Mutants resistant to either podophyllotoxin, or to its topoisomerase II inhibitory derivatives such as etoposide (VP-16), have been described in Chinese hamster cells.
Mutanter resistenta mot antingen podofyllotoxin, eller till dess topoisomeras-Il-inhiberande derivat såsom etoposid (VP-16), har beskrivits i kinesiska hamsterceller.