Issoufou was the Prime Minister of Niger from 1993 to 1994, President of the National Assembly from 1995 to 1996, and he has been a candidate in each presidential election since 1993.
Issoufou var Nigers premiärminister 1993–1994, talman i Nigers nationalförsamling 1995–1996 och har kandiderat i samtliga presidentval sedan 1993.