She was South Africa's Minister of Health from 1994–99, under President Nelson Mandela, and then Minister of Foreign Affairs, under presidents Thabo Mbeki and Kgalema Motlanthe.
Hon var hälsominister 1994-1999 under president Nelson Mandela, därefter utrikesminister 1999-2009 under presidenterna Thabo Mbeki och Kgalema Molanthe.