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The relative expression of Mig6 and EGFR is associa... [PLoS One. 2013] - PubMed - NCBI
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PLoS One. 2013 Jul 31;8(7):e68966. doi: 10.1371/journal.pone.0068966. Print 2013.The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors.Chang X1, Izumchenko E, Solis LM, Kim MS, Chatterjee A, Ling S, Monitto CL, Harari PM, Hidalgo M, Goodman SN, Wistuba II, Bedi A, Sidransky D.Author information 1Department of Otolaryngology-Head and Neck Surgery, Division of Head and Neck Cancer Research, Johns Hopkins University, Baltimore, Maryland, USA.AbstractThe sensitivity of only a few tumors to anti-epidermal growth factor receptor EGFR tyrosine kinase inhibitors (TKIs) can be explained by the presence of EGFR tyrosine kinase (TK) domain mutations. In addition, such mutations were rarely found in tumor types other than lung, such as pancreatic and head and neck cancer. In this study we sought to elucidate mechanisms of resistance to EGFR-targeted therapies in tumors that do not harbor TK sensitizing mutations in order to identify markers capable of guiding the decision to incorporate these drugs into chemotherapeutic regimens. Here we show that EGFR activity was markedly decreased during the evolution of resistance to the EGFR tyrosine kinase inhibitor (TKI) erlotinib, with a concomitant increase of mitogen-inducible gene 6 (Mig6), a negative regulator of EGFR through the upregulation of the PI3K-AKT pathway. EGFR activity, which was more accurately predicted by the ratio of Mig6/EGFR, highly correlated with erlotinib sensitivity in panels of cancer cell lines of different tissue origins. Blinded testing and analysis in a prospectively followed cohort of lung cancer patients treated with gefitinib alone demonstrated higher response rates and a marked increased in progression free survival for patients with a low Mig6/EGFR ratio (approximately 100 days, P = 0.01). PMID: 23935914 [PubMed - indexed for MEDLINE] PMCID: PMC3729565 Free PMC ArticleShareImages from this publication.See all images (6)Free textFigure 1Mig6 is upregulated in an erlotinib resistant cell line which suppresses EGFR phosphorylation.A) Erlotinib-sensitive (SCC-S) and -resistant (SCC-R) cells were treated with erlotinib and cell viability was assayed. Values were set at 100% for untreated controls. B) Immunoblot analysis of protein expression in SCC-S and -SCC-R cell lines. C) SCC-S and SCC-R cells were treated with EGF at the indicated times and Mig6 protein expression was analyzed. D) Mig6 mRNA expression was examined by real-time quantitative PCR after EGF treatment at the indicated times. Mig6 mRNA expression was normalized to GAPDH expression. E) SCC-S and SCC-R cells were serum-stripped and stimulated with EGF for 60 min. Immunoprecipitation (IP) was performed against EGFR, followed by immunoblotting against Mig6 and EGFR. F) Densitometric quantification of Mig6 and EGFR. Data are presented as the ratio of Mig6/EGFR to indicate how many Mig6 molecules are associated with each EGFR molecule. All ratios are presented in relative arbitrary values. G) SCC-R cells were transfected with either scrambled siRNA or siRNA targeting Mig6 for 48 hrs. Cells were stripped in serum free medium overnight and stimulated with EGF for 15 or 60 min.The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase InhibitorsPLoS One. 2013;8(7):e68966.Figure 2Mig6 expression is upregulated by elevated phospho-AKT in SCC-R cells.A) Immunoblot analysis of phospho-AKT, total AKT, and loading control β-actin in SCC-S and SCC-R cells. B) SCC-R cells were treated with AKI (AKT1/2 kinase inhibitor, at 5 or 10 µM), U0126 (MEK1/2 inhibitor, at 5 or 10 µM), or DMSO (control) for 24 hrs and subjected to immunoblot analysis with indicated antibodies. C) SCC-R cells were treated with LY294002 (PI3K inhibitor, at 5 or 10 µM), rapamycin (mTOR inhibitor, at 1 or 2 µM) or DMSO (control) for 24 hrs and subjected to immunoblot analysis with the indicated antibodies. D) SCC-R cells were transfected with either scrambled siRNA or siRNA targeting PTEN for 48 hrs and subjected to immunoblot analysis. E) SCC-R cells were treated with 0.2 or 1 µM erlotinib (T0.2, T1, respectively) for 24 hrs, or pretreated with 0.2 or 1 µM erlotinib for 30 min and then co-treated with 10 ng/ml EGF for an additional 24 hrs. Mig6 levels were then evaluated with immunoblot analysis. F) SCC-R cells were treated with 10 µM LY294002, 10 µM AKT1/2 kinase inhibitor, 1 µM rapamycin, or 10 µM U0126 for 24 hrs. Cells were then treated with 10 ng/ml EGF for 30 min to induce EGFR phosphorylation and subjected to immunoblot analysis. G) Densitometric analysis of phospho-EGFR/total EGFR. DMSO-treated samples were arbitrarily assigned a value of 1 and values of the remaining samples represent fold changes of phospho-EGFR per EGFR molecule. Note that fresh Mig6 antibody recognizes a nonspecific band above the Mig6 protein, which gradually disappears after antibody re-suing or recycling.The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase InhibitorsPLoS One. 2013;8(7):e68966.Figure 3Mig6 upregulation is associated with erlotinib resistance.Head and neck (with PC-3 as prostate), bladder, and lung were treated with indicated doses of erlotinib for 72 hrs and then viable cells were evaluated (A). Value was set at 100% for each vehicle-treated cell line. They were evaluated for total and tyrosine phosphorylated forms of EGFR and Mig6 by immunoblot analysis. β-actin or GAPDH were used as internal loading controls (B). The exposure density of both EGFR and Mig6 blotted on the same membrane were quantified by densitometry and the values of Mig6/EGFR were plotted against IC50 (C). Bladder (D) and lung cancer cell lines (E) were stripped in serum-free medium overnight and treated with vehicle or 10 ng/ml EGF for 10 min, following pretreatment with vehicle or 0.1 µM erlotinib for 3 hrs. Cells were then subjected to immunoblot analysis for phospho-EGFR and total EGFR. β-actin was used as a loading control. Both shorter (p-EGFR-shorter) and longer (p-EGFR-longer) exposure times for phospho-EGFR are shown to provide more detail for each cell line.The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase InhibitorsPLoS One. 2013;8(7):e68966.Figure 4Mig6 knockdown per se did not alter cells sensitivity to erlotinib.A) Cells were transfected with either control siRNA, or siRNA targeting Mig6 and erlotinib sensitivity assay was performed. B) Cells were transfected with either control siRNA, or siRNA targeting Mig6 and immunoblot blots were performed. C) Cells were infected with MSCV-HA-Mig6 and immunoblot blots were performed. End. Mig6: endogenous Mig6. D) Erlotinib sensitivity was tested in control or HA-Mig6 expressing cells. Data are plotted as mean ± SD and values were set at 100% for untreated controls. * indicates P<0.01.The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase InhibitorsPLoS One. 2013;8(7):e68966.Figure 5Mig6 expression correlated with erlotinib response in directly xenografted low passage lung and pancreatic tumors.A) Effect of erlotinib on growth of directly xenografted lung tumors. Data are plotted as mean ± SEM. B) Real-time PCR of Mig6 on directly xenografted tumors. Data are plotted as mean ± SD after normalization with GAPDH. C) Immunoblot analysis of protein lysates of lung xenografts. D) Efficiency of erlotinib in inhibiting growth of tumor xenografts was displayed from most sensitive (left) to most resistant (right) as a bar graph. Relative expression of Mig6 in each tumor xenograft is displayed underneath the tumor growth inhibition bar as a heatmap. FC: fold change. Scale used was Log2FC.The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase InhibitorsPLoS One. 2013;8(7):e68966.Figure 6Mig6/EGFR ratio correlates with the response of patients to gefitinib.A) Selected pictures of IHC staining against Mig6 and EGFR. B) Box plot of Mig6/EGFR ratio distribution. C) The response of patients to gefitinib treatment. PD, progressive disease; SD, stable disease; PR, partial response. D) Kaplan-Meier survival curves showed that patients with low Mig6/EGFR ratio survived significantly longer than the high ratio patients and EGFR negative patients (Log-Rank test P = 0.0112). E) The number of patients as risk at the time point of 0, 100, 200, 400 and 800 days was displayed in the table.The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase InhibitorsPLoS One. 2013;8(7):e68966.Publication Types, MeSH Terms, Substances, Grant SupportPublication TypesResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tMeSH TermsAdaptor Proteins, Signal Transducing/geneticsAdaptor Proteins, Signal Transducing/metabolism*AnimalsCarcinoma, Non-Small-Cell Lung/drug therapy*Carcinoma, Non-Small-Cell Lung/geneticsCarcinoma, Non-Small-Cell Lung/metabolismCell Line, TumorDrug Resistance, Neoplasm/drug effectsDrug Resistance, Neoplasm/geneticsFemaleHumansImmunoblottingKaplan-Meier EstimateLung/drug effectsLung/metabolismLung/pathologyLung Neoplasms/drug therapy*Lung Neoplasms/geneticsLung Neoplasms/metabolismMaleMiceMiddle AgedPhosphatidylinositol 3-Kinases/metabolismProtein Kinase Inhibitors/pharmacologyProtein Kinase Inhibitors/therapeutic use*Proto-Oncogene Proteins c-akt/metabolismQuinazolines/pharmacologyQuinazolines/therapeutic useRNA InterferenceReceptor, Epidermal Growth Factor/antagonists & inhibitorsReceptor, Epidermal Growth Factor/geneticsReceptor, Epidermal Growth Factor/metabolism*Signal Transduction/drug effectsTumor Suppressor Proteins/geneticsTumor Suppressor Proteins/metabolism*Xenograft Model Antitumor AssaysSubstancesAdaptor Proteins, Signal TransducingMIG-6 protein, humanProtein Kinase InhibitorsQuinazolinesTumor Suppressor ProteinsPhosphatidylinositol 3-KinasesEGFR protein, humanReceptor, Epidermal Growth FactorProto-Oncogene Proteins c-akterlotinibgefitinibGrant SupportP50 DE019032/DE/NIDCR NIH HHS/United StatesR37DE012588/DE/NIDCR NIH HHS/United StatesU01 CA084986/CA/NCI NIH HHS/United StatesLinkOut - more resourcesFull Text SourcesPublic Library of ScienceEBSCOEurope PubMed CentralProQuestPubMed CentralPubMed Central CanadaMedicalLung Cancer - MedlinePlus Health InformationPubMed Commons home

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Vladimir Putin fights election-tampering accusations with his own shots at US | Fox News
“So our ambassador met someone. That's his job. That's why we pay him,” Putin said, according to a translation. “So what? What's he supposed to do, hit up the bars?”
He described the focus on Kislyak's contacts as “catastrophic nonsense.”
Earlier this week, Putin denied the Russian state had directed any hacking operations designed to influence the U.S. election – though he did say Russian “patriots” could have been behind the plot on their own accord. Friday, Putin went a step further, saying the U.S. claims contained “nothing concrete, only assumptions.” He added that IP addresses allegedly belonging to Russian hackers easily could have been rigged and couldn't stand as evidence.
PUTIN: RUSSIA DOESN'T ENGAGE IN HACKING AT STATE LEVEL

type: global

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2 bedroom terraced house for sale in Manworthy Road, Bristol, BS4
www.rightmove.co.uk/property/55893184
P8273707.JPG
IS THIS THE ONE? TWO DOUBLE BEDROOMS, PERIOD FEATURES, LOFT ROOM, SOUTH FACING GARDEN and situated in a desirable location being a stroll from the many local amenities of Sandy Park Road and within easy access of the city are just a few must haves! In brief, the accommodation comprises entrance hall, bayed lounge with an open fireplace opening into dining area having a wood burner and opening into the kitchen with a utility and cloakroom off. From the landing can be found two double bedrooms, a spacious bathroom completed with a separate shower cubicle plus a staircase rising to the loft room. Beautifully presented and sure to appeal to all, call GREENWOODS on 0117 9777671 to book your appointment.
Vestibule/ Hallway - Part glazed period entrance door with a top light over, stripped part glazed period vestibule door, exposed floorboards, dado rail, radiator, stairs rising to the first-floor landing. Stripped period door accessing:-
Lounge Dining Room - Having an arch divide.
Lounge - 4.16 x 3.65 (13'7" x 11'11") - Sash bay window to the front aspect, period coved ceiling, open tiled fireplace complete with a wooden mantle, stripped floorboards, Tv, telephone and Sky points, radiator.
Dining Area - 3.5 x 3.72 (11'5" x 12'2") - uPVC double glazed window to the rear aspect, open chimney breast housing a wood burner, built in cupboard to an alcove, stripped floorboards, built in under stairs cupboard, radiator, opening into:-
Kitchen - 3.43 x 2.6 (11'3" x 8'6") - UPVC Double glazed window to side. Being fitted with a range of wall, base and drawer units with worktops and tiled splashbacks, inset stainless steel drainer sink, gas cooker point, plumbing for a dishwasher/washing machine and space for a fridge freezer, tiled flooring.
Rear Lobby - Part glazed door opening to the rear garden, and doors to a utility room and a cloakroom having a w.c, radiator and a uPVC double glazed window, door to:-
Utility Room - uPVC double glazed window to the rear aspect, period style part tiled walls, worktop with a stainless steel drainer sink, plumbing for a washing machine and space for a tumble dryer.
Landing - Balustrade landing with a staircase ring to the loft room, stripped floorboards, period doors accessing:-
Bedroom One - 3.37 x 4.7 (11'0" x 15'5") - Sash windows to the front aspect, period cast iron fireplace, stripped floorboards, radiator.
Bedroom Two - 3.55 x 2.9 (11'7" x 9'6") - uPVC double glazed window to the rear aspect, period cast iron fireplace, stripped floorboards, radiator.
Bathroom - 3.45 x 2.4 (11'3" x 7'10" ) - Spacious family bathroom completed with, w.c, pedestal wash hand basin, panelled bath and a separate shower cubicle having a mains shower and glazed door, tiled splash areas. Cupboard housing a Worcester 'combi' boiler, extractor fan, radiator and uPVC double glazed windows to dual aspects.
Loft Room - 4.66 x 3 (plus eves) (15'3" x 9'10" (plus eves)) - A very useful loft area providing the all essential addition space having double glazed roof lights to both the front and rear. Exposed beams, inset spot lighting, storage cupboard. NB: There are no building regulations and therefore can not be classed as a further bedroom.
Outside - FRONT:- Low boundary walling with entrance gate. Frontage with flower/shrub border.
REAR:- Having a Southerly aspect and being of a low maintenance design with a principle patio of which continues to the side return, flower/shrub borders, timber shed. Path leading to a rear access gate.
To view this media, please visit the on-line version of this page at www.rightmove.co.uk/property-for-sale/property-55893184.html
Manworthy Road, Bris
Disclaimer - Property reference 26478832. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Greenwoods , Brislington. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.

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RRJPER-Vol. 1(2)-October, 2016
by Dr.RAJ KUMAR Dhiman
Qué es la web y cómo puedes aprovec...
Básicos sobre internet
by George Galvis Mon...
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JEFFERSON EDUCATION AND CAREER CENTER LOS ANGELES UNIFIED SCHOOL DISTRICT ~~ DIVISION OF ADULT AND CAREER EDUCATION BULLETIN Week of May 9, 2011 #36 Approved by Ann L. Reed, PrincipalCALENDAR PREVIEWMay 10 & 11 CAHSEEMay 18 Graduation MeetingMay 30 Memorial Day Holiday- School ClosedJune 15 JCAS GraduationASIAN-PACIFIC AMERICAN HERITAGE MONTHOne made a splash riding waves in Hawaii. Another made his mark walking the halls of Congress.Still another made history designing an American landmark. As athletes, politicians, architects,and scientists, theyve not only changed the way we view America—theyve transformed theway we experience the world. This month you will meet ten of our countrys most accomplishedAsian Americans. Duke Kahanamoku- King of the WavesDuke Kahanamoku came to be known as the father of international surfing, but the Hawaiian native madehis first splash as a swimmer at the 1912 Olympics in Stockholm, Sweden. Born in Honolulu in 1890,Kahanamoku struck gold by setting a world record in the 100-meter free-style and earned a silver medalin the 200-meter relay. He won two more gold medals at the 1920 Antwerp Olympics, silver at the 1924Paris Olympics, and a bronze at the 1932 Los Angeles Olympics. Kahanamokus swimming and surfingtalents caught the attention of Hollywood, and over the course of nine years, he appeared in nearly 30movies. Kahanamoku went on to serve as sheriff for the City and County of Honolulu for 26 years. Whenthe legendary swimmer and surfer died at the age of 77, he was remembered for his athletic talent andsportsmanship. 2.
Dalip Singh Saund - A Political PioneerDalip Singh Saund made history in 1956 when he became the first Asian elected to Congress. Born inIndia in 1899, Saund came to the United States in 1920 to study at the University of California,Berkeley, where he earned a doctorate degree in mathematics. Despite being highly educated, Saunddiscovered that his career options were limited due to anti-immigrant feelings in the U.S. As a result, heworked in farming for the next 20 years. At the same time, Saund began fighting discriminatory lawsagainst Indians. In 1949, he and other Indians finally earned the right to become U.S. citizens. In 1956,Saund left the fields of California for the halls of Congress. He served three terms in the House ofRepresentatives, working to improve U.S.-Asian relations. Saunds political career was cut short when hesuffered a stroke while campaigning for a fourth term. Still, he opened the door for Asian Americans toenter U.S. politics. Maya Lin - A Monumental ArchitectMaya Lin rose to fame in 1981. Just 21-years-old and still an architectural student at Yale University, Linwon a contest to design the Vietnam Veterans Memorial in Washington, D.C. Her design beat out morethan 1,400 entries. The Memorials 594-foot granite wall features the names of the more than 58,000U.S. soldiers who died during the Vietnam War. Each year, four million people visit the wall to pay theirrespects to these war heroes. Less than a decade later, Lin designed another famous structure—theCivil Rights Memorial in Montgomery, Alabama. The monument outlines the major events of the CivilRights Movement. Today, Lins designs can be found in several American cities and continue to inspirethe entire nation.MOTHER AND DAUGHTER SELF-DEFENSE TRAININGA comprehensive, women-only course in self defense is being offered at Jefferson High School. Thecourse includes lecture, discussion, and self-defense techniques. The course is Saturday, May 21, 2011fro 9am to 5:309m. The cost is $10.00. For more information contact the Parent Center at323-521-1200 xt. 303.CCAE/CAROCP CONFERENCEKUDOS to everyone who participated the CCAE/CAROCP Spring Conference on Saturday, May 7, 2011.The conference was well attended and offered many exciting and informative workshops. Specialcongratulations go to Ms. Cynthia Oliva, APACS, and Ms. Claudia Javier, Academic Teacher Adviser onthe success of their workshop, How to Identify More Graduates. Well done!DEMOGRAPHIC LISTSReaching out to students with that personal touch can make all the difference when it comes tomotivating someone to continue with his or her studies. You may request a demographic list of your classfrom the main office or through any administrator. Please take a few minutes each week to phonestudents whose attendance may have dropped off a bit and let them know they are missed.REMINDER-CBET TUTORING LOGSPlease make sure your students are making weekly entries on their CBET Tutoring Logs. We mustcontinue to be diligent in maximizing our efforts to tap into all available funding sources for the 3.
remainder of the school year. CBET funding is very important to the health of our ESL program and thetutoring hours directly impact resource allocation.JCAS SCHOLARSHIP FUNDPlease don’t miss your opportunity to donate to the JCAS Scholarship fund for this year. No donation istoo small and every donation will help a student. Make checks payable to JEFFERSON CAS FACULTYSCHOLARSHIP FUND. THANK YOU. Yes, cash is always accepted as well.CALPRO WORKSHOP- Enhancing Learner PersistenceWhat’s all the excitement surrounding the topic of learner persistence, how does it differ from studentretention and motivation, and how do I encourage my students to persist in their learning? Based onresearch on factors that promote learner persistence, this workshop engages participants inbrainstorming implications for changing practice in the four areas of intake, orientation, instruction, andprogram activities. Come see what all the excitement is about!Date: Thursday, May 19, 2011Time: 2:15 PM – 5:15 PMRegister online. http://calpro-online.orgLocation: Oxnard Adult School (Oxnard) CONFERENCES AND WORKSHOPS CALPRO Instructors Forum Webinar Series Thursday Learning to Achieve; Instructional May 26, 2011 http://calpro-online.orgStrategies to Support Adults with Learning 2:30-3:30pm Disabilities Facility Alert-Parking-High School Activities on CampusPolicy Review-The LAUSD and all its employees are subject to the provisions of the Copyright Act of 1976. Unlawfulcopies of copyrighted materials may not be produced or used on district-owned equipment, withinDistrict-owned facilities, or at District-sponsored functions. Employees who knowingly and/or willinglyviolate the District’s copyright policies do so at their own risk and may be required to remunerate theDistrict in the event of loss due to litigation. Please see Bulletin # 714 for more detail. Thought for the Week A journey of a thousand miles begins with a single step. Lao-tzu, The Way of Lao-tzu Chinese philosopher (604 BC - 531 BC) 4.
MISSION STATEMENTWe are an education and career center in south Los Angeles. Our mission is to provide educational opportunities toenhance students’ personal, academic, career, and social abilities, as well as facilitate participation in our culturallydiverse and technologically advancing society.Expected School wide Learning Results (ESLRs) 1.) JECC students will be able to use life skills learned as part of their education to improve their lives in a culturally diverse community. 2.) JECC students will be able to adapt to a changing world by setting personal, academic, and/or vocational goals. 3.) JECC students will be able to apply learned skills in their everyday lives such as technology, reading, writing, speaking, and listening. Recommended
Qué es la web y cómo puedes aprovechar sus beneficios
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Croup. A current perspective. [Pediatr Clin North Am. 1999] - PubMed - NCBI
Display Settings:AbstractFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApplySend to:Choose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File1 selected item: 10629679FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mail"SPAM" filtering software noticeAdd to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Create File
Pediatr Clin North Am. 1999 Dec;46(6):1167-78.Croup. A current perspective.Klassen TP.SourceDepartment of Pediatrics, University of Alberta, Edmonton, Canada.AbstractIn the past decade, much progress has been made in the management of patients with croup. Where glucocorticoids have been adopted into practice, evidence shows that a decrease of health-care-service use is occurring in terms of fewer admissions to intensive care units and hospitals. The evidence may be summarized as follows. All children with croup symptoms who demonstrate increased work of breathing in the clinics or emergency departments should be treated with glucocorticoids. This treatment may be with nebulized budesonide (2 mg) or PO or IM dexamethasone (dose may be 0.15-0.6 mg/kg). Oral dexamethasone may be the best option because of its ease of administration, widespread availability, and lower cost. L-Epinephrine (5 mL of 1:1000) or racemic epinephrine (0.5 mL) should be considered for children with croup who have moderate or severe distress. No evidence supports the effectiveness of mist therapy, and physicians are in need of a randomized, controlled trial for this.PMID: 10629679 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, SubstancesPublication TypesReviewMeSH TermsChildChild, PreschoolCroup/diagnosis*Croup/drug therapy*Drug Administration RoutesGlucocorticoids/therapeutic use*HumansInfantSubstancesGlucocorticoidsLinkOut - more resourcesFull Text SourcesMD ConsultMedicalSteroids - MedlinePlus Health Information
Nebulized budesonide and oral dexamethasone for treatment of croup: a randomized controlled trial.Klassen TP, Craig WR, Moher D, Osmond MH, Pasterkamp H, Sutcliffe T, Watters LK, Rowe PC. JAMA. 1998 May 27; 279(20):1629-32. The efficacy of nebulized budesonide in dexamethasone-treated outpatients with croup.
The efficacy of nebulized budesonide in dexamethasone-treated outpatients with croup.Klassen TP, Watters LK, Feldman ME, Sutcliffe T, Rowe PC. Pediatrics. 1996 Apr; 97(4):463-6. A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup.
A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup.Johnson DW, Jacobson S, Edney PC, Hadfield P, Mundy ME, Schuh S. N Engl J Med. 1998 Aug 20; 339(8):498-503. Review Outpatient management of croup.
Review Outpatient management of croup.Klassen TP, Rowe PC. Curr Opin Pediatr. 1996 Oct; 8(5):449-52. Review Recent advances in the treatment of bronchiolitis and laryngitis.
Review Recent advances in the treatment of bronchiolitis and laryngitis.Klassen TP. Pediatr Clin North Am. 1997 Feb; 44(1):249-61. See reviews...
Historical review of croup.
Historical review of croup.Marchessault V. Paediatr Child Health. 2001 Dec; 6(10):721-3. Croup.
[Can J Infect Dis. 2001]
Historical review of croup.Marchessault V. Can J Infect Dis. 2001 Nov; 12(6):337-9. Related information
Turn Off Turn On Croup. A current perspective.
Croup. A current perspective.Pediatr Clin North Am. 1999 Dec ;46(6):1167-78.


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A sensor system comprising a first electrode with an array of carbon nanotubes and a second electrode. The first electrode with an array of carbon nanotubes and the second electrode are positioned to produce an air gap between the first electrode with an array of carbon nanotubes and the second electrode....http://www.google.com/patents/US6946851?utm_source=gb-gplus-sharePatent US6946851 - Carbon nanotube array based sensor
US7818065 * Mar 31, 2006 Oct 19, 2010 New York University Conducting polymer nanowire brain-machine interface systems and methods
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US20100106259 * Mar 31, 2006 Apr 29, 2010 New York University Conducting polymer nanowire brain-machine interface systems and methods
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US20120145988 * Jan 29, 2009 Jun 14, 2012 Quitoriano Nathaniel J Nanoscale Apparatus and Sensor With Nanoshell and Method of Making Same
US20150080770 * Nov 26, 2014 Mar 19, 2015 The Research Foundation For The State University Of New York Differentiation of stem cells with nanoparticles
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CN101713531B Oct 8, 2008 Aug 28, 2013 清华大学 Sounding type lighting device
WO2007111936A2 * Mar 22, 2007 Oct 4, 2007 Fritsch Michael H Intracochlear nanotechnology and perfusion hearing aid device
WO2007111936A3 * Mar 22, 2007 Dec 11, 2008 Michael H Fritsch Intracochlear nanotechnology and perfusion hearing aid device

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Sue Bruja's Documents | Scribd
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Harold Pliskow (Unknown-1974) - Find A Grave Memorial
Harold Pliskow
Section Old (12), Row 13, Lot 19
80528164 · View Source
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Find A Grave, database and images (https://www.findagrave.com : accessed ), memorial page for Harold Pliskow (unknown–Oct 1974), Find A Grave Memorial no. 80528164, citing Mount Sinai Memorial Park, Toronto, Toronto Municipality, Ontario, Canada ; Maintained by Michelle Lutz (contributor 47470711) .
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Observation Deck: Carolina Panthers - ESPN
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text: Jimbo Fisher: 'No regrets' on play calling1216dDavid M. HaleRemembering Ron Rivera's Cal connections1dSarah LangsPat Haden's USC legacy will be written by Clay Helton1dTed MillerMichigan freshmen expect to have instant impact2dDan MurphyOn-field success showcases Dabo Swinney's off-field energy for recruits1dDavid M. HaleThe geography of the Pac-12's 2016 recruiting class2dKevin GemmellHow Illinois landed a solid class despite facing obstacles unlike any other team2dAdam RittenbergWeekly Commitment Roundup2dRecruitingNationFlorida didn't have to make a splash on signing day2dAndrea AdelsonFlorida State's Jimbo Fisher eschews gimmicks en route to No. 1 class2dJared ShankerAll-Big 12 team: signing day edition2dJake TrotterHow Texas pulled off its stunning signing-day haul2dMax OlsonRedshirts not part of Ohio State's 2016 plan as it reloads with a young roster3dAustin WardMiami hopes Mark Richt can turn talent into wins3dDavid M. HaleWatch: Houston coaches destroy fax machine 'Office Space'-style3dSam Khan Jr.Kirby Smart keeps Georgia in stride with solid first class3dEdward AschoffJimbo Fisher: 'No regrets' on play callingEmailcommentOct 8, 2012David M. HaleEmailprintcommentTALLAHASSEE, Fla. -- In the immediate aftermath of the disaster, Jimbo Fisher took the heat, offering a laundry list of things he could have done differently in Florida State's 17-16 loss to NC State.Two days later, that tune has changed.Fisher said he watched film, evaluated his play calling and came to a concise conclusion about what went wrong Saturday.One of the criticisms following FSU's loss to NC State was the lack of touches for James Wilder Jr. Streeter Lecka/Getty Images"You try to keep trying to be aggressive in calls and how you do things, and hindsight is 20/20, but I don't regret calls," Fisher said. "Now that I look at the film, I don't regret."The pronouncement isn't going to make Fisher a fan favorite this week, as he has been lambasted for his conservative approach in the fourth quarter while FSU watched a 16-0 lead slip away.Two situations earned the most criticism.The first came on a third-and-2 at the NC State 19-yard line, when after calling a timeout, Fisher sent EJ Manuel back onto the field to run a bootleg to the right. The play failed miserably and Manuel was stuffed for a 15-yard loss.The irony is, for all the clamor of Fisher's conservative approach, a simple run up the middle would have resulted in at least three points. Instead, the sack meant a 52-yard attempt at a field goal, and Fisher elected to punt instead."I thought we had a play that we'd worked all week," Fisher said of the third-down call. "It was a lack of execution. If we execute the play, it's going to be an excellent play. They got penetration off of it and it wasn't there. It's something we'd worked a bunch."Florida State still had a chance to ice the game with 2:47 left to play.The Seminoles took over at their own 32 with a six-point lead knowing NC State would burn through its timeouts to preserve clock. Fisher called three straight running plays that went nowhere. The ensuing punt was blocked, and NC State cashed in on its next drive for the win. Again, Fisher doesn't quibble with the decisions to run the ball.The first down play was a run by Chris Thompson that had been successful in the first half Saturday. It was a similar play call to the long run Thompson had to ice the previous week's game against USF. But a guard missed a block and Thompson was tackled for a 2-yard loss.The second play went back to Thomspon, who picked up 3, setting up a third-and-9. Rather than looking downfield, Fisher went with a quarterback run. Again, a block was missed and Manuel was dumped for no gain.Fisher said the film showed all three plays had a chance to go for big gains if executed properly, and he suggested the major problem with the drive was the blocked punt that left a short field for NC State."Every play was right there," Fisher said. "Does throwing it make you more aggressive? Or does running it when you're moving the ball? Hindsight is all 20/20. I don't regret any of the calls. I regret we didn't execute some of the things we did, and we've got to play better."Fisher's philosophy is not without merit. Florida State's offensive line had struggled in pass protection, which made a conservative approach at least defensible. But the context of the situation is what caught the ire of so many fans.For one, Fisher continued to give the ball to Thompson, who had a career high 25 carries Saturday. He had been excellent in the first half, but he wore down late and found little room to run. Florida State had 21 yards rushing in the second half.After the game, Fisher said he should have gotten backup James Wilder Jr. more touches, but he backed off those comments Monday as well."Chris has just been playing so daggone well," Fisher said. "The guy is averaging 7.7 yards a carry for the season, and he's catching the ball very well."Thompson's season average is impressive, but he's averaged just 4.1 yards per carry in the second halves of games this year.The passing game was a separate issue altogether.Going into the game, Manuel said he was eager to get his chance to eviscerate the Wolfpack's secondary which had given up an ACC-record 566 yards to Miami quarterback Stephen Morris. Fisher called just 34 passing plays."We didn't throw the ball as much as I thought we would have," Manuel said.Manuel offered no further explanation. He said he hadn't thought the heavy dose of runs would be the game plan coming in, but he didn't specifically criticize the decisions made during the game.The film review essentially boiled down to a simple formula for Fisher: The plays were there, but the execution and the focus was not."Any time you're a leader, you have to look at yourself first and say, 'Did I make the right call?'" Fisher said. "After seeing the video, [NC State] was in what we thought they were in, doing exactly what we thought they were doing. It's not blame. We just didn't execute. It's not the same guy. It's just one guy -- a guy can grade 88 percent in a game and have two bad plays that happen to be at the wrong time. That's what it was an accumulation of in the second half."That's going to be a tough sell to a frustrated fan base, but Fisher's real answers will be delivered in the next six games.


text:
Multiple Sessions in Codeigniter/PHP - Stack Overflow
1 I am developing a e-commerce website in codeigniter having sessions for following:
Now i am unable to figure out a mechanism for managing these three sessions with different sets of data.
I know it can be achieved with session_name() in core php. But with codeigniter i am a bit confused.
Googled it a lot but couldn't found a proper answer.
I want a clear understanding of multiple sessions in codeigniter so that it doesn't create any confusion in future. Any link to tutorial would be great.
codeigniter share|improve this question asked Aug 22 '12 at 18:56
i want to use native PHP sessions
theres a code igniter library for native sessions if you google for it. Not sure how well it works. Regular code igniter sessions are done with a cookie limited to about 4k in size which breaks everything when you go over the size limit. You can use db_sessions as well by changing config option which removes the size limitation.
well i really want to use native PHP Sessions instead of the library provided by codeigniter. I know this can be done but not the specifics.
why would you want "multiple" sessions? Just have one session with all the data in it??
$this->session->set_data('admin',$array_of_admin_data);
$this->session->set_data('user',$array_of_user_data);
$this->session->set_data('cart',$array_of_cart_data);
then retrieve each seesion data ? using
$this->session->userdata('admin');
why wouldnt this work ?
share|improve this answer answered Aug 23 '12 at 6:41
thanks for the reply. But i do not want to use the codeigniter sessions as they store the data using cookies which forces me to think about the security concerns.
Codeigniter's session is completely different from Native PHP Session and it's very secure especially when stored in a database. You can work with codeigniter's sessions and Native PHP Session they would work fine together because PHP would see the as different variables.
If you want to check for the existence of a codeigniter session value use
if(isset($this->session->userdata['course_id']))
$this->data['course_id'] = $this->session->userdata('course_id');
While Native PHP would look like
if(isset($_SESSION['course_id']))
$this->data['course_id'] = $_SESSION['course_id'];
share|improve this answer edited Sep 26 '12 at 13:07
I'm also developing a e-commerce system and have the same problem. I didn't like to manage all the data stored as serialized data in the database, especially not for the cart/basket, as it makes it hard to query the database and i simply think it's kinda messy.
I'm quite new to CI and stackoverflow, but my idea was to set up the ci_session table as it is written in the docs, thus keeping the consistency and security of CI sessions. Then i only add one reference id to the session varialbe for each session data you want to manage. E.g. for the cart:
$unique_cart_id = random_string('unique');
$this->session->set_userdata('cart_id', $unique_cart_id);
and now i reference my cart_id in a separate "basket"-table with all the data. E.g.:
CREATE TABLE basket (
cart_id varchar(32) default NULL,
serialized_data text,
product_id int(11) default NULL,
Now each time someone wants to add something to the basket i get the cart_id from the session variable:
$cart_id = $this->session->userdata('cart_id');
and store the $cart_id together with any other cart data in my "basket"-table, by writing a little insert script.
'cart_id' => $cart_id,
'product_id' => $product_id,
'serialized_data' => serialize(array('what ever you need else'))
$this->db->insert('basket', $data);
Now if someone wants to view the basket I just retrieve the $cart_id from the session variable again and query the database where it matches the cart_id.
$this->db->query("SELECT * FROM basket WHERE cart_id = ?", array($cart_id));
And you use the same principle for the your other session data, admin and user login. Thus I keep only to have a single session cookie for each user but I can manage each type of session data separately in the database.
This was just a rough breakdown of the idea. I hope it helped.
share|improve this answer edited Jun 1 '13 at 20:20
answered May 25 '13 at 7:14
With the userdata() method, you can retrieve the fields you saved during the creation of the session.
For example, you pass the $array_of_admin_data array, which holds some information like userType. If you want to retrieve this value, you must call userdata() like this:
$this->session->userdata('userType');
share|improve this answer edited Nov 21 at 9:08
answered Nov 21 at 8:45
Codeigniter Sessions Checking from a header view file
CodeIgniter, rewrite urls, call custom controller
Multiple Session not working in codeigniter
Codeigniter - Session expiration and “remember me” feature
how to create shopping cart popup window in codeigniter

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Art painting Jmjartstudio Original Painting 24 x 48 Inches | Etsy
You save $61.90 (10%)
Height: 33 Inches; Width: 54 Inches
My name is Sherri . As an artist I paint from the inside out. Each piece has a personal meaning to me. Painting frees my imagination and provides many chances for happy accident to influence the finished piece. In general most of my pieces have a lot of texture and vibrancy. Art should be touched, art should make you happy.I have been selling art on line for several years and I have pieces displayed in public and private collections all around the world. I currently have a piece display in a permanent collection at the Rochester Museum of Fine Arts www.rochestermfa.org. My work was featured on NBC's Today show with Kathy Lee and Hoda as one of their favorite things. Thank you for looking at my work to learn more about me visit my profile page http://www.etsy.com/people/JMJARTSTUDIO?ref=si_pr.
Original Large abstract painting industrial pipe wall hanging rustic wall decor by Jmjartstudio 24 X 48 Inches blue painting
This unique painting will make a statement in any room. Featuring original artwork and industrial black pipe. The painting hangs from heavy wire rope and re purposed pulleys . It is easy to assemble and will hang quickly.
54 inches wide by 33 inches high.
48 inches wide and 24 inches high.
Shades of blue, , red, and orange
SIZE : 24" X 48" ( painting only) 54" X 33" with the hanging system
COLOR PALLET : red, yellow, orange, blue and green
Beautiful and original painting. Arrived on time and packaging was meticulous.
Daren Lowndes Aug 18, 2017
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Industrial Art, Original abstract painting, by JMJArtstudio Large 48 inch painting
Large abstract black and white painting Jmjartstudio

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Nathaniel Armstrong Condolences | Sign the Guest Book | Arch L. Heady-Cralle Funeral Home in partnership with the Dignity Memorial network
Nathaniel Thompson Armstrong II

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Similar articles for PubMed (Select 24490977) - PubMed - NCBI
Summary20 per pageSort by LinkFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListItems per page5102050100200Sort byLinkPublication DateFirst AuthorLast AuthorJournalTitleApplySend to:Choose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVSort byLinkPublication DateFirst AuthorLast AuthorJournalTitleCreate FileSimilar articles for PubMed (Select 24490977)FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataSort byLinkPublication DateFirst AuthorLast AuthorJournalTitleNumber to send5102050100200Start from citationE-mailSubjectAdditional textE-mailDidn't get the message? Find out why...Add to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Number to send5102050100200Start from citationCreate File
Select item 244909771.Overcoming recruitment barriers revealed high readiness to participate and low dropout rate among people with schizophrenia in a randomized controlled trial testing the effect of a Guided Self-Determination intervention.Jørgensen R, Munk-Jørgensen P, Lysaker PH, Buck KD, Hansson L, Zoffmann V.BMC Psychiatry. 2014 Feb 3;14:28. doi: 10.1186/1471-244X-14-28.PMID: 24490977 Free PMC ArticleSimilar articles Select item 225456362.Changes in persistent delusions in schizophrenia using guided self-determination: a single case study.Jørgensen R, Hansson Professor L, Zoffmann V.Issues Ment Health Nurs. 2012 May;33(5):293-300. doi: 10.3109/01612840.2011.653624.PMID: 22545636 Similar articles Select item 182086803.Prevention of suicide and attempted suicide in Denmark. Epidemiological studies of suicide and intervention studies in selected risk groups.Nordentoft M.Dan Med Bull. 2007 Nov;54(4):306-69. Review.PMID: 18208680 Similar articles Select item 216722524.Improving glycaemic control and life skills in adolescents with type 1 diabetes: a randomised, controlled intervention study using the Guided Self-Determination-Young method in triads of adolescents, parents and health care providers integrated into routine paediatric outpatient clinics.Husted GR, Thorsteinsson B, Esbensen BA, Hommel E, Zoffmann V.BMC Pediatr. 2011 Jun 14;11:55. doi: 10.1186/1471-2431-11-55.PMID: 21672252 Free PMC ArticleSimilar articles Select item 234141745.The addition of a goal-based motivational interview to treatment as usual to enhance engagement and reduce dropouts in a personality disorder treatment service: results of a feasibility study for a randomized controlled trial.McMurran M, Cox WM, Whitham D, Hedges L.Trials. 2013 Feb 17;14:50. doi: 10.1186/1745-6215-14-50.PMID: 23414174 Free PMC ArticleSimilar articles Select item 170542136.Early intervention for psychosis.Marshall M, Rathbone J.Cochrane Database Syst Rev. 2006 Oct 18;(4):CD004718. 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Epub 2011 Dec 5.PMID: 22143987 Similar articles Select item 2469040213.Structured, intensive education maximising engagement, motivation and long-term change for children and young people with diabetes: a cluster randomised controlled trial with integral process and economic evaluation - the CASCADE study.Christie D, Thompson R, Sawtell M, Allen E, Cairns J, Smith F, Jamieson E, Hargreaves K, Ingold A, Brooks L, Wiggins M, Oliver S, Jones R, Elbourne D, Santos A, Wong IC, O'Neill S, Strange V, Hindmarsh P, Annan F, Viner R.Health Technol Assess. 2014 Mar;18(20):1-202. doi: 10.3310/hta18200.PMID: 24690402 Free ArticleSimilar articles Select item 1633071814.Dropout rates in placebo-controlled and active-control clinical trials of antipsychotic drugs: a meta-analysis.Kemmler G, Hummer M, Widschwendter C, Fleischhacker WW.Arch Gen Psychiatry. 2005 Dec;62(12):1305-12.PMID: 16330718 Similar articles Select item 2511814615.Effect of guided self-determination youth intervention integrated into outpatient visits versus treatment as usual on glycemic control and life skills: a randomized clinical trial in adolescents with type 1 diabetes.Husted GR, Thorsteinsson B, Esbensen BA, Gluud C, Winkel P, Hommel E, Zoffmann V.Trials. 2014 Aug 12;15:321. doi: 10.1186/1745-6215-15-321.PMID: 25118146 Free PMC ArticleSimilar articles Select item 2445060816.Evaluation of the impact of a psycho-educational intervention on knowledge levels and psychological outcomes for people diagnosed with Schizophrenia and their caregivers in Jordan: a randomized controlled trial.Hasan AA, Callaghan P, Lymn JS.BMC Psychiatry. 2014 Jan 22;14:17. doi: 10.1186/1471-244X-14-17.PMID: 24450608 Free PMC ArticleSimilar articles Select item 2242058017.Modelling and simulation of the Positive and Negative Syndrome Scale (PANSS) time course and dropout hazard in placebo arms of schizophrenia clinical trials.Pilla Reddy V, Kozielska M, Johnson M, Suleiman AA, Vermeulen A, Liu J, de Greef R, Groothuis GM, Danhof M, Proost JH.Clin Pharmacokinet. 2012 Apr 1;51(4):261-75. doi: 10.2165/11598460-000000000-00000.PMID: 22420580 Similar articles Select item 2398147418.Recruitment for a clinical trial of chronic disease self-management for older adults with multimorbidity: a successful approach within general practice.Reed RL, Barton CA, Isherwood LM, Baxter JM, Roeger L.BMC Fam Pract. 2013 Aug 28;14:125. doi: 10.1186/1471-2296-14-125.PMID: 23981474 Free PMC ArticleSimilar articles Select item 2144383819.Processes in recruitment to randomised controlled trials of medicines for children (RECRUIT): a qualitative study.Shilling V, Williamson PR, Hickey H, Sowden E, Smyth RL, Young B.Health Technol Assess. 2011 Mar;15(15):1-116. doi: 10.3310/hta15150.PMID: 21443838 Free ArticleSimilar articles Select item 1054705320.Challenges faced in recruiting patients from primary care practices into a physical activity intervention trial. Activity Counseling Trial Research Group.Margitić S, Sevick MA, Miller M, Albright C, Banton J, Callahan K, Garcia M, Gibbons L, Levine BJ, Anderson R, Ettinger W.Prev Med. 1999 Oct;29(4):277-86.PMID: 10547053 Similar articles << First< PrevPage of 6Next >Last >>


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#5 of 654 B&Bs / Inns in Chiang Mai Hotel website
13 Chaiyapoom Road soi 1 | Sriphoom, Chiang Mai, Thailand 791 Reviews | Ranked #5 of 654 To help you get around Chiang Mai, here's the name and address of this business in the local language
372 more photos Hotel & Grounds (85)View album Room/Suite (64)View album Family/Play Areas (24)View album View All Photos Management photosTraveler photos (358)View Map
Save Book on Check In Check Out 1 room 1 room 2 adults 2 adults 0 children 0 children Ages of Children: change Please provide ages Child 1 Age Age Update Search Update We're finding you the best rooms at the lowest prices from our partner.Book on 4Standard Room Getting you more information on this room See More Free Cancellation Best Price /night taxes & fees Select Show available rooms for Top Garden Boutique Guesthouse You can see room offers from our travel partners starting at *, or change dates. There are no rooms available to book this property on TripAdvisor from – .
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791 Reviews from our TripAdvisor Community Read reviews that mention: All reviews cat house
31rikkir
1 helpful vote “Lovely place, Lovely owners, great stay”
NEW Humble but lovely place with great value and location. Highly recommend. The owners are very helpful and knowledgeable about the area and prices. Located fairly central it was easy to find and get around from there. Make sure you try the cat house(mind the name) just nearby for a great meal too.
Helpful? Thank 31rikkir Report geek2290
NEW The guesthouse was really lovely! The owners are the loveliest people and helped with every question or concern I had. The rooms are nice and big, and the bed are comfortable! It feels like a cozy, very peaceful oasis, even though it's close to all the major attractions and busy streets. A perfect place to see Chiang Mai! The only...
More Helpful? Thank geek2290 Report Miiilkyway
Guesthouse was okay but not very big. A lot of humidity in the room.
We had ants everywhere on the table and in the security deposit box. That wasn't a pleasant surprise.
Shower and toilet are okay.
Location is near the old city.
Helpful? Thank Miiilkyway Report lamphs
95 helpful votes “Not much to add to the already excellent reviews...”
I stayed in the 'suite' on the 3rd floor. Not because I needed a suite, but because it was the only room available for the required dates. The suite was nice in that it includes a room between the bedroom and the bathroom...a little extra space and a desk (as I had some work to do). Room was cleaned each...
More Helpful? Thank lamphs Report Michael C
2 reviews “I HIGHLY recommend Top Garden Boutique in Chiang Mai!!!”
My wife and I stayed in one of the deluxe rooms and we really enjoyed the experience! The room was comfortable and clean and the location was so convenient with many markets and places to eat within close, walking distance. The owners and entire staff were very friendly and welcoming. I very rarely take the time to write reviews but...
More Helpful? Thank Michael C Report Rosieej
We really enjoyed our stay here for two nights. Great location to the old city and night market. Owners were very friendly and organised tuktuks for us which were always in time. Room was very spacious and clean. We enjoyed having a few beers in the 'top garden' watching the activities of the street below and the squrrils on the...
More Helpful? Thank Rosieej Report RockLnelson
Level Contributor 14 reviews 1 helpful vote “Great price, great place to stay”
It is run by a couple who are always attentive to your needs. We've stayed around the place during the day one day and saw 3 cleaners working away much of the day; and it shows!
The place in general and the rooms specifically are kept very clean, they put out towels to wipe your feet when it rains👍
More Helpful? Thank RockLnelson Report Luise G
21 helpful votes “Best place to stay in Chiang Mai”
Always nice to come back to a place that feels familiar.Victor and Tanja make us feel welcome and do everything to make us feel comfortable.The staff is first class and speak excellent English.The rooms are large, clean and have great bathrooms.The beds are just the right hardness & our view from the Windows was excellent.Will be back for sure.
Helpful? Thank Luise G Report Luise G has 1 more review of Top Garden Boutique Guesthouse “best place to relax”
1 helpful vote “Great guesthouse with very friendly staff!”
We stayed for 4 nights in the guesthouse and would recommend it to every one visiting chiang mai. Located at a calm street very close to the old city.Peter and his wife were very helpful during our stay and gave us a lot valuable tips. The rooms are very clean and have a fridge with free water. We had a...
More Helpful? Thank anna g Report Malou160612
14 helpful votes “Wonderful stay in Chiangmai”
We had a great stay for three days in this guesthouse in Chiangmai before we headed to Vientianne, Laos. Victor and Thunya, the owners of this guesthouse, were very accommodating to us. We were able to avail a discount of 100 baht for our cooking class when booked through them. They also helped us find our transport service (owned by...
More Helpful? Thank Malou160612 Report Previous
Updating list... Questions? Get answers from hotel staff and past guests. Ask a question Explore similar hotels Varada Place 548 ReviewsShow Prices 1.3 miles BED Phrasingh Hotel 399 ReviewsShow Prices 0.9 miles Shewe Wana Boutique Resort and Spa 851 ReviewsShow Prices 0.8 miles See all Chiang Mai hotels Browse nearby
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Browse all attractions Top-rated Restaurants Nearby 709 Reviews The Hideout
322 Reviews Cat House Restaurant
Posting guidelines Get notified about new answers to your questions. Ask Typical questions asked: Can tickets for local attractions be purchased at the front desk? Do you have to pay extra for a mini-fridge? At what time does the pool open each day? See which rooms travelers prefer “pay extra for the deluxe, is worth it.”
31rikkir, 4 days ago
scoobsk, Aug 31, 2016

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S&P 500 Rallies to Record on Increased Economic Optimism - Bloomberg
S&P 500 Rallies to Record on Increased Economic Optimism
By Lu Wang and Nikolaj Gammeltoft - May 14, 2013
U.S. stocks rose, sending the Standard & Poor’s 500 Index to its eighth record high in the past nine sessions, on increased optimism over growth in the world’s largest economy.
Financial shares climbed the most among 10 S&P 500 industry as hedge-fund manager David Tepper called U.S. banks “a good sector.” Bank of America Corp. and Citigroup Inc. rose more than 2.4 percent. Edwards Lifesciences Corp. advanced 6.3 percent after announcing a share buyback program. Apple Inc. slipped 2.4 percent, dragging technology companies to the worst performance among the 10 groups.
The S&P 500 increased 1 percent to 1,650.34 at 4 p.m. in New York. The Dow Jones Industrial Average gained 123.57 points, or 0.8 percent, to a record 15,215.25. About 6.2 billion shares changed hands on U.S. exchanges, 1.9 percent below the three-month average.
“There’s an encouraging pattern of continued growth in the economic data,” Alan Gayle, a senior strategist at RidgeWorth Capital Management, which oversees about $48 billion of assets, said in a phone interview. “What is helping the market is the belief that downside risks to stocks are limited right now.”
Tepper, co-founder and owner of Appaloosa Management LP, said in an interview on CNBC that he is still bullish and the economy is getting better. Tepper, who led Institutional Investor’s ranking of the top earners in hedge funds last year with $2.2 billion, said in January in a Bloomberg Television interview that the U.S. “is on the verge of an explosion of greatness.”
Money managers are the most bearish on commodities in more than four years as a majority expected a weaker Chinese economy for the first time in 14 months, a Bank of America survey showed. A net 29 percent of the fund managers surveyed were underweight the asset class in May as their positions “collapsed” to the lowest level since December 2008. One in four now consider a “hard landing” in China as the biggest risk to their investments. The bank surveyed professional investors who together oversee $517 billion.
“There has been a marked uptick” in concern about China, said John Bilton, an investment strategist at Bank of America’s Merrill Lynch unit, at a press conference in London today. “A hard landing is not our core scenario, but certainly investors are right to start thinking they should at least hedge some of that tail risk.”
The U.S. bull market has entered its fifth year. The S&P 500 has surged 144 percent from a 12-year low in 2009, driven by better-than-estimated corporate earnings and three rounds of bond purchases from the Federal Reserve.
The Chicago Board Options Exchange Volatility Index (VIX), or VIX, rose 1.8 percent to 12.77. The benchmark gauge for options, which moves in the opposite direction to the S&P 500 about 80 percent of the time, has fallen 29 percent this year. The S&P 500 has only dropped 3 times in the past 18 days and is up 3.3 percent in May, heading for the seventh straight month of gains.
About 87 percent of S&P 500 stocks traded above their average prices from the past 50 days as of yesterday, according to data compiled by Bloomberg. That’s near the highest level in three months, while below the two-year high of 93 percent in January. There were 67 stocks in the index that closed at a 52-week high yesterday and none at a 52-week low.
All 10 industries in the S&P 500 advanced today as financial and commodity companies climbed at least 1.2 percent. Bank of America added 2.8 percent to $13.34 for the biggest increase in the Dow. Citigroup increased 2.4 percent to $50.09. Goldman Sachs Group Inc. rallied 3.3 percent to $154.52.
Tepper said his firm still owns stock of Citigroup and other U.S. banks. “We have a certain amount of the U.S. banks, which are a good sector,” he told CNBC.
Tepper also said he cut his stake in Apple at the start of the year as the maker of the iPhone and iPad devices hasn’t been “evolutionary” or “revolutionary” recently. Shares of Apple dropped 2.4 percent to $443.86.
Education Shares
Education companies surged as the market rally forced investors who had expected declines in Apollo Group Inc. (APOL) and ITT Educational Services Inc. to buy back the shares to stem losses.
Apollo (APOL), the largest U.S. for-profit college chain, jumped 9.1 percent to $20.49. The stock’s short interest reached 15 percent of its shares available for trading in April, the highest level since at least 2006, according to data compiled by Bloomberg and Markit, a London-based research firm. The ratio has since fallen to 13.6 percent as of May 10. That compared with an average 2.6 percent for the S&P 500, the data show.
ITT Educational, whose short interest has climbed to 30.1 percent from a low of 18.5 percent in January, soared 18 percent to $25.11 today.
Actavis Inc. gained 1 percent to a record $121.68. The generic drugmaker rejected a cash-and-stock offer from Mylan Inc. for $15 billion, deciding instead to pursue talks to take over Warner Chilcott Plc, said people familiar with the matter.
Edwards Lifesciences advanced 6.3 percent to $71.57. The biggest maker of aortic heart valves implanted with a catheter announced a $750 million share-buyback program. Chief Financial Officer Thomas M. Abate plans to retire, the company also said.
Fusion-io Inc. (FIO) climbed 4.2 percent to $15.12 as UBS AG raised its rating on the maker of data storage to buy from neutral. The stock’s drop after the company’s co-founder and chief executive officer resigned last week was overdone, according to UBS analysts led by Steven Milunovich.
SolarCity Corp. slid 12 percent to $31.44. The second-largest U.S. solar company by market value posted a first-quarter loss as it bore higher costs from installing rooftop solar systems at little or no charge to customers.

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Blake tallies twice as Ducks continue to heat upVancouver Canucks Anaheim Ducks1198dJason Blake scored two goals to lift the Anaheim Ducks to a 4-2 victory over the Vancouver Canucks on Sunday night.
Jason Blake's two goals pace Ducks in victory over Flames1/16/2012 - Vancouver Canucks Anaheim Ducks0 SharesEmailComment ANA
Associated Press 0 SharesEmailCommentVANCOUVER, British Columbia -- Jason Blake hasn't lost his touch around the net.The Anaheim winger scored twice and helped set up the first goal as the suddenly surging Ducks beat the Vancouver Canucks 4-2 on Sunday night.The 38-year-old Blake, who returned Jan. 4 after missing 34 games while recovering from a severe skate cut, has three goals in two games.There's an ugly scar on his left forearm, just back of the wrist, a result of an accidental collision with Brent Burns of San Jose in October that put the rest of his season in doubt."A lot of people said it could have been worse," he said, pointing to the artery behind the palm of his hand. "I looked at it and I'm like, I don't know if it could be worse. I can't feel any of this (the back of his hand and index finger), still to this day."Blake scored what proved to be the winning goal on a second-period breakaway when Canucks defenseman Aaron Rome couldn't handle a pass at the Anaheim blue line.He then provided a 4-1 lead with a third-period power-play tip-in."I knew if I just stayed patient and did my rehab and my therapy ... I'm just starting, hopefully to turn that corner," said Blake who scored his first goal of the season Friday in a 5-0 win in Edmonton. "My nerves were so damaged they had to put in a tube or something."Anaheim captain Ryan Getzlaf said Blake and his experience were missed by a team that has won five of its last six games with the only loss coming in overtime."He took a step down to the third line," Getzlaf said of the undrafted former Maple Leaf who had 10 of his club's 34 shots on Vancouver goalie Roberto Luongo. "He could have come back and pouted but the way things are going everybody's buying in and everybody's doing the right thing."The Ducks have eight wins and three regulation ties in 20 games since Bruce Boudreau replaced the fired Randy Carlyle.The Canucks have 59 points, one behind the New York Rangers and Western Conference-leading Chicago.Vancouver coach Alain Vigneault said his club didn't get a scoring chance at even strength in the first period."Defensively I stopped counting the turnovers after a while," Vigneault said. "I think it was pretty evident to anybody watching the game or at the game that it didn't seem like we had a lot of jump and energy tonight."The Ducks, who are playing their best hockey of the season, took an early lead on Nick Bonino's third goal since being called up from Syracuse of the AHL a month ago.He eventually buried a rebound after Luongo made a glove save off Blake but couldn't corral the puck."It's not a usual place to get a rebound, top glove, but it just fell there and I whacked it once," Bonino said. "I didn't realize he saved it so I just kind of tried to stick with it."Bonino was impressed by Blake's effort after the injury."It's amazing," Bonino said. "With the year he's had, how he got hurt and he came back ... I guess plan right now is to get him the puck and it's going to go in the net."Bobby Ryan got the other Anaheim goal.Cody Hodgson, on a power play, and Mason Raymond scored for the listless Canucks, who mustered little offense."I looked up (at the scoreboard) in the second period with five minutes to go and I said 'they only have five shots on goal?' " Boudreau said. "This is unheard of for the Canucks."Luongo, who had to make several saves on his doorstep just to keep the game close, said his club has to be ready to play even if it's tired from a road trip."If we are (tired) we (have to) put on a snoozefest and we play a boring game or whatever it takes, but obviously we weren't good enough tonight as a team," he said.Game notes
Vancouver forward Jannik Hansen got Gene Simmons to autograph a stick during the pregame warmup. He then exchanged fist bumps with the Kiss rocker. ... David Booth returned to the Canuck lineup after missing 18 games with a sprained knee. ... Vancouver D Sami Salo missed a fourth game with concussion symptoms after a low hit along the boards Jan. 7 in Boston by Brad Marchand. ... It was the Canucks' first of four home games in a 10-day stretch leading to the All-Star break. ... The Ducks had outscored opponents 21-9 over their previous five games which included a 1-0 overtime loss in Calgary.