BioRel/Llama-3.2_RelQA
Question Answering
•
Updated
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fb33eab1ad034c82bfc4a34894c60ec5
|
[
{
"content": "Which genes have their expression decreased by the chemical (1-ethylpyrrolidin-2-yl) methyl)-4-hydroxy-7-methoxy-quinoline-3-carboxamide?",
"role": "user"
},
{
"content": "GATA3",
"role": "assistant"
}
] |
a6b420b1efbf4f27b39fbd5fa2ce436e
|
[
{
"content": "Which genes have their activity decreased by the chemical ((3,4-(methylenedioxy)benzyl)amino)-6-chloroquinazoline?",
"role": "user"
},
{
"content": "PDE5A",
"role": "assistant"
}
] |
f976ae6d494e4daa86b7825e7bd0c042
|
[
{
"content": "Which genes are affected by the chemical ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine through binding interactions?",
"role": "user"
},
{
"content": "OPRM1",
"role": "assistant"
}
] |
71874462936a475a8c3b1bb619007f2d
|
[
{
"content": "Which genes are affected by the chemical ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine in relation to the response to substance interaction?",
"role": "user"
},
{
"content": "CYP2D6",
"role": "assistant"
}
] |
226978a211774bf1aedac024de763b79
|
[
{
"content": "Which genes have their activity decreased by the chemical ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)?",
"role": "user"
},
{
"content": "MET",
"role": "assistant"
}
] |
f325420f76f14b0894c891ef70c46cb6
|
[
{
"content": "Which genes are affected by the chemical ((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) through binding interactions?",
"role": "user"
},
{
"content": "CLK3",
"role": "assistant"
}
] |
b5898aa2d0ab49ada3481a1cf3ffaa1b
|
[
{
"content": "Which genes have their activity decreased by the chemical ((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) according to the interaction data?",
"role": "user"
},
{
"content": "DYRK1A",
"role": "assistant"
}
] |
76ffd3fb169a4c328678d115a8bb80a7
|
[
{
"content": "Which genes have their activity decreased by the chemical [(((E)-N-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butyl)-3-phenylacrylamide]]?",
"role": "user"
},
{
"content": "DRD3",
"role": "assistant"
}
] |
c6c718d671404f8bb7db230d215d5576
|
[
{
"content": "Which genes have their activity decreased by the chemical (Z)-1-thiophen-2-ylethylideneamino)thiourea?",
"role": "user"
},
{
"content": "CTSL",
"role": "assistant"
}
] |
c9e4c268048840199ac3e7ccbf90e6af
|
[
{
"content": "Which genes have their activity decreased by the chemical (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid?",
"role": "user"
},
{
"content": "GABBR1",
"role": "assistant"
}
] |
ebb0d5c2c7b44f37b72b40a5f6b7a1ea
|
[
{
"content": "Which genes are affected by the chemical compound (+)-JQ1 in terms of cleavage?",
"role": "user"
},
{
"content": "PARP1",
"role": "assistant"
}
] |
9ffe9b629e504196816eabc42bb1b45b
|
[
{
"content": "Which genes have their localization affected by the chemical compound (+)-JQ1?",
"role": "user"
},
{
"content": "RELA",
"role": "assistant"
}
] |
68b347240d3c4bafa6b1454a312bf3fc
|
[
{
"content": "Which genes have decreased acetylation due to the chemical (+)-JQ1 compound?",
"role": "user"
},
{
"content": "TP53",
"role": "assistant"
}
] |
c9a9140130154124aeef4f00aa9539b8
|
[
{
"content": "Which genes have their response to the chemical (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide increased?",
"role": "user"
},
{
"content": "SSTR4",
"role": "assistant"
}
] |
e8bb593ac0cb4371b99a437834bfc693
|
[
{
"content": "Which genes have their activity decreased by the chemical (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane?",
"role": "user"
},
{
"content": "TXNRD1",
"role": "assistant"
}
] |
3739fba44b29404ba67d3e38d990c5b2
|
[
{
"content": "Which genes have their activity decreased by the chemical (1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)?",
"role": "user"
},
{
"content": "SLC6A3",
"role": "assistant"
}
] |
d56a4870e9a8421fb3659077e9f3e74c
|
[
{
"content": "Which genes have their activity decreased by the chemical (1-hexyl-1H-indol-3-yl)-1-naphthalenylmethanone?",
"role": "user"
},
{
"content": "CYP1A1",
"role": "assistant"
}
] |
e457c07f928a49619564aa8956530767
|
[
{
"content": "Which genes have their expression increased by the chemical (1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl-3-aminopropyl)-3-methyl-1-triazene?",
"role": "user"
},
{
"content": "NFE2L2",
"role": "assistant"
}
] |
364ae2fbf34c4390909eb08f162ba510
|
[
{
"content": "Which genes have their activity affected by the chemical (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone?",
"role": "user"
},
{
"content": "CYP1A1",
"role": "assistant"
}
] |
a6a4f1eb74e04539bf2d2e2c9128f695
|
[
{
"content": "Which genes have their activity increased by the chemical (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one?",
"role": "user"
},
{
"content": "TFEB",
"role": "assistant"
}
] |
baf0a628bcab4412a1473a5f5a64f0be
|
[
{
"content": "Which genes have their localization affected by the chemical (1R,3S,3aR,8bS)-3a-(4-Bromophenyl)-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta(b)benzofuran-1,8b-diol?",
"role": "user"
},
{
"content": "BAX",
"role": "assistant"
}
] |
8e249cc669574f019d995c86ed413d66
|
[
{
"content": "Which genes have their activity increased by the chemical (1R,3S,3aR,8bS)-3a-(4-Bromophenyl)-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta(b)benzofuran-1,8b-diol?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
a064b100c3e6495db48d047a71fc39c6
|
[
{
"content": "Which genes have increased cleavage interactions with the chemical (1R,3S,3aR,8bS)-3a-(4-Bromophenyl)-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta(b)benzofuran-1,8b-diol?",
"role": "user"
},
{
"content": "PARP1",
"role": "assistant"
}
] |
7ce3106b789345a28bec7fefb66ba450
|
[
{
"content": "Which genes are affected by the binding interaction with (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester?",
"role": "user"
},
{
"content": "SLC6A3",
"role": "assistant"
}
] |
265fb512bef745a99f85eee5f32c3b86
|
[
{
"content": "Which genes have their activity decreased by (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester?",
"role": "user"
},
{
"content": "DAT",
"role": "assistant"
}
] |
a3f71d75e3424d4bbfc31e880ea5e8c4
|
[
{
"content": "Which genes have their expression increased by the chemical (2)-5,6,7,8,4'-pentamethoxyflavanone?",
"role": "user"
},
{
"content": "BAX",
"role": "assistant"
}
] |
58057bd71b564d4e931060328ed7ed3c
|
[
{
"content": "Which genes have their activity increased by (2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate?",
"role": "user"
},
{
"content": "NR1I3",
"role": "assistant"
}
] |
d786193434bd4d9d8f676e92d7400045
|
[
{
"content": "Which genes have their expression decreased by the chemical (2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone?",
"role": "user"
},
{
"content": "RNGTT",
"role": "assistant"
}
] |
d803527fd8984061ab892a76ceeddc73
|
[
{
"content": "Which genes have their activity decreased by the chemical (2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide?",
"role": "user"
},
{
"content": "UGCG",
"role": "assistant"
}
] |
72c90d21f7e949e0b12bb20b3b2b0509
|
[
{
"content": "Which genes have their activity affected by (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane?",
"role": "user"
},
{
"content": "HTR1A",
"role": "assistant"
}
] |
a687bcf539aa48669308691dda15a435
|
[
{
"content": "Which genes have their binding affected by the chemical (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane?",
"role": "user"
},
{
"content": "ADRA1A",
"role": "assistant"
}
] |
7dc544e494f445f998156712d60ae60a
|
[
{
"content": "Which genes have their activity decreased by the chemical (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane?",
"role": "user"
},
{
"content": "ADRA2A",
"role": "assistant"
}
] |
3170de95dd6b432898ad8994d0f57ea7
|
[
{
"content": "Which genes have their activity decreased by the chemical (2-(6-fluoro-1H-indol-3-yl)-ethyl)-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)amine?",
"role": "user"
},
{
"content": "HTR6",
"role": "assistant"
}
] |
719b5de6d84d45fdaabfacbd86425072
|
[
{
"content": "Which genes have their activity affected by (2-(trimethylammonium)ethyl)methanethiosulfonate?",
"role": "user"
},
{
"content": "CFTR",
"role": "assistant"
}
] |
a52b3dd585ab448aa316194493087491
|
[
{
"content": "Which genes have their activity decreased by the chemical (2-(trimethylammonium)ethyl)methanethiosulfonate?",
"role": "user"
},
{
"content": "SLC12A2",
"role": "assistant"
}
] |
44a589b684114ac58b77fba5b3159f81
|
[
{
"content": "Which genes have their binding affected by the chemical (2-boronoethyl)-cysteine?",
"role": "user"
},
{
"content": "ARG2",
"role": "assistant"
}
] |
5770eae647cf42f69e2acc11f49f65db
|
[
{
"content": "Which genes have their activity decreased by the chemical (2-boronoethyl)-cysteine?",
"role": "user"
},
{
"content": "ARG1",
"role": "assistant"
}
] |
3260d0e5c443430495aa4bbcc93b46c0
|
[
{
"content": "Which genes have their activity increased by (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide?",
"role": "user"
},
{
"content": "NFE2L2",
"role": "assistant"
}
] |
0b783fe1ee5641bd98b4fe89c902fcee
|
[
{
"content": "Which genes have their activity decreased by the chemical (2-hydroxy-4-(octyloxy)phenyl)phenylmethanone?",
"role": "user"
},
{
"content": "HSD3B1",
"role": "assistant"
}
] |
74142691539a4055967bb20be5a6ca11
|
[
{
"content": "Which genes have their activity decreased by (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide according to the interaction data?",
"role": "user"
},
{
"content": "KCNA5",
"role": "assistant"
}
] |
034d41b2785b44118b99829c9758a22a
|
[
{
"content": "Which genes have their uptake decreased by the chemical (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate?",
"role": "user"
},
{
"content": "APP",
"role": "assistant"
}
] |
fce023cb648b4d2da5c71286bbb8012b
|
[
{
"content": "Which genes have their expression increased by the chemical (2E)-N,N-dibutyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide?",
"role": "user"
},
{
"content": "CDKN1A",
"role": "assistant"
}
] |
30e5c9c9888648ce9506a290f5fc9d32
|
[
{
"content": "Which genes are affected by the chemical (2E)-decenal through reduction?",
"role": "user"
},
{
"content": "AKR1B1",
"role": "assistant"
}
] |
01e7baaeb5b04e29b254e993cb032de2
|
[
{
"content": "Which genes have their phosphorylation decreased by (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid?",
"role": "user"
},
{
"content": "NFKBIA",
"role": "assistant"
}
] |
620163948f07429eb518b4ccd0eda24d
|
[
{
"content": "Which genes have their activity decreased by the chemical (2R, 3S)-2-(((4-(2-butynyloxy)phenyl)sulfonyl)amino)-N,3-dihydroxybutanamide?",
"role": "user"
},
{
"content": "ADAM17",
"role": "assistant"
}
] |
1b294af87aeb4e739c45967b2f5a8372
|
[
{
"content": "Which genes have their activity decreased by the chemical (2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid?",
"role": "user"
},
{
"content": "F10",
"role": "assistant"
}
] |
92b6949a33af4b79aa7bd7ed831acfa8
|
[
{
"content": "Which genes have their activity increased by the chemical (3,3-dibenzylimidazo(1,2-a)pyridin-2-(3H)-one)?",
"role": "user"
},
{
"content": "CHAT",
"role": "assistant"
}
] |
9cb9c81ac7214e6d8e1d9ee3bd7d3040
|
[
{
"content": "Which genes have their activity increased by the chemical (3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide?",
"role": "user"
},
{
"content": "ANO1",
"role": "assistant"
}
] |
c073535a2dfe471f9e20bef04e8ece1f
|
[
{
"content": "Which genes have their activity decreased by the chemical (3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridin-4-yl)(1-ethylpropyl)amine according to the interaction data?",
"role": "user"
},
{
"content": "CRHR1",
"role": "assistant"
}
] |
ddd5b963d0004365aeda531cf7c091a7
|
[
{
"content": "Which genes have their expression affected by the chemical (3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester?",
"role": "user"
},
{
"content": "CDKN1A",
"role": "assistant"
}
] |
d8ffa0b9a98743b296e35a94e783bbda
|
[
{
"content": "Which genes have their expression decreased by the chemical (3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester?",
"role": "user"
},
{
"content": "SKP2",
"role": "assistant"
}
] |
62947515cda44ee4be2355b4f1492c84
|
[
{
"content": "Which genes have their cleavage increased by the chemical (3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester?",
"role": "user"
},
{
"content": "PARP1",
"role": "assistant"
}
] |
ff176744acaa4db494dcb4bc78d76f40
|
[
{
"content": "Which genes have their expression increased by the chemical (3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester?",
"role": "user"
},
{
"content": "CDKN1B",
"role": "assistant"
}
] |
2cc0ff4d89de468ca9dcb6ba2761a101
|
[
{
"content": "Which genes have their response to the substance decreased by (3-aminopropyl)(n-butyl)phosphinic acid?",
"role": "user"
},
{
"content": "HOMER1",
"role": "assistant"
}
] |
9eb1161532b8486b9721ab4571a9466b
|
[
{
"content": "Which genes have their activity decreased by the chemical (3-chloro-4-fluoro-phenyl)-(6-(4-diethylaminomethyl-piperidin-1yl)-pyrimido(5,4-d)pyrimidin-4-yl)amine according to the interaction data?",
"role": "user"
},
{
"content": "EGFR",
"role": "assistant"
}
] |
546c1291aba54c5d8f5ce8e7c905f502
|
[
{
"content": "Which genes have their activity decreased by (3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate?",
"role": "user"
},
{
"content": "GRM1",
"role": "assistant"
}
] |
50ea5b7e73044ba4ae999acc0a41f424
|
[
{
"content": "Which genes have their activity decreased by (3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride?",
"role": "user"
},
{
"content": "DRD2",
"role": "assistant"
}
] |
57978db55dba4427874d25afed224e93
|
[
{
"content": "Which genes have their activity increased by the chemical (3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride?",
"role": "user"
},
{
"content": "HTR1A",
"role": "assistant"
}
] |
9478ab6e85d24e5c9afd7af1f4ee7c9b
|
[
{
"content": "Which genes have their activity affected by the chemical (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone?",
"role": "user"
},
{
"content": "ABCG2",
"role": "assistant"
}
] |
7d465b908ec04df792672ed6b6aa7ebc
|
[
{
"content": "Which genes are affected by the binding interaction of (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone?",
"role": "user"
},
{
"content": "CNR2",
"role": "assistant"
}
] |
72230064060b40818033a5a160dea48b
|
[
{
"content": "Which genes have their phosphorylation decreased by the chemical (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone?",
"role": "user"
},
{
"content": "NFKBIA",
"role": "assistant"
}
] |
2aeb40bba7804817a9aabbed6bd12987
|
[
{
"content": "Which genes have their response to the chemical (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone decreased?",
"role": "user"
},
{
"content": "ADORA2A",
"role": "assistant"
}
] |
3ae2ad89c7064d39890b45940921e73d
|
[
{
"content": "Which genes have their localization increased by the chemical (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone?",
"role": "user"
},
{
"content": "NFATC4",
"role": "assistant"
}
] |
7941a0a7e57f41deb55defb72cd75c37
|
[
{
"content": "Which genes have their activity decreased by the chemical (3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid?",
"role": "user"
},
{
"content": "NR3C1",
"role": "assistant"
}
] |
be27acc218064a98b6ca56d0c4f1e5a6
|
[
{
"content": "Which genes have their cleavage increased by the chemical (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid?",
"role": "user"
},
{
"content": "PARP1",
"role": "assistant"
}
] |
9fd49f1c15554879bd95cecc2b2f806b
|
[
{
"content": "Which genes are affected by the binding interaction with (4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester?",
"role": "user"
},
{
"content": "CD274",
"role": "assistant"
}
] |
58c3d684f13644dabcb3abcd7c9f7652
|
[
{
"content": "Which genes have their activity decreased by the chemical (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine according to the interaction data?",
"role": "user"
},
{
"content": "MAPK14",
"role": "assistant"
}
] |
8ea3287c6c4146d7b06a3f586f9f3cf4
|
[
{
"content": "Which genes have their activity increased by the chemical (4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
7a4d07ed57c844d5b256160a339f4c36
|
[
{
"content": "Which genes are affected by the binding interaction with (4-chloro-2-((2-fluoro-5-(propylsulfonyl)phenyl)ethynyl)phenoxy)acetic acid?",
"role": "user"
},
{
"content": "PTGDR2",
"role": "assistant"
}
] |
f5a5b01fb24d4bc4958d4042fe627db6
|
[
{
"content": "Which genes are affected by the binding interaction of (4-chloro-2-((2-methyl-5-(propylsulfonyl)phenyl)ethynyl)phenoxy)acetic acid?",
"role": "user"
},
{
"content": "PTGDR2",
"role": "assistant"
}
] |
d6b21c7fe8b546128394882ec4b2826a
|
[
{
"content": "Which genes have their activity decreased by (4-chloro-2-((2-methyl-5-(propylsulfonyl)phenyl)ethynyl)phenoxy)acetic acid?",
"role": "user"
},
{
"content": "PTGDR",
"role": "assistant"
}
] |
337905963c9f4c08a3392b53de5812b5
|
[
{
"content": "Which genes have their localization affected by the chemical (4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone?",
"role": "user"
},
{
"content": "BCL2",
"role": "assistant"
}
] |
1d19b694528d4e65a18812a8c15ef402
|
[
{
"content": "Which genes have their activity increased by the chemical (4S,5S)-4,5-dihydroxy-1,2-dithiane?",
"role": "user"
},
{
"content": "CYP2A5",
"role": "assistant"
}
] |
28c85a4271454dd18bb4bb0285f7f15a
|
[
{
"content": "Which genes have increased cleavage interactions with the chemical (4S,5S)-4,5-dihydroxy-1,2-dithiane?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
5fb92fbf3b3a43d0aac73ba53ec70482
|
[
{
"content": "Which genes have their activity decreased by the chemical (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid?",
"role": "user"
},
{
"content": "DGAT1",
"role": "assistant"
}
] |
be1ccbea14c44dc7aab18999296ff469
|
[
{
"content": "Which genes have their activity increased by the chemical (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid?",
"role": "user"
},
{
"content": "GPT",
"role": "assistant"
}
] |
ceb9e51300224a128a381c6fcba43b14
|
[
{
"content": "Which genes have their activity decreased by the chemical (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol?",
"role": "user"
},
{
"content": "MTOR",
"role": "assistant"
}
] |
17057ce1a7cf476aa8b22d3127fbc4d8
|
[
{
"content": "Which genes have their activity decreased by the chemical (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid according to the interaction data?",
"role": "user"
},
{
"content": "SCD1",
"role": "assistant"
}
] |
055788828d6d4c0e9098abb93ba61b34
|
[
{
"content": "Which genes have their expression decreased by (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride?",
"role": "user"
},
{
"content": "CTNNB1",
"role": "assistant"
}
] |
f6ac764b52d94e24a5484b1b83e59d00
|
[
{
"content": "Which genes have increased phosphorylation due to the chemical (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride?",
"role": "user"
},
{
"content": "VASP",
"role": "assistant"
}
] |
ddebfafcf3b94fdaa0838d2531279b9d
|
[
{
"content": "Which genes have their expression increased by (6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
6b08ade4946d43cfac9977566cd6273d
|
[
{
"content": "Which genes have their activity decreased by the chemical (7-(2-(4-difluorophenyl)-1-piperazinyl)ethyl)-2-(2-furanyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine?",
"role": "user"
},
{
"content": "ADORA2A",
"role": "assistant"
}
] |
6d2ef44f12f6448fbc457ddeebee204f
|
[
{
"content": "Which genes have their activity increased by the chemical (Cr(salprn)(H2O)2)ClO4?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
6f36cb810b3141cda7099c9204709b20
|
[
{
"content": "Which genes have their expression decreased by the chemical (E)-2-((2-(benzo(d)thiazol-2-yl)hydrazono)methyl)-4-nitrophenol?",
"role": "user"
},
{
"content": "MYC",
"role": "assistant"
}
] |
116e19a474714442997a3400bf5c8b08
|
[
{
"content": "Which genes are affected by the chemical (E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid through binding interactions?",
"role": "user"
},
{
"content": "CYSLTR1",
"role": "assistant"
}
] |
0a07be67d9c14ed3a4178078ebb27a09
|
[
{
"content": "Which genes have their activity decreased by the chemical (E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid according to the interaction data?",
"role": "user"
},
{
"content": "ALOX5",
"role": "assistant"
}
] |
f54934934a7e449e9b67c80a895ec73b
|
[
{
"content": "Which genes have their oxidation increased by the chemical N1-acetylisoniazid?",
"role": "user"
},
{
"content": "MPO",
"role": "assistant"
}
] |
61f7e7ae8d694a3187fadabc810a8eb1
|
[
{
"content": "Which genes have their activity decreased by the chemical (N-(1-(((cyanoimino)(5-quinolinylamino)methyl)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)?",
"role": "user"
},
{
"content": "P2RX7",
"role": "assistant"
}
] |
62b02869f0a7481db8b5fbef2bb929d9
|
[
{
"content": "Which genes have their transport increased by (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine?",
"role": "user"
},
{
"content": "ABCB1",
"role": "assistant"
}
] |
10ddbf3c568244008b04a3a62a627cad
|
[
{
"content": "Which genes have their activity decreased by the chemical (N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide)?",
"role": "user"
},
{
"content": "TACR2",
"role": "assistant"
}
] |
10e7d12b392148fb8e6bb3fc4bb32d08
|
[
{
"content": "Which genes have their activity decreased by the chemical (Nphe(1),Arg(14),Lys(15))N-OFQ NH(2)?",
"role": "user"
},
{
"content": "OPRL1",
"role": "assistant"
}
] |
6600bf98b8134cf9aea9c6e5c86531aa
|
[
{
"content": "Which genes have their activity increased by the chemical (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide?",
"role": "user"
},
{
"content": "KCNQ1",
"role": "assistant"
}
] |
ff3c309f17b74bed9ab8056d8b82f8db
|
[
{
"content": "Which genes have their activity decreased by the chemical [(R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine]?",
"role": "user"
},
{
"content": "TRPM7",
"role": "assistant"
}
] |
4ce19ad6e5e1465b805eea915f4aa44f
|
[
{
"content": "Which genes have their activity increased by the chemical (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine?",
"role": "user"
},
{
"content": "PLG",
"role": "assistant"
}
] |
cc16954751e24e33b660970d063ce529
|
[
{
"content": "Which genes have their activity decreased by the chemical (R)-N-cycloheptyl-6-((((tetrahydro-2-furyl)methyl)amino)methyl)thieno(2,3-d)pyrimidin-4-ylamine?",
"role": "user"
},
{
"content": "GRM1",
"role": "assistant"
}
] |
e350fdc82a70417cba544b3fd130e5cb
|
[
{
"content": "Which genes have their response to the chemical (S)-2-methylbutyronitrile increased?",
"role": "user"
},
{
"content": "CYP2E1",
"role": "assistant"
}
] |
c5b20db932f0432da577485cd31a33d3
|
[
{
"content": "Which genes have their expression decreased by (arginine)9-cysteinyl-glutaminyl-cysteinyl-arginyl-arginyl-lysyl-asparagine?",
"role": "user"
},
{
"content": "MYC",
"role": "assistant"
}
] |
6a89ceed199e47d1908bcd04e937e1ed
|
[
{
"content": "Which genes have their activity increased by (dichloro)tetraammineruthenium(III)?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
60edae4a3cfb46fdaa6f3a1afee0fea7
|
[
{
"content": "Which genes have their activity increased by the chemical (endo-N-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1H-benzimidazol-1-carboxamide?",
"role": "user"
},
{
"content": "HTR4",
"role": "assistant"
}
] |
4efa4ee9b60a4f9fadd7eaff8462615c
|
[
{
"content": "Which genes have their expression increased by the chemical (gamma-CyD)2 C60?",
"role": "user"
},
{
"content": "CDKN1A",
"role": "assistant"
}
] |
End of preview. Expand
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Dataset Summary
BioRel-CTD-Relational-QA is a biomedical relational question–answering dataset created by transforming curated relationships from the Comparative Toxicogenomics Database (CTD) into natural-language Q&A pairs. The question–answer formatting was generated with the assistance of the gpt-4o-mini model, while all underlying relational facts originate from CTD.
This dataset is derived from CTD, and all usage must comply with the CTD Terms of Use: https://ctdbase.org/about/legal.jsp
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Size of downloaded dataset files:
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Size of the auto-converted Parquet files:
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Number of rows:
141,677
Models trained or fine-tuned on BioRel/Chemical-gene_protein_QA