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Patent US7095503 - Method of full-color optical coherence tomography - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsTwo-dimensional and three-dimensional optical coherence tomography is obtained by differential imaging of full-frame interference images using a white light source. Full-color tomographic imaging is also possible by processing the three-color channels of the interference images. A technique is described...http://www.google.com/patents/US7095503?utm_source=gb-gplus-sharePatent US7095503 - Method of full-color optical coherence tomographyAdvanced Patent SearchPublication numberUS7095503 B2Publication typeGrantApplication numberUS 11/063,499Publication dateAug 22, 2006Filing dateFeb 22, 2005Priority dateFeb 20, 2004Fee statusPaidAlso published asCA2556865A1, EP1716388A2, EP1716388A4, US20050185192, WO2005082046A2, WO2005082046A3Publication number063499, 11063499, US 7095503 B2, US 7095503B2, US-B2-7095503, US7095503 B2, US7095503B2InventorsMyung K. Kim, Lingfeng YuOriginal AssigneeUniversity Of South FloridaExport CitationBiBTeX, EndNote, RefManPatent Citations (3), Non-Patent Citations (15), Referenced by (10), Classifications (14), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetMethod of full-color optical coherence tomography
US 7095503 B2Abstract
Two-dimensional and three-dimensional optical coherence tomography is obtained by differential imaging of full-frame interference images using a white light source. Full-color tomographic imaging is also possible by processing the three-color channels of the interference images. A technique is described to obtain two-dimensional OCT images with full natural color representation. In a particular embodiment, the interference image is acquired using a color camera and the three-color channels are processed separately, recomposing the final image. In an additional embodiment, the interference images are acquired using separate red, blue and green light sources and the three color channels are combined to recompose the final image.
1. A method of generating an object image by optical coherence tomography with natural color representation, the method comprising the steps of:
performing optical coherence tomography imaging on the object illuminated with a red LED resulting in a first image;
performing optical coherence tomography imaging on the object illuminated with a blue LED resulting in a second image;
performing optical coherence tomography imaging on the object illuminated with a green LED resulting in a third image; and
combining the first, second and third images to generate a fourth image having full natural color representation.
2. The method of claim 1, wherein the step of performing optical coherence tomography imaging on the object illuminated with a red LED further comprises the steps of:
illuminating the object with a reference wave;
performing phase-shift interference imaging resulting in four image frames acquired at quarter wavelength intervals of the reference wave;
extracting the first image from the resulting four image frames.
3. The method of claim 1, wherein the step of performing optical coherence tomography imaging on the object illuminated with a red LED further comprises the steps of:
positioning the object at a first z-position;
performing phase-shift interference imaging resulting in four first z-position image frames acquired at quarter wavelength intervals of the reference wave;
extracting a first z-position image from the resulting four first z-position image frames;
positioning the object at a plurality of z-positions over a predetermined range resulting in a plurality of four z-position image frames acquired at quarter wavelength intervals of the reference wave; and
extracting the first image from the resulting plurality of z-position four image frames resulting in a three-dimensional image of the object.
4. The method of claim 1, wherein the step of performing optical coherence tomography imaging on the object illuminated with a blue LED further comprises the steps of:
5. The method of claim 1, wherein the step of performing optical coherence tomography imaging on the object illuminated with a blue LED further comprises the steps of:
6. The method of claim 1, wherein the step of performing optical coherence tomography imaging on the object illuminated with a green LED further comprises the steps of:
7. The method of claim 1, wherein the step of performing optical coherence tomography imaging on the object illuminated with a green LED further comprises the steps of:
8. The method of claim 1, wherein the first image is a two-dimensional contour image.
9. The method of claim 1, wherein the second image is a two-dimensional contour image.
10. The method of claim 1, wherein the third image is a two-dimensional contour image.
11. The method of claim 1, wherein the fourth image is a two-dimensional contour image.
12. The method of claim 1, wherein the first image is a three-dimensional image.
13. The method of claim 1, wherein the second image is a three-dimensional image.
14. The method of claim 1, wherein the third image is a three-dimensional image.
15. The method of claim 1, wherein the fourth image is a three-dimensional image.
16. The method of claim 1, wherein the object of interest is biological tissue.
17. A method of generating an object image by optical coherence tomography with natural color representation, the method comprising the steps of:
illuminating an object of interest with a white light source;
illuminating the object of interest with a reference wave;
performing phase-shift interference imaging on the object of interest resulting in at least two color image frames acquired at predetermined wavelength intervals of the reference wave;
separating the color image frames resulting in at least two red image frames, at least two green image frames and at least two blue image frames;
extracting a red image from the at least two red image frames;
extracting a blue image from the at least two blue image frames;
extracting a green image from the at least two green image frames;
combining the red image, blue image and green image to generate an image having full natural color representation.
18. The method of claim 17, wherein the step of performing phase-shift interference imaging on the object of interest results in four color image frames acquired at quarter wavelength intervals of the reference wave.
19. The method of claim 17, wherein the step of performing optical coherence tomography imaging on the object further comprises the steps of:
performing phase-shift interference imaging resulting in four first z-position color image frames acquired at quarter wavelength intervals of the reference wave;
extracting a first z-position red image from the resulting four first z-position color image frames;
extracting a first z-position blue image from the resulting four first z-position color image frames;
extracting a first z-position green image from the resulting four first z-position color image frames;
positioning the object at a plurality of z-positions over a predetermined range resulting in a plurality of four z-position color image frames acquired at quarter wavelength intervals of the reference wave;
extracting the first red image from the resulting plurality of z-position four image frames resulting in a red three-dimensional image of the object;
extracting the first blue image from the resulting plurality of z-position four image frames resulting in a blue three-dimensional image of the object.
extracting the first green image from the resulting plurality of z-position four image frames resulting in a green three-dimensional image of the object; and
combining the red three-dimensional image, blue three-dimensional image and green three-dimensional image to generate a three-dimensional image having full natural color representation.
20. The method of claim 17, wherein the object of interest is biological tissue.
This disclosure claims priority from a provisional application filed Feb. 20, 2004, entitled: “Method and Apparatus for Full-Color Two-Dimensional Optical Coherence Tomography,” bearing application No. 60/546,408. Priority is also claimed to a second provisional application filed Dec. 10, 2004 entitled: “Full-Color Three-Dimensional Microscopy by Wide-Field Optical Coherence Tomography” bearing application No. 60/635,162.
In the field of biomedical imaging, various methods of optical imaging of biomedical tissues known in the art offer significant advantages over other biomedical imaging approaches. These advantages include non-ionizing radiation, wide range of resolution, numerous and effective contrast mechanisms, and relatively compact and inexpensive instrumentation. Optical imaging can be applied to a wide range of biological systems, from cells and subcellular organelles, in vivo and ex vivo tissues, to organs and whole body of a subject, covering the length scales of nanometers and micrometers to millimeters and centimeters. The contrast mechanisms include absorption, transmission, polarization, fluorescence, phase interference, nonlinear and multiphoton processes, as well as time behavior of these processes. Another very important dimension in optical imaging is the effect of these processes as functions of the wavelength of the light—i.e. the spectroscopy of the images. Through spectral imaging, one can monitor for detailed biochemical and biomedical parameters of the specimen.
Optical microscopy and its applications in biomedical imaging have been experiencing a remarkable growth over past few decades, thanks to such technological developments as lasers and digital acquisition and processing of images. One of the main thrust areas of the development of modem microscopy is three-dimensional microscopy, where one acquires a three-dimensional image with every image plane sharply in focus. This is in contrast to conventional microscopy where the image of the in-focus plane is superposed with a blurred image of out-of-focus planes.
In confocal scanning microscopy, CSM, the out-of-focus signal is spatially filtered out by confocal aperturing of the object illumination and the detector points. The three-dimensional image is constructed by pixel-by-pixel mechanical scanning of the entire object volume, which places a fundamental limit on the image acquisition speed.
Another more recent development in 3D microscopy is optical coherence tomography (OCT), where the axial resolution of a few μm is provided by interferometric measurement of the time-of-flight of short-coherence light. In a typical arrangement, a Michelson-type interferometer is illuminated by femtosecond laser or superluminescent LED, and the reference arm is dithered to generate a heterodyne signal in the interference with the back-scattered light from the sample point. The two- or three-dimensional image is constructed from the mechanical scanning over the sample area or volume, as in confocal scanning microscopy. In order to maintain the high speed of the z-scan, a considerably large depth of field, approximately a mm, is needed, which compromises the lateral resolution to a few μm. It is known in the art to sue a confocal adaptation to improve the resolution. The heterodyne detection allows for very high sensitivity and unique capabilities such as Doppler velocity detection of blood flow. OCT-based imaging systems are being developed for diverse areas of medical imaging including retinal structures, endoscopy of gastrointestinal tract and catheter-based intravascular imaging. As a coherent imaging technique, the OCT is capable of penetrating a larger distance into highly scattering media such as biological tissues and ceramics.
Scanning microscopies, including the confocal microscopy and optical coherence tomography, have a number of distinct advantages such as relaxed requirements on the imaging optics and high sensitivity and high resolution. On the other hand, the mechanical scanning is a major limiting factor in the image acquisition speed. Parallel acquisition of two-dimensional images while maintaining the optical sectioning characteristics of CSM or OCT would have obvious advantages. In CSM, such 2D imaging is approximated with a large number of well-spaced apertures, such as rotating Nipkow disk or multi-aperture scanning using an electro-optic spatial light modulator, but the light efficiency or image contrast tends to be low. Wide field optical sectioning is also achieved by structured light microscopy where a moving grating pattern illuminates the object and processing of several images extracts the in-focus sectioned image.
With OCT, it is known that full-field interferometric images can be acquired using broadband light sources, and the regions of the image that do contain interferometric information can be extracted by digital processing of the CCD images, thus generating optical section images variously known as wide-field, full-field, or two-dimensional OCT. The 3D image is constructed by mechanical scanning of the axial direction only. In a simple 2DOCT system, the light source illuminates the entire area of object to be imaged and its interference with the reference beam is imaged using a CCD array. For example, the reference optical path length is modulated by half wavelength, and pair of images is taken with a □ phase shift between them. The difference image then highlights the areas of interference within an axial depth equal to the coherence length, while the rest of the image area is significantly attenuated. A quasi-lock-in image acquisition is known in the art demonstrating synchronous illumination, instead of synchronous detection, due to the limited frame rate of the CCD camera, 30 Hz. High-frequency (50 kHz) true lock-in image acquisition has also been demonstrated in the art using custom made smart array detector, although with a limited number of pixels (58�58).
As such, the prior art demonstrates the potential for high-speed high-resolution 3D microscopy with very respectable sensitivity or dynamic range, at least ˜80 db, and promises to have significant impact on OCT applications where acquisition speed is critical, as in real-time in-vivo ophthalmic and endoscopic imaging.
Unlike conventional microscopy, most of the current developments of 3D microscopy usually discard the natural color information of the object, whereas in some of the critical application areas of OCT such as ophthalmic and dermatological imaging, the color and texture of relatively thin top layers of the tissues can provide vital information in a format that is familiar to medical specialists in these areas.
Accordingly, what is needed in the art is a full-color 3D microscopic imaging system and method utilizing wide-field optical coherence tomography resulting in a 3D image with full natural color representation.
In accordance with the present invention a novel method of optical tomography for surface and sub-surface imaging of biomedical tissues is provided. The method is based on the principle of wide field optical coherence tomography (OCT) and is capable of providing full-color three-dimensional views of a tissue structure with high-resolution and high frame rate.
In a particular embodiment, the three-dimensional profile and structure of microscopic objects are obtained by processing CCD images of an object in an interferometric apparatus.
In an additional embodiment, a novel method of full color two-dimensional optical coherence tomography is provided for surface and sub-surface imaging of biomedical tissues. The method as described is based on the principle of wide field optical coherence tomography and is capable of providing full-color two-dimensional and three-dimensional images of a tissue structure with high-resolution and high frame rate.
In an exemplary embodiment, contour or tomographic images are obtained with a phase locked interferometric imaging system using broadband light sources and tri-color cameras. The interferometric images are analyzed in the three-color channels and recombined to generate 3D microscopic images of tissue structures with full natural color representation. In contrast to most existing biomedical optical tomographic methods, the proposed technique allows monitoring of tissue structures close to its natural color, and can provide critical information on the physiological and pathological states of tissues, such as in the retinal tissues affected by glaucoma.
In another exemplary embodiment in accordance with the present invention, full-color 3D microscopic imaging by WFOCT (wide-field optical coherence tomography) is provided using three color LED's. The WFOCT imaging is performed on an object three times using red, green, and blue LED's, and the resulting three RGB channels of the 3D images are combined to generate a final 3D image with full natural color representation.
The patent application file contains at least one drawing executed in color. Copies of the patent or patent application publication with color drawings will be provided by the Office upon request and payment of the necessary fee. For a fuller understanding of the invention, reference should be made to the following detailed description, taken in connection with the accompanying drawings, in which:
FIG. 1 is an exemplary for color wide-field optical coherence tomography in accordance with the present invention;
FIG. 2 is an illustration of phase-shift interference imaging in which four quadrature phase interferograms and the extracted interferences images are shown, as well as cross-sectional profiles of the interferograms;
FIG. 3( a) is an illustration of the spectra of red, green and blue LEDs and FIG. 3( b) is an illustration of the interference profiles of the LEDs vs. the axial distance z;
FIG. 4 is an illustration of the phase-shift interference imaging of a coin surface in accordance with the present invention in which, a) is a direct image of the object; b) is an image of the object with the reference wave; c) is an illustration of the contour image extracted by the phase-shift interference; d) is a flat view of the accumulated contour images and where the image volume=12 mm�9 mm�405 μm; voxels=640�480�82; voxel volume=19 μm�19 μm�5 μm;
FIG. 5 is an illustration of the color WFOCT of a painted coin surface in accordance with the present invention;
FIG. 6 is an illustration of the color WFOCT movies of a painted coin surface in which a) (1.17 MB) xy-section images; b) (0.26 MB) xz-section images; c) (0.90 MB) 3D perspective views and where the image volume=7.2 mm�7.2 mm�335 μm; voxels=480�480�67; voxel volume=15 μm�15 μm�5 μm;
FIG. 7 is an illustration of a monochrome WFOCT movies of a bee in which a) (0.73 MB) xy-section images; b) (0.26 MB) xz-section images; c) (0.64 MB) 3D perspective views; d) direct image of the specimen and where the image volume=6.0 mm�7.8 mm�980 μm; voxels=400�520�99; voxel volume=15 μm�15 μm�10 μm;
FIG. 8 is an illustration of color WFOCT movies of an insect wing in which a) (0.81 MB) xy-section images; b) (0.38 MB) xz-section images; c) (0.78 MB) 3D perspective views; d) direct image of the specimen and where the image volume=7.2 mm�9.7 mm�810 μm; voxels=480�640�82; voxel volume=15μm�15 μm�10 μm;
FIG. 9 is an illustration of a color WFOCT of a piece of apple skin in accordance with the present invention;
FIG. 10 is an illustration of a color WFOCT movies of apple skin in which a) (0.27 MB) xy-section images; b) (0.10 MB) xz-section images; c) (0.90 MB) 3D perspective views and where the image volume=4.7 mm�4.7 mm�170 μm; voxels=313�313�34; voxel volume=15 μm�15 μm�5 μm;
FIG. 11 is an illustration of a color WFOCT movies of a leaf in which a) (0.48 MB) xy-section images; b) (0.15 MB) xz-section images; c) (0.92 MB) 3D perspective views and where the image volume=6.3 mm�6.3 mm�145 μm; voxels=420�420�30; voxel volume=15 μm�15 μm�5 μm; and
FIG. 12 is an illustrative example of images obtained in accordance with the system and method of the present invention, the images include color WFOCT movies of a leaf, wherein a) (0.065 MB) xy-section images; b) (0.22 MB) xz-section images; c) (0.93 MB) 3D perspective views and wherein image volume=7.2 mm�7.2 mm�190 μm; voxels=480�640�39; voxel volume=15 μm�15 μm�5 μm.
The principle of color 3D microscopy by wide-field optical coherence tomography (WFOCT) is described referring to the diagram of the apparatus illustrated in FIG. 1. A high-brightness LED (˜30 lumens) illuminates the Michelson interferometer through a collimating lens L1, a polarizer P, and the broadband polarizing beam splitter BS. The quarterwave plates Q1 and Q2 in the object or reference arms change the orthogonal polarization states, so that all of the reflections from the object or the reference mirror are steered toward the monochrome CCD camera through the imaging lens L2. The analyzer A combines the two beams into a common polarization to affect the interference between them. The combination of the polarizer and the analyzer allows continuous adjustment of the relative intensity and the interference contrast between the object and reference beams. The computer acquires the CCD image using an image acquisition board and a function generator is used to strobe the LED and to dither the reference mirror mounted on a piezo-transducer. The object is mounted on a three-axis micrometer translation stage to bring the appropriate object plane into focus.
The reference mirror is positioned at an equal distance with respect to the object focal plane within the coherence length of the LED, and the object contour is imaged by phase-shift interferometry. The light intensity distribution I(x,y) on the CCD array is written as:
I = I O ( x , y ) + I B ( x , y ) + I R ( x , y ) + 2 I O ( x , y ) I R ( x , y ) cos [ φ i + φ ( x , y ) ] ( 1 ) where IO(x, y) is the portion of the object reflection that is coherent with respect to the reference IR(x,y) and IB(x, y) is the incoherent background. Φ(x, y) is the relative phase profile between the object and the reference beams, whereas Φi is the phase shift introduced by the piezo-driven reference. The reference mirror is dithered by a sawtooth wave applied to the reference piezo mount over a few micron amplitude. Four image frames are acquired at quarter wavelength intervals corresponding to reference phases of Φi=0, λ/2, λ, and 3λ/2. These interference images are expressed as:
The amplitude of the coherent object image is then given by
I O = ( I 0 - I π ) 2 + ( I π / 2 - I 3 π / 2 ) 2 16 I R ( 3 ) and the phase map
In FIG. 2, a plane mirror is used as the object, tilted by a small angle with respect to the optical axis. The four interference images show that the fringes are shifted by quarter periods. The interference profiles are also plotted in FIG. 2. The bottom image and curve show the envelope of the interference profile as obtained by Eq. (3). The coherence length of the light source can be determined by comparing the width of the interference profile with the fringe periods. They are found to be δR=5.8 μm, δG=4.8 μm, and δB=4.0 μm for the three red, green, and blue LED's, respectively. The normalized spectra and the interference profiles of the LED's are shown in FIG. 3. The center wavelengths of the LED's are λR=638.4 nm, λG=528.5 nm, and λB=457.4 nm, while the spectral widths are λR=22.9 nm, ΔG=33.2 nm, and ΔB=28.6 nm. The measured coherence lengths are consistent with the expected values of (2 ln 2/π)λ2/Δ within a factor of 1.3.
FIG. 4 illustrates the WFOCT by phase-shifting interferometry using a coin surface as the test object. FIG. 4 a) is the direct image of the object in the absence of the reference wave, while FIG. 4 b) is when the reference wave is present. Although the two images are mostly indistinguishable, one can observe fluctuating speckles in portions of the object when the camera image is viewed in real time while the reference mirror is dithered. The coherent portion of the image is extracted as described above to obtain a contour of the object at a height that corresponds to the reference mirror position, as shown in FIG. 4 c). The contour imaging is repeated a number of times (˜40) and averaged to improve the signal-to-noise ratio. The three dimensional imaging is completed by stepping the object z-position over a desired range to obtain a stack of the contour images. The three-dimensional image can then be presented in a number of different ways. In FIG. 4 d) all the contour images are added together resulting in a ‘flat view’, where all the image planes are in focus and additionally the overall haze in FIG. 4 a) or b) due to stray reflections from various optical surfaces has been removed.
In an exemplary embodiment, for generation of color images in accordance with the present invention, the WFOCT procedure is repeated three times by using red, green, and blue LED's. Each of these generates a three-dimensional image of the object under the respective color illumination. The three 3D images are then combined as RGB channels to generate the final 3D image with full natural color representation of the volume.
FIG. 5 and FIG. 6 illustrate experimental results in accordance with an embodiment of the present invention in which a colored coin is used as the test object. The backside of a dime is painted with red, green, and blue ink and the background is painted white. The first three columns of FIG. 5 represent separate results obtained using the three different LED's. In each column, the top square is a 7.2 mm�335 μm xz-section view of the 3D image, the middle square is a 7.2 mm�7.2 mm xy-section or a contour image, while the bottom square is the flat view for the color channel. The last column is the RGB composite images. In FIG. 6, the 3D image is presented in a few different modes. FIG. 6 a) is a series of xy-sections and FIG. 6 b) is a series of xz-sections. In FIG. 6 c) the reconstructed 3D image is viewed from varying perspective angles. Notice the strong color-independent (white) reflection at the air-paint interface and strong colored reflection from underneath. Penetration depth in some areas is at least about 100 μm. In the x-z RGB image, top right corner of FIG. 5, the thin and abrupt layer of red probably accounts for thin layer of paint on the metal surface, whereas there is a pool of white paint in the valley next to it. Also note that the RGB flat image has very respectable color and image quality, compared to the direct photographic image in the lower right corner of FIG. 5.
Two examples of biological imaging by monochrome WFOCT are shown with reference to FIG. 7 and FIG. 8. FIG. 7 is an image of the body of a bee and FIG. 8 is an image of the wing of an unidentified insect. The XY- and XZ-section movies start with the flat view followed by a series of cross-sectional tomographic views in the respective directions. The image volumes are several millimeters in the lateral direction and less than a millimeter in the longitudinal direction. The relatively opaque body of the bee is seen to have a penetration depth of about 100 μm or so, whereas it is a few hundred microns for the more transparent wing. The typical signal to noise ratio of these images has been measured to be between approximately 50 and 60 db.
Examples of color 3D microscopy using the three-channel WFOCT in accordance with the present invention are illustrated with reference to FIG. 9. The images shown in FIG. 9 are arranged in the same manner as those identified in FIG. 5, with the XZ- and XY-sectional views and the flat view for each of the three color channels and the RGB composite color images, for a 4.7 mm�4.7 mm�170 μm volume of a piece of apple skin. Here the penetration depth is at least 150 μm, and it displays details of the top surface and the skin tissue. Because of the large difference in the longitudinal and lateral scales, the minute surface texture is seen greatly exaggerated in the flat views. The cross sectional views clearly show the outer skin layer and a portion of the internal tissue layers. One can also notice the correspondence of the internal structure of a blemish area in the x-z sections and flat view images. The extra picture in the lower right corner is a direct photograph of the approximate area of the imaging experiment. Although the color variation of the apple skin is rather subtle and continuous compared to the colored coin experiment, the RGB flat view reproduces the color variation at least approximately. In this data set the colored images are not as one would expect from common macroscopic views of an apple skin. However, under a microscope, the coloring of apple skin appears not as a solid layer of red surface, but the red pigments are embedded as numerous particles in otherwise colorless matrix. Still one observes some variation of color that can be attributed to the actual color variation of the surface. FIG. 10 illustrates the movies for XY- and XZ-sections and the 3D images of the data set.
In FIGS. 11 and 12, the color WFOCT in accordance with the present invention is used to generate color 3D images of plant leaves. In FIG. 11, one clearly sees the pattern of pores on the surface as well as a minor stem. A careful examination of the interior of the leaf also shows a fibrous structure running the length of the leaf. In FIG. 12, a piece of scotch tape was present over a part of the leaf in the imaged area. The 3D imaging system clearly imaged through this slightly diffusing layer. As illustrated by these exemplary embodiment and experimental results, the overall quality of the images acquired using the method and apparatus in accordance with the present invention are quite convincing in terms of the resolution, signal level, and the overall capability to generate 3D images with close to natural color information.
The present invention provides a system and method to generate three-dimensional microscopic images with natural color representation. The present invention provides the ability to generate images of biological specimens with about 10 μm axial resolution, about 100–200 μm penetration depth, and 50–60 db dynamic range. These images are generated with close to natural color representation.
Optical section (or tomographic) imaging and imaging through turbid media are very active areas of current research. The method of full color WFOCT microscopy in accordance with the present invention can be used for the generation of optical section images in a wide range of fields of study including biology, medicine, geology, material sciences, and microelectronics. Optical sectioning or tomographic capabilities allow generation of images with the entire 3D volume of the object sharply in focus. The color imaging techniques provided by the method of the present invention provide additional critical information in many of these application areas. Some of the foreseeable applications in biomedicine will be in the imaging of the eyes, the optical biopsy of external tissues, and epithelial layers of gastrointestinal and pulmonary tissues.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4641971 *Nov 30, 1984Feb 10, 1987International Business Machines CorporationWhite light interferometerUS6057920 *Mar 30, 1999May 2, 2000Carl Zeiss Jena GmbhOptical coherence tomography with dynamic coherent focusUS6498948 *Aug 18, 2000Dec 24, 2002Pentax CorporationEndoscope system* Cited by examinerNon-Patent CitationsReference1Bordenave et al., Wide-Field Optical Coherence Tomography: Imaging of Biological Tissues, Applied Optics, Apr. 2002, p. 2059-2064, vol. 41 No. 10.2Dakoff et al., Microscopic Three-Dimensional Imaging by Digital Interference Holography, Journal of Electronic Imaging, Oct. 2003, p. 1-5, vol. 12(4).3Ding et al., Real-Time Phase-Resolved Optical Coherence Tomography and Optical Doppler Tomography, Optics Express, Mar. 2002, p. 236-245, vol. 10 No. 5.4Dubois et al., High-Resolution Full-Field Optical Coherence Tomography with a Linnik Microscope, Applied Optics, Feb. 2002, p. 805-812, vol. 41 No. 4.5Ducros et al., Parallel Optical Coherence Tomography in Scattering Samples Using a Two-Dimensional Smart-Pixel Detector Array, Optics Communications, 2002, 29-35, vol. 202.6Fercher et al., Optical Coherence Tomography-Principles and Applications, Reports on Progress in Physics, 2003, p. 239-303, vol. 66 (2003).7Hitzenberger et al., Three-dimensional Imaging of the Human Retina by High-Speed Optical Coherence Tomography, Optics Express, 2003, p. 2753-2761, vol. 11 No. 21.8Laude et al., Full-Field Optical Coherence Tomography with Thermal Light Applied Optics, Nov. 2002, p. 6637-6645, vol. 41 No. 31.9M.K. Kim, Tomographic Three-dimensional Imaging of a Biological Specimen Using Wavelength-Scanning Digital Interference Holography, Optics Express, 2000, 305-310, vol. 7 No. 9.10Neil et al., Method of Obtaining Optical Sectioning by Using Structured Light in a Conventional Microscope, Optics Letters, 1997, p. 1905-1907, vol. 22 No. 24.11Sando et al., Color-Computer-Generated Holograms for Projection Images, Optics Express, 2004, p. 2487-2493, vol. 12 No. 11.12Smith et al., Programmable Array Microscopy with a Ferroelectric Liquid-Crystal Spatial Light Modulator, Applied Optics, 2000, p. 2664-2669, vol. 39 No. 16.13Swanson et al., In Vivo Retinal Imaging by Optical Coherence Tomography, Optics Letters, 1993, p. 1864-1866, vol. 18 No. 21.14Xu et al., Confocal Enhanced Optical Coherence Tomography for Nondestructive Evaluation of Paints and Coatings, Optics Letters, 1999, p. 1808-1810, vol. 24 No. 24.15Yamaguchi et al., Phase-Shifting Color Digital Holography, Optics Letters, 2002, p. 1108-1110, vol. 27 No. 13.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS7317540 *Nov 30, 2005Jan 8, 2008University Of South FloridaMethod of full-color optical coherence tomographyUS7345770 *Nov 3, 2005Mar 18, 2008Kabushiki Kaisha TopconOptical image measuring apparatus and optical image measuring method for forming a velocity distribution image expressing a moving velocity distribution of the moving matterUS8570530 *Jun 3, 2009Oct 29, 2013Carestream Health, Inc.Apparatus for dental surface shape and shade imagingUS9282304Jun 2, 2014Mar 8, 2016Bruker Nano Inc.Full-color images produced by white-light interferometryUS9310186Apr 15, 2013Apr 12, 2016Ben-Gurion University Of The Negev Research And Development AuthorityTrue-spectroscopic dual mode high resolution full-field optical coherence tomography using liquid crystal devicesUS20060100528 *Nov 3, 2005May 11, 2006Kabushiki Kaisha TopconOptical image measuring apparatus and optical image measuring methodUS20080297764 *Nov 13, 2007Dec 4, 2008Weinmann Gerate Fur Medizin Gmbh + Co. KgSensor for determining body parametersUS20100311005 *Jun 3, 2009Dec 9, 2010Carestream Health, Inc.Apparatus for dental surface shape and shade imagingUS20140226150 *Feb 6, 2014Aug 14, 2014Zygo CorporationSurface topography interferometer with surface colorWO2012114164A1Sep 26, 2011Aug 30, 2012Ecole Polytechnique Federale De Lausanne (Epfl)Light filter and method for using such filter* Cited by examinerClassifications U.S. Classification356/497International ClassificationG01B9/02, A61B5/00Cooperative ClassificationG01B9/02087, G01B9/02091, G01B9/02007, G01B2290/70, A61B5/0066, G01N21/4795, A61B5/0073European ClassificationA61B5/00P1C, A61B5/00P6, G01B9/02, G01N21/47SLegal EventsDateCodeEventDescriptionMar 28, 2005ASAssignmentOwner name: UNIVERSITY OF SOUTH FLORIDA, FLORIDAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KIM, MYUNG K;YU, LINGFENG;REEL/FRAME:015827/0311Effective date: 20050318Dec 19, 2006CCCertificate of correctionJan 22, 2010FPAYFee paymentYear of fee payment: 4Jan 24, 2014FPAYFee paymentYear of fee payment: 8RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services


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China Education Resources To Significantly Expand Its Online Teacher Training Program Into China’s
Mar 29, 2011, 09:00 ET from China Education Resources Inc.
Initial Rollout to Cover Over 100,000 Teachers in 4,000 Schools
VANCOUVER, March 29 /PRNewswire/ - China Education Resources, Inc. ("CER") (TSXV: CHN) (OTCQX: CHNUF), a leading technology provider of online learning, training courses and tools for teachers, students and education professionals in China, announced today that it has received official authorization from the Liaoning provincial education officials to provide online teacher training and study programs in conjunction with the country's mandated continuing education credit program.
The Liaoning Province with over 43 million residents in 14 cities, covering 56,300 square miles, has 9,000 schools with 294, 961 teachers instructing 4.5 million students. The Provincial Education Commission selected five cities, representing approximately 104.490 teachers and 1.6 million students, to initially start the program in March. These five cities will each select 800 teachers, for a total 4,000 teachers, to participate in the initial program. The fee per teacher for the training program, which will be financed by the provincial and municipal governments, will be 200 RMB (US$30). The program will be administered using CER's School Platform and is an ongoing program requiring teachers to achieve continuing training credits during their careers.
Commenting on the provincial endorsement, Chengfeng Zhou, China Education Resources' CEO, said, "This is a milestone achievement for our company. The Liaoning Province offers an incredible opportunity for our company to participate in China's education initiative. We have built a powerful infrastructure to provide efficient and dynamic on-line training in support of the initiative. Our four-step growth plan has now been expanded to fourteen provinces throughout China. As our comprehensive training resource portal gains traction throughout the educational system, we anticipate achieving similar endorsements as we achieved in the Liaoning Province."
In collaboration with China's education administrators and experts, China Education Resources is helping to transform the curriculum of the world's largest educational system from memory based system to a creative thinking and interactive method. China Education Resources has created educational tools and curricula for China's entire kindergarten through twelfth grade system. Presently, China Education Resources has over 1 million kindergarten through 12th grade teachers registered through its Web portal.
Preview: China Education Resources Inc. Generated Revenues of $5,436,165 in 2010
Preview: China Education Resources Along With Prominent Education Experts & Institutions Establish The "China Primary & Secondary School Online Education Academy" To Help Improve Teacher Training & The Classroom Experience In China

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Cameroon torturing suspects in Boko Haram fight: New report | Fox News
DAKAR, Senegal – More than 100 people have been tortured by Cameroon security forces and held incommunicado in the past four years on suspicion of involvement with the Nigeria-based Islamic extremist group Boko Haram, according to a report released Thursday by Amnesty International.
A letter from the U.S. Embassy in Cameroon to Amnesty International said it takes such allegations seriously, and "in accordance with the Leahy Law, do not furnish assistance to any security force unit if the secretary of state has credible information that such a unit has committed a gross violation of human rights."

value: This website is an American multinational conservative cable news television channel based in New York City. It is owned by Fox News Media, which itself is owned by the Fox Corporation.


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P. 1QBE Technical Claims Brief October 2012QBE Technical Claims Brief October 2012Ratings: (0)|Views: 48|Likes: 0Published by QBE European Operations Risk ManagementTechical claims brief Techical claims brief More info:Categories:Business/LawPublished by: QBE European Operations Risk Management on Jul 11, 2013Copyright:Attribution Non-commercialAvailability:Read on Scribd mobile: iPhone, iPad and Android.download as PDF, TXT or read online from ScribdFlag for inappropriate content|Add to collectionSee MoreSee lesshttp://www.scribd.com/doc/153128297/QBE-Technical-Claims-Brief-October-201207/11/2013pdftextoriginal Technical claims brief
Court of Appeal to review decision ondamages increase 1Police officially recognise“Mandate Fraud” as new crime 2US “Popcorn Lung” sufferer wins$7.2 million 3More claimants suing their solicitors 3
Court of Appeal departs from normalPart 36 Rules: SG v Hewett– Court of Appeal 4
Motor insurers must compensateinjured passengers who have permitteduninsured driving: Churchill InsuranceCo Ltd v Wilkinson and Evansv Equity Claims Ltd –Court of Appeal 2012 5Outdoor pursuits company not liablefor “Welly-Wanging” Accident:Glenroy Blair-Ford v CRS AdventuresLtd – High Court (2012)2 6
NewsCourt of Appeal to reviewdecision on damagesincrease
In the August 2012 edition of the Brief we reported on the Court of Appealannouncement in the case of Simmonsv Castle
that a ten percent increase ingeneral damages will apply to all casesheard in England and Wales where judgment is given on or after 1 April 2013.Following intervention from the Associationof British Insurers (ABI), the Court of Appeal agreed to re-open the case and on25 September 2012 heard an applicationfrom the ABI, that the ruling shouldbe amended to exclude cases whereConditional Fee Agreements have beenentered into prior to 1 April. This would prevent claimants frombenefiting from both success fees underthe pre-Jackson regime and the damagesincrease intended to recompenseclaimants for the loss of these same fees.Judgment is expected imminently.
Comment: Defendants fear that unless the judgment is amended claimants will either press for enhanced damages now or simply delay settlement.

value: This website is an American e-book and audiobook subscription service that includes one million titles.


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R310 road (South Africa) - Wikipedia
R310 road (South Africa)
Its beginning in Muizenberg is an intersection with Cape Town's M4. It runs east, hugging the coast, passing through Mitchell's Plain and Khayelitsha. It thens veers inland, heading north-east skirting Blue Downs to the east to reach Stellenbosch. Here, it is cosigned with the R44 to the north, before again heading north-east, through the Hellshoogte Pass. On the other side, it passes through Pniel to end at the R45.
Retrieved from "https://en.wikipedia.org/w/index.php?title=R310_road_(South_Africa)&oldid=642927485"	Categories: Regional Routes in the Western CapeSouth Africa road stubsHidden categories: All stub articles	Navigation menu
Add links	This page was last modified on 17 January 2015, at 16:58.

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Backyard Horsekeeping: The Only Guide You'll Ever Need: Joan Fry: 9781592282494: Amazon.com: Books
› Visit Amazon's Joan Fry Page
More and more people are enjoying pleasure riding to the point of wanting to own their own horse. And with the cost and distance considerations of maintaining the animal at a boarding stable often an off-putting factor, the possibility of homeowners keeping a horse on their property becomes very appealing. But just how possible and practical would it be? According to Joan Fry, an experienced horse owner and longtime backyard horse keeper, the answer is more times than not yes. Beginning with such initial factors as sufficient and suitable land and access to veterinarian, farrier, and feed, Fry leads the prospective backyard keeper through constructing and furnishing a small barn, paddock, and corral; locating and purchasing the horse; and then feeding and otherwise tending to the animal's creature comforts. Of special value to both novice and experienced owners are the sections on feed, which takes into account the most up-to-date nutrition research, and on training the horse for safe and enjoyable trail riding. Written with encouraging cheer and plenty of "horse sense," BACKYARD HORSEKEEPING will lead the way to maintaining and enjoying your very own horse on your very own property. Read more
Basic Horse Care (Doubleday Equestrian  › Eleanor F. Prince
Horse Housing: How to Plan, Build, and  › Richard Klimesh
Complete Horse Riding Manual › William Micklem
All Horse Systems Go: The Horse Owner's  Nancy S. Loving DVM
158017535X,0385261993,1580171753,1570762163,0789493381,1570763321
ISBN-10: 1592282490
ISBN-13: 978-1592282494
Amazon Best Sellers Rank: #2,033,255 in Books (See Top 100 in Books)
"Acton resident Joan Fry has turned out a responsible but entertaining manual. Fry adroitly covers hundreds of topics on horse-keeper basics. Even the advanced horse owner will benefit from Fry's insights."--Antelope Valley Press "While comprehensive, it is the author's voice and commitment to detail that makes this book stand apart. She has a wry sense of humor that pops up unexpectedly and invites the reader to keep reading."--Horsemen's Yankee Pedlar
More and more people are enjoying pleasure riding to the point of wanting to own their own horse. And with the cost and distance considerations of maintaining the animal at a boarding stable often an off-putting factor, the possibility of homeowners keeping a horse on their property becomes very appealing. But is it really possible—and practical?According to Joan Fry, an experienced horse owner and longtime backyard horsekeeper, the answer, more often than not, is yes. Beginning with such initial qualifications as sufficient and suitable land and access to a veterinarian, farrier, and feed supplies, Fry leads the prospective backyard horsekeeper through constructing and furnishing a small barn, paddock and corral, locating and purchasing the horse, and then feeding, grooming, and otherwise tending to the animal’s creature comforts.Of special value to both novice and experienced owners are the sections on feed, which takes into account the most up-to-date nutrition research; veterinary considerations; training your horse for safe and enjoyable trail riding; trailering; horse showing; and rider fitness.Written with encouraging cheer and plenty of “horse sense,” Backyard Horsekeeping will lead the way to maintaining and enjoying your very own horse on your very own property.
See all 6 customer reviews Joan Fry's book Backyard Horsekeeping has a subtitle - The only guide you'll ever need.Bonnie D. StoneMany practical ideas; the author covers all details very thoroughly and explains her opinions on the matter too.Farmer MomFry's practical advice will work well for any type of horse owner and is very comprehensive!J. Weis
Joan Fry's book Backyard Horsekeeping has a subtitle - The only guide you'll ever need. And she's absolutely correct. With wit and wisdom, Ms Fry has written a very comprehensive book about all you'd ever need or want to know about horses before you buy one of your own. Sprinkled throughout the text are photos and drawings that serve to enhance your knowledge of the subject. It's definitely the first book you need if you're thinking of buying and keeping your own horse.
3 of 3 people found the following review helpfulEvery book you'll ever need, all rolled up in 1.
Fry has written the most comprehensive, practical guide I've ever seen. I first bought my horse in July of 2006 and her book was one of the first one I checked out of the library. I didn't buy it at the time because I wanted to wait and see what other books were available and how I liked them before spending money on one. 6 months later, I was still stuck on "Backyard Horsekeeping: The Only Guide You'll Ever Need."Fry's book covers everything from how much space you would need to keep one horse to nutrition to health issues to training. A lot of books are written for people who are going to have more than one horse or who are interested in showing their horse. I'm neither of those. Fry's practical advice will work well for any type of horse owner and is very comprehensive!I LOVE this book!
This book is so amazing the title is so true. I have read millions of books on taking care of horses and training them and just everything you can think of. This is by far the best book I have read about horses so far.
This book is FABULOUS, and the title is very accurate - it really IS the only guide you'll need. As someone who hasn't owned a horse in 30 years and just bought a place (in...
Published on February 23, 2010 by Jennifer R. Tait
Still Reading; Still Learning; Still Enjoying
Easy to understand, not too stuffy or down-grading to the reader. Many practical ideas; the author covers all details very thoroughly and explains her opinions on the matter too.
Published on May 25, 2009 by Farmer Mom
Gina Cresse an extremely talented family member - great book - EXCELLENT art work
Published on April 11, 2007 by likz2so
Backyard Horsekeeping, New and Revised: The Only Guide You'll Ever Need by Joan Fry Paperback


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Top Reviewer Ranking: 1,442,524 (Learn More) (Learn More) - Total Helpful Votes: 45 of 45
Karrimor Mens Meridian Mid eVent Gunsmoke K135GNS157 10 Karrimor
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Whole-genome sequencing of liver cancers identifie... [Nat Genet. 2012] - PubMed - NCBI
Display Settings:AbstractFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApplySend to:Choose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation managerFormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File1 selected item: 22634756FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mail"SPAM" filtering software noticeAdd to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software.Create File
See comment in PubMed Commons belowNat Genet. 2012 May 27;44(7):760-4. doi: 10.1038/ng.2291.Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.Fujimoto A1, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, Nakagawa H.Author information 1Center for Genomic Medicine, RIKEN, Yokohama, Japan.AbstractHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were associated with hepatitis B or C virus infections, including two sets of multicentric tumors. Although no common somatic mutations were identified in the multicentric tumor pairs, their whole-genome substitution patterns were similar, suggesting that these tumors developed from independent mutations, although their shared etiological backgrounds may have strongly influenced their somatic mutation patterns. Statistical and functional analyses yielded a list of recurrently mutated genes. Multiple chromatin regulators, including ARID1A, ARID1B, ARID2, MLL and MLL3, were mutated in ∼50% of the tumors. Hepatitis B virus genome integration in the TERT locus was frequently observed in a high clonal proportion. Our whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in HCCs.Comment inNext generation sequencing of HCC from European and Asian HCC cohorts. Back to p53 and Wnt/β-catenin. [J Hepatol. 2013]Next generation sequencing of HCC from European and Asian HCC cohorts. Back to p53 and Wnt/β-catenin.Teufel A, Marquardt JU, Galle PR. J Hepatol. 2013 Mar; 58(3):622-4. Epub 2012 Oct 11.PMID: 22634756 [PubMed - indexed for MEDLINE] SharePublication Types, MeSH Terms, Substances, Secondary Source IDPublication TypesResearch Support, Non-U.S. Gov'tMeSH TermsAdultAgedAged, 80 and overCarcinoma, Hepatocellular/genetics*Carcinoma, Hepatocellular/pathologyCarcinoma, Hepatocellular/virologyChromatin/genetics*FemaleGenome, Viral/geneticsHepatitis B/geneticsHepatitis B virus/geneticsHepatitis C/geneticsHumansLiver Neoplasms/genetics*Liver Neoplasms/pathologyLiver Neoplasms/virologyMaleMiddle AgedMutation*Telomerase/geneticsVirus Integration/geneticsSubstancesChromatinTERT protein, humanTelomeraseSecondary Source IDGEO/GSE36390LinkOut - more resourcesFull Text SourcesNature Publishing GroupEBSCOProQuestOther Literature SourcesAccess more work from the authors - ResearchGateMedicalLiver Cancer - MedlinePlus Health InformationLibraries

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3 bedroom semi-detached house for sale in Thatch Leach Lane, Whitefield, Manchester, Lancashire, M45
www.rightmove.co.uk/property/44975478
Thatch Leach Lane, Whitefield, Manchester, Lancashire
!!! A superbly finished extended semi-detached family home !!!
The property re-shaped & re-modelled over recent years
Fully fitted modern extended kitchen
!!! A superbly finished extended semi-detached family home !!! The property has been re-shaped and extended over recent years and now offers spacious open plan family living throughout !!! Ideally placed on the Whitefield/ Prestwich boarder with local amenities to hand and excellent links to transport networks !!! Internal viewing is an absolute must to appreciate the accommodation on offer !!!
Property ref: 121_1329_4279604
To view this media, please visit the on-line version of this page at www.rightmove.co.uk/property-for-sale/property-44975478.html
Disclaimer - Property reference 4279604. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by JonSimon Estate Agents, Radcliffe. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.
15 May 2015 118 Thatch Leach Lane, M45 £148,000
28 Oct 2011 106 Thatch Leach Lane, M45 £120,000

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Laptop Stand Desk Lap Bed Table Tray Sofa Computer Portable Folding + Mouse Tray
chunbicc-5 (6613 )
chunbicc-5 has no other items for sale.
463432876439
163858594861
Last updated on Dec 05, 2019 16:49:33 PST View all revisions
Product size:: 23.6x15.7x11 inches (60x 40 x 28 cm) Brand:
Product weight:: 2494.0g （4.6pounds） Material: high quality thick steel pipe,black brushed sheet

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Mini Wanderlust Festival - Philadelphia - Yoga in the City - Sat, Sept 7 - South Jersey Hoopdance (Elmer, NJ)
Mini Wanderlust Festival - Philadelphia - Yoga in the City - Sat, Sept 7
Hi all!! Since I know we have several yogis amongst us (including me) or interested in yoga, I wanted to post this awesome news!! Hoops are welcome and thinking...We can hang and jam to the music!! ...Watch the fun video with footage of last year's festival!
Normally, Wanderlust is a 3-4 day festival located at a few popular mountain resort destinations each year (ski villages with a lake, surrounded by nature). They have expanded their offerings to include more happenings in a few cities for all to attend, and it's Free!
Space is limited so register to reserve your spot!
It's Free, but you still need to register and choose which yoga class (of 4 Classes) you would like to attend: http://phi.wanderlustfestival.com/
Please feel free to contact me via email or talk to me at the next meetup with any questions you have, or to find out which class I'm going to attend .
Wanderlust Yoga Festival Is Coming to Philly
Free yoga at the Piazza
from: http://blogs.phillymag.com/bewellphilly/2013/07/16/wanderlust-yoga-festival-coming-philly/
Big news, yogis: The Wanderlust Yoga Festival is making a mini pit stop in Philly this fall, with a one-day yoga block party at the Piazza at Schmidt’s. It’s a small taste of the full Wanderlust experience, a four-day yoga and music festival—think Bonnaroo for the yoga set—with upcoming stops in Whistler and California. While we won’t get the whole shebang here, our version offers something better: It’s completely free.
The Yoga Block Party will set up shop in the Piazza on Saturday, September 7th from noon to 8 p.m., with 90-minute yoga classes running all day long. Local instructors will be teaching the sessions, including Alex Holmes of Dhyana Yoga, Mariel Freeman of DIG Yoga, Maura Manzo of the Yoga Garden and Hot Box, and Justicia DeClue of Maha Yoga, among others. Yoganonymous’s Dan Wilf will emcee, and DJ Gregg Nyce will spin tunes.
Check out all the action and register—yup, even though it’s free - http://phi.wanderlustfestival.com/
https://www.facebook.com/#!/Wanderlust?fref=ts
Danielle Perfect Viv! And here I was going to email to ask you if were interested in going, knowing you're a yogi too...bc it would work out perfect for you to pick up your hoop in Philly! Registration (free) is still open...I signed up for 2:30 class & 6:30 class...I signed up twice. 0 · September 5, 2013 patricia Sadly am not able to attend. 0 · September 4, 2013 Danielle that's ok...thanks for letting me know. Look forward to meeting and hooping with ya at another meetup event ; ) 0 · September 5, 2013 Danielle : )) Everyone still in??Just sent a private email msg to everyone who RSVPd with my contact info, cell ph#. ; ) Namaste! 0 · September 3, 2013 2 went
134 Babywearers
273 like minded people

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Rocky Road - San Diego - Scout
Rocky RoadSDBoltReport.com Staff11/29/2007The road has not been kind to the Chargers. And if they want to stay in the AFC West catbird seat, they need to spread their wings away from Qualcomm Stadium. The Chargers play at Kansas City on Sunday.While they are in first place, the Chargers limp into rowdy Arrowhead Stadium with a dismal 1-4 road record. They've lost their past two road games at Jacksonville and Minnesota. What's crazy is that lone road win came at Denver, which is usually a house of horrors for the Chargers. But they demolished the Broncos 41-3, and they expected that would change their road fortunes.
Instead, it was just a tease.
"It could be the home crowd or the comfort of playing at home," running back LaDainian Tomlinson said of the road woes. "I don't know what it is, but we have played better at home and we need to find a way to play better on the road."
But many a Chargers team has crumbled in the Show Me State. And the Chiefs have shown they aren't intimidated by the Chargers after giving the team its lone home loss earlier this year. Overall, the Chargers are 5-1 at Qualcomm Stadium.
"What better place to test ourselves than by going to Kansas City, which is always a tough place to play," Tomlinson said. "And I'm sure it will be no different Sunday."
The Chargers' disappointing season will be made or broken on the road. After spending Sunday in Kansas City, the Chargers have road dates at Tennessee and Oakland. The Raiders game will close the regular season.
If nothing else, the Chargers will be used to being booed. Their fans let them have it early in Sunday's win over the Ravens.
"Don't get me started on that," said center Nick Hardwick, who is back in the lineup after missing four games with a foot injury. "Just give us time, let us work."
Their Sunday work will come in the hubbub of Arrowhead, a place where line calls and audibles can be lost in the wave of noise ricocheting around the venerable venue.
But the Chargers have to be encouraged about the Chiefs' struggles at home this year (2-4), despite the fact Kansas City is going for their first sweep of the Chargers since 2003.
The Chargers can't afford too many more road stumbles, as they lead the Broncos by just one game.
"We got five more games to go," wide receiver Vincent Jackson said. "We got out heads down and we're pushing hard."
What's been difficult is getting a win away from sunny San Diego. The weather won't be dreadful Sunday, but it won't be 72 degrees with a soft sea breeze, either.
"We definitely want to put a run together," defensive end Igor Olshansky said. "This has been an up-and-down, roller-coaster season for us. So this is going to be the biggest month for us. This is where our history is going to be written."
December's first chapter gets penned on Sunday. If the Chargers can survive their visit to Kansas City, this season just might have a happy ending.
SERIES HISTORY: 96th meeting. Chiefs lead, 50-44-1. The Chiefs have had their way in this matchup of late, winning three of the past four games. The Chargers have won just once in their last 10 visits to Arrowhead Stadium, where they were suffered one of their two regular-season losses last year. Earlier this year, the Chiefs handed the Chargers their lone home loss, 30-16.
--RB LaDainian Tomlinson said QB Philip Rivers' big day last week should carry over to Sunday's contest in Kansas City. "I think it was important because success brings confidence," Tomlinson said of Rivers, who threw for three touchdowns in the win over the Ravens. "When you have it, you're going to continue to believe that you're going to be successful."
--For the first since 2002, the Chargers head to Kansas City without Marty Schottenheimer at the helm. New coach Norv Turner hasn't fared well against the Chiefs, going 0-6 against them. Turner was 0-4 with Oakland, and he lost his other two games as coach of the Redskins and Chargers.
--Since 2000, Kansas City is 15-1 in December home games.
--K John Carney, the former Chargers Pro Bowler, was signed earlier this week by the Chiefs, and he will kick against his old team on Sunday.
--LB Donnie Edwards is in his first year during his second stint with the Chiefs. Edwards led the Chargers in tackles for five years before joining the Chiefs over the offseason. Once again, he is atop his team's tackles list, recording 87 to pace the Chiefs.
--It's believed Tomlinson, who raced past the 10,000-yard rushing mark last Sunday, would have to play for six to seven more years if he wants a shot at Emmitt Smith's NFL record of 18,355 yards. Tomlinson, 28, doesn't sound as if he will aim for that mark. "I've never set out to break Emmitt's record," Tomlinson said. "But if the opportunity presented itself, obviously, it would be huge. But if my heart is not in it, I'm not going to keep playing to break a record. I would never do that."
--Chiefs T Kyle Turley and WR Jeff Webb played at San Diego State.
--Hall of Fame WR Charlie Joiner, one of the Chargers' all-time greats, is the receivers coach for the Chiefs.
--S Eric Weddle, a rookie, is getting used to his sporadic playing time. "It was tough at the beginning not playing every down, going from college to here," said Weddle, a second-round pick who is used in the dime package. "I played so much in college and now I adhere to a certain role. I know what my job is here on this team."
--OL Damion McIntosh, a former Charger, is with the Chiefs.
--Chiefs head coach Herm Edwards and offensive coordinator Mike Solari played at San Diego State.
BY THE NUMBERS: 1994 -- Last time the Chargers won at Denver and at Kansas City in the same season. The Chargers prevailed at Denver earlier this year for their lone road win in five attempts.
QUOTE TO NOTE: "It's going to happen, and he's going to get through it and he's coming out of it." -- RB LaDainian Tomlinson on QB Philip Rivers lifting his game down the stretch.
Share on Facebook Share on TwitterTrending on ScoutFournette sets record while out of shapeReal Talk, Scrimmage and More for BearsCowboys 1st + 10: Bigger-In-Texas Dinner BillPSU's Franklin Gets Emotional After WinThis Marine Was a Vietnam "American Sniper"Share & EmbedKeenan Allen Hurt: Four Replacement Pickups Full StorySD Super Chargers Top StoriesDaily Dr. Roto: Thursday Night PreviewDr. Roto previews Thursday Night Football's matchup between the San Diego Chargers and Denver Broncos from a Fantasy Football perspective!by Dr. RotoScout Fantasy10/13/20163 Keys To Victory: Broncos vs. ChargersThe Broncos are coming off their first loss. On their first divisional road trip of 2016, what must the Broncos do to emerge victorious? Chad Jensen turns to the film room.by Chad JensenMile High Huddle10/13/2016MHH Predicts: Broncos vs. ChargersWill the Broncos rebound on a short week or will the losses start to snowball?by Will KeysMile High Huddle10/12/2016Week 6: IDP InsiderFantasy Football Expert Mark Morales-Smith provides a must-start IDP list and a few recommendations per position if you need to hit the waiver wire!by Mark Morales-SmithScout Fantasy10/12/2016Trevor Siemian Will Start vs. ChargersThe Broncos' starting QB appears to be on his way back.by Will KeysMile High Huddle10/11/2016Week 5: Inman Worth The DFS Gamble!Senior Fantasy Football Expert Shawn Childs looks at each position player on the San Diego Chargers to determine whether they are worthy of a spot on your Week 5 DraftKings lineup!by Shawn ChildsScout Fantasy10/07/2016Dr. Roto's Week 2 Visionary DFS PlaysDr. Roto lists his Week 2 Visionary DFS plays for DraftKings and FanDuel as we approach NFL Sunday!by Dr. RotoScout Fantasy09/16/2016Week 2 DFS: DraftKings Secret StarsHave you experienced the fun of daily fantasy sports (DFS)? You can win $1,000,000 at DraftKings this weekend. For just $27, you can become a Fantasy millionaire. Or for $2, you…by Nate WeitzerScout Fantasy09/15/2016Keenan Allen Hurt: Four Replacement PickupsSan Diego's stud wide receiver Keenan Allen has been diagnosed with a torn ACL. How do Fantasy owners and the Chargers deal with this significant blow?by Mark Morales-SmithScout Fantasy09/12/2016Chargers OL Wiggins hopes for silent SaturdayThe offensive lineman is looking to make the active roster out of camp for the first time in his career.by Annie HeilbrunnSD Super Chargers09/01/2016Bosa returns to practice with ChargersNo. 99 is back on the field with his teammates.by Annie HeilbrunnSD Super Chargers08/30/2016Chargers cut WR James JonesThe former Packer was having trouble learning the offense.by Annie HeilbrunnSD Super Chargers08/29/2016Load More

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2 Bedroom Retirement Properties For Sale in Leamington Spa, Warwickshire
2 Bedroom Retirement Properties For Sale in Leamington Spa, Warwickshire, flat
See properties to rent in Leamington Spa
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£695,000 2 bedroom apartment for sale
Claverdon House, Binswood Avenue, Leamington Spa
This spacious ground floor apartment has two bedrooms, and the master bedroom has an en suite. There is a large south facing living room and a separate fully fitted SieMatic kitchen with a balcony. This apartment has a third room which could be used as an additional bedroom, study or dining room.
by ehB Residential, Leamington Spa
01926 937064
Audley Binswood, Binswood Hall, Leamington Spa
An impressive ground floor retirement apartment providing very well proportioned two bedroomed and two bathroomed accommodation in, what is proving to be, a highly successful retirement village, located close to the town centre and incorporates an exceptionally high level of facilities and amenit...
£525,000 2 bedroom apartment for sale
Walton Court, Binswood Avenue, Leamington Spa
This two double bedroom, spacious second floor apartment enjoys a large living room with a south facing Juliet balcony, bedroom with en suite, large kitchen and additional bathroom.
£516,000 2 bedroom retirement property for sale
Milligan Mews, Gallagher Way, Warwick
This apartment is the "Star in the Crown" of this sought after and highly regarded retirement village. Offering a huge 1339 sq.ft. this 2 bedroom apartment forms a luxury opportunity for the retired. This exceptional apartment has a self-contained kitchen, large open plan living area, kitchen an...
Added on 12/11/2015
by Margetts, Warwick
01926 937050
£468,000 2 bedroom retirement property for sale
Connolly Walk, Gallagher Way, Warwick
This beautiful ground floor purpose built luxury retirement village apartment offers a large 1123 sq.ft. floor plan accompanied by delightful luxury 2 bedroom accommodation. CommercialNew Home
£450,000 2 bedroom retirement property for sale
This two double bedroom ground floor apartment enjoys a large living room opening onto a terrace, master bedroom with en-suite, large kitchen and additional bathroom.
£435,000 2 bedroom retirement property for sale
This two double bedroom cottage enjoys a large living room with a south facing terrace, bedroom with en suite, fully fitted SieMatic handleless units in the kitchen and additional bathroom.
£415,000 2 bedroom retirement property for sale
This two bedroom apartment has a living/dining room with doors opening to a south facing terrace. The apartment includes a fully fitted SieMatic kitchen, separate bathroom, and master bedroom with en suite all finished to Augley's high standard.
£399,995 2 bedroom retirement property for sale
Brunswick House, Binswood Avenue, Leamington Spa
READY FOR IMMEDIATE OCCUPATION This large second floor apartment has two bedrooms. There is an open plan living/dining room with doors opening to balcony. The master bedroom has an en suite and there is a separate fully fitted SieMatic kitchen.
£390,000 2 bedroom retirement property for sale
Wise Manor, Gallagher Way, Warwick
This spacious first floor apartment built to the Shakespeare design provides spacious 963 sq. ft. accommodation with 2 large bedrooms and 2 bathroom facilities forming part of this luxury Inspired Villages development.
£355,950 Offers Over
Arlington Lodge, Arlington Avenue, Leamington Spa, CV32
Reeds Rains Estate Agents are delighted to bring to the market a selection of over 60's apartment situated in one of Royal Leamington Spa's most sought after locations.Arlington Lodge is a delightful development of 51 one and two bedroom apartments located in the historic town of Royal ...
01926 937079
Carlton House, Regent Street, Leamington Spa
Immaculately presented and recently refurbished duplex over 55's apartment located in the heart of the town. Beautiful roof garden, underground parking, communal lounge. Living room/kitchen/dining room with balcony, bedroom two and shower room, master bedroom, bathroom, living room/guest bedroo...
Hawkesford are proud to market this first floor, two bedroom, retirement apartment for the over 55's in Leamington Spa town centre. The property is offered for sale with no chain and has the added benefit of having shared communal facilities including large communal lounge, lift to all floors, la...
by Hawkesford, Leamington Spa
01926 937060
Oakfield House, Binswood Avenue, Leamington Spa
A superb opportunity to acquire a two bedroomed second floor retirement apartment in this well regarded development, situated just north of the town centre.
Carlton House, Regent Street, Leamington Spa, CV32 from station
Being situated within a highly convenient central location to the corner of Regent Street and Dale Street, this purpose built second floor retirement apartment offers two bedroomed accommodation and is offered for sale with the benefit of no onward chain. Having electric heating and double glaze...
by Wiglesworth, Leamington Spa
01926 937056


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Paul Bridger Obituary - Genoa, IL | The MidWeek News
More Obituaries for Paul Bridger
Born: April 25, 1952; in Sycamore, IL
Died: January 9, 2018; in Genoa, IL
Paul M. Bridger, 65, of Genoa, IL, died on Tuesday, January 9, 2018 peacefully at his home.
He was born April 25, 1952 in Sycamore, IL to Marvin and Gladys (Chaplin) Bridger. Paul married Linda Salyer in Niagara Falls, on August 2, 1986. He was a graduate of Genoa Kingston High School and Kishwaukee Community College. Paul was a local farmer in the Genoa area for many years. He enjoyed motorcycling, traveling, fishing, golfing, and especially spending time with his grandchildren.
Paul is survived by his loving wife, Linda; one son, Jeffrey (Beth) Bridger; one daughter, Sandra (Tom) Hobbs; 5 grandchildren, Reagan, Harper, Brynn, Beau, and Blake; one brother, John Bridger; two sisters, Mary Ellen (Tim) Miner and Carol (John) Schoenfeld; and several nieces and nephews.
He is preceded in death by his parents; and one daughter, Rebecca.
His visitation will be held from 9:00 to 11:00 am on Saturday, January 13th with a service beginning at 11:00am, at the Trinity Lutheran Church, 33930 N. State Road, Genoa, with Rev. Jeremy Heilman officiating. Burial will follow the service at the Genoa Cemetery.
Published in Daily-Chronicle on Jan. 12, 2018
"I was floored today when I heard about Paul. I am so sorry..."
-Karen Scherer-Noftz
"Linda & family, I am so sorry to hear of Paul's passing. ..."

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May Book Discussion of Gone Girl - Pretty Fabulous Book Club for Ladies (Alexandria, VA)
May Book Discussion of Gone Girl
Please join us for our May discussion of Gone Girl by GillianFlynn. Discussion questions will be posted a few days prior to our meeting. Two days prior to our meeting I will reconfirm all Yes RSVPs and adjust the initial reservation as needed. We had a great time last month and I'm looking forward to seeing all of you. Also please feel free to bring a friend or guest. See you in May.
June Book Discussion will be: "A Week in Winter" by Maeve Binchy.
Robin Great discussion and great venue! 0 · May 6, 2013 Julie T. Hi, Great meet up, great book. Tossing out suggestions for July, but I will read anything: nonfiction, "The Cancer Journals" Audrey Lorde " Meridian" Alice Walker, " Maya's Notebook" Isabele Allende, " Swift As Desire" Laura Esquival 0 · May 5, 2013 Kandyce M. Thats fine. We are here 0 · May 5, 2013 A former member Will be 20 min late! 0 · May 5, 2013 A former member Sorry to miss this. 0 · May 3, 2013 Julie T. Hi, I look forward to meeting everyone. I was a little reluctant to post too much info until I was confirmed. Do you know what metro the venue is near? 0 · April 27, 2013 Kandyce M. The closest Metro is Ballston, but you would still have to take a bus.Please send me an email, one of us may be able to pick you up from the metro. 0 · May 1, 2013 Julie T. Thank you. I have a car. I am just not familiar with this part of Arlington. I pulled the directions up on the computer. 0 · May 1, 2013 Robin Racing to finish the book! Looking forward to meeting you ladies... 0 · April 30, 2013 Shandra I'm a maybe bc I just got the book today and may not finish in time for the meetup. 0 · April 28, 2013 Karen D barely started. 0 · April 25, 2013 Jennifer Thanks Kandyce! This venue sounds great. Looking forward to it! 0 · April 9, 2013 A former member Ugh. I have to miss another one! My son's birthday party is that day. I hope to make June's outing! 0 · April 9, 2013 9 went


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