In an experiment conducted by Zechiedrich, Khodursky and Cozzarelli in 1997, it was found that topoisomerase IV is the only important decatenase of DNA replication intermediates in bacteria.
在1997年，一个由Zechiedrich、Khodursky和Cozzarelli主导的实验发现，Topo IV酶是细菌DNA复制中间过程中唯一一种发挥作用的解链酶。