The major issues with using the CA-125 biomarker are its lack of sensitivity, particularly for detecting early stages of ovarian cancer, and its lack of specificity, especially in premenopausal women.
使用CA-125这一生物标志物的主要问题是它缺乏敏感性，特别是在检测卵巢癌时其缺乏特异性，尤其是在绝经前妇女的早期阶段。