In August 1762 and January 1763 Isabella suffered two separate miscarriages that aggravated her mental unrest, causing her to fall into a depression that eroded her will to live.
1762年8月和1763年1月，伊莎贝拉经历了两次流产，这两次流产加剧了她的精神不安，使她陷入抑郁，削弱了她的生活意志。