Datasets:

ClarusC64
/

pharma-pharmacological-vs-contextual-signal-separation-v0.1

id stringclasses 6 values	trial_id stringclasses 3 values	condition stringclasses 3 values	arm_type stringclasses 2 values	belief_score float64 0.55 0.78	expectancy_score float64 0.6 0.74	clinician_signal_strength float64 0.6 0.7	setting_support_score float64 0.58 0.72	baseline_symptom_severity float64 5.9 7.1	outcome_change_short_term float64 -1.9 -0.7	biomarker_shift_short_term float64 0.01 0.2	adherence_proxy float64 0.75 0.86	pure_pharmacological_effect float64 0.06 0.95	contextual_amplification_factor float64 0.28 0.55	nocebo_risk_index float64 0.1 0.22	signal_separation_confidence float64 0.66 0.78	effect_stability_score float64 0.57 0.7	notes stringclasses 6 values	constraints stringclasses 1 value	gold_checklist stringclasses 1 value
SSM-001	T3001	Chronic pain	drug	0.78	0.74	0.7	0.65	7.1	-1.9	0.2	0.86	0.95	0.35	0.12	0.78	0.7	drug effect strong; moderate context	<=320 words	pharm+context+nocebo+confidence+stability
SSM-002	T3001	Chronic pain	placebo	0.78	0.74	0.7	0.65	7.1	-1	0.02	0.84	0.1	0.55	0.1	0.74	0.66	placebo lift high	<=320 words	pharm+context+nocebo+confidence+stability
SSM-003	T3002	Depression	drug	0.55	0.6	0.68	0.72	6.4	-1.2	0.12	0.8	0.62	0.28	0.18	0.72	0.63	mixed signal	<=320 words	pharm+context+nocebo+confidence+stability
SSM-004	T3002	Depression	placebo	0.55	0.6	0.68	0.72	6.4	-0.7	0.03	0.79	0.08	0.45	0.16	0.7	0.62	moderate placebo	<=320 words	pharm+context+nocebo+confidence+stability
SSM-005	T3003	IBS	drug	0.72	0.7	0.6	0.58	5.9	-1.1	0.05	0.77	0.4	0.32	0.22	0.68	0.58	weak biomarker shift; context heavy	<=320 words	pharm+context+nocebo+confidence+stability
SSM-006	T3003	IBS	placebo	0.72	0.7	0.6	0.58	5.9	-0.9	0.01	0.75	0.06	0.52	0.2	0.66	0.57	placebo dominates	<=320 words	pharm+context+nocebo+confidence+stability

What this dataset tests

Whether a system can separate pharmacological effect from contextual modulation
in placebo-controlled clinical trial settings.

It treats context as a learnable component of the outcome manifold.

Required outputs

pure_pharmacological_effect
contextual_amplification_factor
nocebo_risk_index
signal_separation_confidence
effect_stability_score

Use case

Second layer of the Placebo/Nocebo Response Disentanglement Matrix.

Improves efficacy estimation by preventing:

placebo lift being counted as drug effect
nocebo effects being misread as toxicity
unstable effects being over-trusted

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