Name stringlengths 14 548 | Synonym stringlengths 14 790 ⌀ | CAS RN stringlengths 7 12 | Y int64 0 1 | Detailed Page stringlengths 57 580 | Evidence stringlengths 40 2.31k ⌀ | OECD TG 404 stringclasses 1
value | Data Source stringclasses 34
values | Frequency int64 1 6 | SMILES stringlengths 2 255 | SMILES URL stringlengths 45 101 | SMILES Source stringclasses 4
values | Canonical SMILES stringlengths 2 248 | Split stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EU_REACH:
2,2-bis[(decanoyloxy)methyl]butyl decanoate; 2,2-bis[(octanoyloxy)methyl]butyl decanoate; 2-[(decanoyloxy)methyl]-2-[(octanoyloxy)methyl]butyl decanoate | null | 73947-34-9 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20848/7/4/2/?documentUUID=58669a32-4bf5-4f40-9162-17e9cd99a16e | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCC)COC(=O)CCCCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/22833312 | PubChem | CCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCC)COC(=O)CCCCCCC | Train |
NZ_CCID:
1-Decanamine, N-decyl-N-methyl- | null | 7396-58-9 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C204482D-7507-48BC-B8C4-5296BA30E615 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CCCCCCCCCCN(C)CCCCCCCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/81880 | PubChem | CCCCCCCCCCN(C)CCCCCCCCCC | Train |
JP_CHRIP:
Butyl hydroxyacetate | null | 7397-62-8 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0041e.html | JP_CHRIP:
On the basis of a "not irritating" result in a test using rabbits (OECD TG 404; GLP) (IUCLID (2000)), it was classified as "Not classified." | Provided | JP_CHRIP | 1 | CCCCOC(=O)CO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.924H | J-GLOBAL | CCCCOC(=O)CO | Train |
EU_REACH:
5,5'-{ethane-1,2-diylbis[thio-1,3,4-thiadiazole-5,2-diyldiazene-2,1-diyl(5-amino-3-tert-butyl-1H-pyrazole-4,1-diyl)]}diisophthalic acid | null | 741248-63-5 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21051/7/4/2/?documentUUID=ea91a847-0941-4ca6-9eaa-e6d97a4cede5 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)(C)C1=NN(C(=C1N=NC2=NN=C(S2)SCCSC3=NN=C(S3)N=NC4=C(N(N=C4C(C)(C)C)C5=CC(=CC(=C5)C(=O)O)C(=O)O)N)N)C6=CC(=CC(=C6)C(=O)O)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/136500903 | PubChem | CC(C)(C)c1nn(-c2cc(C(=O)O)cc(C(=O)O)c2)c(N)c1N=Nc1nnc(SCCSc2nnc(N=Nc3c(C(C)(C)C)nn(-c4cc(C(=O)O)cc(C(=O)O)c4)c3N)s2)s1 | Train |
EU_REACH:
4-methoxy-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2-nitrophenyl]benzamide | null | 74149-73-8 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6755/7/4/2/?documentUUID=44f8f04c-be6a-432c-b21e-e83917c39f81 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1CC(=O)NN=C1C2=CC(=C(C=C2)NC(=O)C3=CC=C(C=C3)OC)[N+](=O)[O-] | https://pubchem.ncbi.nlm.nih.gov/compound/13850880 | PubChem | COc1ccc(C(=O)Nc2ccc(C3=NNC(=O)CC3C)cc2[N+](=O)[O-])cc1 | Train |
EU_REACH:
N-[2-amino-4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]-4-methoxybenzamide | null | 74149-74-9 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6756/7/4/2/?documentUUID=e1e17d46-d6ed-4b67-9c4c-0241e5daf8ca | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1CC(=O)NN=C1C2=CC(=C(C=C2)NC(=O)C3=CC=C(C=C3)OC)N | https://pubchem.ncbi.nlm.nih.gov/compound/13850881 | PubChem | COc1ccc(C(=O)Nc2ccc(C3=NNC(=O)CC3C)cc2N)cc1 | Train |
EU_REACH:
4-amino-N-(4-carbamoylphenyl)benzamide | null | 74441-06-8 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11122/7/4/2/?documentUUID=4717829d-a4cc-4baf-8e68-8154d7f60913 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N)N | https://pubchem.ncbi.nlm.nih.gov/compound/3018508 | PubChem | NC(=O)c1ccc(NC(=O)c2ccc(N)cc2)cc1 | Train |
EU_REACH:
N-[3,5-bis(2,2-dimethylpropanamido)phenyl]-2,2-dimethylpropanamide | null | 745070-61-5 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10725/7/4/2/?documentUUID=00c1f6a2-2c74-417a-9830-61eb2eb1e5ae | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)(C)C(=O)NC1=CC(=CC(=C1)NC(=O)C(C)(C)C)NC(=O)C(C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/53421640 | PubChem | CC(C)(C)C(=O)Nc1cc(NC(=O)C(C)(C)C)cc(NC(=O)C(C)(C)C)c1 | Train |
NZ_CCID:
9,12-Octadecadienoyl chloride, (9Z,12Z)- | null | 7459-33-8 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/26F9D34E-6562-44C4-AE0B-46698BE74678 | null | null | NZ_CCID | 1 | CCCCCC=CCC=CCCCCCCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/98987 | PubChem | CCCCCC=CCC=CCCCCCCCC(=O)Cl | Train |
EU_REACH:
(5Z)-5-(phenylmethylidene)imidazolidine-2,4-dione | null | 74805-60-0 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5652/7/4/2/?documentUUID=cf88cc61-f25a-4f24-baec-31e2e7684d66 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC=C(C=C1)/C=C\2/C(=O)NC(=O)N2 | https://pubchem.ncbi.nlm.nih.gov/compound/5706042 | PubChem | O=C1NC(=O)/C(=C/c2ccccc2)N1 | Train |
EU_REACH:
2-({9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-10-yl}methyl)-2,3-dihydro-1H-isoindole-1,3-dione | null | 74860-00-7 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5205/7/4/2/?documentUUID=9d8ff5f7-9e46-4450-b4e1-58db618ae204 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1C2=CC=CC=C2C(=NC3=CC=CC=C31)CN4C(=O)C5=CC=CC=C5C4=O | https://pubchem.ncbi.nlm.nih.gov/compound/11142718 | PubChem | O=C1c2ccccc2C(=O)N1CC1=Nc2ccccc2Cc2ccccc21 | Train |
JP_CHRIP:
Methylamine
KR_NCIS:
Methylamine; Methanamine, Monomethylamine
NZ_CCID:
Methanamine (methylamine)
US_HSDB:
Methylamine | JP_CHRIP:
Aminomethane
Methanamine
methylamine, in aqueous solution
Monomethylamine
NZ_CCID:
Aminomethane, Carbinamine, Methanamine, Methylamine, Monomethylamine, R630 | 74-89-5 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-2004e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4C777067-A395-4629-A8BA-64F4B178F458
US_HSDB: https://pubch... | JP_CHRIP:
Although there is no data of skin irritation test with this substance (gas), the solution seems to have a skin corrosion from descriptions that 40% solution causes a necrosis on skin of rabbits (Patty (5th, 2001)) and that "40% solution causes a necrosis on skin of guinea pig 40%" (ACGIH (7th, 2001)). It was ... | null | JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 4 | CN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.431A | J-GLOBAL | CN | Train |
EU_REACH:
2-ethylhexyl 2-{[1,1'-biphenyl]-4-carbonyl}benzoate | null | 75005-95-7 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31361/7/4/2/?documentUUID=070fb787-b3a5-4b50-9849-487140409031 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)C2=CC=C(C=C2)C3=CC=CC=C3 | https://pubchem.ncbi.nlm.nih.gov/compound/135606 | PubChem | CCCCC(CC)COC(=O)c1ccccc1C(=O)c1ccc(-c2ccccc2)cc1 | Train |
JP_CHRIP:
Ethanamine
NZ_CCID:
Ethanamine, anhydrous (ethylamine) | JP_CHRIP:
Aminoethane
Ethylamine
NZ_CCID:
1-Aminoethane, Aminoethane, Ethanamine, Ethylamine, Monoethylamine, R631 | 75-04-7 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0657e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/815E0EDF-D7A8-4AFB-AE73-7F98E7AFC76B | JP_CHRIP:
Based on the descriptions the necrosis of skin and burn (ACGIH (2001) and PATTY (5th, 2001)), and corrosion (IUCLID (2000)) in animal experiments, it was classified as Category 1A-1C.
NZ_CCID:
Skin Irritation
SPECIES: Guinea pig
RESULT: Severe
Skin Irritation with extensive necrosis and deep scarring from 0.... | null | JP_CHRIP, NZ_CCID | 2 | CCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.437K | J-GLOBAL | CCN | Train |
EU_REACH:
(methylsulfanyl)methane
JP_CHRIP:
Dimethyl sulfide | JP_CHRIP:
Methylsulphide
Thiobismethane | 75-18-3 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13649/7/4/2/?documentUUID=b055a0b6-dd88-46ee-afc0-90af881659c0
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2134e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
There are reports that slight irritation was observed after occlusive application of this substance (undiluted) to rabbits for 24 hours (SIDS (2007)), and that when this substance was applied to the skin of rabbits (application time unknown), a primary irritati... | Provided | EU_REACH, JP_CHRIP | 2 | CSC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.443E | J-GLOBAL | CSC | Train |
AU_HCIS:
2-aminopropane
JP_CHRIP:
Isopropylamine
NZ_CCID:
2-Propanamine
US_HSDB:
Isopropylamine | AU_HCIS:
isopropylamine
2-Propanamine
JP_CHRIP:
1-methylethylamine
2-Aminopropane
2-Propaneamine
Isopropylamine
NZ_CCID:
1-Methylethylamine, 2-Aminopropane, 2-Propaneamine, 2-Propylamine, Isopropylamine, Monoisopropylamine, sec-Propylamine | 75-31-0 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=217
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2120e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6F078C37-326C-4B79-9DE0-3BBFE4A01267
US_HSDB: https://pu... | JP_CHRIP:
Based on the description that in a skin irritation test with rabbits (equivalent to OECD TG 404), necrosis, followed by eschar, occurred within 24 hours after 3-minute application of this substance, and a description that corrosion was seen in both of other two tests with rabbits (application time: 1, 5, 15 m... | Provided | AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB | 4 | CC(C)N | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.451F | J-GLOBAL | CC(C)N | Train |
EU_REACH:
(S)-pyrrolidine-2-carboxamide | null | 7531-52-4 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25124/7/4/2/?documentUUID=1e3ecb2c-81f0-4ac4-8185-39c9412dc9a4 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1C[C@H](NC1)C(=O)N | https://pubchem.ncbi.nlm.nih.gov/compound/111306 | PubChem | NC(=O)[C@@H]1CCCN1 | Train |
JP_CHRIP:
acetyl chloride
NZ_CCID:
Acetyl chloride
US_HSDB:
Acetyl chloride | JP_CHRIP:
Acetic acid chloride
Acetic chloride
Ethanoyl chloride
NZ_CCID:
Acetic acid, chloride, Ethanoyl chloride | 75-36-5 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0004e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3AECAFF3-C0BA-47E7-A3A4-944E864DC6F1
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/662 | JP_CHRIP:
Cases of skin burns in humans have been documented (HSDB (2003), SITTING (5th ED 2008)), and the substance is classified into R34 by the EU. In addition, it is rated UN Subsidiary Risks 8 according to UN1717. Thus the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
R-PHRASE: R 34 Irritatin... | null | JP_CHRIP, NZ_CCID, US_HSDB | 3 | CC(=O)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.453B | J-GLOBAL | CC(=O)Cl | Train |
JP_CHRIP:
Dichloro(methy)lsilane
KR_NCIS:
Silane, dichloromethyl- | JP_CHRIP:
Dichloromethylsilane
Monomethyldichlorosilane
KR_NCIS:
Dichloro(methyl)silane; Dichlorohydridomethylsilicon; Dichloromethylsilane; Methyldichlorosilane; Methylsilicon dichloride | 75-54-7 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0046e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | JP_CHRIP:
There is a report that skin reaction was "severe" in a Draize test where 2 mg was applied to rabbits for 24-hour (IUCLID (2000)) and "highly corrosive" was produced in an animal test (IUCLID (2000)). In addition, there is a report of "causes severe skin burns for human" (HSDB (2006)). The substance was classi... | null | JP_CHRIP, KR_NCIS | 2 | C[SiH](Cl)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J44.081G | J-GLOBAL | C[SiH](Cl)Cl | Train |
EU_REACH:
2-methyloxirane | null | 75-56-9 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16091/7/4/2/?documentUUID=34c8823d-505b-4d14-ab3d-6aab8298c9f8 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1CO1 | https://pubchem.ncbi.nlm.nih.gov/compound/6378 | PubChem | CC1CO1 | Train |
NZ_CCID:
Cyclohexanamine, N-cyclohexyl-N-methyl- | null | 7560-83-0 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/027576ED-75F0-4AA4-9ECB-B0FFBFBBE43C | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CN(C1CCCCC1)C2CCCCC2 | https://pubchem.ncbi.nlm.nih.gov/compound/24210 | PubChem | CN(C1CCCCC1)C1CCCCC1 | Train |
EU_REACH:
1,1,1,3,4,4,4-heptafluoro-3-(trifluoromethyl)butan-2-one | null | 756-12-7 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31606/7/4/2/?documentUUID=989d47b9-2232-4492-8361-4f8f0714d755 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(=O)(C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F | https://pubchem.ncbi.nlm.nih.gov/compound/14175377 | PubChem | O=C(C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F | Train |
EU_REACH:
1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)pentan-3-one | null | 756-13-8 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19473/7/4/2/?documentUUID=db9c868f-5288-4658-a437-4579282d50bc | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(=O)(C(C(F)(F)F)(C(F)(F)F)F)C(C(F)(F)F)(F)F | https://pubchem.ncbi.nlm.nih.gov/compound/2782408 | PubChem | O=C(C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F | Train |
NZ_CCID:
2-Propanamine, 2-methyl- | NZ_CCID:
1,1-Dimethylethanamine, 1,1-Dimethylethylamine, 2-Amino-2-methylpropane, 2-Aminoisobutane, 2-Methyl-2-aminopropane, 2-Methyl-2-propanamine, Erbumine, Trimethylaminomethane, t-Butylamine, tert-Butylamine | 75-64-9 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E180BC1B-115A-4245-9914-88E350ADAEC1 | NZ_CCID:
Skin Irritation
UN CLASS: Packing Group II
Eye Irritation
R PHRASE: R 35 [Company Data] | null | NZ_CCID | 1 | CC(C)(C)N | https://pubchem.ncbi.nlm.nih.gov/compound/6385 | PubChem | CC(C)(C)N | Train |
JP_CHRIP:
tert-Butyl mercaptan | JP_CHRIP:
Benzenemethanethiol
tert-Butyl mercaptan | 75-66-1 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-0024e.html | JP_CHRIP:
As for a 4-hour application in skin irritation tests (corresponding to OECD TG 404 and OPPTS 870.2500), it is reported that it was mildly irritating (SIDS (2012)) and that it was not irritating (ECHA registration dossier (Access on December 2017)). Also, there are descriptions that mild irritation was observe... | Provided | JP_CHRIP | 1 | CC(C)(C)S | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.161K | J-GLOBAL | CC(C)(C)S | Train |
JP_CHRIP:
methanesulphonic acid
KR_NCIS:
Methanesulfonic acid
NZ_CCID:
Methanesulphonic acid | JP_CHRIP:
Methanesulfonic acid | 75-75-2 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0138e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/69F8BEA0-B5E3-4FB8-A93E-7E368E23BB5C | JP_CHRIP:
Since it is documented that in an irritation test with 1-h exposure to mouse skin, it was corrosive (PATTY (5th, 2001)), and in an irritation test using guinea pigs, it resulted in numerous small lesions resembling acid burns (PATTY (5th, 2001)), the substance was classified into Category 1.
NZ_CCID:
Skin Ir... | null | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | CS(=O)(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.465F | J-GLOBAL | CS(=O)(=O)O | Train |
EU_REACH:
3-[(3-sulfanylpropanoyl)oxy]-2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})propyl 3-sulfanylpropanoate | null | 7575-23-7 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10120/7/4/2/?documentUUID=433dcae7-1400-4bc4-a1cc-26a3c7fd1ed8 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(CS)C(=O)OCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS | https://pubchem.ncbi.nlm.nih.gov/compound/82056 | PubChem | O=C(CCS)OCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS | Train |
EU_REACH:
tetramethylsilane | null | 75-76-3 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14468/7/4/2/?documentUUID=0aeb8566-8767-4249-b76c-989d33775d5d | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[Si](C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/6396 | PubChem | C[Si](C)(C)C | Train |
JP_CHRIP:
Chlorotrimethylsilane
NZ_CCID:
Silane, chlorotrimethyl- | JP_CHRIP:
chlorotrimethylsilane
Chlorotrimethylsilicane
Trimethyl silyl chloride
NZ_CCID:
Monochlorotrimethylsilicon, Trimethylsilyl chloride | 75-77-4 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0058e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0036D01A-4B62-4627-B792-16E149A31F1B | JP_CHRIP:
There is a report of "Necrosis, accompanied by severe erythema, moderate edema, and desquamation was observed within 1-hour after application of 0.5 mL to the skin of rabbits for 4-hour. The effects persisted through 1-week observation period. Although the skin primary irritation index was 2.2/8.0 (HSDB (2007... | null | JP_CHRIP, NZ_CCID | 2 | C[Si](C)(C)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.466D | J-GLOBAL | C[Si](C)(C)Cl | Train |
JP_CHRIP:
Dichloro(dimethyl)silane
NZ_CCID:
Silane, dichlorodimethyl- | JP_CHRIP:
Chlorodimethylsilane
NZ_CCID:
Dichlorodimethyl silane, Dimethyldichlorosilane | 75-78-5 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0054e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FD91E8A4-D757-4E4A-BE6C-F879266F2EA1 | JP_CHRIP:
Based on a result of "corrosive" in a rabbit test (IUCLID (2002)) and "contact with liquid causes severe burns of the skin" (HSDB (2002)), the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
Based on sub risk 8 PG II [UNTDGMR]
Eye Irritation
SPECIES: Rabbit
RESULT: Corrosive. Severe damage... | null | JP_CHRIP, NZ_CCID | 2 | C[Si](C)(Cl)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.467B | J-GLOBAL | C[Si](C)(Cl)Cl | Train |
JP_CHRIP:
Trichloro(methyl)silane
NZ_CCID:
Silane, trichloromethyl- | JP_CHRIP:
Trichloromethylsilane
NZ_CCID:
Methyltrichlorosilane, Trichloromethylsilane, trichloro(methyl)silane | 75-79-6 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0057e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A46368C7-36B8-4DA8-8F19-FA7CB121916A | JP_CHRIP:
Based on a result of "corrosive" in a rabbit test (IUCLID (2000)) and "causes severe skin burns" as a human health effects (HSDB (2007)), the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into Xi: R36/37/38 (EU-Annex I (access on Aug. 2009... | null | JP_CHRIP, NZ_CCID | 2 | C[Si](Cl)(Cl)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.325J | J-GLOBAL | C[Si](Cl)(Cl)Cl | Train |
AU_HCIS:
Hydroperoxide, 1,1-dimethylethyl
JP_CHRIP:
tert-Butyl hydroperoxide
NZ_CCID:
Hydroperoxide, 1,1-dimethylethyl, 70% aqueous solution
US_HSDB:
tert-Butyl hydroperoxide | AU_HCIS:
tert-butyl hydroperoxide
1,1-dimethylethyl hydroperoxide
2-hydroperoxy-2-methylpropane
Perbutyl H
TBHP
JP_CHRIP:
tert-Butyl-hydroperoxide
1,1-Dimethylethylhydroxiperoxide
2-Hydroperoxy-2-methylpropane
Hydroperoxide, 1,1-dimethylethyl
tert-Butyl hydroperoxide
tert-Butylhydroperoxide
NZ_CCID:
tert-Butyl hydrop... | 75-91-2 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5493
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2058e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DB51077E-DE08-40B3-A86A-0BB623CA787F
US_HSDB: https://p... | JP_CHRIP:
Based on reports that in skin irritation tests with rabbits, corrosivity or severe irritation with necrosis was observed in all of the three tests (EU-RAR (2006)), it was classified in Category 1.
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT: Corrosive
REFERENCE SOURCE: RCO Chemical Europe, Inc. Maidenhea... | null | AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB | 4 | CC(C)(C)OO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.397C | J-GLOBAL | CC(C)(C)OO | Train |
JP_CHRIP:
Trichloro(vinyl)silane
NZ_CCID:
Trichlorovinylsilane | null | 75-94-5 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0019e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40A9A9DD-3785-4F8C-8299-664C8EB71466 | JP_CHRIP:
Based on reports of "corrosive" in a skin primary irritation test with rabbits (IUCLID (2000)), and "corrosive" in another test with rabbits (IUCLID (2000)), the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into C; R34.
NZ_CCID:
Skin Irr... | null | JP_CHRIP, NZ_CCID | 2 | Cl[Si](Cl)(Cl)C=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.505K | J-GLOBAL | C=C[Si](Cl)(Cl)Cl | Train |
JP_CHRIP:
3,4-Dichloro-1-butene | JP_CHRIP:
3,4-dichloro-1-butene | 760-23-6 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0047e.html | JP_CHRIP:
In the 4-hour rabbit test (OECD TG404, GLP-compliant), application of 0.5 ml of the undiluted test substance for three animals caused slightly irritating with erythema (grade 1 or 2) until 72 hours after removal of patch in all animals. And the mean scores of erythema or edema at 24, 48 and 72 hours after rem... | Provided | JP_CHRIP | 1 | ClCC(Cl)C=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.728K | J-GLOBAL | C=CC(Cl)CCl | Train |
NZ_CCID:
Trichloroacetyl chloride | null | 76-02-8 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FADD646-63DF-407C-B5F3-A800A3525013 | NZ_CCID:
Skin Irritation
R PHRASE: R 35 [Company Data]
Eye Irritation
R PHRASE: R 35 [Company Data] | null | NZ_CCID | 1 | C(=O)(C(Cl)(Cl)Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/6420 | PubChem | O=C(Cl)C(Cl)(Cl)Cl | Train |
AU_HCIS:
TCA (ISO)
JP_CHRIP:
Trichloroacetic acid
KR_NCIS:
Trichloroacetic acid
NZ_CCID:
Trichloroacetic acid | JP_CHRIP:
Aceto-caustin
TCA
Trichloroethanoic acid
NZ_CCID:
Aceto-caustin, Acetic acid, trichloro-, TCA, Trichloracetic acid, Trichloroacetate, Trichloroethanoic acid | 76-03-9 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4337
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2011e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-in... | JP_CHRIP:
There is a result of corrosive to the skin of rabbits (SIDS (access on April. 2009)). In another rabbit test, there are results of "slight irritation" after application of 0.21 mg and "severe irritation" after application of 3.5 mg (BUA 167 (1995)). Additionally, it has been reported that depending upon conce... | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID | 4 | OC(=O)C(Cl)(Cl)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.400G | J-GLOBAL | O=C(O)C(Cl)(Cl)Cl | Train |
JP_CHRIP:
Trifluoroacetic acid
NZ_CCID:
Trifluoroacetic acid | JP_CHRIP:
Acetic acid, trifluoro-
Perfluoroacetic acid | 76-05-1 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0142e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C6566382-DE45-45E2-805C-FDC81EB750CD | JP_CHRIP:
From the information that this substance has a pH of 1 (10 g/L) (GESTIS (Access on Nov. 2011)), it was classified in Category 1.
Besides, it is classified in C; R35 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
NZ_CCID:
Skin Irritation
R PHRASE: R 35 [Company Data]
Eye Irritation
R PHRASE: R 35... | null | JP_CHRIP, NZ_CCID | 2 | OC(=O)C(F)(F)F | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.401E | J-GLOBAL | O=C(O)C(F)(F)F | Train |
JP_CHRIP:
2-Ethylhexanoyl chloride | JP_CHRIP:
2-Ethylhexanoyl chloride | 760-67-8 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0035e.html | JP_CHRIP:
It was classified in Category 1 from a result as "corrosive" in a test using rabbits (OECD TG404, GLP compliance) (IUCLID (2000)).
Besides, another rabbit test reports that necrosis was observed 72 hours and 7 days after application (Directive 84/449/EEC B.4, GLP compliance) (IUCLID (2000)). | Provided | JP_CHRIP | 1 | CCCCC(CC)C(=O)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.162C | J-GLOBAL | CCCCC(CC)C(=O)Cl | Train |
EU_REACH:
2-propynyl-butylcarbamate | null | 76114-73-3 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12315/7/4/2/?documentUUID=1045670c-9e91-4b66-b0f6-a791a27ab2ab | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCNC(=O)OCC#C | https://pubchem.ncbi.nlm.nih.gov/compound/10877354 | PubChem | C#CCOC(=O)NCCCC | Train |
EU_REACH:
616-307-3 | null | 76205-19-1 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27100/7/4/2/?documentUUID=f1cd3aee-6590-4a76-8280-f69d1845acc2 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC(=CC=C1N2C=CC(=O)N2)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/11356026 | PubChem | O=c1ccn(-c2ccc(Cl)cc2)[nH]1 | Train |
EU_REACH:
decanoyl decaneperoxoate | null | 762-12-9 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5297/7/4/2/?documentUUID=692adb48-9c50-4adc-ba00-250cabbe0b6f | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCCCCCCC(=O)OOC(=O)CCCCCCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/69802 | PubChem | CCCCCCCCCC(=O)OOC(=O)CCCCCCCCC | Train |
NZ_CCID:
2-Chloropropionyl chloride | null | 7623-09-8 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6CA10ED-7755-47ED-9907-FA0539BCF9A9 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC(C(=O)Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/111019 | PubChem | CC(Cl)C(=O)Cl | Train |
NZ_CCID:
Dimethyl acetylenedicarboxylate | null | 762-42-5 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D464ACD-E0FD-47CF-9100-162F5EC966AB | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | COC(=O)C#CC(=O)OC | https://pubchem.ncbi.nlm.nih.gov/compound/12980 | PubChem | COC(=O)C#CC(=O)OC | Train |
EU_REACH:
(2R,3R,4R,5S)-6-(dimethylamino)hexane-1,2,3,4,5-pentol | null | 76326-99-3 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18179/7/4/2/?documentUUID=c3191a12-02d1-4a9a-8bdf-b433b2dcdc05 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CN(C)C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O | https://pubchem.ncbi.nlm.nih.gov/compound/11564307 | PubChem | CN(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO | Train |
JP_CHRIP:
2-Butene, 1,4-dichloro-
NZ_CCID:
2-Butylene dichloride | JP_CHRIP:
1,4-Dichloro-2-butene
NZ_CCID:
2-Butene, 1,4-dichloro- | 764-41-0 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2029e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8338B2DC-1229-4D51-8042-BD9984B882A8 | JP_CHRIP:
The treatment of the forearms of human volunteers for 0.5 to 1 hour with the undiluted substance caused marked erythema, edema, and development of blisters (SIDS (2006)). Liquid and vapors of the substance caused extremely corrosive to human skin (SIDS (2006)). Based on the information, the substance was clas... | null | JP_CHRIP, NZ_CCID | 2 | ClCC=CCCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.024D | J-GLOBAL | ClCC=CCCl | Train |
EU_REACH:
N-(2-hydroxyethyl)prop-2-enamide | null | 7646-67-5 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33694/7/4/2/?documentUUID=2421b2c3-50e9-41e4-8cb7-4d92c5aee492 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C=CC(=O)NCCO | https://pubchem.ncbi.nlm.nih.gov/compound/193628 | PubChem | C=CC(=O)NCCO | Train |
NZ_CCID:
Nonanoyl chloride | null | 764-85-2 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0C514427-0911-4AD2-ADAB-0567AF3C7B63 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCCCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/69819 | PubChem | CCCCCCCCC(=O)Cl | Train |
EU_REACH:
{2-[2-(ethenyloxy)ethoxy]ethoxy}ethene | null | 764-99-8 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11118/7/4/2/?documentUUID=32175c7c-fc1f-406c-97df-777b04a22f58 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C=COCCOCCOC=C | https://pubchem.ncbi.nlm.nih.gov/compound/12998 | PubChem | C=COCCOCCOC=C | Train |
EU_REACH:
3,6,9,12-tetraoxatetradeca-1,13-diene | null | 765-12-8 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10352/7/4/2/?documentUUID=b60d6f4a-929a-4b14-9ac3-b0dc6316c185 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C=COCCOCCOCCOC=C | https://pubchem.ncbi.nlm.nih.gov/compound/3033992 | PubChem | C=COCCOCCOCCOC=C | Train |
NZ_CCID:
Cyclopropylamine | null | 765-30-0 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/70475B82-FDF8-48BE-B608-87FF41C4A025 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1CC1N | https://pubchem.ncbi.nlm.nih.gov/compound/69828 | PubChem | NC1CC1 | Train |
EU_REACH:
2-ethylhexyl 2-sulfanylacetate
JP_CHRIP:
2-Ethylhexyl thioglycolate | JP_CHRIP:
2-ethylhexyl mercaptoacetate
2-Ethylhexyl mercaptoacetate; 2-Ethylhexyl mercaptoacetate; 2-Ethylhexyl thioglycolate
2-ethylhexyl thioglycolate | 7659-86-1 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13385/7/4/2/?documentUUID=0c3d17b1-e1c3-47f4-a848-27c7dfe0185d
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0147e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
In the rabbit test (OECD TG404, GLP-compliant), average scores of each 3 animals at 24, 48 and 72 hours after application were 1.3, 1.7, and 1.3 for erythema, 0.0, 0.0, and 0.3 for edema, respectively, and the symptoms were all reversible within 6 days and 3 da... | Provided | EU_REACH, JP_CHRIP | 2 | CCCCC(CC)COC(=O)CS | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.356A | J-GLOBAL | CCCCC(CC)COC(=O)CS | Train |
NZ_CCID:
Piperidine, 1-ethyl- | NZ_CCID:
1-Ethylpiperidine | 766-09-6 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A64BAB75-D32E-4AAC-92C9-AB79E3063A7F | NZ_CCID:
Skin Irritation
SPECIES:
RESULT: Severe burns.
REEFERENCE SOURCE: [MSDS]
Eye Irritation
SPECIES:
RESULT: Can cause severe burns leading to permanent damage.
REFERENCE SOURCE: [NJHS] | null | NZ_CCID | 1 | CCN1CCCCC1 | https://pubchem.ncbi.nlm.nih.gov/compound/13007 | PubChem | CCN1CCCCC1 | Train |
NZ_CCID:
1-(Bromomethyl)-3-chlorobenzene | null | 766-80-3 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/345D64EB-32AC-4074-BF1D-FD9424CAA2A3 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | C1=CC(=CC(=C1)Cl)CBr | https://pubchem.ncbi.nlm.nih.gov/compound/69838 | PubChem | Clc1cccc(CBr)c1 | Train |
EU_REACH:
2-(4-{4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butanoyl}phenyl)-2-methylpropanoic acid | null | 76811-98-8 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6505/7/4/2/?documentUUID=0d63ea2e-b63c-4474-b6a0-50146e9544ba | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)(C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/9935699 | PubChem | CC(C)(C(=O)O)c1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | Train |
NZ_CCID:
Chlorotriphenylsilane | NZ_CCID:
triphenylsilyl chloride | 76-86-8 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F47F505C-8984-4379-AA6C-596F759A9939 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC=C(C=C1)[Si](C2=CC=CC=C2)(C3=CC=CC=C3)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/6458 | PubChem | Cl[Si](c1ccccc1)(c1ccccc1)c1ccccc1 | Train |
EU_REACH:
bis(ethenyldimethylsilyl)amine | null | 7691-02-3 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5675/7/4/2/?documentUUID=d0eb5a4d-f291-4152-9581-3f75b0ccada4 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[Si](C)(C=C)N[Si](C)(C)C=C | https://pubchem.ncbi.nlm.nih.gov/compound/82126 | PubChem | C=C[Si](C)(C)N[Si](C)(C)C=C | Train |
NZ_CCID:
4-Nitrophenyl chloroformate | null | 7693-46-1 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/099E9397-8468-4947-93F2-7EC65102EF98 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC(=CC=C1[N+](=O)[O-])OC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/82129 | PubChem | O=C(Cl)Oc1ccc([N+](=O)[O-])cc1 | Train |
EU_REACH:
phenyl dichlorophosphate
NZ_CCID:
Phenyl dichlorophosphate | null | 770-12-7 | 1 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20440/7/4/2/?documentUUID=3eea564c-d01c-4e0a-86b8-5a2fa86332d3
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A45219D1-39BA-409F-8BC2-2399D99198F3 | EU_REACH:
Experimental study (OECD TG 404, GLP)
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | Provided | EU_REACH, NZ_CCID | 2 | C1=CC=C(C=C1)OP(=O)(Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/13038 | PubChem | O=P(Cl)(Cl)Oc1ccccc1 | Train |
JP_CHRIP:
1-Phenoxy-2-propanol | JP_CHRIP:
1-Phenoxy-2-propanol; 1-Phenoxy-2-propanol | 770-35-4 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0010e.html | JP_CHRIP:
It was classified as "Not classified" because no irritation was observed in a skin irritation test with rabbits according to OECD TG 404 (SIDS (2006)) | Provided | JP_CHRIP | 1 | CC(O)COc1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.817B | J-GLOBAL | CC(O)COc1ccccc1 | Train |
JP_CHRIP:
2-Amino-4-[hydroxy(methyl)phosphoryl]butanoic acid,ammonium salt; Glufosinate-ammonium | null | 77182-82-2 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0007e.html | JP_CHRIP:
[Rationale for the Classification]
It was classified as "Not classified" from (1), (2).
[Evidence Data]
(1) In skin irritation tests with rabbits on this substance by 24-hour semi-occlusive application or by methods according to OECD TG 404, only erythema was observed in part of the animals, and it was judge... | Provided | JP_CHRIP | 1 | CP(=O)(O)CCC(N)C(=O)O[N+] | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J309.363H | J-GLOBAL | CP(=O)(O)CCC(N)C(=O)O[N+] | Train |
NZ_CCID:
2,4,6-Trimethylbenzenesulphonyl chloride | NZ_CCID:
2-mesitylenesulfonyl chloride | 773-64-8 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/764121D3-2A9C-41D3-B105-3E3341407B5A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC1=CC(=C(C(=C1)C)S(=O)(=O)Cl)C | https://pubchem.ncbi.nlm.nih.gov/compound/13046 | PubChem | Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1 | Train |
NZ_CCID:
2-Bromo-4-nitrotoluene | null | 7745-93-9 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/034186FF-9449-4B71-8A52-32ACE8E33682 | null | null | NZ_CCID | 1 | CC1=C(C=C(C=C1)[N+](=O)[O-])Br | https://pubchem.ncbi.nlm.nih.gov/compound/82189 | PubChem | Cc1ccc([N+](=O)[O-])cc1Br | Train |
JP_CHRIP:
Hexachlorocyclopentadiene
KR_NCIS:
Hexachlorocyclopentadiene | JP_CHRIP:
1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene
1,2,3,4,5,5-Hexachlorocyclopenta-1,3-diene
HCCPD
Hexachlorocyclopentadiene
Perchlorocyclopentadiene
KR_NCIS:
Perchlorocyclopentadiene; Hexachloro-1,3-cyclopentadiene; 1,2,3,4,5,5-Hexachloro-1,3-Cyclopentadiene; Graphlox | 77-47-4 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2086e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | JP_CHRIP:
In a skin irritation test with rabbits, it was found corrosive in tests in which the undiluted liquid or a 10% aqueous solution of this substance was applied (EU-RAR (2007)). In addition, there are reports that it was also found corrosive in a test in which 40-90% aqueous solutions of this substance were appl... | null | JP_CHRIP, KR_NCIS | 2 | ClC1=C(Cl)C(Cl)(Cl)C(=C1Cl)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.949F | J-GLOBAL | ClC1=C(Cl)C(Cl)(Cl)C(Cl)=C1Cl | Train |
NZ_CCID:
1,3-Dibromo-5,5-dimethylhydantoin | null | 77-48-5 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E81547F1-5A68-4290-B24C-239E70B42266 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC1(C(=O)N(C(=O)N1Br)Br)C | https://pubchem.ncbi.nlm.nih.gov/compound/6479 | PubChem | CC1(C)C(=O)N(Br)C(=O)N1Br | Train |
EU_REACH:
(2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate | null | 77501-63-4 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6560/7/4/2/?documentUUID=f46e7653-b19a-43ec-9bd8-8269c371f3a5 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC(=O)C(C)OC(=O)C1=C(C=CC(=C1)OC2=C(C=C(C=C2)C(F)(F)F)Cl)[N+](=O)[O-] | https://pubchem.ncbi.nlm.nih.gov/compound/62276 | PubChem | CCOC(=O)C(C)OC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-] | Train |
EU_REACH:
2-methylprop-1-ene | null | 7756-94-7 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5319/7/4/2/?documentUUID=6faff624-dd19-4b52-8885-d83a809ec126 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=CC(C)(C)CC(C)(C)C)C | https://pubchem.ncbi.nlm.nih.gov/compound/170244 | PubChem | CC(C)=CC(C)(C)CC(C)(C)C | Train |
EU_REACH:
2-{[2-hydroxy-5-methyl-3-(1-methylcyclohexyl)phenyl]methyl}-4-methyl-6-(1-methylcyclohexyl)phenol | null | 77-62-3 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22349/7/4/2/?documentUUID=178e25f8-8a7c-473e-b701-7683ea2399f5 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CC(=C(C(=C1)C2(CCCCC2)C)O)CC3=C(C(=CC(=C3)C)C4(CCCCC4)C)O | https://pubchem.ncbi.nlm.nih.gov/compound/6486 | PubChem | Cc1cc(Cc2cc(C)cc(C3(C)CCCCC3)c2O)c(O)c(C2(C)CCCCC2)c1 | Train |
NZ_CCID:
Bromodiphenylmethane | NZ_CCID:
diphenylmethyl bromide | 776-74-9 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/58B7B1D2-6879-44BB-820A-E3BD64346A5F | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC=C(C=C1)C(C2=CC=CC=C2)Br | https://pubchem.ncbi.nlm.nih.gov/compound/236603 | PubChem | BrC(c1ccccc1)c1ccccc1 | Train |
EU_REACH:
3-butyl-1-[4-({4-[(butylcarbamoyl)amino]phenyl}methyl)phenyl]urea | null | 77703-56-1 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13359/7/4/2/?documentUUID=f924baf8-521f-4986-a8ba-b7b61f3f1b7e | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCNC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)NCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/3576105 | PubChem | CCCCNC(=O)Nc1ccc(Cc2ccc(NC(=O)NCCCC)cc2)cc1 | Train |
EU_REACH:
tris(2-methylnonacosyl) phosphite | null | 77745-66-5 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14205/7/4/2/?documentUUID=b6cc35a4-48f7-4316-be66-9eee5733f8a6 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)OCCCCCCCCCCC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/22630279 | PubChem | CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)OCCCCCCCCCCC(C)C | Train |
NZ_CCID:
Phosphorodichloridic acid, 4-nitrophenyl ester | null | 777-52-6 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EC33D186-2158-4A4A-9BB4-3B32CA997777 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | C1=CC(=CC=C1[N+](=O)[O-])OP(=O)(Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/69898 | PubChem | O=[N+]([O-])c1ccc(OP(=O)(Cl)Cl)cc1 | Train |
JP_CHRIP:
Divinyl sulfone
NZ_CCID:
Divinyl sulphone | JP_CHRIP:
Divinyl sulfone
NZ_CCID:
vinyl sulfone | 77-77-0 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0143e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/497E866C-E77A-4D92-AA8F-953927ECFC90 | JP_CHRIP:
The substance was classified as Category 1 based on the document that application of the substance to rabbit skin caused necrosis (PATTY, 5th (2001)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | C=CS(=O)(=O)C=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.478H | J-GLOBAL | C=CS(=O)(=O)C=C | Train |
AU_HCIS:
dimethyl sulphate
JP_CHRIP:
Dimethyl sulfate
KR_NCIS:
Dimethyl sulfate
NZ_CCID:
Dimethyl sulphate | AU_HCIS:
dimethyl sulfate
JP_CHRIP:
Dimethyl sulfate
Dimethyl monosulfate
dimethyl sulphate
DMS
Sulfuric acid dimethyl ester
Sulfuric acid, dimethyl ester
KR_NCIS:
Sulfuric acid dimethyl ester
NZ_CCID:
Dimethyl monosulfate, Methyl sulfate, Sulfuric acid, dimethyl ester | 77-78-1 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1420
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0619e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-in... | JP_CHRIP:
Based on descriptions that it has strong irritative and corrosive effect on human skin (CERI Hazard Data (1999)) and that necrosis was seen in rabbit skin application test (CERI Hazard Data (1999), EU-RAR (2002)), it was classified as Category 1A-1C.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye... | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID | 4 | COS(=O)(=O)OC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.823A | J-GLOBAL | COS(=O)(=O)OC | Train |
NZ_CCID:
Hexahydro-1,3,5-triethyl-s-triazine | null | 7779-27-3 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2A03FCDE-A27E-4EAC-9C76-BFFF220AB917 | NZ_CCID:
Skin Irritation
R PHRASE: R 35 [Company Data]
Eye Irritation
R PHRASE: R 41[Company Data] | null | NZ_CCID | 1 | CCN1CN(CN(C1)CC)CC | https://pubchem.ncbi.nlm.nih.gov/compound/24512 | PubChem | CCN1CN(CC)CN(CC)C1 | Train |
EU_REACH:
2,2'-[Ethylenebis(oxyphenyl-2,1-eneazo)]bis[N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutyramide | null | 77804-81-0 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14248/7/4/2/?documentUUID=76110feb-15db-4282-93c7-3797a77f89a0 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=O)C(C(=O)NC1=CC2=C(C=C1)NC(=O)N2)N=NC3=CC=CC=C3OCCOC4=CC=CC=C4N=NC(C(=O)C)C(=O)NC5=CC6=C(C=C5)NC(=O)N6 | https://pubchem.ncbi.nlm.nih.gov/compound/166497 | PubChem | CC(=O)C(N=Nc1ccccc1OCCOc1ccccc1N=NC(C(C)=O)C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1)C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1 | Train |
EU_REACH:
dichloro(3-chloropropyl)methylsilane | null | 7787-93-1 | 1 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11206/7/4/2/?documentUUID=178ecaf1-0774-4a73-a85f-6b56f501b26a | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[Si](CCCCl)(Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/82235 | PubChem | C[Si](Cl)(Cl)CCCCl | Train |
EU_REACH:
2-chloro-1-fluoro-4-(trifluoromethyl)benzene | null | 78068-85-6 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27506/7/4/2/?documentUUID=209cd6c1-58e0-43fa-aa20-43da89c1374b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC(=C(C=C1C(F)(F)F)Cl)F | https://pubchem.ncbi.nlm.nih.gov/compound/157153 | PubChem | Fc1ccc(C(F)(F)F)cc1Cl | Train |
JP_CHRIP:
Triethyl phosphate | JP_CHRIP:
Ethyl phosphate
TEP
Triethoxyphosphine oxide
Triethyl phosphate | 78-40-0 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0109e.html | JP_CHRIP:
Moderate irritation was noted in 1 of 3 tested animals in the animal experiment (OECD TG 404, GLP-compliant), but SIDS concluded that the substance was not a skin irritant in accordance with guideline (SIDS (Access on Nov. 2010)). The substance caused slight irritation to guinea pig, but caused non irritation... | Provided | JP_CHRIP | 1 | CCOP(=O)(OCC)OCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.406F | J-GLOBAL | CCOP(=O)(OCC)OCC | Train |
EU_REACH:
6-(4-methylbenzenesulfonamido)hexanoic acid | null | 78521-39-8 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5536/7/4/2/?documentUUID=92b56796-fdb7-4e50-be01-6ce73a576bc0 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CC=C(C=C1)S(=O)(=O)NCCCCCC(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/95822 | PubChem | Cc1ccc(S(=O)(=O)NCCCCCC(=O)O)cc1 | Train |
JP_CHRIP:
2,2'-Azobisisobutyronitrile | JP_CHRIP:
2,2'-Azobis(2-methylpropanenitrile)
2,2'-Azobisisobutyronitrile | 78-67-1 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0024e.html | JP_CHRIP:
There is a description that in the skin irritation test (OECD TG 404), as a result of a 4-hour semi-occlusive application of 500 mg of this substance to rabbits, no irritation was observed (SIDS (2002), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). Other than this, there is a report that no irrita... | Provided | JP_CHRIP | 1 | CC(C)(N=NC(C)(C)C#N)C#N | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.955K | J-GLOBAL | CC(C)(C#N)N=NC(C)(C)C#N | Train |
EU_REACH:
2-{4'-[difluoro(3,4,5-trifluorophenoxy)methyl]-3',5'-difluoro-[1,1'-biphenyl]-4-yl}-5-ethyloxane | null | 787582-75-6 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30133/7/4/2/?documentUUID=c0c81aef-3001-4edb-a95e-6502de724a6b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCC1CCC(OC1)C2=CC=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F | https://pubchem.ncbi.nlm.nih.gov/compound/58995748 | PubChem | CCC1CCC(c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)cc2)OC1 | Train |
JP_CHRIP:
2-Bromobutane | JP_CHRIP:
2-Bromobutane | 78-76-2 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2068e.html | JP_CHRIP:
Based on a report that erythema and edema were seen after the application of this substance in a rabbit skin irritation test (OECD TG 404-compliant) and the skin primary irritation index was 2.44 (erythema 1.78, edema 0.66) (ECETOC TR 66 (1995)), it was classified as "Not classified" (Category 3 in UN GHS cla... | Provided | JP_CHRIP | 1 | CCC(C)Br | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.481H | J-GLOBAL | CCC(C)Br | Train |
JP_CHRIP:
Isobutylamine
KR_NCIS:
Isobutylamine | JP_CHRIP:
1-Amino-2-methylpropane
2-Methyl-1-propanamine
2-Methylpropylamine
KR_NCIS:
1-Amino-2-methylpropane; 1-Propanamine, 2-methyl-; 2-Methyl-1-aminopropane; 2-Methyl-1-propanamine; 2-Methylpropan-1-amine; 2-Methylpropanamine; 2-Methylpropylamine; 3-Methyl-2-propylamine | 78-81-9 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0008e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | JP_CHRIP:
It was classified in Category 1 because it was judged that exposure causes irreversible damage to skin from a description as "skin contact can result in erythema and blistering" (PATTY (5th, 2001)), and a description as "a powerful irritant to skin, eyes and mucous membrane" accompanied by pain, redness, and ... | null | JP_CHRIP, KR_NCIS | 2 | CC(C)CN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J46.573I | J-GLOBAL | CC(C)CN | Train |
JP_CHRIP:
Isobutyraldehyde | JP_CHRIP:
2-Methyl-1-propanal
2-Methylpropanal
Isobutanal
isobutylaldehyde | 78-84-2 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2006e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1) and (2), it was classified as "Not classified." Besides, because (3)-(5) are data in 1952, and the test details are unknown, and (6) is information from ICSC, these were not adopted for classification.
[Evidence Data]
(1) There is a report that in a skin irrita... | Provided | JP_CHRIP | 1 | CC(C)C=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.483D | J-GLOBAL | CC(C)C=O | Train |
JP_CHRIP:
2-Methyl-2-propenal
KR_NCIS:
2-Methyl-2-propenal | JP_CHRIP:
2-Methyl-2-propenal
Isobutenal
Methacrolein | 78-85-3 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0065e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | JP_CHRIP:
In rabbit test (OECD TG404), 4-hour application of 0.5 mL produced moderate erythema and oedema and skin primary irritation index was 4.11. Blanching was observed from day 3 and necrosis was observed from day 9 and persisted to the end of the observation period (ECETOC TR 66 (1995)). The substance was classif... | Provided | JP_CHRIP, KR_NCIS | 2 | CC(=C)C=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.484B | J-GLOBAL | C=C(C)C=O | Train |
JP_CHRIP:
1,2-Propanediamine
NZ_CCID:
1,2-Diaminopropane | JP_CHRIP:
1,2-Diaminopropane
1,2-Propanediamine
NZ_CCID:
1,2-propylenediamine | 78-90-0 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0128e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6501D508-797D-4E37-8053-90046273E16F | JP_CHRIP:
There are results of "corrosive" in a rabbit test by occluded dermal application of 500 microL for 24-hour (IUCLID (2000)) and "corrosive" in another rabbit test by dermal application of undiluted substance for 15 min (IUCLID (2000)). The substance is classified into C; R35 in EU classification (EU-Annex I (a... | null | JP_CHRIP, NZ_CCID | 2 | CC(N)CN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.225K | J-GLOBAL | CC(N)CN | Train |
JP_CHRIP:
2-Butanol | JP_CHRIP:
1-Methyl propanol
2-Butanol
Butylene hydrate
Methyl ethyl carbinol
sec-Butyl alcohol | 78-92-2 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2080e.html | JP_CHRIP:
There is a report that in a skin irritation test (OECD TG 404) with rabbits, the primary irritation score was 0, and it was not irritating (SIDS (2012), ECETOC JACC (2003)), and there are descriptions that it was not irritating to the skin (EHC 65 (1987), ACGIH (2002), DFGOT vol. 19 (2003)), and that it was v... | Provided | JP_CHRIP | 1 | CCC(C)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.832K | J-GLOBAL | CCC(C)O | Train |
JP_CHRIP:
Methyl vinyl ketone
KR_NCIS:
Methyl vinyl ketone
NZ_CCID:
Methyl vinyl ketone | JP_CHRIP:
3-Buten-2-one
3-Butene-2-one
Methylene acetone
KR_NCIS:
1-Buten-3-one; 2-Butenone; 3-Buten-2-one; 3-Oxo-1-butene; 3-Oxobutene; Acetyl ethylene; Butenone; Methyl vinyl ketone; Methylene acetone
NZ_CCID:
1-Buten-3-one, 2-Butenone, 3-Buten-2-one, Butenone, Methylvinyl ketone, Methylvinylketone, Vinyl methyl ke... | 78-94-4 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2004e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40D0F8D4-93EA-4DF3-B988-BCCE7CE6866F | JP_CHRIP:
[Rationale for the Classification]
It was classified in Category 1 from (1) - (4).
[Evidence Data]
(1) This substance is a severe skin, eye, and respiratory tract irritant in humans and one of the more potent irritants of mucous membranes, particularly of the eye and respiratory tract (ACGIH (7th, 2001)).
(2... | null | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | CC(=O)C=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7H | J-GLOBAL | C=CC(C)=O | Train |
JP_CHRIP:
2-Propanone, 1-chloro-
NZ_CCID:
Chloroacetone | JP_CHRIP:
1-Chloro-2-propanone
Acetonyl chloride
Monochloroacetone
NZ_CCID:
1-Chloro-2-propanone, 1-Chloroacetone, 2-Propanone, 1-chloro-, 3-Chloro-2-propanone, Acetonyl chloride, Chloro-2-propanone, Chloromethyl methyl ketone, Chloropropanone, Monochloracetone, Monochloroacetone | 78-95-5 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0699e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78B28B2C-9C04-42F6-9710-F0EBB272887F | JP_CHRIP:
Based on statements that moderate to severe erythemas and edemas were observed on the rabbit (BUA 226 (2000)) and that this product indicates skin corrosivenesses (ICSC (J) (1996)), it was classified as Category 1A-1C.
NZ_CCID:
Skin Irritation
UN #1695 UN CLASS: 8 PG I
Eye Irritation
UN #1695 UN CLASS: 8 PG ... | null | JP_CHRIP, NZ_CCID | 2 | CC(=O)CCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.487G | J-GLOBAL | CC(=O)CCl | Train |
AU_HCIS:
2-Propanol, 1-amino-
JP_CHRIP:
1-aminopropan-2-ol; isopropanolamine
NZ_CCID:
Aminopropanol | AU_HCIS:
1-aminopropan-2-ol
isopropanolamine
JP_CHRIP:
1-aminopropan-2-ol
2-Propanol, 1-amino-
Isopropanolamine
Threamine
NZ_CCID:
1-Amino-2-hydroxypropane, 1-Amino-2-propanol, 1-Aminopropan-2-ol, 1-Methyl-2-aminoethanol, 2-Amino-1-methylethanol, 2-Hydroxy-1-propylamine, 2-Hydroxypropanamine, 2-Hydroxypropylamine, 2-... | 78-96-6 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3674
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0072e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB896F26-395E-4244-BFED-E1176F9F5452 | JP_CHRIP:
Exposure time of 15 minutes and longer to undiluted application to rabbit skin led to the development of necrosis (DFGOT (1998)), and in a DOT corrosivity test, the substance was classified as corrosive to the skin (DFGOT (1998)). Thus, it was classified into Category 1. As relevant information, the pH of its... | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | CC(O)CN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.961E | J-GLOBAL | CC(O)CN | Train |
EU_REACH:
4-(2-{4-[2-(3-cyanophenyl)ethenyl]phenyl}ethenyl)benzonitrile | null | 79026-02-1 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18823/7/4/2/?documentUUID=c6c46ec9-abee-4f2f-ad77-498d73cd9c9c | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC(=CC(=C1)C#N)/C=C/C2=CC=C(C=C2)/C=C/C3=CC=C(C=C3)C#N | https://pubchem.ncbi.nlm.nih.gov/compound/19982709 | PubChem | N#Cc1ccc(/C=C/c2ccc(/C=C/c3cccc(C#N)c3)cc2)cc1 | Train |
NZ_CCID:
Propionyl chloride
US_HSDB:
Propionyl chloride | null | 79-03-8 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1182FB1-AE66-44B5-A2C3-A4A429138564
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8374 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID, US_HSDB | 2 | CCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/62324 | PubChem | CCC(=O)Cl | Train |
JP_CHRIP:
Chloroacetyl chloride
KR_NCIS:
Chloroacetyl chloride
NZ_CCID:
Chloroacetyl chloride
US_HSDB:
Chloroacetyl chloride | JP_CHRIP:
2-chloroacetyl chloride
Chloroacetic acid chloride
Chloroacetyl chloride
Monochloroacetyl chloride
KR_NCIS:
2-Chloroacetyl chloride; Acetyl chloride, 2-chloro-; Acetyl chloride, chloro-; Chloroacetic Acid chloride; Chloroacetic chloride; Monochloroacetyl chloride
NZ_CCID:
Acetyl chloride, chloro-, Chloracet... | 79-04-9 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2037e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/304FEE4E-B4E4-48B6-A12A-480E0768125F
US_HSDB: https://pubch... | JP_CHRIP:
Based on a report that it was corrosive when the undiluted liquid of this substance was applied to rabbits for 24 hours (HSDB (Access on June 2014)), and on a description that this substance was corrosive to the skin (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Ha... | null | JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 4 | ClCC(=O)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.490G | J-GLOBAL | O=C(Cl)CCl | Train |
JP_CHRIP:
Bromoacetic acid
NZ_CCID:
Bromoacetic acid
US_HSDB:
Bromoacetic acid | JP_CHRIP:
Bromoacetic acid
NZ_CCID:
Acetic acid, bromo- | 79-08-3 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0027e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/21A01F8E-6D73-49DC-9FF1-77A9F4B830AF
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7627 | JP_CHRIP:
Based on a report of "Skin contact causes severe burns" (HSDB (2009)) and classification as R35 in EU classification (EU-Annex I (2009)), the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
REMARK: UN1938 class 8: PGII
Eye Irritation
EXPERT JUDGEMENT: Classified 8.3A on the basis of the 8.... | null | JP_CHRIP, NZ_CCID, US_HSDB | 3 | OC(=O)CBr | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.492C | J-GLOBAL | O=C(O)CBr | Train |
AU_HCIS:
propionic acid … %
JP_CHRIP:
Propionic acid
NZ_CCID:
Propionic acid | JP_CHRIP:
Ethanecarboxylic acid
Ethylformic acid
Methylacetic acid
Propanoic acid
NZ_CCID:
Carboxyethane, Ethanecarboxylic acid, Ethylformic acid, Luprosil, Metacetonic acid, Methyl acetic acid, Methylacetic acid, Monoprop, Propanoic acid, Prozoin, Pseudoacetic acid | 79-09-4 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3694
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2083e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/790EA423-1E34-4175-A6F2-661589F53EAA | JP_CHRIP:
Since after application of 0.5 mL of the undiluted liquid of this substance to guinea pigs, mild to moderate edema, moderate to severe erythema and necrosis were observed at 2 hours after application, and necrosis was observed after 24 and 48 hours, it is considered to be corrosive (SIDS (2008)). In addition,... | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | CCC(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.963A | J-GLOBAL | CCC(=O)O | Train |
AU_HCIS:
acrylic acid
EU_REACH:
prop-2-enoic acid
JP_CHRIP:
Acrylic acid
KR_NCIS:
2-Propenoic acid; Acrylic acid
NZ_CCID:
Acrylic acid
US_HSDB:
Acrylic acid | AU_HCIS:
prop-2-enoic acid
2-Propenoic acid
acroleic acid
glacial acrylic acid
ethylenecarboxylic acid
JP_CHRIP:
2-Propenoic acid
Acroleic acid
Ethylenecarboxylic acid
NZ_CCID:
2-Propenoic acid, Acroleic acid, Ethylenecarboxylic acid, Propenoic acid, Vinylformic acid | 79-10-7 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=93
EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15803/7/4/2/?documentUUID=a3ed58c4-466a-4606-8160-ab9d148aa4bf
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2001e.html
KR_NCIS: https://ncis.nier.... | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
There is a report that in a skin irritation test (OECD TG compliant) in which the undiluted liquid of this substance was applied semi-occlusively to rabbits for 3 minutes, superficial necrosis, slight edema, and discoloration were observed, and on histopatholog... | Provided | AU_HCIS, EU_REACH, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 6 | OC(=O)C=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.493A | J-GLOBAL | C=CC(=O)O | Train |
AU_HCIS:
chloroacetic acid
JP_CHRIP:
Chloroacetic acid [monochloroacetic acid]
KR_NCIS:
Chloroacetic acid
NZ_CCID:
Chloroacetic acid
US_HSDB:
Chloroacetic acid | JP_CHRIP:
Chloroethanoic acid
MCA
Monochloroacetic acid
KR_NCIS:
Chloracetic acid; alpha-Chloroacetic acid; Chloroethanoic acid; MCA; MCAA; MKhUK; Monochloroacetic acid; Monochloroethanoic acid; Acetic acid, chloro-
NZ_CCID:
Acetic acid, chloro-, Chloracetic acid, Chloroethanoic acid, Monochloracetic acid, Monochloro... | 79-11-8 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=911
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0051e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-inf... | JP_CHRIP:
This substance is strongly acidic (pH <1 at 800g/L, 20 degrees C, GESTIS (Access on July 2015)). It is reported that in a skin irritation test using rabbits that 2 animals died after 24-hour occlusive application with 500 mg, and severe erythema and edema were observed, and a primary dermal irritation index w... | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 5 | OC(=O)CCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.409K | J-GLOBAL | O=C(O)CCl | Train |
JP_CHRIP:
Hydroxyacetic acid
NZ_CCID:
Glycolic acid
US_HSDB:
HYDROXYACETIC ACID | JP_CHRIP:
Acetic acid, hydroxy-
Alpha-hydroxyacetic acid
Glycolic acid
hydroxyacetic acid
Hydroxyethanoic acid | 79-14-1 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0051e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/08614520-C000-418C-8BBA-8D63504D958E
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5227 | JP_CHRIP:
In skin irritation tests with rabbits on this substance of purity 99% (cosmetic grade) and a 70% aqueous solution of this substance (technical grade) (tests according to OECD TG404 or similar protocols, GLP-compliant), visible necrosis through the epidermis and into the dermis was observed after a 1-hour appl... | Provided | JP_CHRIP, NZ_CCID, US_HSDB | 3 | OCC(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.494J | J-GLOBAL | O=C(O)CO | Train |
EU_REACH:
N-methylacetamide | null | 79-16-3 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26228/7/4/2/?documentUUID=4f8331e4-3ec2-4692-b8d8-6d8e471fd4ba | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=O)NC | https://pubchem.ncbi.nlm.nih.gov/compound/6582 | PubChem | CNC(C)=O | Train |
AU_HCIS:
peracetic acid . . . %
JP_CHRIP:
Peroxyacetic acid | AU_HCIS:
peroxyacetic acid
acetic peroxide
acetyl hydroperoxide
estosteril
JP_CHRIP:
Acetyl hydroperoxide
Ethaneperoxoic acid | 79-21-0 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3414
JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2032.html | JP_CHRIP:
【分類根拠】
（１）～（３）より、区分1Aとした。なお、新たな知見に基づき、分類結果を変更した。
【根拠データ】
（１）本物質0.013％～0.34％溶液は非刺激性～軽度の刺激性物質であるが、3.4％以上の濃度で45分間以上適用した場合、ウサギの皮膚に腐食性影響を示した。5％溶液を3分間適用した場合は中程度～重度の刺激性がみられ、10％～40％溶液では3分以内に腐食性影響を示した（SIAR (2008)、AICIS IMAP (2013)）。
（２）ウサギを用いた皮膚刺激性試験（3分間適用、本物質10％溶液）において、腐食性影響がみられたとの報告がある（SIAR (2008)、AICIS IMAP (2013)... | null | AU_HCIS, JP_CHRIP | 2 | CC(=O)OO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.833I | J-GLOBAL | CC(=O)OO | Train |
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