Several countries, including the UK, have taken steps to ban the oral LD50, and the Organisation for Economic Co-operation and Development (OECD) abolished the requirement for the oral test in 2001.
一些國家如英國已開始禁止口服LD50測試，而經濟合作與發展組織（OECD）亦在2001年廢除對口服毒性測試的要求。