Interracial relations between Indigenous Americans and African Americans is a part of American history that has been neglected. The earliest record of African and Indigenous American relations in the Americas occurred in April 1502, when the first Africans kidnapped were brought to Hispaniola to serve as slaves. Some escaped, and somewhere inland on Santo Domingo, the first Black Indians were born. In addition, an example of African slaves' escaping from European colonists and being absorbed by Indigenous Americans occurred as far back as 1526. In June of that year, Lucas Vasquez de Ayllon established a Spanish colony near the mouth of the Pee Dee River in what is now eastern South Carolina. The Spanish settlement was named San Miguel de Gualdape. Amongst the settlement were 100 enslaved Africans. In 1526, the first African slaves fled the colony and took refuge with local Indigenous Americans.
Where did Ayllon lay down a Spanish colony?
near the mouth of the Pee Dee River