Matter may be converted to energy (and vice versa), but mass cannot ever be destroyed; rather, mass/energy equivalence remains a constant for both the matter and the energy, during any process when they are converted into each other. However, since  is extremely large relative to ordinary human scales, the conversion of ordinary amount of matter (for example, 1 kg) to other forms of energy (such as heat, light, and other radiation) can liberate tremendous amounts of energy (~ joules = 21 megatons of TNT), as can be seen in nuclear reactors and nuclear weapons. Conversely, the mass equivalent of a unit of energy is minuscule, which is why a loss of energy (loss of mass) from most systems is difficult to measure by weight, unless the energy loss is very large. Examples of energy transformation into matter (i.e., kinetic energy into particles with rest mass) are found in high-energy nuclear physics.
Why is a loss of energy difficult to measure by weight?
mass equivalent of a unit of energy is minuscule