Portland served in a large number of engagements including the Battle of Coral Sea, the Battle of Midway and the Guadalcanal Campaign, where she was severely damaged but nonetheless able to return to service.
波特兰号参加了大量的战役，包括珊瑚海海战、中途岛战役和瓜达尔卡纳尔战役，在这些战役中它曾遭到严重破坏，但仍然能够重回现役。