't work. as far as i am concerned give it a big miss
Helpful? Thank TownsvillePonytail Report Updating list... Questions? Get answers from hotel staff and past guests. Ask a question Explore similar hotels Leichhardt Accommodation 21 ReviewsShow Prices 0.1 miles Central Point Motel 44 ReviewsShow Prices 0.6 miles Spinifex Motel & Serviced Apartments 89 ReviewsShow Prices 1.0 miles See all Mount Isa hotels Browse nearby
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Show Prices Show Prices Show Prices Near Waltons Motor Court Motel Top-rated Attractions Nearby 132 Reviews City Look Out
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Additional Information about Waltons Motor Court Motel
Address: 23 Camooweal St, Mount Isa, Queensland 4825, Australia Location:
Questions? Get answers from Waltons Motor Court Motel staff and past guests.
Posting guidelines Get notified about new answers to your questions. Ask Typical questions asked: Can tickets for local attractions be purchased at the front desk? Do you have to pay extra for a mini-fridge? At what time does the pool open each day? See which rooms travelers prefer “Couldn't recommend it at all”
648Rosie, Jul 15, 2012
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From Single Cells to Multicellular Organisms - Molecular Biology of the Cell - NCBI Bookshelf
From Single Cells to Multicellular
Organisms18IntroductionSingle-cell organisms, such as bacteria and protozoa, have been so successful
in adapting to a variety of different environments that they comprise more than
half of the total biomass on earth. Unlike animals, many of these unicellular
organisms can synthesize all of the substances they need from a few simple
nutrients, and some of them divide more than once every hour. What, then, was the
selective advantage that led to the evolution of multicellular
organisms?A short answer is that by collaboration and by division of labor it
becomes possible to exploit resources that no single cell could utilize so well. This
principle, applying at first to simple associations of cells, has been taken to an
extreme in the multicellular organisms we see today. Multicellularity enables a plant,
for example, to become physically large; to have roots in the ground, where one
set of cells can take up water and nutrients; and to have leaves in the air,
where another set of cells can efficiently capture radiant energy from the sun.
Specialized cells in the stem of the plant form channels for transporting water and
nutrients between the roots and the leaves. Yet another set of specialized cells
forms a layer of epidermis to prevent water loss and to provide a protected
internal environment (see Panel 1-2, pp. 28-29). The plant as a whole does not
compete directly with unicellular organisms for its ecological niche; it has found a
radically different way to survive and propagate.Panel 1-2>The cell types and tissues from which higher plants are constructed. As different animals and plants appeared, they changed the environment
in which further evolution occurred. Survival in a jungle calls for different
talents than survival in the open sea. Innovations in movement, sensory detection,
communication, social organization - all enabled eucaryotic organisms to
compete, propagate, and survive in ever more complex ways.Single Cells Can Associate to Form ColoniesIt seems likely that an early step in the evolution of multicellular organisms
was the association of unicellular organisms to form colonies. The simplest
way of achieving this is for daughter cells to remain together after each cell
division. Even some procaryotic cells show such social behavior in a primitive
form. Myxobacteria, for example, live in the soil and feed on insoluble organic
molecules that they break down by secreting degradative enzymes. They stay
together in loose colonies in which the digestive enzymes secreted by individual cells
are pooled, thus increasing the efficiency of feeding (the "wolf-pack" effect).
These cells indeed represent a peak of social sophistication among procaryotes,
for when food supplies are exhausted, the cells aggregate tightly together and
form a multicellular fruiting body (Figure 1-31), within which the bacteria
differentiate into spores that can survive even in extremely hostile conditions. When
conditions are more favorable, the spores in a fruiting body germinate to
produce a new swarm of bacteria.Figure 1-31Fruiting bodies
formed by a myxobacterium (Chondromyces
crocatus), seen by scanning electron microscopy. Each fruiting body, packed with spores, is created by
the aggregation and differentiation of about a million myxobacteria.
(From P.L. Grilione and (more...)
Green algae (not to be confused with the procaryotic "blue-green algae"
or cyanobacteria) are eucaryotes that exist as unicellular, colonial, or
multicellular forms (Figure 1-32). Different species of green algae can be arranged in order
of complexity, illustrating the kind of progression that probably occurred in
the evolution of higher plants and animals. Unicellular green algae, such
as Chlamydomonas, resemble flagellated protozoa except that they possess
chloroplasts, which enable them to carry out photosynthesis. In closely related
genera, groups of flagellated cells live in colonies held together by a matrix of
extracellular molecules secreted by the cells themselves. The simplest species (those
of the genus Gonium) have the form of a concave disc made of 4, 8, 16, or 32
cells. Their flagella beat independently, but since they are all oriented in the same
direction, they are able to propel the colony through the water. Each cell is
equivalent to every other, and each can divide to give rise to an entirely new
colony. Larger colonies are found in other genera, the most spectacular being Volvox, some of whose species have as many as 50,000 or more cells linked together
to form a hollow sphere. In Volvox the individual cells forming a colony are
connected by fine cytoplasmic bridges so that the beating of their flagella is
coordinated to propel the entire colony along like a rolling ball (see Figure 1-32).
Within the Volvox colony there is some division of labor among cells, with a small
number of cells being specialized for reproduction and serving as precursors of
new colonies. The other cells are so dependent on one another that they cannot
live in isolation, and the organism dies if the colony is disrupted.Figure 1-32Four closely related genera of green algae, showing a progression from unicellular to colonial and multicellular organization. (Courtesy of
David Kirk.) The Cells of a Higher Organism Become Specialized and CooperateIn some ways Volvox is more like a multicellular organism than a simple
colony. All of its flagella beat in synchrony as it spins through the water, and the
colony is structurally and functionally polarized and can swim toward a distant
source of light. The reproductive cells are usually confined to one end of the
colony, where they divide to form new miniature colonies, which are initially
sheltered inside the parent sphere. Thus, in a primitive way, Volvox displays the two essential features of all multicellular organisms: its cells become specialized, and they cooperate. By specialization and cooperation the cells combine to form a
coordinated single organism with more capabilities than any of its component parts.Organized patterns of cell differentiation occur even in some procaryotes.
For example, many kinds of cyanobacteria remain together after cell division,
forming filamentous chains that can be as much as a meter in length. At regular
intervals along the filament, individual cells take on a distinctive character and
become able to incorporate atmospheric nitrogen into organic molecules. These few
specialized cells perform nitrogen fixation for their neighbors and share the
products with them. But eucaryotic cells appear to be very much better at this sort
of organized division of labor; they, and not procaryotes, are the living units
from which all the more complex multicellular organisms are constructed.Multicellular Organization Depends on Cohesion Between CellsTo form a multicellular organism, the cells must be somehow bound
together, and eucaryotes have evolved a number of different ways to satisfy this need.
In Volvox, as noted above, the cells do not separate entirely at cell division but
remain connected by cytoplasmic bridges. In higher plants the cells not only
remain connected by cytoplasmic bridges (called plasmodesmata), they also are imprisoned in a rigid honeycomb of chambers walled with cellulose that the
cells themselves have secreted (cell walls).The cells of most animals do not have rigid walls, and cytoplasmic
bridges are unusual. Instead, the cells are bound together by a relatively loose
meshwork of large extracellular organic molecules (called the extracellular matrix) and by adhesions between their plasma membranes. Very often, side-to-side
attachments between the cells hold them together to form a multicellular sheet, or
epithelium.Epithelial Sheets of Cells Enclose a Sheltered Internal EnvironmentOf all the ways in which animal cells are woven together into multicellular
tissues, the epithelial arrangement is perhaps the most fundamentally
important. The epithelial sheet has much the same significance for the evolution of
complex multicellular organisms that the cell membrane has for the evolution of
complex single cells.The importance of epithelial sheets is well illustrated in the lowly group
of animals known as coelenterates. The group includes sea anemones, jellyfish,
and corals, as well as the small freshwater organism Hydra. Coelenterates are constructed from two layers of epithelium, the outer layer being the ectoderm, the inner being the endoderm. The endodermal layer surrounds a cavity, the coelenteron, in which food is digested (Figure 1-33). Among the endodermal
cells are some that secrete digestive enzymes into the coelenteron, while other
cells absorb and further digest the nutrient molecules that these enzymes release.
By forming a tightly coherent epithelial sheet that prevents all these molecules
from being lost to the exterior, the endodermal cells create for themselves an
environment in the coelenteron that is suited to their own digestive tasks.
Meanwhile, the ectodermal cells, facing the exterior, remain specialized for encounters
with the outside world. In the ectoderm, for example, are cells that contain a
poison capsule with a coiled dart that can be unleashed to kill the small animals
on which Hydra feeds. The majority of other ectodermal and endodermal cells
have musclelike properties, enabling Hydra to move, as a predator must.Figure 1-33The body plan of Hydra. (A) Hydra oligactis in its
natural environment; in this species of Hydra, the tentacles hang down to catch prey. The projections budding
from the side of the body are progeny that will eventually detach from
their parent. (B) Diagram (more...)Within the double layer of ectoderm and endoderm is another
compartment, separate both from the coelenteron and from the outside world. Here nerve cells lie, occupying narrow enclosed spaces between the epithelial cells, below
the external surface where the specialized cell
junctions between the epithelial cells form an impermeable barrier. The animal can change its shape and move by
contractions of the musclelike cells in the epithelia, and it is the nerve cells that
convey electrical signals to control and coordinate these contractions (Figures 1-33, 1-34, and 1-35). As we shall see later, the concentrations of simple inorganic
ions in the medium surrounding a nerve cell are crucial for its function. Most
nerve cells - our own included - are designed to operate when bathed in a solution
with an ionic composition roughly similar to that of seawater. This may well
reflect the conditions under which the first nerve cells evolved. Most coelenterates
still live in the sea, but not all. Hydra, in particular, lives in fresh water. It has
evidently been able to colonize this new habitat only because its nerve cells are
contained in a space that is sealed and isolated from the exterior within sheets of
epithelial cells that maintain the internal environment necessary for nerve cell function.Figure 1-34Hydra feeding.. Feeding is one of a range of fairly
complex activities this animal can perform. A single Hydra is photographed catching small water fleas in
its tentacles; in the last panel it is stuffing these prey into
its coelenteron for digestion. (more...)Figure 1-35Hydra traveling.. A Hydra can swim, glide on its base,
or, as shown here, travel by somersaulting. Cell-Cell Communication Controls the Spatial Pattern
of Multicellular Organisms19The cells of Hydra are not only bound together mechanically and connected
by junctions that seal off the interior from the exterior environment, they also
communicate with one another along the length of the body. If one end of a Hydra is cut off, the remaining cells react to the absence of the amputated part by
adjusting their characters and rearranging themselves so as to regenerate a
complete animal. Evidently, signals pass from one part of the organism to the
other, governing the development of its body pattern - with tentacles and a mouth
at one end and a foot at the other. Moreover, these signals are independent of
the nervous system. If a developing Hydra is treated with a drug that prevents
nerve cells from forming, the animal is unable to move about, catch prey, or feed
itself. Its digestive system still functions normally, however, so that it can be kept
alive by anyone with the patience to stuff its normal prey into its mouth. In such
force-fed animals the body pattern is maintained, and lost parts are regenerated
just as well as in an animal that has an intact nervous system.The vastly more complex higher animals have evolved from simpler
ancestors resembling coelenterates, and these higher animals owe their complexity
to more sophisticated exploitation of the same basic principles of cell
cooperation that underlie the construction of Hydra. Epithelial sheets of cells line all
external and internal surfaces in the body, creating sheltered compartments and
controlled internal environments in which specialized functions are performed
by differentiated cells. Specialized cells interact and communicate with one
another, setting up signals to govern the character of each cell according to its place in
the structure as a whole. To show how it is possible to generate multicellular
organisms of such size, precision, and complexity as a tree, a fly, or a
mammal, however, it is necessary to consider more closely the sequence of events in
development.Cell Memory Permits the Development of Complex PatternsThe cells of almost every multicellular organism are generated by repeated
division from a single precursor cell; they constitute a clone. As proliferation
continues and the clone grows, some of the cells, as we have seen, become
differentiated from others, adopting a different structure, a different chemistry,
and a different function, usually in response to cues from their neighbors. It is
remarkable that eucaryotic cells and their progeny will usually persist in their
differently specialized states even after the influences that originally directed their
differentiation have disappeared - in other words, these cells have a memory. Consequently, their final character is not determined simply by their final
environment, but rather by the entire sequence of influences to which the cells have been
exposed in the course of development. Thus as the body grows and matures,
progressively finer details of the adult body pattern become specified,
creating an organism of gradually increasing complexity whose ultimate form is the
expression of a long developmental history.Basic Developmental Programs Tend to Be
Conserved in Evolution20The final structure of an animal or plant reflects its evolutionary history,
which, like development, presents a chronicle of progress from the simple to the
complex. What then is the connection between the two perspectives, of evolution
on the one hand and development on the other?During evolution many of the developmental devices that evolved in the
simplest multicellular organisms have been conserved as basic principles for
the construction of their more complex descendants. We have already
mentioned, for example, the organization of cells into epithelia. Some specialized cell
types, such as nerve cells, are found throughout nearly the whole of the animal
kingdom, from Hydra to humans. Molecular studies, to be discussed later in this
book, reveal an astonishing number of developmental resemblances at a
fundamental genetic level, even between species as remotely related as mammals and
insects. In terms of anatomy, furthermore, early developmental stages of
animals whose adult forms appear radically different are often surprisingly similar; it
takes an expert eye to distinguish, for example, a young chick embryo from a
young human embryo (Figure 1-36).Figure 1-36Comparison of the embryonic development of a fish, an amphibian, a reptile, a bird, and a selection of mammals. The early stages
(above) are very similar; the later stages
(below) are more divergent. The earliest stages
are drawn roughly to scale; the (more...)Such observations are not difficult to understand. Consider the process
by which a new anatomical feature - say, an elongated beak - appears in the
course of evolution. A random mutation occurs that changes the amino acid
sequence of a protein or the timing of its synthesis and hence its biological activity.
This alteration may, by chance, affect the cells responsible for the formation of
the beak in such a way that they make one that is longer. But the mutation must
also be compatible with the development of the rest of the organism; only then
will it be propagated by natural selection. There would be little selective
advantage in forming a longer beak if, in the process, the tongue was lost or the ears
failed to develop. A catastrophe of this type is more likely if the mutation affects
events occurring early in development than if it affects those near the end. The early
cells of an embryo are like cards at the bottom of a house of cards - a great deal
depends on them, and even small changes in their properties are likely to result
in disaster. Fundamental steps appear to have been "frozen" into
developmental processes, just as the genetic code or protein synthesis mechanisms have
become frozen into the basic biochemical organization of the cell. In contrast, cells
produced near the end of development (or produced early but forming
accessory structures such as the placenta that are not incorporated in the adult body)
have more freedom to change. It is presumably for this reason that the embryos
of different species so often resemble each other in their early stages and, as
they develop, seem sometimes to replay the steps of evolution.The Cells of the Vertebrate Body Exhibit More Than 200 Different Modes of SpecializationThe wealth of diverse specializations to be found among the cells of a
higher animal is far greater than any procaryote can show. In a vertebrate more than
200 distinct cell types are plainly distinguishable, and many of these types of
cells certainly include, under a single name, a large number of more subtly
different varieties. Panel 1-3 (pp. 36-37) shows a small selection. In this profusion of
specialized behaviors one can see displayed, in a single organism, the
astonishing versatility of the eucaryotic cell. Much of our current knowledge of the
general properties of eucaryotic cells has depended on the study of such specialized
types of cells, because they demonstrate exceptionally well particular features on
which all cells depend in some measure. Each feature and each organelle of the
prototype that we have outlined in Panel 1-1 (pp. 18-19) is developed to an
unusual degree or revealed with special clarity in one cell type or another. To take
one arbitrary example, consider the neuromuscular
junction, where just three types of cells are involved: a muscle cell, a nerve cell, and a Schwann cell. Each has
a very different role (Figure 1-37):Panel 1-3Some of the different types of cells present in the vertebrate body. Figure 1-37A nerve cell, with its associated Schwann cells, contacting a muscle cell at a neuromuscular junction. Schematic diagram. 1. The muscle cell has made contraction its specialty. Its cytoplasm is
packed with organized arrays of protein filaments, including vast numbers of
actin filaments. There are also many mitochondria interspersed among
the protein filaments, supplying ATP as fuel for the contractile apparatus.2. The nerve cell stimulates the muscle to contract, conveying an
excitatory signal to the muscle from the brain or spinal cord. The nerve cell is
therefore extraordinarily elongated: its main body, containing the nucleus,
may lie a meter or more from the junction with the muscle. The cytoskeleton
is consequently well developed so as to maintain the unusual shape of the
cell and to transport materials efficiently from one end of the cell to the
other. The most crucial specialization of the nerve cell, however, is its
plasma membrane, which contains proteins that act as ion pumps and ion channels, causing a movement of ions that is equivalent to a flow of
electricity. Whereas all cells contain such pumps and channels in their plasma
membranes, the nerve cell has exploited them in such a way that a pulse of
electricity can propagate in a fraction of a second from one end of the cell
to the other, conveying a signal for action.3. Lastly, Schwann cells are specialists in the mass production of
plasma membrane, which they wrap around the elongated portion of the nerve
cell, laying down layer upon layer of membrane like a roll of tape, to form
a myelin sheath that serves as insulation.Genes Can Be Switched On and OffThe various specialized cell types in a single higher plant or animal appear
as different from one another as any cells could be. This seems paradoxical,
since all of the cells in a multicellular organism are closely related, having recently
descended from the same precursor cell - the fertilized egg. Common lineage
implies similar genes; how then do the differences arise? In a few cases cell
specialization involves the loss of genetic material. An extreme example is
the mammalian red blood cell, which loses its entire nucleus in the course of
differentiation. But the overwhelming majority of cells in most plant and animal
species retain all of the genetic information contained in the fertilized egg.
Specialization depends on changes in gene
expression, not on the loss or acquisition of genes.Even bacteria do not make all of their types of protein all of the time but
are able to adjust the level of synthesis according to external conditions.
Proteins required specifically for the metabolism of lactose, for example, are made
by many bacteria only when this sugar is available for use; and when conditions
are unfavorable for cell proliferation, some bacteria arrest most of their
normal metabolic processes and form spores, which have tough, impermeable outer
walls and a cytoplasm of altered composition.Eucaryotic cells have evolved far more sophisticated mechanisms for
controlling gene expression, and these affect entire systems of interacting gene
products. Groups of genes are activated or repressed in response to both external
and internal signals. Membrane composition, cytoskeleton, secretory products,
even metabolism - all these and other features must change in a coordinated
manner when cells become differentiated. The radical differences of character
between cell types reflect stable changes in gene expression. The controls that bring
about these changes have evolved in eucaryotes to a degree unmatched in
procaryotes, defining the complex rules of cell behavior that can generate an organized
multicellular organism from a single egg.Sequence Comparisons Reveal Hundreds of Families
of Homologous Genes12, 21To outward appearances, evolution has transformed the universe of living
things to such a degree that they are no longer recognizable as relatives. A human
being, a fly, a daisy, a yeast, a bacterium - they seem so different that it
scarcely makes sense to compare them. Yet all are descendants of one ancestor, and
as we probe their inner workings more and more deeply, we find more and
more evidence of their common origins. We now know that the basic molecular
machinery of life has been conserved to an extent that would surely have
astonished the originators of the theory of evolution. As we have seen, all life forms have
essentially the same chemistry, based on amino acids, sugars, fatty acids,
and nucleotides; all synthesize these chemical constituents in an essentially
similar way; all store their genetic information in DNA and express it through RNA
and protein. But the degree of evolutionary conservatism becomes even more
striking when we examine the detailed sequences of nucleotides in specific genes and
of amino acids in specific proteins. The chances are that the bacterial enzyme
catalyzing any particular common reaction, such as the splitting of a six-carbon
sugar into two three-carbon sugars in glycolysis, will have an amino acid sequence
(and a three-dimensional structure) unmistakably similar to the enzyme catalyzing
the same reaction in human beings. The two enzymes - and, equivalently, the
genes that specify them - not only have a similar function, but also almost certainly
a common evolutionary origin. One can exploit these relationships to trace
ancient evolutionary pathways; and by comparing gene sequences and recognizing
homologies, one discovers hidden parallels and similarities between different
organisms.Family resemblances are also often found among genes coding for
proteins that carry out related functions within a single organism. These genes are
also evolutionarily related, and their existence reveals a basic strategy by which
increasingly complex organisms have arisen: genes and portions of genes
become duplicated, and the new copies then diverge from the old by mutation and
recombination to serve new, additional purposes. In this way, starting from
a relatively small set of genes in primitive cells, the more complex life forms
have been able to evolve the more than 50,000 genes thought to be present in a
higher animal or plant. From an understanding of one gene or protein, we
consequently gain insight into a whole family of others homologous to it. Thus molecular
biology both underscores the unity of the living world and gives us tools to
discover the general mechanisms that underlie its endless variety of inventions.In the next chapter we begin our account of these mechanisms with a
discussion of the most basic components of the biological construction
kit - the small molecules from which all larger components of living cells are made.SummaryThe evolution of large multicellular organisms depended on the ability of
eucaryotic cells to express their hereditary information in many different ways and to
function cooperatively in a single collective. In animals one of the earliest developments
was probably the formation of epithelial cell sheets, which separate the internal space
of the body from the exterior. In addition to epithelial cells, primitive differentiated
cell types would have included nerve cells, muscle cells, and connective tissue cells, all
of which can be found in very simple present-day
animals. The evolution of higher animals and plants (Figure 1-38) depended on production of an increasing
number of specialized cell types and more sophisticated methods of coordination
among them, reflecting an increasingly elaborate system of controls over gene expression
in the individual component cells.Figure 1-38Evolutionary relationships among some of the organisms mentioned in this book. The branches of the evolutionary
tree show paths of descent but do not indicate by their length the passage
of time. (Note, similarly, that the vertical axis of the diagram
shows (more...)
Lewis, Martin Raff, Keith Roberts, and James D Watson.Bookshelf ID: NBK28332
ViewsCite this PageAlberts B, Bray D, Lewis J, et al. Molecular Biology of the Cell. 3rd edition. New York: Garland Science; 1994. From Single Cells to Multicellular Organisms.In this PageIntroductionSingle Cells Can Associate to Form ColoniesThe Cells of a Higher Organism Become Specialized and CooperateMulticellular Organization Depends on Cohesion Between CellsEpithelial Sheets of Cells Enclose a Sheltered Internal EnvironmentCell-Cell Communication Controls the Spatial Pattern
of Multicellular OrganismsCell Memory Permits the Development of Complex PatternsBasic Developmental Programs Tend to Be
Conserved in EvolutionThe Cells of the Vertebrate Body Exhibit More Than 200 Different Modes of SpecializationGenes Can Be Switched On and OffSequence Comparisons Reveal Hundreds of Families
of Homologous Genes, Summary

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Words containing harmast | Words that contain harmast
Words containing harmast | Words that contain harmast http://www.thefreedictionary.com/words-containing-harmastPrinter Friendly
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text: Competition and Profitability in European Financial Services: Strategic, Systemic and Policy Issues by Morten Balling, Frank Lierman, Andy Mullineux | | NOOK Book (eBook) | Barnes & Noble® B&N Top 100 NY Times Bestsellers


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Patent US7330839 - Method and system for dynamic pricing - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe method and system of the present invention enables Internet businesses to conduct real-time, online experiments on a sample of transactions to determine marketplace sensitivities. Analysis of the results of the experiments reveal optimal values of key market decision variables such as price, content...http://www.google.com/patents/US7330839?utm_source=gb-gplus-sharePatent US7330839 - Method and system for dynamic pricingAdvanced Patent SearchPublication numberUS7330839 B2Publication typeGrantApplication numberUS 09/804,729Publication dateFeb 12, 2008Filing dateMar 13, 2001Priority dateMar 13, 2000Fee statusPaidAlso published asUS20010051932Publication number09804729, 804729, US 7330839 B2, US 7330839B2, US-B2-7330839, US7330839 B2, US7330839B2InventorsKannan Srinivasan, Michael I. ShamosOriginal AssigneeIntellions, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (8), Non-Patent Citations (1), Referenced by (12), Classifications (18), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetMethod and system for dynamic pricing
6. The method of claim 1, wherein said configuration data includes a minimum threshold for auto

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Top 10 Luxury Hotels in Sant Jordi de Ses Salines, Spain | Hotels.comEnglish (United States)Book online or call 800-246-8357This call is free. 24 hours a day; 7 days a week.HotelsHotel DealsPackages & FlightsGroupsGift CardsHelpWebsite feedbackSign in & AccountSign inCreate an accountYour bookingsTrip PlannerReview a hotelHotels.com® RewardsYour bookingsHotelsHotels in SpainSant Jordi de Ses Salines HotelsLuxury Hotels in Sant Jordi de Ses SalinesLuxury Hotels in Sant Jordi de Ses SalinesSearch for luxury hotels in Sant Jordi de Ses SalinesCity, landmark, hotel name, address or zip codeCheck inCheck out Rooms123456789+Room 1:Adults12345678Aged 18+Children01230-17Age at check in:Child 1:-?-<11234567891011121314151617Show dealsGet Secret Prices on select hotelsThese prices aren’t available to everyone.Unlock nowDeal of the dayIbiza Sun Apartments from $143$129See all Sant Jordi de Ses Salines dealsPay now or later on most roomsFree cancellation on most roomsPrice GuaranteeMap of luxury hotels in Sant Jordi de Ses SalinesLandmarksBossa BeachAguamar Water ParkAnfibiosGran Piruleto Park P. BossaHotel typesPool hotels (12 hotels)Spa hotels (6 hotels)Family-friendly hotels (7 hotels)Sant Jordi de Ses Salines Luxury HotelsBy using Hotels.com to book your travel reservations, you can find and compare Sant Jordi de Ses Salines luxury hotels by price, star rating, theme, locations, neighborhoods, brands, and the amenities offered. Luxury hotels offer a broad range of amenities like an indoor hotel pool, health club, business center, and concierge services. Prices for luxury hotels in Sant Jordi de Ses Salines start at $60.
Most luxury hotels are located near the city center and are near popular tourist destinations and landmarks. Whether you are searching for a place to crash after a busy day of business meetings, or looking for the perfect family-friendly hotel that everyone can enjoy, the perfect luxury hotel in Sant Jordi de Ses Salines can be found on Hotels.com. Here are luxury hotels in Sant Jordi de Ses Salines travelers have booked in the last hour:
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If you want to get a sense of how good the British space sector feels about itself right now, take a look at the shiny new building that's just gone up on the Surrey Research Park. The Kepler facility is a major new centre for the production and testing of satellites. It's where the first big batch of operational spacecraft for Europe's Galileo sat-nav project is being assembled - a total of 14 satellites. There are other platforms in various states of readiness - for Kazakhstan, for Canada, Russia, China and the UK.The building represents must-have capacity for Surrey Satellite Technology Limited (SSTL) which has now outgrown the cleanroom area - workspace with a controlled environment to minimise contamination - on its existing site in Guildford.Leaving aside the UK's investment in Galileo, key upcoming British projects to be put together in the Kepler facility include a novel radar satellite called NovaSAR, and a spacecraft to demonstrate the smartest new ideas in space technology, appropriately called TechDemoSat. The latter is farther along in its build and, although it might not look like it right now, should be ready for launch this year.Kepler was officially opened by European Space Agency (Esa) Director General Jean-Jacques Dordain, alongside Universities and Science Minister David Willetts. The minister has been banging the drum for space ever since he came to office. The coalition government considers the sector to be a "winner" - one that can help put "UK plc" back on track. Image caption
Inside the SSTL cleanroom - hi-tech manufacturing is one path to re-balance the British economy
Space has been one of the few areas of the economy to experience continued growth, even through the recession, and the Kepler building is a clear symbol of that upward trajectory.As I've written before, government and industry now have a joint plan to push the sector forward, and Mr Willetts has been steadily ticking off the boxes in a checklist that broadly follows the recommendations in the Space Innovation and Growth Strategy (S-IGS) published in 2010.This document laid out the path it believed could take the UK from a position where it currently claims about 6% of the world market in space products and services to about 10%, by 2030, creating perhaps 100,000 new hi-tech jobs in the process.Key S-IGS recommendations implemented so far include the establishment of the UK Space Agency (UKSA). Government support for NovaSAR and TechDemoSat are ticks in the boxes that called for investment in Earth observation and R&D. Other ticks go next to the International Space Innovation Centre (Isic) set up at Harwell, Oxfordshire, and the Catapult Centre in Space Applications at a yet-to-be decided location, although quite possibly alongside Isic. These institutions are very much industry-focused and will seek to foster near and far ideas and bring them to market."The story of Surrey Satellite Technology Ltd for me is an absolute model," said Mr Willetts."It began in the labs of Surrey University and then became a full-blown space business. "It has grown and grown, and now has hundreds of people working for it. So this is an example of how successful businesses can be spun out of university research, and it's now become a key part of the British space sector. "I hope as you look back over the first 18 months of the coalition that you will see that we are absolutely committed to the space sector as one of the key sectors that can re-balance the economy, as we escape from dependence on financial services, and as we remind ourselves of our strengths in science and innovation."
There is, however, a big box looming that many people are now wondering how the minister will tick, and this is the S-IGS recommendation that government substantially increase its subscription to the European Space Agency. At present, the UK is the fourth largest contributor (260m euros/£215m in 2012) behind Italy (350m euros), France (717m euros) and Germany (750m euros).All 19 member states of Esa will meet in November to agree programmes and budgets for the next three to five years. The last round in 2008 was valued at some 10bn euros, but at that stage the economic situation was nothing like as bad as it is now, and the euro crisis had yet to show itself.Nonetheless, Mr Dordain expects to put a bold programme before the Esa family at the end of the year that he hopes will invigorate the hi-tech sector across Europe."I am shooting for more," he told me. "Obviously, it's the member states' decision but we have so many good ideas that I shall make ambitious proposals at the ministerial meeting. "But, as I keep saying, I don't live on a different planet - I understand the economic situation, and that's why I am taking actions to make Esa more efficient. However, the current situation is not a reason to be pessimistic about the future."It is of course in the nature of the space industry that one of the biggest customers for its products is government. Look at the satellites in preparation in the new Kepler facility and many of them are heavily dependent on tax-payer money. Galileo is the classic example - a European Commission project being procured on its behalf by Esa. So, money invested in Esa is money that will come back to the UK in the form of contracts for companies like SSTL.Colin Paynter is the UK chief executive officer for Astrium UK, which like SSTL is a subsidary of EADS Astrium. He's hopeful the UK will arrive at a meaningful settlement on its Esa subscription after looking at individual business cases in Earth observation, remote sensing, communications and so on. "I think we have some good business cases," he said. "So, I'm fairly optimistic that the government will come forward with a reasonable financial package at the Esa ministerial. "We would certainly hope the government would take the long-term view because these are commitments that will be cashed out over a long period of time, and we all hope that the economy recovers over that period."
Latest Tweets From Jonathan Amos @BBCAmos RT @NERCscience: We’d like to say a huge thank you to everyone who suggested names, shared tweets & got involved with #NameOurShip https://… 19 minutes ago Mock-up of the RRS Sir D.A. Remember: whatever your thoughts on #Boaty it's the capability that ultimately matters. https://t.co/MHF3iLZr7p 2 hours ago #BoatyMcBoatface to live on as the name of the RRS Sir David Attenborough's high-tech remotely operated undersea vehicle. 2 hours ago Content from Twitter. Learn more about content from Twitter. Top Stories


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Notated Music, English, Ohio, Newhall, Geo. D., Carol | Library of Congress
Results: 1-3 of 3 | Refined by: Original Format: Notated Music Remove Language: English Remove Location: Ohio Remove Contributor: Newhall, Geo. D. Remove Subject: Carol Remove

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text:
Really Riding! book by Catherine Hapka | 2 available editions | Alibris Books
It's time for Meg and Annie's first-ever riding lesson on Jill's farm, followed by a Pony Scouts sleepover! With so many fun things planned, the girls couldn't ask for any more excitement--until a small surprise turns out to be their biggest thrill of all. Full color. Read More
It's time for Meg and Annie's first-ever riding lesson on Jill's farm, followed by a Pony Scouts sleepover! With so many fun things planned, the girls couldn't ask for any more excitement--until a small surprise turns out to be their biggest thrill of all. Full color. Read Less
ISBN-13: 9780061255366
ISBN-13: 9780061255380
ISBN-13: 9781448725168
ISBN 006125536X
ISBN-13 9780061255366
Alibris ID 13186189397
Alibris ID 14116200575
Alibris ID 14241554463
Alibris ID 14204085721
Alibris ID 14081906287
Alibris ID 14268359110
Alibris ID 14211733082
Alibris ID 14083345483
ISBN 0061255386
ISBN-13 9780061255380
Alibris ID 14216483082
New in New jacket. Really Riding! (Paperback or Softback)
ISBN 144872516X
ISBN-13 9781448725168
Alibris ID 12839486191
All Editions of Really Riding!
Royal Champions: An Enchanted Stables Storybook

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