This concept was first introduced in 1961 by the Council of Europe and later, the Joint FAO/WHO Expert Committee on Food Additives (JECFA), a committee maintained by two United Nations bodies: the Food and Agriculture Organization (FAO) and the World Health Organization (WHO).
這一概念於1961年由歐洲理事會首先提出，後來由糧農組織/世衛組織食品添加劑聯合專家委員會（JECFA）聯合研究，該委員會由聯合國兩個機構，即糧食及農業組織（FAO）和世界衛生組織（WHO）组成。