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Senior IT Auditor Jobs, Employment in White Plains, NY
Senior IT Auditor jobs in White Plains, NY
This role will lead and develop a team of approximately 320 auditors globally, and will be responsible for building and managing relationships with senior...
Our client a International corporation seeks a Senior IT Risk Associate to join its expanding team. Experience with IT security within an international...
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Assist in the development and maintenance of appropriate testing strategies and test plans to enable management to assess the operating effectiveness of key IT...
View all Atlas Air, Inc jobs in Purchase, NY - Purchase jobsSalary Search: Senior Internal Auditor salaries in Purchase, NYLearn more about working at Atlas Air, IncAtlas Air, Inc questions about work, benefits, interviews and hiring process:How long does it take to get hired from start to finish? What are the st...What is the interview process like?Related forums: Atlas Air, Inc
View all PepsiCo jobs in Purchase, NY - Purchase jobsSalary Search: Senior IT Auditor salaries in Purchase, NYLearn more about working at PepsiCoPepsiCo questions about work, benefits, interviews and hiring process:How long will it take for PepsiCo to call you back in after a scheduled ...Does PepsiCo pay weekly or bi weekly?Related forums: PepsiCo - IT Auditor
Conversant in current IT Governance and IT Operational issues. The Senior IT Auditor will support the the Audit department in the execution of information...
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Broad industry experience in internal audit, IT, project management and process improvement roles. Broad range of audits including financial, operational,...
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Senior IT Auditor salaries in White Plains, NY$99,298 per yearBased on 10 salariesMin$83,184Max$118,532Senior IT Auditor salaries by company in White Plains, NY


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jfk and philadelphia 1
all the resources they have right now. we learned overnight dorner sent a package to cnn anchor anderson cooper and in it was a dvd, a note and a bullet ridden coin. former lapd chief william bratton said it's the kind of decorative coin he might have given to dorner to wish him good luck in the military. authorities don't expect a peaceful ending to this ordeal. he wrote, self preservation is no longer important to me. i do not fear death as i died long ago." in the newsroom, anne makovec kpix 5. >>> another round of rain is moving through the bay area overnight. this is the city last night. let's get the latest from lawrence karnow. >> cold enough out there that i think we are going to see some snow. the sun comes up and it looks like snow across our mountains. it should be interesting this morning as we have some cold temperatures in place and showers beginning to sag a little bit further to the south right now. you can see it on our high-def doppler radar. some of that moisture really south of the golden gate bridge and becoming more widely scattered and i think that will be KPIX 5 News Early Edition
watched the state of the union were impressed with the president's address. according to a cnn poll, 53% had a very positive reaction with 24% saying they had a somewhat positive response. and there was a peculiar moment during the official republican response when florida senator marco rubio suddenly stopped speaking to get a swig of water. it normally would not have been awkward but in this case the bottle was not within easy reach. he made light of the moment posting a photo of the water bottle on twitter. he was thirsty. >> he should have just taken his eyes off the teleprompter, relaxed, went over, snl. we'll take that to be sure. >>> 4:41. a cruise from hell. we are going to hear from the passengers stranded without a toilet or hot food for days. >> pope benedict makes his first public appearance since his announcement he is stepping down. we'll share his comments. >> and forget the rain. revelers in the big easy get the party going. we'll be right back. he's resigning, effective the end of this month... the first pope to do so, in about six >>> today is the last wednesday for KPIX 5 News Early Edition
using all the resources they have and we learned overnight dorner isn't a package to cnn anchor anderson cooper with a dvd, note and bullet ridden corn. william bratton said it's the kind of coin he would have given dorner to wish him luck in the military. >>> we're talking weather now. this was san francisco last night. the rain was coming down. we got a bit of a break but i think round number 2 is on its way. >> i'm still missing my umbrella. >> you have to go pick it up. >> i left it at the coffee shop so i'm hoping it dries out but i think it will be dry before we take a break. still scattered showers out there right now. coal enough that we have seen snow over the local mountains. our high-def doppler radar is showing you some of that precipitation that's dragging southward. south of the golden gate bridge is where we are seeing showers. you see some picks up and whites over the mountaintops. that's some of that snow that's beginning to fall up there. in the south bay in milpitas, we have a couple of scattered light showers in that direction but through probably about the m Search Results 0 to 2 of about 3

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Building partner capacity : key practices to effectively manage Department of Defense efforts to promote security cooperation : testimony before the Committee on Armed Services, House of Representatives (eBook, 2013) [WorldCat.org]
I thought you might be interested in this item at http://www.worldcat.org/oclc/837380759 Title: Building partner capacity : key practices to effectively manage Department of Defense efforts to promote security cooperation : testimony before the Committee on Armed Services, House of Representatives Author: Janet A St Laurent; United States. Government Accountability Office, Publisher: [Washington, D.C.] : United States Government Accountability Office, 2013. OCLC:837380759
Janet A St Laurent; United States. Government Accountability Office,
Testimony, GAO-13-335 T.
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Building partner capacity : key practices to effectively manage Department of Defense efforts to promote security cooperation : testimony before the Committee on Armed Services, House of Representatives/Janet A St Laurent; United States. Government Accountability Office,; [Washington, D.C.] : United States Government Accountability Office, 2013.

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Patent US4251995 - Method of freezing human blood platelets in glycerol-glucose using a ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsAn inexpensive, statically controlled cooling rate device comprising a cassette of metal plates and cardboard insulation in a plastic bag was used to freeze platelets in liquid nitrogen with glycerol-glucose as cryoprotectant. Depending on the thermocouple location, the cooling rate in the freezing bag...http://www.google.com/patents/US4251995?utm_source=gb-gplus-sharePatent US4251995 - Method of freezing human blood platelets in glycerol-glucose using a statically controlled cooling rate deviceAdvanced Patent SearchPublication numberUS4251995 APublication typeGrantApplication numberUS 06/033,306Publication dateFeb 24, 1981Filing dateApr 25, 1979Priority dateApr 25, 1979Publication number033306, 06033306, US 4251995 A, US 4251995A, US-A-4251995, US4251995 A, US4251995AInventorsGeorge Dayian, James H. PertOriginal AssigneeHedbergska StiftelsenExport CitationBiBTeX, EndNote, RefManPatent Citations (8), Non-Patent Citations (12), Referenced by (33), Classifications (18) External Links: USPTO, USPTO Assignment, EspacenetMethod of freezing human blood platelets in glycerol-glucose using a statically controlled cooling rate deviceUS 4251995 AAbstract An inexpensive, statically controlled cooling rate device comprising a cassette of metal plates and cardboard insulation in a plastic bag was used to freeze platelets in liquid nitrogen with glycerol-glucose as cryoprotectant. Depending on the thermocouple location, the cooling rate in the freezing bag varied between 22.1.degree. and 38.6.degree. C. per minute, averaging 33.6.degree..+-.1.1 The post-thaw recovery of platelets frozen with this device and reconstituted in plasma averaged 88.6.+-.11.7 percent, compared to 86.1.+-.9.9 percent for nonfrozen but identically processed platelets. [.sup.14 C]Serotonin uptake after 0.5-hour incubation was 95.9.+-.1.9 percent for fresh platelets in platelet-rich plasma, 92.7.+-.4.4 percent for nonfrozen processed platelets, and 81.4.+-.11.8 percent for frozen platelets, increasing to 85.9.+-.7.7 percent after one-hour incubation.
What is claimed is: 1. A method for cryopreserving cellular suspensions, such as red blood cells, granulocytes and platelets, comprising:placing a freezing bag containing the suspension to be preserved and a cryprotective agent between a pair of hinged metal plates including a small angle between them so that the freezing bag assumes wedge shape when viewed from the side, placing a layer of thermally insulating material between the metal plates and the freezing bag, placing the metal plates with the freezing bag held in position between them in an outer bag, the outer bag being prevented from directly contacting the freezing bag, submerging the outer bag with the metal plates and the freezing bag in a freezing medium; and then transferring the outer bag with the metal plates and the freezing bag to a cryostorage. 2. A method in accordance with claim 1 wherein said freezing bag consists of a plastic material.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1A shows a freezing bag containing platelets between two hinged cardboard sheets.
DETAILED DESCRIPTION OF THE INVENTION MATERIALS AND METHODS Preparation of Platelet Concentrate To prepare platelet-rich plasma (PRP), 450 ml of whole blood, collected in CPD anticoagulant, was centrifuged at 1,800 rpm and 22 minutes after reaching speed in a Sorvall RC-3 centrifuge with a HG-4 rotor. The PRP was allowed to equilibrate at 23 and 10 ml of acidifying solution per 100 g of PRP was added to lower the pH to 6.5. The PRP was then centrifuged for five minutes after reaching a speed of 4,000 rpm, and the supernatant platelet-poor plasma (PPP) was removed. (If red cells were inadvertently carried along with PRP, they were removed by centrifugation of PRP for three minutes after it reached 900 rpm.)
Assembly and Use of Freezing Cassette The freezing bag is placed between two sheets of corrugated cardboard (single-wall, bursting strength 19.4 kg/cm.sup.2 [275 pounds/inch.sup.2 ], C flute obtained from Longview Fibre Co., Amsterdam, N.Y.). Each sheet measures 13.3 by 15.2 cm; two corners of one sheet are removed to accommodate the bag ports (FIG. 1). The cardboard and freezing bag are then placed between hinged, 0.64-cm-thick aluminum plates, one 12.7.times.15.2 cm, the other 15.2.times.15.2 cm (Aluminum type 2024T3, Alcoa, Pittsburgh, Pa.) so as to rest on the flange of the hinge. The plates are taped tightly together at the upper side corners of the metal, and this assembly is placed in an outer plastic bag which measures 25.4.times.35.6 cm and varies in thickness between 0.01-0.015 cm., e.g., polyethylene bags 10 Bel-Art, Pequannock, N.J. This unit is submerged for 15 minutes in liquid nitrogen, with the level of liquid nitrogen above the metal plates throughout freezing.
Storage, Thawing and Reconstitution After freezing, the tapes holding the cassette closed are cut, and the frozen bag of platelets with the cardboard sheets is transferred immediately into the vapor phase of a liquid nitrogen freezer for storage. In these studies, storage time was at least 18 hours.
For use, 50 ml of PFP is thawed, and the pH is adjusted to 6.5, if necessary. Next the freezing bag is removed from its cardboard covers, promptly immersed in water at room temperature (22 and gently agitated by hand. Immediately after the platelets have thawed and warmed to water temperature, 10 ml of the PFP is added slowly by syringe through an entry port while the freezing bag is rocked gently. After 15 minutes rest at room temperature, an additional 20 ml of PFP is added with occasional agitation, and ten minutes later the remaining 20 ml of PFP is added.
Evaluation of Post-Thaw Yield and Function Platelet yield: To differentiate the processing losses from freeze-thaw injury, the PRP from two units of whole blood of the same ABO type were pooled and then separated into two equal volumes. These preparations were processed similarly, except that one unit was frozen and the other was not. The reconstituted platelet concentrates were diluted with PFP to approximate the platelet number in PRP and were counted in duplicate by two observers, using the method of Brecher and Cronkite, Appl. Physiol. 3, 365 (1950). The four readings were averaged. The yields were calculated from the platelet counts and volumes, compared to the total number of platelets in the starting PRP.
Serotonin uptake: Radiolabeled serotonin ([2'-.sup.14 C] hydroxytryptamine creatinine sulphate; 55 mCi/mmol)* was dissolved in 70 percent alcohol to give a final concentration of 10 μCi/ml and stored at -20 according to the method of Jerushalmy, Z. and Zucker, M. B., Thromb. Diath. Haemorrh., 15, 413 (1966). For assay, 0.01 ml of the [.sup.14 C] serotonin was added to 4-ml portions of platelet suspension, which had been held at 37 incubated at 37 determined on samples of platelet suspensions and platelet-free aliquots to determine the percentage of sorotonic taken up.
Cooling Rate Determinations Temperature was monitored with a #30-55-1 copper-constantan thermocouple and a Leeds and Northrup Speedomax W recorder, standardized with the company's millivolt potentiometer, model 8690. The platelet freezing bag with the thermocouple in place contained 10 ml of air and 10 ml of a 1:1 mixture of 0.85 percent NaCl and freezing solution. For this study the cooling rate is defined as the rate in degrees centigrade per minute at the steepest slope after release of the heat of fusion.
Acidifying and Freezing Solutions One liter of aqueous acidifying solution contained 53.2 g of Na.sub.3 -citrate (dihydrate), 17.7 g of citric acid (monohydrate), 60.5 g of anhydrous dextrose, and 4.4 g of NaOH.
One liter of aqueous freezing solution contained 100 ml of glycerol (density at 25 g pf Na.sub.3 -citrate, and 0.5 g of citric acid (monohydrate).
RESULTS In blank runs without platelets, a series of cooling curves were obtained with the thermocouple positioned at five different points within the freezing bag, which was filled with 10 ml of freezing solution at final concentrations of 5 percent glycerol and 4 percent glucose. The maximum cooling rates varied from 22.1.degree. to 38.6.degree. C. per minute (FIG. 2). In a separate study of ten replicate determinations with the thermocouple in the center of the freezing bag (position 3) the cooling rate averaged 33.6.degree..+-.1.1
Little difference in recovery was indicated by platelet counts of 17 paired samples, processed identically except that only one of each pair was frozen with the new device and then thawed (Table 1). The mean platelet recovery was 86.1.+-.9.9 percent for the nonfrozen units and 88.6.+-.11.7 percent for the frozen units.
TABLE 1.______________________________________Recovery of Platelets as a Percentage of Platelets in PRP        Nonfrozen     FrozenExperiment   Platelets     Platelets______________________________________1            98.7          95.12            59.7          73.93            82.8          81.94            72.0          77.65            86.1          94.06            90.1          91.77            86.2          80.88            86.8          103.09            93.6          87.610           95.5          103.011           74.7          104.012           98.6          75.113           87.0          86.014           84.9          77.815           86.0          73.616           87.4          92.117           94.0          110.0Mean .+-. SD 86.1 .+-. 9.9 88.6 .+-. 11.7______________________________________
Pairs of nonfrozen and frozen samples were tested for platelet function by comparing their ability to take up [.sup.14 C] serotonin with that of fresh PRP. After 30 minutes of incubation, uptake by nonfrozen platelet samples was 92.7.+-.4.4 percent, close to that of fresh platelets at 95.9.+-.1.9 percent (Table 2). The uptake by frozen platelets was perceptibly lower at 81.4.+-.11.8 percent, but it increased somewhat to 85.9.+-.7.7 percent when the incubation time was increased to one hour. In one instance the outer bag broke, allowing liquid nitrogen to contact the freezing bag directly. The resulting increase in cooling rate adversely affected platelet function, and this value was omitted from the calculations.
TABLE 2.______________________________________[.sup.14 C]Serotonin Uptake (%)  Platelet Type (Incubation Time)  Fresh   Nonfrozen FrozenExperiment    (0.5 h)   (0.5 h)   (0.5 h) (1 h)______________________________________1        96.5      96.2      --      94.52        96.6      96.1      77.2    86.13        96.1      91.6      88.9    91.9*4        97.2      96.5      93.7    94.25        96.6      80.8      83.9    88.4*6        96.1      89.9      88.6    91.77        96.6      81.7      78.2    83.58        88.7      89.6      52.1    66.7*9        96.0      95.4      93.1    94.810       96.8      96.0       3.0    2sup.t11       99.0      96.1      89.0    93.612       96.8      96.1      70.0    76.513       96.6      96.2      --      86.114       95.7      94.4      89.1    93.315       95.7      94.9      92.0    93.716       95.9      94.0      85.9    81.217       95.6      90.4      77.5    85.1*18       95.3      93.1      --      --*19       95.4      91.2      56.2    57.0*20       95.4      93.9      86.9    88.8Mean .+-. SD    95.9 .+-. 1.9              92.7 .+-. 4.4                        81.4 .+-. 11.8                                85.9 + 8.7______________________________________ *Unit aggregated on thawing or reconstitution, irreversibly in Exp. 18 .sup.t Outer plastic bag cover broke on freezing; uptake value omitted from calculations (see results). --Uptake not measured.
DISCUSSION The functions of the separate components of the freezing cassette may be described briefly as follows. The outer plastic bag improves the heat transfer rate by preventing the formation of an insulating layer of gaseous nitrogen and by protecting the platelet freezing bag from direct contact with liquid nitrogen. The metal plates act as heat sinks, while the cardboard insulators moderate the heat flow from the sample to the metal plates. The cardboard also protects the freezing bag against warming and breakage during storage and retrieval, since the cardboard and bag can be transferred as a unit. The cardboard can be marked for sample identification. Repeated use of the cardboard insulators is not advised, as they tend to soften and change in insulating property.
Although this device was developed to freeze platelets derived from one unit of PRP, it could be modified to freeze multi-unit preparations obtained either by pooling single-donor units or by plateletpheresis. It has given very reproducible freezing rates of about 30 minute on repeated use. The yield of reconstituted, thawed platelets is similar to that obtained with the nonfrozen control; therefore, there was no indication that the process lyses platelets. In four experiments the yield of platelets was calculated as above 100 percent (Table 1); this is within the limit of experimental error in the platelet counting procedure.
The average recovery of 88.6 percent is an increase of 25 percent over that reported originally, Dayian, G. and Rowe, A. W., Crybiology 13, 1 (1976). The increase is due to the deletion of a centrifugation step. Previously, a large volume of a solution containing glycerol (5 g/dl) and glucose (4 g/dl) was added with plasma to a small volume of concentrate in order to minimize osmotic stress. This suspension was centrifuged to reduce the volume of concentrate to be frozen, but some platelets were lost with the supernatant freezing solution. The alternative employed here, subjecting platelets to a greater osmotic stress by mixing equal volumes of platelet suspension and cryoprotectant at twice the final concentration, does not require centrifugation and is no more injurious than exposing platelets to the final concentration of cryoprotectant, as judged by [.sup.14 C]serotonin uptake. This modification saves platelets from mechanical losses and further simplifies the procedure.
Other modifications designed to reduce platelet clumping during thawing and reconstitution include reduction of the thawing temperature from 40 pH 6.5 with citrate, which also chelates divalent cations. This shift in the temperature, pH, and divalent cation concentration away from the optima for ADP-induced aggregation [Stoza, L. et al., Thromb, Diath. Haemorrh. 18, 713 (1967); Valdorf-Hansen, J. F. and Zucker, M. B., Amer. J. Physiol. 220, 105 (1971)] reduced the spontaneous, often irreversible aggregation observed during post-thaw processing but did not abolish it. The influence of post-thaw aggregation is shown in Table 2. Of the six units which showed aggregation during thawing and reconstitution, four had a decrease in serotonin uptake. However, in most samples serotonin uptake was only slightly reduced from that obtained by fresh PRP.
The observed reshaping and the restoration of function, which are initiated soon after reconstitution, are strongly suggestive of a competition for energy. Platelets depend upon an intact marginal microtubular bundle maintained by metabolic energy to keep their disc shape. [White, J. G. and Krivit, W., Blood 30, 625 (1967)]. The microtubular structure can be disrupted by osmotic shock [White, J. G., Amer. J. Path., 56, 267 (1969); Zucker-Franklin, D., J. Clin. Invest. 48, 165 (1969)] as in the reconstitution step, so that energy would be required to restructure the microtubular system as well as to restore the fluid volume and electrolyte concentration to normal. The microtubular system can also be disrupted by cold, in which case frozen platelets may need to expend additional energy to reassemble it. Such a depletion of energy would affect the platelets' ability to perform other energy-dependent functions, such as serotonin uptake. [Born, G. V. R. and Gillson, R. E., J. Physiol. 146, 472 (1959)]. Swirling appears to occur more quickly at 37 advantage may outweigh the potential danger of aggregation, which would be reduced at 22 reconstitution medium that would better supply the platelets' metabolic requirements.
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Physiol. 3 365 (1950): Morphology and Enumeration of Human Blood Platelets.3 *Dayian, G. et al.: Cryobiology 13, 1-8 (1976), Cryopreservation of Human Platelets for Transfusion.4 *Dayian, G. et al.: Transfusion, May-Jun. 1979, vol. 19, No. 3, A Simplified Method . . . Cooling Rate.5 *Gaarder, A. et al.: Nature, 192, 531 (1961), Adenosine Diphosphate in Red Cells as a Factor . . . Blood Platelets.6 *Pert, J. H. et al.: Cryobiology 16, 90-96 (1979): Statically Controlled Cooling Rate Device.7 *Valdorf-Hansen, J. F. et al: Amer. Jour. of Physiology 1.220, No. 1, 1/1971, USA, Effect of Temp. & Inhibitors on Serotonin-.sup.14 C Release from Human Platelets.8 *White et al.: An Ultrastructural Basis for the Shape Changes Induced in Platelets by Chilling, Blood, vol. 30, No. 5 (Nov. 1967), pp. 625-635.9 *White, J. G.: The Submembrane Filaments of Blood Platelets, Amer. J. Path. 56, 267 (1969).10 *Z. 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Clinical Investigation, vol. 48, 165 (1969), Microfibrils of Blood Platelets.* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS4327799 *Feb 27, 1980May 4, 1982Helmholtz-Institut Fur Biomedizinische TechnikProcess and apparatus for freezing living cellsUS4469227 *Aug 17, 1983Sep 4, 1984Clifford FaustPackage for cryogenically frozen liquidsUS4565073 *Feb 7, 1985Jan 21, 1986Armour Pharmaceutical Co.Freezing frame for a plasma containerUS4623620 *Aug 2, 1983Nov 18, 1986Stichting Vrienden Van De Stichting Dr. Karl LandsteinerEnucleated granulocytes, their preparation and useUS4630448 *Oct 25, 1985Dec 23, 1986Baxter Travenol Laboratories, Inc.Container for storing solid living tissue portionsUS4764463 *Oct 30, 1986Aug 16, 1988The University Of Tennessee Research CorporationPlatelet cyropreservationUS4940581 *Aug 15, 1988Jul 10, 1990The University Of Tennessee Research CorporationPlatelet cryopreservationUS5103651 *Aug 31, 1990Apr 14, 1992Instacool Inc Of North AmericaPlasma storage freezer and thermal transport deviceUS5168712 *Mar 19, 1990Dec 8, 1992Instacool Inc. 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Patent US20090271527 - Caching signatures - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsThe performance of a network system having one or more requestor nodes, one or more provider nodes, and one or more intermediate nodes is improved by determining the digital signature of a received file, looking up the digital signature in an index of signatures, and forwarding a previously compressed...http://www.google.com/patents/US20090271527?utm_source=gb-gplus-sharePatent US20090271527 - Caching signaturesAdvanced Patent SearchPublication numberUS20090271527 A1Publication typeApplicationApplication numberUS 12/429,742Publication dateOct 29, 2009Filing dateApr 24, 2009Priority dateApr 11, 1996Also published asUS7543018, US8024484, US20020184333Publication number12429742, 429742, US 2009/0271527 A1, US 2009/271527 A1, US 20090271527 A1, US 20090271527A1, US 2009271527 A1, US 2009271527A1, US-A1-20090271527, US-A1-2009271527, US2009/0271527A1, US2009/271527A1, US20090271527 A1, US20090271527A1, US2009271527 A1, US2009271527A1InventorsBarry AppelmanOriginal AssigneeAol Llc, A Delaware Limited Liability CompanyExport CitationBiBTeX, EndNote, RefManPatent Citations (6), Referenced by (81), Classifications (19), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetCaching signatures
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Matanza : the 1932 "slaughter" that traumatized a nation, shaping US-Salvadoran policy to this day (Book, 1992) [WorldCat.org]
I thought you might be interested in this item at http://www.worldcat.org/oclc/26218537 Title: Matanza : the 1932 "slaughter" that traumatized a nation, shaping US-Salvadoran policy to this day Author: Thomas P Anderson Publisher: Willimantic, CT : East Haven, CT : Curbstone Press ; Distributed in the U.S. by InBook, 1992. ISBN/ISSN: 1880684047 9781880684047 OCLC:26218537
Matanza : the 1932 "slaughter" that traumatized a nation, shaping US-Salvadoran policy to this day
Willimantic, CT : Curbstone Press ; East Haven, CT : Distributed in the U.S. by InBook, 1992.
Communism -- El Salvador.
Willimantic, CT : Curbstone Press ; East Haven, CT : Distributed in the U.S. by InBook, 1992
(OCoLC)657195893
Find more information about: Thomas P Anderson
1880684047 9781880684047
26218537
220 pages : maps ; 22 cm
The political and social background --
The election of Arturo Araujo --
Araujo's presidency and the coup of December 2 --
Martí organizes the masses --
The communist revolt begins --
The revolt in Juayúa and Nahuizalco --
The revolt in other areas --
The attack on Sonsonate and the repression --
The trial and execution of Martí, Luna, and Zapata --
El Salvador since 1932.
Thomas P. Anderson.
Add tags for "Matanza : the 1932 "slaughter" that traumatized a nation, shaping US-Salvadoran policy to this day". Be the first.
Salvador -- Histoire -- 1838-1944.
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Matanza : the 1932 "slaughter" that traumatized a nation, shaping US-Salvadoran policy to this day/Thomas P Anderson; Willimantic, CT : Curbstone Press ; East Haven, CT : Distributed in the U.S. by InBook, 1992.


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Patent US4712867 - Retroreflector - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsRetroreflector (10) has a base (12) with an even back surface (24) and an uneven forward surface (14). The uneven forward surface is illustrated as grooved with one of the grooves shown at (22) with groove sides (30) and (32). The uneven forward surface (14) is coated with retroreflector elements (16)...http://www.google.com/patents/US4712867?utm_source=gb-gplus-sharePatent US4712867 - RetroreflectorAdvanced Patent SearchPublication numberUS4712867 APublication typeGrantApplication numberUS 06/817,765Publication dateDec 15, 1987Filing dateJan 7, 1986Priority dateMar 9, 1983Fee statusLapsedPublication number06817765, 817765, US 4712867 A, US 4712867A, US-A-4712867, US4712867 A, US4712867AInventorsFritz J. MalekOriginal AssigneeSanta Barbara Research CenterExport CitationBiBTeX, EndNote, RefManPatent Citations (9), Referenced by (38), Classifications (9), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetRetroreflectorUS 4712867 AAbstract Retroreflector (10) has a base (12) with an even back surface (24) and an uneven forward surface (14). The uneven forward surface is illustrated as grooved with one of the grooves shown at (22) with groove sides (30) and (32). The uneven forward surface (14) is coated with retroreflector elements (16) so that incident light from almost 90 is retroreflected.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS1671086 *Jul 9, 1923May 22, 1928Stimson Jonathan CReflecting deviceUS3830682 *Nov 6, 1972Aug 20, 1974Rowland Dev CorpRetroreflecting signs and the like with novel day-night colorationUS3836226 *Jul 23, 1973Sep 17, 1974Cechetini JReflective pavement markerUS3851947 *Sep 24, 1973Dec 3, 1974Gen Motors CorpReflex reflectorUS3989775 *Nov 20, 1973Nov 2, 1976Bakelite Xylonite LimitedMethod of making a retro-reflective beaded materialUS4066331 *Jun 25, 1976Jan 3, 1978Beatrice Foods Co.Cube corner type retroreflectors with improved cube corner unit relationshipsFR1020520A * Title not availableGB456398A * Title not availableGB1107799A * Title not available* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS4989948 *May 8, 1989Feb 5, 1991Minnesota Mining And Manufacturing CompanyReflective sheeting materialUS5019745 *Aug 24, 1989May 28, 1991Rca Licensing Corp.UV-curable adhesive attachment means and method for a cathode-ray tube-yoke combinationUS5118930 *Feb 6, 1990Jun 2, 1992Sony CorporationRetroreflective sheet having a stickable surfaceUS5132841 *Dec 14, 1990Jul 21, 1992Bennett Reginald BRibbed reflectorUS5245454 *Dec 31, 1991Sep 14, 1993At&T Bell LaboratoriesLcd display with microtextured back reflector and method for making sameUS5288591 *Mar 29, 1993Feb 22, 1994At&T Bell LaboratoriesLCD display with microtextured back reflector and method for making sameUS5349503 *Apr 23, 1993Sep 20, 1994At&T Bell LaboratoriesIlluminated transparent display with microtextured back reflectorUS5575550 *Feb 6, 1995Nov 19, 1996Minnesota Mining And Manufacturing CompanyPole light having a programmable footprintUS5696627 *Oct 20, 1994Dec 9, 1997Minnesota Mining And Manufacturing CompanyDirectly machined raised structure retroreflective cube corner article and method of manufactureUS5724183 *Jan 27, 1994Mar 3, 1998Asahi Kogaku Kogyo Kabushiki KaishaLight gathering apparatusUS5734501 *Nov 1, 1996Mar 31, 1998Minnesota Mining And Manufacturing CompanyHighly canted retroreflective cube corner articleUS5764413 *Jun 6, 1996Jun 9, 1998Minnesota Mining And Manufacturing CompanyTiled retroreflective sheetingUS5812315 *Jun 6, 1996Sep 22, 1998Minnesota Mining And Manufacturing CompanyCube corner articles exhibiting improved entrance angularity in one or more planesUS5822121 *Jun 6, 1996Oct 13, 1998Minnesota Mining And Manufacturing CompanyRetroreflective cube corner article having scalene base trianglesUS5831767 *Jun 6, 1996Nov 3, 1998Minnesota Mining And Manufacturing CompanyAsymmetric cube corner articleUS5837350 *Jun 27, 1996Nov 17, 1998Minnesota Mining And Manufacturing CompanyWide range vertical retroreflective delineatorUS5880885 *Jun 27, 1996Mar 9, 1999Minnesota Mining And Manufacturing CompanyHigh entrance angle retroreflective article and method of makingUS5896227 *Oct 1, 1997Apr 20, 1999Minnesota Mining And Manufacturing CompanyRetroreflective sheeting and method for forming sameUS5926314 *Jul 17, 1998Jul 20, 1999Minnesota Mining And Manufacturing CompanyRetroreflective cube corner article having scalene base trianglesUS5975706 *Mar 30, 1998Nov 2, 19993M Innovative Properties CompanyWide incident angle reflective plateUS6021559 *Nov 1, 1996Feb 8, 20003M Innovative Properties CompanyMethods of making a cube corner article master moldUS6067143 *Jun 4, 1998May 23, 2000Tomita; AkiraHigh contrast micro display with off-axis illuminationUS6127020 *May 7, 1999Oct 3, 20003M Innovative Properties CompanyMethod of making wet retroreflective marking materialUS6303058Oct 30, 1998Oct 16, 20013M Innovative Properties CompanyMethod of making profiled retroreflective marking materialUS6451408Apr 2, 1999Sep 17, 20023M Innovative Properties CompanyRetroreflective articleUS6517923Jun 22, 2000Feb 11, 20033M Innovative Properties CompanyReflective article and method for manufacturing the sameUS6597507 *Nov 27, 2000Jul 22, 2003Ando Electric Co., Ltd.V-groove grating mirror and external resonator type wavelength variable light source using the mirrorUS6703108Aug 29, 2000Mar 9, 20043M Innovative Properties CompanyWet retroreflective marking materialUS6967053 *Jan 20, 2000Nov 22, 2005Reflexite CorporationDurable, open-faced retroreflective prismatic constructionUS7506987Feb 29, 2008Mar 24, 2009Technology Solutions & Invention LlcTwo-sided corner-cube retroreflectors and methods of manufacturing the sameUS7670013 *Dec 2, 2004Mar 2, 2010Nippon Carbide Kogyo Kabushiki KaishaTriangular-pyramidal cube-corner retroreflective article having curved reflective lateral faceUS7703931Mar 19, 2009Apr 27, 2010Technology Solutions & Invention LlcTwo-sided corner-cube retroreflectors and methods of manufacturing the sameUS7815319Jan 27, 2010Oct 19, 2010Nippon Carbide Kogyo Kabushiki KaishaTriangular-pyramidal cube-corner retroreflective article having curved reflective lateral faceUS8245973Nov 21, 2007Aug 21, 2012The Boeing CompanyMethods and systems for improving aircraft visibilityWO1997001673A1 *Jun 27, 1996Jan 16, 1997Minnesota Mining & MfgWide range vertical retroreflective delineatorWO1998014803A1 *Oct 1, 1997Apr 9, 1998Minnesota Mining & MfgRetroreflective sheeting with embedded retroreflective elements in a binder layer with shape memory and method for forming the sameWO1998044202A1 *Mar 30, 1998Oct 8, 1998Minnesota Mining & MfgWide incident angle reflective plateWO2001001172A1 *Jun 22, 2000Jan 4, 20013M Innovative Properties CoReflective article and method for manufacturing the same* Cited by examinerClassifications U.S. Classification359/539, 359/530, 427/162International ClassificationE01F9/04, G02B5/128Cooperative ClassificationE01F9/044, G02B5/128European ClassificationE01F9/04B3, G02B5/128Legal EventsDateCodeEventDescriptionFeb 18, 1992FPExpired due to failure to pay maintenance feeEffective date: 19911215Dec 15, 1991LAPSLapse for failure to pay maintenance feesJul 16, 1991REMIMaintenance fee reminder mailedRotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google


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18k Rose Gold Pave Diamond Ruby Mother Of Pearl Dangle Earrings For GIFT Jewelry | eBay
SmileMissH 18k Rose Gold Palace of The Vase Dangle Earrings for Womens
Details about 18k Rose Gold Pave Diamond Ruby Mother Of Pearl Dangle Earrings For GIFT Jewelry
Original priceUS $4,719.00
US $2,359.50 (50% off)
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172892990331
Last updated on Sep 24, 2018 08:28:27 EDT View all revisions
Jewelry Type: Earrings Clarity: I3
Fastening: Butterfly Main Stone: Mother of pearl
Natural/Lab-Created: Natural Gemstone Name 3: Ruby
Main Stone Creation: Natural Total Carat Weight (TCW): 34.52
Size: 65X29 mm Total Carat Weight: 10.00 & Over

value: This website is an American multinational e-commerce corporation based in San Jose, California, that facilitates consumer-to-consumer and business-to-consumer sales through its website.


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Patent US6767440 - Biosensor - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign in<nobr>Advanced Patent Search</nobr>PatentsA biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support substrate, a sensor support substrate coupled to the electrode support substrate, and electrically conductive tracks positioned on the...http://www.google.com/patents/US6767440?utm_source=gb-gplus-sharePatent US6767440 - BiosensorAdvanced Patent SearchPublication numberUS6767440 B1Publication typeGrantApplication numberUS 09/840,843Publication dateJul 27, 2004Filing dateApr 24, 2001Priority dateApr 24, 2001Fee statusPaidAlso published asCA2383031A1, CA2383031C, DE60212895D1, DE60212895T2, EP1253204A2, EP1253204A3, EP1253204B1, EP1253204B8, US7479211, US20040144644, US20040206625Publication number09840843, 840843, US 6767440 B1, US 6767440B1, US-B1-6767440, US6767440 B1, US6767440B1InventorsRaghbir S. Bhullar, John T. Austera, Brian S. Hill, Christopher D. WilseyOriginal AssigneeRoche Diagnostics CorporationExport CitationBiBTeX, EndNote, RefManPatent Citations (24), Non-Patent Citations (2), Referenced by (26), Classifications (8), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetBiosensorUS 6767440 B1Abstract A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support substrate, a sensor support substrate coupled to the electrode support substrate, and electrically conductive tracks positioned on the sensor support substrate. Each track is in electrical communication with one of the electrodes.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4963814Dec 15, 1989Oct 16, 1990Boehringer Mannheim CorporationRegulated bifurcated power supplyUS4968400 *Jul 19, 1989Nov 6, 1990Terumo Kabushiki KaishaElectroconductive coating, redox system, fixed enzymeUS4999582Dec 15, 1989Mar 12, 1991Boehringer Mannheim Corp.Biosensor electrode excitation circuitUS4999632Dec 15, 1989Mar 12, 1991Boehringer Mannheim CorporationAnalog to digital conversion with noise reductionUS5018527 *Jul 28, 1988May 28, 1991Siegert GmbhSensor for the measurement of ion activityUS5098545 *Dec 14, 1990Mar 24, 1992Patko Martin JPrecalibrated, disposable electrochemical sensing deviceUS5243516Dec 15, 1989Sep 7, 1993Boehringer Mannheim CorporationBiosensing instrument and methodUS5352351Jun 8, 1993Oct 4, 1994Boehringer Mannheim CorporationBiosensing meter with fail/safe procedures to prevent erroneous indicationsUS5366609Jun 8, 1993Nov 22, 1994Boehringer Mannheim CorporationBiosensing meter with pluggable memory keyUS5405511Jun 8, 1993Apr 11, 1995Boehringer Mannheim CorporationPeriodically acquiring temperatue reading from sensor when meter is both in on and off state, in on state estimating said ambient temperature by employing atleast two most recent readings, using data to compensate determined analyte valueUS5413690Jul 23, 1993May 9, 1995Boehringer Mannheim CorporationPotentiometric biosensor and the method of its useUS5438271Nov 22, 1994Aug 1, 1995Boehringer Mannheim CorporationBiosensing meter which detects proper electrode engagement and distinguishes sample and check stripsUS5762770Jun 30, 1995Jun 9, 1998Boehringer Mannheim CorporationElectrochemical biosensor test stripUS5798031May 12, 1997Aug 25, 1998Bayer CorporationElectrochemical biosensorUS5997817Dec 5, 1997Dec 7, 1999Roche Diagnostics CorporationElectrochemical biosensor test stripUS6071392 *Jun 3, 1998Jun 6, 2000Matsushita Electric Industrial Co., Ltd.Cholesterol sensorUS6132683 *Dec 23, 1998Oct 17, 2000Matsushita Electric Industrial Co., Ltd.Cell potential measuring electrode and measuring apparatus using the sameUS6212416 *May 22, 1998Apr 3, 2001Good Samaritan Hospital And Medical CenterDevice for monitoring changes in analyte concentrationUS6432720 *Oct 12, 2001Aug 13, 2002Caliper Technologies Corp.Analytical system and methodEP1195441A1Oct 2, 2001Apr 10, 2002F. Hoffmann-La Roche AgBiosensorWO1999058709A1May 6, 1999Nov 18, 1999Abbott LabTest stripWO2000073778A1May 31, 2000Dec 7, 2000Nova Biomedical CorpDisposable sub-microliter volume sensor and method of makingWO2000073785A2May 31, 2000Dec 7, 2000Nova Biomedical CorpLow interference disposable sensor and method of makingWO2001025775A1Oct 3, 2000Apr 12, 2001Roche Diagnostics CorpPatterned laminates and electrodes with laser defined features* Cited by examinerNon-Patent CitationsReference1LPKF MicrolineLaser II, LPKF Laser & Electronics AG; LPKF; Art.-Nr. 107645-2 (01/00) (2pp.).2Microline Solutions, LPKF Laser & Electronics AG; LPKF; Art.-Nr. 107658-1 (01/00) (4pp.).Referenced byCiting PatentFiling datePublication dateApplicantTitleUS7305896Aug 31, 2004Dec 11, 2007Inverness Medical Switzerland GmbhCapillary fill test deviceUS7465597Jun 29, 2006Dec 16, 2008Home Diagnostics, Inc.Method of manufacturing a diagnostic test stripUS7512432Jul 27, 2004Mar 31, 2009Abbott LaboratoriesSensor arrayUS7802467Dec 22, 2006Sep 28, 2010Abbott Diabetes Care Inc.Analyte sensors and methods of useUS7824616Jul 26, 2002Nov 2, 2010Arkray, Inc.Capillary for transferrring sample liquid; dehumidification zonesUS7879211 *Jul 11, 2002Feb 1, 2011Arkray, Inc.Analyzing instrument, lancet-integrated attachment for concentration measuring device provided with analyzing instrument, and body fluid sampling toolUS7955484Dec 14, 2005Jun 7, 2011Nova Biomedical CorporationGlucose biosensor and methodUS7981678May 29, 2008Jul 19, 2011Bayer Healthcare LlcSystem and method for automatic calibrationUS8033162May 8, 2009Oct 11, 2011Abbott Diabetes Care Inc.Analyte sensors and methods of useUS8241488Oct 10, 2008Aug 14, 2012Bayer Healthcare LlcAuto-calibrating test sensorsUS8257258Jul 30, 2007Sep 4, 2012Abbott LaboratoriesIntegrated lancet and blood glucose meter systemUS8287703 *Sep 25, 2008Oct 16, 2012Roche Diagnostics Operations, Inc.Biosensor and method of makingUS8424763Sep 1, 2009Apr 23, 2013Bayer Healthcare LlcMethod of forming an auto-calibration circuit or labelUS8425841Oct 12, 2010Apr 23, 2013Arkray, Inc.Analyzing instrumentUS8436251 *Jul 8, 2009May 7, 2013Medtronic, Inc.Ribbon connecting electrical componentsUS8511147Sep 12, 2011Aug 20, 2013Abbott Diabetes Care Inc.Analyte sensors and methods of useUS8551308 *Sep 25, 2008Oct 8, 2013Roche Diagnostics Operations, Inc.Biosensor and method of makingUS8586911Oct 21, 2009Nov 19, 2013Bayer Healthcare LlcOptical readhead and method of using the sameUS8597570Oct 27, 2009Dec 3, 2013Panasonic CorporationMeasurement device, insulin infusion device, measurement method, method for controlling insulin infusion device, and programUS8742327Oct 10, 2013Jun 3, 2014Bayer Healthcare LlcMethod of determining auto-calibration of a test sensorUS8753470May 29, 2012Jun 17, 2014Abbott Diabetes Care Inc.Analyte sensors and methods of useUS20090056120 *Sep 25, 2008Mar 5, 2009Bhullar Raghbir SBiosensor and method of makingUS20110005813 *Jul 8, 2009Jan 13, 2011Steven BoydRibbon connecting electrical componentsUS20120067743 *Nov 22, 2011Mar 22, 2012Bayer Healthcare LlcMethod of correcting for oxygen effect on test sensorsUSRE42924 *Oct 23, 2003Nov 15, 2011Roche Diagnostics Operations, Inc.Electrochemical biosensor test stripWO2010052849A1Oct 27, 2009May 14, 2010Panasonic CorporationMeasurement device, insulin infusion device, measurement method, method for controlling insulin infusion device, and program* Cited by examinerClassifications U.S. Classification204/403.01, 204/403.14International ClassificationG01N27/403, G01N27/30, G01N27/327Cooperative ClassificationG01N27/3272European ClassificationG01N27/327B, G01N27/403Legal EventsDateCodeEventDescriptionSep 23, 2011FPAYFee paymentYear of fee payment: 8Jan 4, 2008FPAYFee paymentYear of fee payment: 4Sep 2, 2004ASAssignmentOwner name: ROCHE DIAGNOSTICS OPERATIONS, INC., INDIANAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ROCHE DIAGNOSTICS CORPORATION;REEL/FRAME:015215/0061Effective date: 20040101Owner name: ROCHE DIAGNOSTICS OPERATIONS, INC. 9115 HAGUE ROADFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ROCHE DIAGNOSTICS CORPORATION /AR;REEL/FRAME:015215/0061Owner name: ROCHE DIAGNOSTICS OPERATIONS, INC.,INDIANAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ROCHE DIAGNOSTICS CORPORATION;REEL/FRAME:15215/61Apr 24, 2001ASAssignmentOwner name: ROCHE DIAGNOSTICS CORPORATION, INDIANAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BHULLAR, RAGHBIR S.;AUSTERA, JOHN T.;HILL, BRIAN S.;AND OTHERS;REEL/FRAME:011772/0974;SIGNING DATES FROM 20010419 TO 20010420Owner name: ROCHE DIAGNOSTICS CORPORATION 9115 HAGUE RD. P.O.Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BHULLAR, RAGHBIR S. /AR;REEL/FRAME:011772/0974;SIGNING DATES FROM 20010419 TO 20010420RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google


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Groebe Management Services
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In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. - PubMed - NCBI
1 selected item: 28790199
El Refaey M1, Xu L1, Gao Y1, Canan BD1, Adesanya TMA1, Warner SC1, Akagi K1, Symer DE1, Mohler PJ1, Ma J1, Janssen PML1, Han R2.
From the Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program (M.E.R., L.X., Y.G., T.M.A.A., J.M., R.H.) and Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute (B.D.C., P.J.M., P.M.L.J.), The Ohio State University Wexner Medical Center, Columbus; Genomics Shared Resource, The Ohio State University Comprehensive Cancer Center, Columbus (S.C.W., D.E.S.); and Department of Cancer Biology and Genetics (K.A., D.E.S.) and Human Cancer Genetics Program, and Department of Biomedical Informatics (adjunct) (D.E.S.), The Ohio State University, Columbus. renzhi.han@osumc.edu.
Duchenne muscular dystrophy is a severe inherited form of muscular dystrophy caused by mutations in the reading frame of the dystrophin gene disrupting its protein expression. Dystrophic cardiomyopathy is a leading cause of death in Duchenne muscular dystrophy patients, and currently no effective treatment exists to halt its progression. Recent advancement in genome editing technologies offers a promising therapeutic approach in restoring dystrophin protein expression. However, the impact of this approach on Duchenne muscular dystrophy cardiac function has yet to be evaluated. Therefore, we assessed the therapeutic efficacy of CRISPR (clustered regularly interspaced short palindromic repeats)-mediated genome editing on dystrophin expression and cardiac function in mdx/Utr+/- mice after a single systemic delivery of recombinant adeno-associated virus.
To examine the efficiency and physiological impact of CRISPR-mediated genome editing on cardiac dystrophin expression and function in dystrophic mice.
Here, we packaged SaCas9 (clustered regularly interspaced short palindromic repeat-associated 9 from Staphylococcus aureus) and guide RNA constructs into an adeno-associated virus vector and systemically delivered them to mdx/Utr+/- neonates. We showed that CRIPSR-mediated genome editing efficiently excised the mutant exon 23 in dystrophic mice, and immunofluorescence data supported the restoration of dystrophin protein expression in dystrophic cardiac muscles to a level approaching 40%. Moreover, there was a noted restoration in the architecture of cardiac muscle fibers and a reduction in the extent of fibrosis in dystrophin-deficient hearts. The contractility of cardiac papillary muscles was also restored in CRISPR-edited cardiac muscles compared with untreated controls. Furthermore, our targeted deep sequencing results confirmed that our adeno-associated virus-CRISPR/Cas9 strategy was very efficient in deleting the ≈23 kb of intervening genomic sequences.
This study provides evidence for using CRISPR-based genome editing as a potential therapeutic approach for restoring dystrophic cardiomyopathy structurally and functionally.
cardiomyopathies; dystrophin; gene editing; mice; muscular dystrophy
Gene Editing for the Heart: Correcting Dystrophin Mutations. [Circ Res. 2017]
PMC5623072
Comparison of SpCas9/gRNAs and SaCas9/gRNAs for deletion of exon 23 of the mouse Dmd gene in C2C12 cells
(A) Diagram showing the genomic locus of mouse Dmd around exon 23. The gRNA targeting sites and sequences for both SpCas9 and SaCas9 were labeled. The mutant exon 23 is highlighted in red. (B) PCR analysis of genomic DNA extracted from C2C12 cells treated without or with SpCas9/gRNAs or SaCas9/gRNAs. (C) Quantitative RT-PCR analysis of the dystrophin expression in C2C12 cells treated without or with SpCas9/gRNAs or SaCas9/gRNAs. (D) DNA sequencing analysis of RT-PCR product of SaCas9-gRNA transduced C2C12 cells. *P<0.05 and **P<0.01. All data are representative of a minimum of three experiments.
Circ Res. ;121(8):923-929.
Immunofluorescence staining of the heart sections from mdx/Utr+/− mice at 10 weeks following AAV-SaCas9/gRNAs treatment
(A, B) Immunofluorescence images of dystrophin in the entire heart sections of mdx/Utr+/− mice treated with 3 × 1011 (A) or 1 × 1012 (B) vg AAV-SaCas9/gRNA systemically (N=4 per group). Scale bar: 500 μm. (C) Immunofluorescence images of dystrophin (red) and caveolin-3 (green) in the heart sections of WT and mdx/Utr+/− mice treated with or without 1 × 1012 vg AAV-SaCas9/gRNA systemically. Scale bar: 50 μm.
Restoration of dystrophin in the cardiomyocytes of mdx/Utr+/− mice
(A) Measurement of dystrophin-positive cardiomyocytes (% of total caveolin-3-positive cardiomyocytes; mean ± SD) in mdx/Utr+/− heart cryosections treated with or without 1 × 1012 vg AAV-SaCas9/gRNAs (N=4 per group). (B) RT-PCR analysis of heart tissues from mdx/Utr+/− mice treated with (N=5) or without (N=3) 1 × 1012 vg AAV-SaCas9/gRNA. Genome editing is expected to produce a smaller (~500 bp) dystrophin band. (C) Immunoblotting of heart lysates from WT, mdx/Utr+/− and mdx/Utr+/− with AAV-SaCas9/gRNAs using anti-dystrophin and anti-GAPDH antibodies. (D) Quantitative analysis of dystrophin expression by immunoblotting of heart lysates from wild-type (WT), mdx/Utr+/− and AAV treated mdx/Utr+/− (N=3 per group). # p < 0.01.
Functional restoration of cardiac contractility after in vivo genome editing
(A) Upper lane: H&E stained WT and mdx/Utr+/− heart cryosections with or without AAV-SaCas9/gRNAs. Lower lane: Sirius Red/Fast Green stained WT and mdx/Utr+/− heart cryosections with or without AAV-SaCas9/gRNAs (N≥3 per group). (B) Quantitative analysis of fibrotic area from Sirius Red/Fast Green stained mdx/Utr+/− heart cryosections with or without AAV-SaCas9/gRNAs (N≥3 per group). (C) Length-dependent activation of heart contractility evaluated by recording the contractile parameters at 85, 90, 95, and 100% of optimal length (N=5 for untreated mdx/Utr+/− and 6 for AAV-mdx/Utr+/−). (D) The force-frequency response measured at optimal length by adjusting the stimulation frequency from 4 to 6, 8, 10, 12 and 14 Hz (N=4 for untreated mdx/Utr+/− and 6 for AAV-mdx/Utr+/−). (E) β-adrenergic responsiveness in mdx/Utr+/− mice with or without SaCas9/gRNA-AAV (N=5 for untreated mdx/Utr+/− and 6 for AAV-mdx/Utr+/−). # p ≤ 0.01 and * p ≤ 0.05.
Papillary Muscles/metabolism*

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I stayed in a room with a King-sized bed - Review of Courtyard Baltimore Hunt Valley - TripAdvisor
I stayed in a room with a King-sized bed - Review of Courtyard Baltimore Hunt Valley
and 7 more sites! Courtyard Baltimore Hunt Valley Hotel
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48 helpful votes “Score!.... for this Courtyard.....It turned out to be....... a nice Winter wonderland weekend”
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Tzomborgha: Amazon.co.uk: Music
Tzomborgha [CD]
Ruins | Format: Audio CD 4.0 out of 5 stars See all reviews (2 customer reviews)
Mandala 2000 Ruins
Pallaschton Ruins
B00005NDVY,B0000560BM
ASIN: B0000787GX
Amazon Bestsellers Rank: 209,597 in Music (See Top 100 in Music)
1. Komnigriss 1:59�0.89
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By "nickt5000"
Format:Audio CD The Ruins are definitely a group that sits firmly on the boundary of noise but not so much metal like fellow Ipecac gurus Fantomas. The music begins slowly but constructively before the true form of the album takes shape. It reminds you of Mr Bungle during the Disco Volante days but perhaps not as disfunctional. The music is initially quite hard to listen to but after a few plays the music becomes very fluid. However the vocals give it a deranged feel that give it bursts of energy. Definitely not for the faint hearted but what do you expect for something off Ipecac. All in all, it is very good but you do have to perservere with it like all Ipecac related music.
Progressive postrock
Format:Audio CD Ruins are a John Zorn derived project with all the twists and instrumental virtuosity needed to produce fast rifts, speed drumming, with micronomic precision and an heavy sound at times, just like, for instance, Fantomas and Mike Patton drived projects. But the inspiration behind is lying, quite evidently in three of the major progressive bands of the 70's: King Crimson (KC II), Magma and Henry Cow. Good stuff.
By James Brinegar
- Published on Amazon.com Format:Audio CD Hyderomastgroningem has always been my favorite Ruins album. I love all their albums, some more than others, but I tend to like the more tightly compositioned of their songs as opposed to the messy (but still cool) improv songs. Tzomborgha is the best Ruins album I have heard, and I've heard almost all of them... and THANK GOD Ipecac put it on their label alongside Magaibutsu to make it easier to get a hold of in the US.This album is extremely complex, super tight, and includes a variety of different sounds with pedals and voice effects never before heard in any Ruins album. The album is simply amazing. I never thought Ruins could possibly come up with anything more original than Hyderomastgroningem but they have by going into a new abstract style. Take any number of their super complex signature-changing songs and add 100 more beats to each pattern... meaning a lot of the patterns are so long and complex that it must have taken them months just to memorize one measure. All the while remaining fast and upbeat... not just a single complex pattern slowed down.Every song on it's own sounds like a combo of all my favorite Ruins songs rolled into one... times 15. I've been waiting for this album for a very very long time. If you only buy one Ruins album in your life, make it this one. THANK YOU Yoshida Tatsuya for being born!
We all need more Japanese prog-rock
- Published on Amazon.com Format:Audio CD This is better than Hyderomastgroningem (the only other Ruins album I own) simply because it's all music. Hyderomastgroningem has a few tracks of howling gibberish and static. This time, every track is super-tight bass-and-drums. It sounds like twenty Rush instrumentals squished into 50 minutes.If you like crazy, genre-hopping music like Mr. Bungle or just about anything by John Zorn (especially Naked City), you'll like this.
By Dirty Pant'loon
- Published on Amazon.com Format:Audio CD You like complex, inhuman, yet oddly coherent music on crack? Look no further. This is like Britney Spears x 10!!!! Insanely technical and absolutely impossible to play. Unless you're japanese. Or RoboCop. Or both. Read the previous section backwards, and put a pineapple on your computer. That is "Tzomborgha".
Mewsick: A list by Mr. H. W. Fung "Sachikowen"


text:
Rufus P. Turner - Wikipedia
This article is about the electronics author and academic. For the character from Supernatural, see Characters of Supernatural § Rufus Turner.
Turner working on an early radio
March 25, 1982(1982-03-25) (aged 74)
Armstrong Tech
California State College (BA, 1958)
University of Southern California (MA, 1960; PhD, 1966)
Transistor radios; popular and technical electronics texts
Rufus Paul Turner (December 25, 1907 – March 25, 1982)[1] was an academic, engineer, and author who published on semiconductor devices, technical writing style, and poet-novelist Charlotte Turner Smith. After three decades working with electronic devices – including developing the first practical transistor radio – he earned a doctorate in literature at age 52 and became an English professor.[1] He wrote over 40 books and 3000 articles during his six-decade career.[1]
Born in 1907 in Houston, Texas, Turner began working with crystal diodes at age 15 and published his first article on radio electronics at age 17.[1] He attended Armstrong Tech in Washington, D.C.[2] In 1925, still a teenager, he built what was then the world's smallest radio set, and was awarded the second commercial radio operator's license in the third district.[2] His station, W3LF, was "the first radio station licensed to a black broadcaster in the U.S."[3] By 1928, he operated W3LF as a 15-watt station on Franklin Street NW in Washington, D.C.[4] He also operated a station for his neighborhood church.[5]
Several of Turner's early transistor radio designs used CK722 transistors (pictured)
Although he did not initially pursue a college degree, Turner's experience with electronics led him to a variety of engineering positions. He was a licensed professional engineer in California and Massachusetts.[6] He taught electronics at a vocational school and the University of Rhode Island, and business communication at the University of Southern California.[1]
Turner's doctoral thesis focused on Charlotte Turner Smith, an 18th-century romantic writer
Turner was involved with creating the 1N34A germanium diode at Sylvania in the 1940s. He began experimenting with germanium transistors soon after their invention in 1947.[6] In 1949, before transistors were commercially available, he published the popular article "Build a Transistor", considered a "benchmark publication" in amateur radio.[1] In January 1950, after commercial units were released, he published "A Crystal Receiver with Transistor Amplifier" in Radio and Television News, along with plans for a three-transistor radio circuit. These plans – printed four years before the Regency TR-1 (the first commercial transistor radio) – were the first time most amateur radio operators were introduced to transistors as viable radio components.[7] He continued development of his pocket-size radios as superior transistors became available, culminating in the 'widely read' "Transistor Portable with a Punch", an 'ambitious' four-transistor non-superheterodyne AM radio published in Popular Electronics in 1956.[1][8]
Over sixty years, Turner published a variety of electronics articles and technical books aimed at both amateurs and professionals. While many early publications on semiconductors focused on theory, his were largely application-based. His semiconductor work included practical guides to components like integrated circuits, solar cells, zener diodes, varactors, thermistors, varistors, and field-effect transistors. He also wrote on technical writing, electronics testing and oscilloscopes, impedance, oscillators, and hobbyist electronics projects, and authored an elementary calculus textbook.[9]
Although his work was primarily in electronics, Turner had varied interests and decided in the mid 1950s to turn his attention to literature. He earned his BA from California State College at Los Angeles in 1958 and his MA in English from the University of Southern California in 1960.[1][6] He was hired in 1960 as an English professor at CSC.[1] His 1966 thesis at U.S.C. for his PhD analyzed the life and writings of Charlotte Turner Smith.[10] Turner taught at California State College until 1973, but continued to publish in electronics. He died in March 1982.[1]
^ a b c d e f g h i j Fikes, Robert. "Turner, Rufus P. (1907-1982)". Black Past. Retrieved December 30, 2013.
^ a b "Young Colored Radio Expert Gets Second Commercial Operator's License". The New York Age. July 18, 1925. Retrieved December 30, 2013.
^ Ryan, William J. (2006). "African-Americans in Local Broadcasting: Kansas City, 1922-1982" (PDF). State Historical Society of Missouri. Retrieved December 30, 2013.
^ Amateur Radio Stations of the United States (PDF). United States Department of Commerce: Radio Division. June 30, 1928. p. 69. Retrieved December 30, 2013.
^ Alexander, Vyron (Fall 1997). "African-American Engineers' Contributions to Communications". The Newsletter of Freshman Engineers. Howard University. Retrieved December 30, 2013.
^ a b c Turner, Rufus (1974). 125 One Transistor Projects. Tab Books. ISBN 0-8306-9537-0.
^ Schiffer, Michael B. (1991). The Portable Radio in American Life. University of Arizona Press. p. 174. ISBN 9780816512843.
^ Turner, Rufus P. (May 1956). "Transistor Portable with a Punch". Popular Electronics. Archived from the original on February 19, 2008. Retrieved December 30, 2013.
^ "Google Books". Google Inc. Retrieved December 30, 2013.
^ Turner, R. P. (1966). Charlotte Smith (1749-1806): New Light on Her Life and Literary Career... A Dissertation Presented to the Faculty of the Graduate School, University of Southern California, in Partial Fulfilment of the Requirements for the Degree Doctor of Philosophy (English). University of Southern California.
James A. Page and Jae Min Roh Selected Black American, African, and Caribbean Authors Littleton, Co.: Libraries Unlimited, 1985
Directory of American Scholars 6th Ed. (New York: R. R. Bowker, 1974
ISNI: 0000 0000 8273 8092
LCCN: n79027011
SNAC: w6zm47tw
SUDOC: 115706186
VIAF: 79302254
Retrieved from "https://en.wikipedia.org/w/index.php?title=Rufus_P._Turner&oldid=863946417"
This page was last edited on 14 October 2018, at 03:13 (UTC).

value: This website is the English-language edition of the free online encyclopedia Wikipedia. It was founded on 15 January 2001 as Wikipedia's first edition and, as of October 2021, has the most articles of any edition, at 6,412,521.


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