ODesign: A World Model for Biomolecular Interaction Design
Biomolecular interactions underpin almost all biological processes, and their
rational design is central to programming new biological functions. Generative
AI models have emerged as powerful tools for molecular design, yet most remain
specialized for individual molecular types and lack fine-grained control over
interaction details. Here we present ODesign, an all-atom generative world
model for all-to-all biomolecular interaction design. ODesign allows scientists
to specify epitopes on arbitrary targets and generate diverse classes of
binding partners with fine-grained control. Across entity-, token-, and
atom-level benchmarks in the protein modality, ODesign demonstrates superior
controllability and performance to modality-specific baselines. Extending
beyond proteins, it generalizes to nucleic acid and small-molecule design,
enabling interaction types such as protein-binding RNA/DNA and RNA/DNA-binding
ligands that were previously inaccessible. By unifying multimodal biomolecular
interactions within a single generative framework, ODesign moves toward a
general-purpose molecular world model capable of programmable design. ODesign
is available at https://odesign.lglab.ac.cn ,
69033a6f274024e4098e3239
Odin Zhang
69033a6f274024e4098e323a
Xujun Zhang
69033a6f274024e4098e323b
Haitao Lin
claimed_verified
2026-01-14T09:57:52.994Z
66f8154e01ab1cdf36c9818a
https://cdn-avatars.huggingface.co/v1/production/uploads/66f8154e01ab1cdf36c9818a/DWqBNcK0pXCAaI6bW_dE2.jpeg
Haitao
Delcher
user
Delcher
69033a6f274024e4098e323c
Cheng Tan
claimed_verified
2025-11-10T09:32:50.650Z
64be296a46cc3cdfbb057f7e
https://cdn-avatars.huggingface.co/v1/production/uploads/64be296a46cc3cdfbb057f7e/jSHeNY2AcPifCZzJyFhr4.jpeg
Cheng Tan
chengtan9907
user
chengtan9907
69033a6f274024e4098e323d
Qinghan Wang
69033a6f274024e4098e323e
Yuanle Mo
69033a6f274024e4098e323f
Qiantai Feng
69033a6f274024e4098e3240
Gang Du
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Yuntao Yu
69033a6f274024e4098e3242
Zichang Jin
69033a6f274024e4098e3243
Ziyi You
69033a6f274024e4098e3244
Peicong Lin
69033a6f274024e4098e3245
Yijie Zhang
69033a6f274024e4098e3246
Yuyang Tao
69033a6f274024e4098e3247
Shicheng Chen
69033a6f274024e4098e3248
Jack Xiaoyu Chen
69033a6f274024e4098e3249
Chenqing Hua
69033a6f274024e4098e324a
Weibo Zhao
69033a6f274024e4098e324b
Runze Ma
69033a6f274024e4098e324c
Yunpeng Xia
69033a6f274024e4098e324d
Kejun Ying
69033a6f274024e4098e324e
Jun Li
69033a6f274024e4098e324f
Yundian Zeng
69033a6f274024e4098e3250
Lijun Lang
69033a6f274024e4098e3251
Peichen Pan
69033a6f274024e4098e3252
Hanqun Cao
69033a6f274024e4098e3253
Zihao Song
69033a6f274024e4098e3254
Bo Qiang
69033a6f274024e4098e3255
Jiaqi Wang
69033a6f274024e4098e3256
Pengfei Ji
69033a6f274024e4098e3257
Lei Bai
69033a6f274024e4098e3258
Jian Zhang
69033a6f274024e4098e3259
Chang-yu Hsieh
69033a6f274024e4098e325a
Pheng Ann Heng
69033a6f274024e4098e325b
Siqi Sun
69033a6f274024e4098e325c
Tingjun Hou
69033a6f274024e4098e325d
Shuangjia Zheng
ODesign: A World Model for Biomolecular Interaction Design
Biomolecular interactions underpin almost all biological processes, and their
rational design is central to programming new biological functions. Generative
AI models have emerged as powerful tools for molecular design, yet most remain
specialized for individual molecular types and lack fine-grained control over
interaction details. Here we present ODesign, an all-atom generative world
model for all-to-all biomolecular interaction design. ODesign allows scientists
to specify epitopes on arbitrary targets and generate diverse classes of
binding partners with fine-grained control. Across entity-, token-, and
atom-level benchmarks in the protein modality, ODesign demonstrates superior
controllability and performance to modality-specific baselines. Extending
beyond proteins, it generalizes to nucleic acid and small-molecule design,
enabling interaction types such as protein-binding RNA/DNA and RNA/DNA-binding
ligands that were previously inaccessible. By unifying multimodal biomolecular
interactions within a single generative framework, ODesign moves toward a
general-purpose molecular world model capable of programmable design. ODesign
is available at https://odesign.lglab.ac.cn ,
ODesign is a generative world model that allows for the design of diverse biomolecular interactions across proteins, nucleic acids, and small molecules with fine-grained control.
generative AI models all-atom generative world model epitopes binding partners protein modality entity-level benchmarks token-level benchmarks atom-level benchmarks modality-specific baselines nucleic acid design small-molecule design protein-binding RNA/DNA RNA/DNA-binding ligands multimodal biomolecular interactions general-purpose molecular world model programmable design