instruction large_stringclasses 3
values | input large_stringlengths 48 801 | output large_stringlengths 1 4.31k | source stringclasses 3
values |
|---|---|---|---|
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 5 H-bond donors, <= 600 Molecular weight, no BRICS substructure, <= 0.4 Fraction sp3, <= 200 TPSA, no macrocycles, <= 3 H-bond acceptors, lacks covalent warheads, <= 10 Rotatable bonds: | C1Oc2ccc(cc2C1)/C=N/O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks covalent warheads, <= 15 H-bond acceptors, > 0.6 Fraction sp3, lacks bad SMARTS, <= 6 LogP, <= 500 Molecular weight: | c1c(cc(c(c1OC)OC)OCCCCCC)C(=O)OCCCC[N+](C)(C)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: no macrocycles, lacks covalent warheads, A formula of C22H25N7O2, <= 7 H-bond donors, <= 5 LogP, <= 10 Rotatable bonds, a substructure of COc1ccccc1: | c1(-c2nc(c(N)nc2)C(=O)Nc2cnccc2N2CCC(N)CC2)ccc(OC)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 3 H-bond donors, > 10 Rotatable bonds, > 0.4 Fraction sp3, > 600 Molecular weight, <= 6 LogP, a substructure of COC(C)=O, lacks bad SMARTS, no macrocycles, A formula of C52H57F2NO21: | c1(ccc(cc1)N1[C@H](c2ccc(cc2)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2OC(=O)C)OC(=O)C)O[C@@H]2O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]2OC(C)=O)OC(C)=O)COC(=O)C)COC(=O)C)[C@@H](CC[C@H](OC(=O)C)c2ccc(F)cc2)C1=O)F | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 0.4 Fraction sp3, <= 7 Rotatable bonds, <= 4 H-bond acceptors, a substructure of Nc1cccc(Cl)c1, lacks covalent warheads: | c12n(cnn1)cc(C(Nc1cc(Cl)ccc1)=O)cc2 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 200 TPSA, <= 300 Molecular weight, no BRICS substructure, <= 10 Rotatable bonds: | C(C)C(CO)(CO)CCCC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 0.4 Fraction sp3, <= 5 LogP, lacks covalent warheads, <= 140 TPSA, <= 10 Rotatable bonds: | C1CN(c2cc(nc(n2)Nc2cccc(N3CCOCC3)c2)-c2cnc(cc2C(F)(F)F)N)CCO1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks covalent warheads, <= 0.4 Fraction sp3, a substructure of CP(=O)(O)O, lacks bad SMARTS, A formula of C24H23N2O4P, <= 10 Rotatable bonds, <= 500 Molecular weight: | O=P(Cc1ccc(cc1)CN1c2ccccc2C(=N[C@H](C1=O)C)c1ccccc1)(O)O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 15 H-bond acceptors, no macrocycles, <= 3 H-bond donors, <= 6 LogP, > 0.4 Fraction sp3, lacks bad SMARTS, <= 400 Molecular weight, a substructure of NC(=O)CCC1CCOCC1: | c1(NC(=O)CCC2CCOCC2)ccc(C(O)=O)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: no macrocycles, A formula of C17H11Br3N2O2, lacks covalent warheads, <= 0.4 Fraction sp3: | c1(c(Nc2ccc(cc2)Br)[nH]c2c(c1=O)c(ccc2Br)Br)C(=O)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: has bad SMARTS, no macrocycles, A formula of C21H31N3O2, <= 4 H-bond donors, <= 6 LogP, <= 500 Molecular weight, <= 10 H-bond acceptors: | c1cc(NC(C)=O)ccc1CN1C[C@@H]2CC[C@H]1CN(C2)C1CCOCC1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 140 TPSA, <= 10 Rotatable bonds, lacks covalent warheads, <= 5 H-bond donors, no macrocycles, <= 5 LogP, <= 400 Molecular weight: | c1(-c2csc(n2)NC(=O)c2cnccc2)ccc(CC)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: A formula of C18H14N4O3, lacks covalent warheads, <= 10 Rotatable bonds, <= 3 H-bond donors, <= 10 H-bond acceptors: | c1(cnccc1)C(=O)N(C(c1ccc(cc1)N)=O)/N=C/c1ccco1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: > 0.4 Fraction sp3, no macrocycles, <= 3 LogP, a substructure of CSC1=Nc2[nH]c(C)c(C)c2C2=NC(=O)CN12, lacks bad SMARTS, lacks covalent warheads, <= 15 H-bond acceptors: | Cc1c(n(c2N=C(SC)N3CC(=O)N=C3c12)CCCC(=O)NCCc1[nH]cnc1)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks covalent warheads, no macrocycles, <= 3 LogP, <= 3 H-bond donors: | C1(CC(N(C(N1Cc1ccc(Cl)cc1)=O)C1CCCC1)=O)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 5 H-bond donors, lacks bad SMARTS, <= 7 Rotatable bonds, <= 10 H-bond acceptors, no macrocycles, lacks covalent warheads: | C1CCC[C@@H]2N(C(C[C@@H](Cc3cc(F)c(cc3F)F)N)=O)[C@@H](C[C@H]12)C(=O)NCc1ccccc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 90 TPSA, <= 500 Molecular weight, no macrocycles, has bad SMARTS, lacks covalent warheads, <= 3 LogP, <= 3 H-bond donors, <= 10 Rotatable bonds, <= 5 H-bond acceptors, A formula of C22H26N2O3: | [C@H]12[C@@]3(C([C@@]4(c5ccccc5N(C)[C@@H]4[C@@H]4C[C@H]3/C(CN41)=C/C)C2)O)C(OC)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 7 H-bond donors, <= 6 LogP, A formula of C22H22N4, lacks bad SMARTS: | CC1C(C)(C)Cn2c1c(-c1ccncc1)c(n2)-c1cccc(c1C#N)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 5 H-bond acceptors, lacks bad SMARTS, <= 4 LogP, lacks covalent warheads, no macrocycles, a substructure of CCOC=O: | c1cc(ccc1C(OCC)=O)NC(CNC(=O)C1CCCCC1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks bad SMARTS, <= 10 Rotatable bonds, <= 6 LogP, no macrocycles, <= 200 TPSA, A formula of C18H20N2OS: | c1cc(Sc2ccccc2OC)cc2c1CC1N2CCNC1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 400 Molecular weight, a substructure of CS(=O)(=O)N1CCCC(C=O)C1, lacks covalent warheads, > 0.5 Fraction sp3, <= 4 LogP: | O=C(C1CN(CCC1)S(C)(=O)=O)Nc1ccccc1OCC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 0.4 Fraction sp3, <= 3 H-bond donors, <= 5 LogP, a substructure of FC(F)F, <= 500 Molecular weight: | N(c1ccc(cc1)C(F)(F)F)C(Nc1cc(c(cc1)C(=O)N1CCN(CC1)C)F)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 200 TPSA, <= 4 LogP, no macrocycles, <= 600 Molecular weight, <= 15 H-bond acceptors, <= 7 Rotatable bonds, a substructure of c1ccccc1: | c1(ccc(cc1)C(=O)N[C@H](C(OC(C)C)=O)Cn1cncc1)-c1ccccc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 400 Molecular weight, lacks covalent warheads, <= 15 H-bond acceptors, <= 7 H-bond donors, <= 90 TPSA, <= 7 Rotatable bonds, no macrocycles: | c1c(cc(cc1F)NC(N1CCN(c2ncccn2)CC1)=S)F | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 140 TPSA, <= 5 H-bond donors, A formula of C29H27Cl2N5O2, <= 0.4 Fraction sp3, <= 10 H-bond acceptors: | c1c(cc2c(Nc3cnc(N4CCC[C@@H](N)C4)cc3)c(cnc2c1)C(=O)C1CC1)-c1cc(Cl)c(c(c1)Cl)O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 140 TPSA, <= 600 Molecular weight, no macrocycles, <= 0.4 Fraction sp3: | C(=S)(NC1=C(C(C2=C(CC(C)(C)CC2=O)N1c1ccc(cc1)S(=O)(=O)N)c1ccc(F)cc1)C#N)NCC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks bad SMARTS, a substructure of N#Cc1ccc(-c2ccc([SH](=O)=O)cc2)cc1, <= 4 LogP, no macrocycles, A formula of C21H14N4O2S, <= 7 Rotatable bonds, <= 3 H-bond donors: | c1cc2nc(NS(c3ccc(-c4ccc(cc4)C#N)cc3)(=O)=O)ccc2nc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: A formula of C17H29BBrNO4, <= 10 Rotatable bonds, a substructure of CC(C)C(C)(C)O, <= 500 Molecular weight, <= 7 H-bond donors, > 0.4 Fraction sp3, lacks bad SMARTS: | Brc1cncc(c1)B(OC(C)(C(O)(C)C)C)OC(C(C)(C)O)(C)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 400 Molecular weight, <= 0.4 Fraction sp3, <= 90 TPSA, <= 6 LogP, A formula of C16H13N3S: | c1c2ccccc2c2ccccc2c1/C=N/NC(=S)N | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: no macrocycles, <= 600 Molecular weight, lacks covalent warheads, <= 140 TPSA, lacks bad SMARTS: | S1c2c(N(C(=O)C1)Cc1ccc(cc1)F)cc(cc2)C(NCCc1ccccc1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 0.4 Fraction sp3, A formula of C23H25FN4O6, a substructure of CC(=O)NC[C@H]1CNC(=O)O1: | O=C1N(C[C@@H](O1)CNC(C)=O)c1ccc(c(c1)F)N1CCC(c2oncc2C(OCC)=O)=CC1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: > 0.4 Fraction sp3, <= 4 H-bond donors, a substructure of COC=O, A formula of C19H22N2O4: | O=C([C@]12c3[nH]c4c(cccc4)c3[C@@H](COC1)[C@]1([C@@H]2CCNC1)O)OC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 600 Molecular weight, no macrocycles, lacks covalent warheads, lacks bad SMARTS, <= 15 H-bond acceptors, <= 5 H-bond donors: | c1c(COP(N(CCCCCl)C)(=O)OCC2C(C(O)C(O2)n2c(nc(N)cc2)=O)O)oc([N+]([O-])=O)c1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks bad SMARTS, <= 5 LogP, <= 200 TPSA, <= 10 Rotatable bonds, <= 4 H-bond donors: | C(c1sccc1)C(N(Cc1cccs1)C(CC)(C(=O)NC1CCCCC1)C)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: a substructure of c1ccccc1, <= 600 Molecular weight, lacks bad SMARTS, <= 200 TPSA, <= 0.4 Fraction sp3, <= 7 Rotatable bonds: | O=c1c(N/C=C(/C(C(F)(F)F)=O)Cl)c(C)n(C)n1-c1ccccc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: no macrocycles, <= 10 Rotatable bonds: | O=C(NC(C1CCNCC1)[C@H]1C[C@@H](O)C1)CSC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks bad SMARTS, <= 200 TPSA, a substructure of Nc1ccon1: | S(=O)(=O)(c1cc2ccc(n(c2cc1)-c1c(cc(c(c1)F)C#CC1CCCC1)OC)=O)Nc1nocc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: no macrocycles, lacks bad SMARTS, <= 10 Rotatable bonds, a substructure of CCCNCCC, A formula of C17H31N3: | n12c(ccc2CN(C)C)C[C@H](CC1)N(CCC)CCC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: a substructure of CC(=O)Nc1ccc(N)cc1, <= 7 Rotatable bonds, <= 600 Molecular weight, <= 0.4 Fraction sp3: | O=c1n(CC(=O)Nc2ccc(cc2)NC(=O)C)c2ccccc2nc1-c1c(NC(CC)=O)ccc(c1)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 5 LogP, <= 200 TPSA, lacks bad SMARTS, no macrocycles, <= 10 Rotatable bonds: | c1ccc(cc1)COC(N1CCC(CS(NC(C)Cc2sccc2)(=O)=O)C1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: a substructure of c1ccccc1, no macrocycles, <= 7 H-bond donors, <= 0.4 Fraction sp3: | Clc1ccc(NC(NC2CC3CCC(N3Cc3ccccc3)C2)=S)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 0.4 Fraction sp3, lacks covalent warheads, <= 90 TPSA, has bad SMARTS, A formula of C23H24N4O2: | c1(=O)n(C)ccc(c1)-c1cnc(C)nc1OC[C@@H]1[C@@H](c2ccc3c(n2)CCC3)C1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 600 Molecular weight, <= 200 TPSA, <= 10 H-bond acceptors, lacks covalent warheads, > 0.5 Fraction sp3: | [C@H]12/C=C(/C(=O)[C@@]3([C@H]([C@@H](O)[C@@H](C)C3)[C@@H](OC(=O)c3cnc(NC(C)=O)s3)C(CC[C@@H]2C1(C)C)=C)O)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 140 TPSA, <= 7 Rotatable bonds, <= 0.4 Fraction sp3: | c12sc(nc2c(ccc1)Cl)N(C(C1(CCOCC1)n1nnnc1)=O)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 140 TPSA, <= 500 Molecular weight, A formula of C18H16N6, <= 10 H-bond acceptors, no macrocycles: | c1cccc2c1/C(N(C2)c1ccc(N)nc1)=N\c1cnc(N)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 5 H-bond acceptors, a substructure of CCNCC, <= 90 TPSA, A formula of C24H36N2O2, <= 6 LogP, no macrocycles, > 0.4 Fraction sp3, lacks covalent warheads, <= 10 Rotatable bonds, <= 5 H-bond donors, <= 500 Molecular weight, lacks bad SMARTS... | CCN(C([C@H]1CC[C@@H]2[C@@]1(CC[C@@H]1[C@]3(C=CC(=O)C(=C3NC[C@@H]21)C)C)C)=O)CC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 10 Rotatable bonds, <= 0.4 Fraction sp3, lacks covalent warheads, no macrocycles, a substructure of Nc1nc2cc3c(cc2s1)OCCO3, <= 200 TPSA, lacks bad SMARTS: | N(S(=O)(c1cc(C(Nc2sc3cc4OCCOc4cc3n2)=O)ccc1)=O)(CC)CC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks covalent warheads, a substructure of Cc1cccc(N)c1C, <= 5 H-bond donors: | c1c(c(-n2c3nc([nH]c(=O)c3c(CC)n2)Cc2c(c(ccc2)N)C)c(Cl)cc1Cl)Cl | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 3 H-bond donors, lacks covalent warheads, a substructure of O=C(CO)NCc1ccc2c(c1)OCO2, <= 140 TPSA, <= 500 Molecular weight: | C(COC(c1cc(ccc1)O)=O)(=O)NCc1cc2c(cc1)OCO2 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 0.4 Fraction sp3, <= 200 TPSA, <= 10 H-bond acceptors, <= 10 Rotatable bonds, a substructure of CCc1ccccc1, A formula of C14H13N3O2, <= 600 Molecular weight, <= 3 H-bond donors: | c1c(cccc1)CCn1c2c(nc1)[nH]c(=O)c(O)c2 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 90 TPSA, lacks bad SMARTS, lacks covalent warheads, <= 7 Rotatable bonds, <= 0.4 Fraction sp3, a substructure of O=Cc1ccc(Nc2ccncn2)cc1, no macrocycles, <= 3 H-bond donors, A formula of C20H14ClN5OS: | c1c(nsc1NC(c1ccc(Nc2ccncn2)cc1)=O)-c1ccc(cc1)Cl | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 140 TPSA, <= 6 LogP, A formula of C24H24O5, lacks covalent warheads, no macrocycles: | c1(O)c(ccc(C(C)C)cc1=O)C(c1ccc(cc1)OC)c1c(O)cc(O)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 5 LogP, > 0.6 Fraction sp3, <= 3 H-bond donors, A formula of C20H30O3, a macrocycle: | [C@@H]1(O)/C=C(\C)CCC2[C@H](OCC=2C)/C=C(\C)CC[C@@H]2O[C@]2(C1)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 10 Rotatable bonds, <= 140 TPSA, <= 15 H-bond acceptors, has bad SMARTS, a substructure of CN1CCNCC1, <= 600 Molecular weight: | c1ccc(-c2ccc3n2nc(Nc2ccc(cc2)N2CCN(C)CC2)nc3)c(C(=O)N)c1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 15 H-bond acceptors, <= 400 Molecular weight, lacks covalent warheads, <= 200 TPSA, <= 5 LogP, A formula of C20H21ClN2O2, no macrocycles, <= 0.4 Fraction sp3, a substructure of CCCl: | C(c1nccc2cc(c(cc21)OC)OC)c1ccc(cc1)NCCCl | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks covalent warheads, <= 0.4 Fraction sp3, <= 10 Rotatable bonds, no macrocycles: | c1(C(OCC)=O)ccccc1NC(=O)Cn1c(=O)c2cnn(-c3ccccc3)c2nc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 10 H-bond acceptors, lacks covalent warheads, no macrocycles, <= 4 H-bond donors: | CC(c1nc(sc1Cc1cc2OCOc2cc1)Nc1c(Br)cc(OC(F)(F)F)cc1Br)(C)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 4 LogP, A formula of C24H36N2O3, lacks bad SMARTS, no macrocycles, <= 4 H-bond donors, <= 7 Rotatable bonds, <= 500 Molecular weight, <= 15 H-bond acceptors: | C[C@@]12C(CC[C@H]1[C@@H]1CC(=O)[C@H]3C/C(CC[C@@]3([C@H]1CC2)C)=N/OC1CCNCC1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 200 TPSA, no macrocycles, > 6 LogP, <= 10 Rotatable bonds, <= 0.4 Fraction sp3, A formula of C44H34N4O4: | C(=C/C(c1c[nH]c2ccc(O)cc12)c1c[nH]c2c1cc(cc2)O)\c1ccc(cc1)/C=C/C(c1c2cc(ccc2[nH]c1)O)c1c2cc(ccc2[nH]c1)O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks bad SMARTS, <= 0.4 Fraction sp3, a substructure of O=CN1CCN(CCO)CC1, <= 7 Rotatable bonds, <= 600 Molecular weight, <= 6 LogP, A formula of C26H28BrN3O6: | c12c(cc(c(c2)OC)OC)c(-c2cc(Br)ncc2)c(C(OC)=O)c(c1)C(N1CCN(CC1)CCO)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 140 TPSA, no macrocycles, lacks bad SMARTS, <= 5 LogP, a substructure of O=[N+]([O-])c1ccc(CN2CCNCC2)cc1, <= 3 H-bond donors, <= 15 H-bond acceptors: | C(c1ccc([N+](=O)[O-])cc1)N1CCN(c2c(F)cc3c(c2)n(C2CC2)cc(C(=O)O)c3=O)CC1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: a substructure of NC1CC1, <= 400 Molecular weight, <= 4 H-bond donors, between 0.4 and 0.6 Fraction sp3, lacks covalent warheads, <= 7 Rotatable bonds, <= 5 H-bond acceptors, no macrocycles: | n1n2c(nnc2ccc1NC1CC1)CC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: A formula of C9H13NO3, <= 300 Molecular weight, <= 5 H-bond acceptors, a substructure of Cc1ccc([C@H](CN)CC(=O)O)o1, between 0.4 and 0.6 Fraction sp3, lacks bad SMARTS: | c1([C@@H](CC(=O)O)CN)oc(C)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 7 H-bond donors, lacks bad SMARTS, no macrocycles: | c1(ccc2c(c1)c(C(OC)=O)c[nH]2)Br | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 5 LogP, <= 3 H-bond donors, <= 0.4 Fraction sp3, A formula of C16H21N5O2S, no macrocycles, <= 500 Molecular weight: | c1c(ccc(CNC(=O)C(NC(=O)N)CCSC)c1)-n1nccc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks bad SMARTS, between 0.4 and 0.6 Fraction sp3, <= 600 Molecular weight, <= 10 Rotatable bonds, lacks covalent warheads, <= 3 LogP: | C1CN(CCN1c1sc(cn1)C(F)(F)F)CCc1nccnc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks covalent warheads, <= 7 H-bond donors, <= 600 Molecular weight, <= 4 LogP: | C(=O)(CN1C(=O)c2ccccc2C1=O)Nc1cc(ccc1C)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 600 Molecular weight, <= 6 LogP, > 0.5 Fraction sp3, <= 15 H-bond acceptors, a substructure of CCCOCc1ccccc1, has bad SMARTS, A formula of C27H37NO5, <= 10 Rotatable bonds: | c1ccccc1COCCCC1/C(=C/C(=O)OCC)N2CCC3(C[C@]42[C@@H]1CCC4)OCCO3 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 4 H-bond donors, lacks covalent warheads, <= 300 Molecular weight, lacks bad SMARTS, <= 6 LogP, no macrocycles, <= 10 Rotatable bonds, A formula of C6H3Cl2N3O3: | Clc1cnn(c(=O)c1Cl)C(C(=O)N)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 3 LogP, <= 140 TPSA, <= 400 Molecular weight, <= 15 H-bond acceptors, A formula of C18H26N4O2, <= 4 H-bond donors, lacks covalent warheads: | C1CN(CC2(C1)COCCN(C2)CC1CC1)C(c1cnccn1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: a substructure of CCCCN, lacks bad SMARTS, lacks covalent warheads, A formula of C54H98N14O10, > 7 H-bond donors, a macrocycle, > 200 TPSA, > 600 Molecular weight, > 0.5 Fraction sp3, <= 5 LogP: | C1CC[C@@H]2N1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(C)C)NC([C@H](CCCN)NC([C@H](C(C)C)NC(=O)[C@H]1N(C(=O)[C@@H](CCCCN)NC([C@H](CC(C)C)NC(=O)[C@@H](CCCN)NC([C@@H](NC2=O)C(C)C)=O)=O)CCC1)=O)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 3 H-bond donors, <= 90 TPSA, lacks covalent warheads, <= 600 Molecular weight, lacks bad SMARTS, a substructure of COc1ccnc(NC2CCNCC2)n1: | C1CCCN1C(CN1CCC(Nc2nc(OC)ccn2)CC1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: A formula of C21H29N3O5S2, a macrocycle, a substructure of NS(=O)(=O)c1cccs1, <= 6 LogP, <= 3 H-bond donors, <= 600 Molecular weight, <= 10 Rotatable bonds: | C[C@@H](N1C(c2cccc(c2O[C@H](CN(C)C)[C@H](C1)C)NS(=O)(c1cccs1)=O)=O)CO | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 400 Molecular weight, <= 5 H-bond donors, a substructure of Oc1ccccc1, lacks bad SMARTS, <= 200 TPSA, lacks covalent warheads: | c1ccccc1C(Cc1cc(ccc1)O)N1CCN(CC)CC1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 10 H-bond acceptors, <= 7 Rotatable bonds, lacks covalent warheads, <= 300 Molecular weight, lacks bad SMARTS: | c1cc(ccc1/N=C/c1ccccc1)C(=O)O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 3 H-bond acceptors, no macrocycles, <= 10 Rotatable bonds, a substructure of CC(C)S, lacks bad SMARTS: | Fc1cccc(c1C(c1nc([nH]c(=O)c1CC)SC(C)C)C)F | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: a substructure of N#Cc1ccccc1, <= 5 LogP, <= 0.4 Fraction sp3, <= 3 H-bond donors, <= 15 H-bond acceptors, lacks covalent warheads, A formula of C25H22FN3, <= 400 Molecular weight: | Fc1ccccc1CN1C[C@H]2[C@H]([C@@H](C1)N2)c1ccc(cc1)-c1ccc(C#N)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: no macrocycles, <= 10 Rotatable bonds, <= 500 Molecular weight, lacks bad SMARTS, A formula of C10H11N3O, <= 4 H-bond acceptors: | N1(c2ccccc2)C(=N)N(C)C(C1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 10 Rotatable bonds, A formula of C24H27FN4O5S, <= 6 LogP, <= 600 Molecular weight, <= 10 H-bond acceptors, <= 200 TPSA, no macrocycles, lacks bad SMARTS, lacks covalent warheads, between 0.4 and 0.6 Fraction sp3: | o1nc(c2c1cc(cc2)F)C1CCN(CC2CCN(CC2)S(=O)(=O)c2cccc([N+](=O)[O-])c2)CC1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks bad SMARTS, no macrocycles, <= 600 Molecular weight, a substructure of CCCc1nc(CC)c(C(C)=O)n1C, <= 200 TPSA, <= 10 H-bond acceptors, lacks covalent warheads, <= 3 H-bond donors: | C(n1c(c(CC)nc1CCC)C(C)=O)c1ccc(-c2ccccc2S(=O)(NC(OCCCC)=O)=O)cc1C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: a substructure of Cc1cc(F)cc(F)c1, A formula of C16H11ClF2N2, <= 7 Rotatable bonds, <= 140 TPSA, <= 5 LogP, <= 0.4 Fraction sp3, <= 10 H-bond acceptors: | c1ncc(n1-c1ccc(cc1)Cl)-c1c(F)cc(C)cc1F | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks bad SMARTS, lacks covalent warheads, A formula of C18H22N2O4, <= 3 H-bond donors, <= 400 Molecular weight: | C(=O)(N1CCN(Cc2occc2)CC1)c1c(OC)c(OC)ccc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 4 H-bond acceptors, a substructure of NC(=O)/C=C/c1ccccc1[N+](=O)[O-], <= 5 H-bond donors, no macrocycles: | C1C(C(NC(=O)/C=C/c2c([N+](=O)[O-])cccc2)C)C2CC1CC2 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: A formula of C18H16N4O2S2, lacks covalent warheads, <= 0.4 Fraction sp3, a substructure of c1cscn1: | c1(CNc2ccc(S(=O)(Nc3sccn3)=O)cc2)cccc2cc[nH]c12 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: > 0.4 Fraction sp3, <= 4 H-bond donors, <= 140 TPSA, <= 5 LogP, no macrocycles, <= 10 Rotatable bonds, a substructure of C[C@H](CSS)C(=O)N1CCC[C@@H]1C(=O)O: | O=C([C@H]1CCCN1C([C@@H](CSSC[C@@H](C)C(N1[C@H](CCC1)C(O)=O)=O)C)=O)O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 200 TPSA, a substructure of Nc1ccccc1Cl, <= 0.4 Fraction sp3, <= 10 Rotatable bonds, no macrocycles, <= 5 H-bond donors, lacks bad SMARTS, <= 10 H-bond acceptors, has covalent warheads (acrylamides): | Clc1c(NC(=O)Nc2ccc(cc2)-c2cnc(NC(=O)C=C)cc2)cccc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: lacks covalent warheads, <= 10 Rotatable bonds, <= 5 LogP, a substructure of Clc1ccccc1, <= 0.4 Fraction sp3, <= 10 H-bond acceptors, A formula of C20H18ClN5: | c1(-c2c3nc(C)cc(NCc4ccccn4)n3nc2C)c(cccc1)Cl | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 5 H-bond donors, <= 7 Rotatable bonds, <= 4 LogP, > 0.6 Fraction sp3, a substructure of CCNC(=O)Nc1cn[nH]c1, A formula of C13H23N5O, no macrocycles: | c1(cn[nH]c1)NC(NCCN(C1CCCCC1)C)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: A formula of C27H19F2N3S, <= 7 Rotatable bonds: | c1(/C=C/c2ccccc2)nc(NCc2ccc(F)c(F)c2)c2c(n1)cc(cc2)-c1sccc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 15 H-bond acceptors, no macrocycles, <= 7 Rotatable bonds, <= 500 Molecular weight, A formula of C15H15N7O2, lacks bad SMARTS, <= 140 TPSA, lacks covalent warheads: | c1(cnc2c(nc([nH]c2=O)N)n1)C(NCCNc1ccccc1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 500 Molecular weight, <= 10 Rotatable bonds, no macrocycles, lacks covalent warheads: | c1(C)c([nH]c(c1C(=O)C)C)C(Nc1cc(S(=O)(=O)N(C)C)c(Cl)cc1)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 7 Rotatable bonds, A formula of C15H22O2, lacks bad SMARTS, <= 400 Molecular weight, <= 4 H-bond donors, <= 5 LogP, <= 200 TPSA, no macrocycles: | C(c1c(O)c(cc(C=O)c1)C(C)(C)C)(C)(C)C | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 90 TPSA, <= 0.4 Fraction sp3, <= 7 Rotatable bonds, A formula of C18H20O3, no macrocycles, <= 3 H-bond donors, lacks bad SMARTS, a substructure of Cc1cc(C)c(C)cc1C, lacks covalent warheads: | c1cc(ccc1)C(O)(c1c(c(C)cc(c1C)C)C)C(O)=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 7 Rotatable bonds, lacks bad SMARTS, <= 3 H-bond acceptors, between 0.4 and 0.6 Fraction sp3, <= 6 LogP, <= 500 Molecular weight, <= 90 TPSA: | c1ccc(NC2=NC[C@H](Cc3ccccc3)N2CC2CCC(CC2)C)cc1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: a substructure of c1ccc2scnc2c1, no macrocycles, lacks bad SMARTS, <= 500 Molecular weight, <= 15 H-bond acceptors, <= 6 LogP, <= 0.4 Fraction sp3, <= 200 TPSA: | CN(C)c1ccnc2sc3c(c21)ccn(-c1cc2scnc2cc1)c3=O | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 200 TPSA, A formula of C30H35N3O5S, <= 5 H-bond donors, <= 10 H-bond acceptors, lacks covalent warheads, <= 5 LogP, <= 600 Molecular weight, <= 0.4 Fraction sp3, lacks bad SMARTS, a substructure of CN(C)Cc1cccnc1: | C(N(Cc1cnccc1)C)[C@H]1Oc2cc(ccc2S(N(C[C@H]1C)[C@H](CO)C)(=O)=O)C#Cc1ccccc1OC | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: A formula of C23H17F4N5O2S, <= 15 H-bond acceptors, <= 140 TPSA, lacks covalent warheads, a substructure of CCC(F)(F)F: | c1(cccnc1)-n1c2cc(C)c(F)cc2c(c1-c1ncc(cc1)S(=O)(N[C@H](C(F)(F)F)C)=O)C#N | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 0.4 Fraction sp3, <= 5 H-bond donors, <= 600 Molecular weight, <= 5 LogP, a substructure of FC(F)F, A formula of C16H12ClF3N2O3S2, <= 140 TPSA: | c1c(ccc(c1C(F)(F)F)Cl)NS(=O)(=O)c1ccc2SCCC(=O)Nc2c1 | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 15 H-bond acceptors, <= 3 H-bond donors, <= 140 TPSA, A formula of C14H15ClN2O2S, no macrocycles, lacks bad SMARTS, lacks covalent warheads: | c1(ccc(cc1)CCNS(c1ccc(N)cc1)(=O)=O)Cl | smileyllama |
You love and excel at generating SMILES strings of drug-like molecules | Output a SMILES string for a drug-like molecule with the following properties: <= 600 Molecular weight, lacks covalent warheads, A formula of C22H18Cl2O6, <= 5 LogP, a substructure of CCOC=O, has bad SMARTS, <= 4 H-bond donors, <= 0.4 Fraction sp3, <= 10 H-bond acceptors: | c12c([C@@H]3[C@@]([C@@]4(C(=O)OCC)[C@@H]3c3c(O4)ccc(c3)Cl)(O1)C(OCC)=O)cc(cc2)Cl | smileyllama |
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